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Colorectal Sarcoma

MedGen UID:
474464
•Concept ID:
C3272831
•
Neoplastic Process
Synonym: Large Intestinal Sarcoma

Definition

A malignant soft tissue neoplasm that arises from the colon or rectum. Representative examples include angiosarcoma, Kaposi sarcoma, and leiomyosarcoma. [from NCI]

Professional guidelines

PubMed

Treatment of Advanced BRAF-Mutated Colorectal Cancer: Where We Are and Where We Are Going.
Sun C, España S, Buges C, Layos L, Hierro C, Manzano JL
Clin Colorectal Cancer 2022 Jun;21(2):71-79. Epub 2022 Feb 3 doi: 10.1016/j.clcc.2022.01.009. PMID: 35277355
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer.
Zhu G, Pei L, Xia H, Tang Q, Bi F
Mol Cancer 2021 Nov 6;20(1):143. doi: 10.1186/s12943-021-01441-4. PMID: 34742312Free PMC Article
Pharmacokinetic and pharmacodynamic evaluation of panitumumab in the treatment of colorectal cancer.
Lo L, Patel D, Townsend AR, Price TJ
Expert Opin Drug Metab Toxicol 2015;11(12):1907-24. Epub 2015 Nov 16 doi: 10.1517/17425255.2015.1112787. PMID: 26572750

Recent clinical studies

Etiology

Definitive Local Consolidative Therapy for Oligometastatic Solid Tumors: Results From the Lead-in Phase of the Randomized Basket Trial EXTEND.
Sherry AD, Bathala TK, Liu S, Fellman BM, Chun SG, Jasani N, Guadagnolo BA, Jhingran A, Reddy JP, Corn PG, Shah AY, Kaiser KW, Ghia AJ, Gomez DR, Tang C
Int J Radiat Oncol Biol Phys 2022 Dec 1;114(5):910-918. Epub 2022 Jun 9 doi: 10.1016/j.ijrobp.2022.05.023. PMID: 35691448Free PMC Article
Stereotactic ablative radiation therapy for pulmonary metastases: Improving overall survival and identifying subgroups at high risk of local failure.
Pasalic D, Lu Y, Betancourt-Cuellar SL, Taku N, Mesko SM, Bagley AF, Chance WW, Allen PK, Tang C, Antonoff MB, Balter PA, Mehran RJ, Welsh JW, Liao Z, Gomez D, Erasmus JJ, Nguyen QN
Radiother Oncol 2020 Apr;145:178-185. Epub 2020 Feb 7 doi: 10.1016/j.radonc.2020.01.010. PMID: 32044530
Colorectal sarcoma: analysis of failure patterns.
Luna-Pérez P, Rodríguez DF, Luján L, Alvarado I, Kelly J, Rojas ME, Labastida S, González JL
J Surg Oncol 1998 Sep;69(1):36-40. doi: 10.1002/(sici)1096-9098(199809)69:1<36::aid-jso7>3.0.co;2-l. PMID: 9762889
Primary colorectal sarcoma. A retrospective review and prognostic factor study of 50 consecutive patients.
Meijer S, Peretz T, Gaynor JJ, Tan C, Hajdu SI, Brennan MF
Arch Surg 1990 Sep;125(9):1163-8. doi: 10.1001/archsurg.1990.01410210089014. PMID: 2400310

Diagnosis

NUTM1-rearranged colorectal sarcoma: a clinicopathologically and genetically distinctive malignant neoplasm with a poor prognosis.
Van Treeck BJ, Thangaiah JJ, Torres-Mora J, Stevens TM, Rothermundt C, Fassan M, Loupakis F, Diebold J, Hornick JL, Halling KC, Folpe AL
Mod Pathol 2021 Aug;34(8):1547-1557. Epub 2021 Mar 13 doi: 10.1038/s41379-021-00792-z. PMID: 33714983
Outcomes of Primary Colorectal Sarcoma: A National Cancer Data Base (NCDB) Review.
Thiels CA, Bergquist JR, Krajewski AC, Lee HE, Nelson H, Mathis KL, Habermann EB, Cima RR
J Gastrointest Surg 2017 Mar;21(3):560-568. Epub 2017 Jan 17 doi: 10.1007/s11605-016-3347-0. PMID: 28097468

Therapy

Definitive Local Consolidative Therapy for Oligometastatic Solid Tumors: Results From the Lead-in Phase of the Randomized Basket Trial EXTEND.
Sherry AD, Bathala TK, Liu S, Fellman BM, Chun SG, Jasani N, Guadagnolo BA, Jhingran A, Reddy JP, Corn PG, Shah AY, Kaiser KW, Ghia AJ, Gomez DR, Tang C
Int J Radiat Oncol Biol Phys 2022 Dec 1;114(5):910-918. Epub 2022 Jun 9 doi: 10.1016/j.ijrobp.2022.05.023. PMID: 35691448Free PMC Article
Stereotactic ablative radiation therapy for pulmonary metastases: Improving overall survival and identifying subgroups at high risk of local failure.
Pasalic D, Lu Y, Betancourt-Cuellar SL, Taku N, Mesko SM, Bagley AF, Chance WW, Allen PK, Tang C, Antonoff MB, Balter PA, Mehran RJ, Welsh JW, Liao Z, Gomez D, Erasmus JJ, Nguyen QN
Radiother Oncol 2020 Apr;145:178-185. Epub 2020 Feb 7 doi: 10.1016/j.radonc.2020.01.010. PMID: 32044530

Prognosis

NUTM1-rearranged colorectal sarcoma: a clinicopathologically and genetically distinctive malignant neoplasm with a poor prognosis.
Van Treeck BJ, Thangaiah JJ, Torres-Mora J, Stevens TM, Rothermundt C, Fassan M, Loupakis F, Diebold J, Hornick JL, Halling KC, Folpe AL
Mod Pathol 2021 Aug;34(8):1547-1557. Epub 2021 Mar 13 doi: 10.1038/s41379-021-00792-z. PMID: 33714983
Colorectal sarcoma: analysis of failure patterns.
Luna-Pérez P, Rodríguez DF, Luján L, Alvarado I, Kelly J, Rojas ME, Labastida S, González JL
J Surg Oncol 1998 Sep;69(1):36-40. doi: 10.1002/(sici)1096-9098(199809)69:1<36::aid-jso7>3.0.co;2-l. PMID: 9762889
Primary colorectal sarcoma. A retrospective review and prognostic factor study of 50 consecutive patients.
Meijer S, Peretz T, Gaynor JJ, Tan C, Hajdu SI, Brennan MF
Arch Surg 1990 Sep;125(9):1163-8. doi: 10.1001/archsurg.1990.01410210089014. PMID: 2400310

Clinical prediction guides

Definitive Local Consolidative Therapy for Oligometastatic Solid Tumors: Results From the Lead-in Phase of the Randomized Basket Trial EXTEND.
Sherry AD, Bathala TK, Liu S, Fellman BM, Chun SG, Jasani N, Guadagnolo BA, Jhingran A, Reddy JP, Corn PG, Shah AY, Kaiser KW, Ghia AJ, Gomez DR, Tang C
Int J Radiat Oncol Biol Phys 2022 Dec 1;114(5):910-918. Epub 2022 Jun 9 doi: 10.1016/j.ijrobp.2022.05.023. PMID: 35691448Free PMC Article
Outcomes of Primary Colorectal Sarcoma: A National Cancer Data Base (NCDB) Review.
Thiels CA, Bergquist JR, Krajewski AC, Lee HE, Nelson H, Mathis KL, Habermann EB, Cima RR
J Gastrointest Surg 2017 Mar;21(3):560-568. Epub 2017 Jan 17 doi: 10.1007/s11605-016-3347-0. PMID: 28097468
Primary colorectal sarcoma. A retrospective review and prognostic factor study of 50 consecutive patients.
Meijer S, Peretz T, Gaynor JJ, Tan C, Hajdu SI, Brennan MF
Arch Surg 1990 Sep;125(9):1163-8. doi: 10.1001/archsurg.1990.01410210089014. PMID: 2400310

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