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Non-Neoplastic Gallbladder Disorder

MedGen UID:
474613
•Concept ID:
C3272980
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the gallbladder. Representative examples include cholecystitis and adenomyomatosis. [from NCI]

Professional guidelines

PubMed

Ultrasound-based scoring system for differential diagnosis of polypoid lesions of the gallbladder.
Liu XS, Chen T, Gu LH, Guo YF, Li CY, Li FH, Wang J
J Gastroenterol Hepatol 2018 Jun;33(6):1295-1299. Epub 2018 Mar 9 doi: 10.1111/jgh.14080. PMID: 29280187
Updated clinical practice guidelines for the management of biliary tract cancers: revision concepts and major revised points.
Yoshitomi H, Miyakawa S, Nagino M, Takada T, Miyazaki M
J Hepatobiliary Pancreat Sci 2015 Apr;22(4):274-8. Epub 2015 Mar 18 doi: 10.1002/jhbp.234. PMID: 25783164
Clinical usefulness of endoscopic ultrasonography in the differential diagnosis of gallbladder wall thickening.
Kim HJ, Park JH, Park DI, Cho YK, Sohn CI, Jeon WK, Kim BI, Choi SH
Dig Dis Sci 2012 Feb;57(2):508-15. Epub 2011 Aug 31 doi: 10.1007/s10620-011-1870-0. PMID: 21879282

Recent clinical studies

Etiology

Preoperative prediction model for non-neoplastic and benign neoplastic polyps of the gallbladder.
Wang Y, Peng J, Liu K, Sun P, Ma Y, Zeng J, Jiang Y, Tan B, Cao J, Hu W
Eur J Surg Oncol 2024 Feb;50(2):107930. Epub 2023 Dec 27 doi: 10.1016/j.ejso.2023.107930. PMID: 38159390
Non-neoplastic Lesions of Gallbladder Among Cholecystectomy Specimens of a Tertiary Care Center: A Descriptive Cross-sectional Study.
Ghartimagar D, Shrestha MK, Jhunjhunwala A, Ghosh A, Thapa S, Regmi S, Talwar OP
JNMA J Nepal Med Assoc 2021 Oct 15;59(242):970-974. doi: 10.31729/jnma.5861. PMID: 35199708Free PMC Article
Non-neoplastic Polyps of the Gallbladder: A Clinicopathologic Analysis of 447 Cases.
Taskin OC, Bellolio E, Dursun N, Seven IE, Roa JC, Araya JC, Villaseca M, Tapia O, Vance C, Saka B, Balci S, Bagci P, Losada H, Sarmiento J, Memis B, Pehlivanoğlu B, Basturk O, Reid MD, Koshiol J, Cheng JD, Kapran Y, Adsay V
Am J Surg Pathol 2020 Apr;44(4):467-476. doi: 10.1097/PAS.0000000000001405. PMID: 31725469Free PMC Article
Quantitative contrast-enhanced US helps differentiating neoplastic vs non-neoplastic gallbladder polyps.
Bae JS, Kim SH, Kang HJ, Kim H, Ryu JK, Jang JY, Lee SH, Paik WH, Kwon W, Lee JY, Han JK
Eur Radiol 2019 Jul;29(7):3772-3781. Epub 2019 Apr 8 doi: 10.1007/s00330-019-06123-w. PMID: 30963274
Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract.
Feakins RM
Histopathology 2016 Apr;68(5):630-40. Epub 2016 Jan 19 doi: 10.1111/his.12907. PMID: 26599607

Diagnosis

The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D
Surg Pathol Clin 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. PMID: 36049837
Non-neoplastic Polyps of the Gallbladder: A Clinicopathologic Analysis of 447 Cases.
Taskin OC, Bellolio E, Dursun N, Seven IE, Roa JC, Araya JC, Villaseca M, Tapia O, Vance C, Saka B, Balci S, Bagci P, Losada H, Sarmiento J, Memis B, Pehlivanoğlu B, Basturk O, Reid MD, Koshiol J, Cheng JD, Kapran Y, Adsay V
Am J Surg Pathol 2020 Apr;44(4):467-476. doi: 10.1097/PAS.0000000000001405. PMID: 31725469Free PMC Article
Quantitative contrast-enhanced US helps differentiating neoplastic vs non-neoplastic gallbladder polyps.
Bae JS, Kim SH, Kang HJ, Kim H, Ryu JK, Jang JY, Lee SH, Paik WH, Kwon W, Lee JY, Han JK
Eur Radiol 2019 Jul;29(7):3772-3781. Epub 2019 Apr 8 doi: 10.1007/s00330-019-06123-w. PMID: 30963274
Transabdominal ultrasound and endoscopic ultrasound for diagnosis of gallbladder polyps.
Wennmacker SZ, Lamberts MP, Di Martino M, Drenth JP, Gurusamy KS, van Laarhoven CJ
Cochrane Database Syst Rev 2018 Aug 15;8(8):CD012233. doi: 10.1002/14651858.CD012233.pub2. PMID: 30109701Free PMC Article
"Periportal neoplasms"--a CT perspective: review article.
Singh A, Chandrashekhara SH, Handa N, Baliyan V, Kumar P
Br J Radiol 2016;89(1060):20150756. Epub 2016 Jan 22 doi: 10.1259/bjr.20150756. PMID: 26800313Free PMC Article

Therapy

Age, operation time and surgical approach can be used to detect incidental gallbladder carcinoma in cholecystectomy specimens from low-incidence settings.
Echelard P, Roy SF, Trinh VQ, Garant MP, Collin Y, Nguyen BN, Geha S
Histopathology 2021 Oct;79(4):667-673. Epub 2021 Aug 6 doi: 10.1111/his.14423. PMID: 34061406
Transabdominal ultrasound and endoscopic ultrasound for diagnosis of gallbladder polyps.
Wennmacker SZ, Lamberts MP, Di Martino M, Drenth JP, Gurusamy KS, van Laarhoven CJ
Cochrane Database Syst Rev 2018 Aug 15;8(8):CD012233. doi: 10.1002/14651858.CD012233.pub2. PMID: 30109701Free PMC Article
Intraoperative cholangiography during cholecystectomy among hospitalized medicare beneficiaries with non-neoplastic biliary disease.
Lilley EJ, Scott JW, Jiang W, Krasnova A, Raol N, Changoor N, Salim A, Haider AH, Weissman JS, Schneider EB, Cooper Z
Am J Surg 2017 Oct;214(4):682-686. Epub 2017 Jun 23 doi: 10.1016/j.amjsurg.2017.06.021. PMID: 28669532
Surgical procedure determination based on tumor-node-metastasis staging of gallbladder cancer.
He XD, Li JJ, Liu W, Qu Q, Hong T, Xu XQ, Li BL, Wang Y, Zhao HT
World J Gastroenterol 2015 Apr 21;21(15):4620-6. doi: 10.3748/wjg.v21.i15.4620. PMID: 25914471Free PMC Article
Post-menopausal hormonal therapy and gallbladder cancer risk.
Gallus S, Negri E, Chatenoud L, Bosetti C, Franceschi S, La Vecchia C
Int J Cancer 2002 Jun 10;99(5):762-3. doi: 10.1002/ijc.10411. PMID: 12115514

Prognosis

Preoperative prediction model for non-neoplastic and benign neoplastic polyps of the gallbladder.
Wang Y, Peng J, Liu K, Sun P, Ma Y, Zeng J, Jiang Y, Tan B, Cao J, Hu W
Eur J Surg Oncol 2024 Feb;50(2):107930. Epub 2023 Dec 27 doi: 10.1016/j.ejso.2023.107930. PMID: 38159390
A Bayesian network model to predict neoplastic risk for patients with gallbladder polyps larger than 10 mm based on preoperative ultrasound features.
Li Q, Dou M, Zhang J, Jia P, Wang X, Lei D, Li J, Yang W, Yang R, Yang C, Zhang X, Hao Q, Geng X, Zhang Y, Liu Y, Guo Z, Yao C, Cai Z, Si S, Geng Z, Zhang D
Surg Endosc 2023 Jul;37(7):5453-5463. Epub 2023 Apr 11 doi: 10.1007/s00464-023-10056-3. PMID: 37041283
Gallbladder polyps growth rate is an independent risk factor for neoplastic polyps.
Han JW, Choi YH, Lee IS, Choi HJ, Hong TH, You YK
United European Gastroenterol J 2022 Sep;10(7):651-656. Epub 2022 Sep 10 doi: 10.1002/ueg2.12274. PMID: 36087036Free PMC Article
The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D
Surg Pathol Clin 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. PMID: 36049837
Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract.
Feakins RM
Histopathology 2016 Apr;68(5):630-40. Epub 2016 Jan 19 doi: 10.1111/his.12907. PMID: 26599607

Clinical prediction guides

Preoperative prediction model for non-neoplastic and benign neoplastic polyps of the gallbladder.
Wang Y, Peng J, Liu K, Sun P, Ma Y, Zeng J, Jiang Y, Tan B, Cao J, Hu W
Eur J Surg Oncol 2024 Feb;50(2):107930. Epub 2023 Dec 27 doi: 10.1016/j.ejso.2023.107930. PMID: 38159390
A Bayesian network model to predict neoplastic risk for patients with gallbladder polyps larger than 10 mm based on preoperative ultrasound features.
Li Q, Dou M, Zhang J, Jia P, Wang X, Lei D, Li J, Yang W, Yang R, Yang C, Zhang X, Hao Q, Geng X, Zhang Y, Liu Y, Guo Z, Yao C, Cai Z, Si S, Geng Z, Zhang D
Surg Endosc 2023 Jul;37(7):5453-5463. Epub 2023 Apr 11 doi: 10.1007/s00464-023-10056-3. PMID: 37041283
Gallbladder polyps growth rate is an independent risk factor for neoplastic polyps.
Han JW, Choi YH, Lee IS, Choi HJ, Hong TH, You YK
United European Gastroenterol J 2022 Sep;10(7):651-656. Epub 2022 Sep 10 doi: 10.1002/ueg2.12274. PMID: 36087036Free PMC Article
Non-neoplastic Lesions of Gallbladder Among Cholecystectomy Specimens of a Tertiary Care Center: A Descriptive Cross-sectional Study.
Ghartimagar D, Shrestha MK, Jhunjhunwala A, Ghosh A, Thapa S, Regmi S, Talwar OP
JNMA J Nepal Med Assoc 2021 Oct 15;59(242):970-974. doi: 10.31729/jnma.5861. PMID: 35199708Free PMC Article
Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract.
Feakins RM
Histopathology 2016 Apr;68(5):630-40. Epub 2016 Jan 19 doi: 10.1111/his.12907. PMID: 26599607

Recent systematic reviews

Transabdominal ultrasound and endoscopic ultrasound for diagnosis of gallbladder polyps.
Wennmacker SZ, Lamberts MP, Di Martino M, Drenth JP, Gurusamy KS, van Laarhoven CJ
Cochrane Database Syst Rev 2018 Aug 15;8(8):CD012233. doi: 10.1002/14651858.CD012233.pub2. PMID: 30109701Free PMC Article
Therapeutic approaches for portal biliopathy: A systematic review.
Franceschet I, Zanetto A, Ferrarese A, Burra P, Senzolo M
World J Gastroenterol 2016 Dec 7;22(45):9909-9920. doi: 10.3748/wjg.v22.i45.9909. PMID: 28018098Free PMC Article

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