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Moderately Differentiated Hepatocellular Carcinoma

MedGen UID:
474667
•Concept ID:
C3273034
•
Neoplastic Process

Definition

A hepatocellular carcinoma characterized by the presence of malignant cells with abundant eosinophilic cytoplasm forming trabecular and pseudoglandular patterns. It is usually associated with tumors that are larger than 3 cm in diameter. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerately Differentiated Hepatocellular Carcinoma

Professional guidelines

PubMed

Improving pathological early diagnosis and differential biomarker value for hepatocellular carcinoma via RNAscope technology.
Bakheet AMH, Zhao C, Chen JN, Zhang JY, Huang JT, Du Y, Gong LP, Bi YH, Shao CK
Hepatol Int 2020 Jan;14(1):96-104. Epub 2019 Dec 12 doi: 10.1007/s12072-019-10006-z. PMID: 31832976
Surgical management of children and adolescents with upfront completely resected hepatocellular carcinoma.
D'Souza AM, Shah R, Gupta A, Towbin AJ, Alonso M, Nathan JD, Bondoc A, Tiao G, Geller JI
Pediatr Blood Cancer 2018 Nov;65(11):e27293. Epub 2018 Jul 3 doi: 10.1002/pbc.27293. PMID: 29968976
Lysosomal storage diseases as differential diagnosis of hepatosplenomegaly.
vom Dahl S, Mengel E
Best Pract Res Clin Gastroenterol 2010 Oct;24(5):619-28. doi: 10.1016/j.bpg.2010.09.001. PMID: 20955964

Recent clinical studies

Etiology

Overlap syndrome of autoimmune hepatitis and primary biliary cholangitis complicated with atypical hepatocellular carcinoma: a case report.
Surdea-Blaga T, Cărăguț RL, Caraiani C, Spârchez Z, Al Hajjar N, Dumitrașcu DL
J Med Case Rep 2023 Jul 25;17(1):328. doi: 10.1186/s13256-023-03932-y. PMID: 37488645Free PMC Article
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.
Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Hepatocellular carcinoma presenting with obstructive jaundice: a clinicopathological study of eight cases.
Murata K, Shiraki K, Kawakita T, Yamamoto N, Okano H, Sakai T, Ohmori S, Deguchi M, Shimizu A, Nakano T
Hepatogastroenterology 2003 Nov-Dec;50(54):2057-60. PMID: 14696464
Diagnosis of small hepatocellular carcinoma--imaging diagnosis and significance of tumor biopsy.
Horigome H, Nomura T, Saso K, Joh T, Ohara H, Akita S, Sobue S, Mizuno Y, Kato Y, Kanematsu T, Murasaki G, Itoh M
Hepatogastroenterology 2000 Nov-Dec;47(36):1659-62. PMID: 11149027

Diagnosis

Overlap syndrome of autoimmune hepatitis and primary biliary cholangitis complicated with atypical hepatocellular carcinoma: a case report.
Surdea-Blaga T, Cărăguț RL, Caraiani C, Spârchez Z, Al Hajjar N, Dumitrașcu DL
J Med Case Rep 2023 Jul 25;17(1):328. doi: 10.1186/s13256-023-03932-y. PMID: 37488645Free PMC Article
Diagnosis of hepatocellular carcinoma nodules in patients with chronic liver disease using contrast-enhanced sonography: usefulness of the combination of arterial- and kupffer-phase enhancement patterns.
Suzuki K, Okuda Y, Ota M, Kojima F, Horimoto M
J Ultrasound Med 2015 Mar;34(3):423-33. doi: 10.7863/ultra.34.3.423. PMID: 25715363
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.
Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Diagnosis of small hepatocellular carcinoma--imaging diagnosis and significance of tumor biopsy.
Horigome H, Nomura T, Saso K, Joh T, Ohara H, Akita S, Sobue S, Mizuno Y, Kato Y, Kanematsu T, Murasaki G, Itoh M
Hepatogastroenterology 2000 Nov-Dec;47(36):1659-62. PMID: 11149027

Therapy

De novo hepatocellular carcinoma in a non-cirrhotic allograft 27 years after liver transplantation: A case report.
El-Domiaty N, Saliba F, Sebagh M, Salloum C, Vibert E, Azoulay D, Hamelin J, Cherqui D, Adam R, Samuel D
Am J Transplant 2021 May;21(5):1953-1958. Epub 2021 Jan 23 doi: 10.1111/ajt.16476. PMID: 33382179
Diagnosis of hepatocellular carcinoma nodules in patients with chronic liver disease using contrast-enhanced sonography: usefulness of the combination of arterial- and kupffer-phase enhancement patterns.
Suzuki K, Okuda Y, Ota M, Kojima F, Horimoto M
J Ultrasound Med 2015 Mar;34(3):423-33. doi: 10.7863/ultra.34.3.423. PMID: 25715363
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Successful treatment of dissemination of hepatocellular carcinoma to the pleura and diaphragm after percutaneous liver biopsy.
Uenishi T, Kubo S, Hirohashi K, Tanaka H, Ohba K, Kinoshita H
Dig Surg 2001;18(3):225-7. doi: 10.1159/000050137. PMID: 11464017
Needle track seeding after percutaneous ethanol injection therapy for small hepatocellular carcinoma.
Shimada M, Maeda T, Saitoh A, Morotomi I, Kano T
J Surg Oncol 1995 Apr;58(4):278-81. doi: 10.1002/jso.2930580416. PMID: 7723374

Prognosis

Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.
Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Hepatocellular carcinoma presenting with obstructive jaundice: a clinicopathological study of eight cases.
Murata K, Shiraki K, Kawakita T, Yamamoto N, Okano H, Sakai T, Ohmori S, Deguchi M, Shimizu A, Nakano T
Hepatogastroenterology 2003 Nov-Dec;50(54):2057-60. PMID: 14696464
Pathological characteristics, PCNA labeling index and DNA index in prognostic evaluation of patients with moderately differentiated hepatocellular carcinoma.
Zeng WJ, Liu GY, Xu J, Zhou XD, Zhang YE, Zhang N
World J Gastroenterol 2002 Dec;8(6):1040-4. doi: 10.3748/wjg.v8.i6.1040. PMID: 12439921Free PMC Article
Hepatoid adenocarcinoma of the stomach.
Inagawa S, Shimazaki J, Hori M, Yoshimi F, Adachi S, Kawamoto T, Fukao K, Itabashi M
Gastric Cancer 2001;4(1):43-52. doi: 10.1007/s101200100016. PMID: 11706627

Clinical prediction guides

De novo hepatocellular carcinoma in a non-cirrhotic allograft 27 years after liver transplantation: A case report.
El-Domiaty N, Saliba F, Sebagh M, Salloum C, Vibert E, Azoulay D, Hamelin J, Cherqui D, Adam R, Samuel D
Am J Transplant 2021 May;21(5):1953-1958. Epub 2021 Jan 23 doi: 10.1111/ajt.16476. PMID: 33382179
Carcinosarcoma of the liver.
Goto H, Tanaka A, Kondo F, Takeshita K, Nagashima I, Hanawa N, Aiso M, Takamori Y, Kato K, Takahashi Y, Fukushima J, Furui S, Fukusato T, Asano T, Takikawa H
Intern Med 2010;49(23):2577-82. Epub 2010 Dec 1 doi: 10.2169/internalmedicine.49.3581. PMID: 21139295
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Hepatocellular carcinoma presenting with obstructive jaundice: a clinicopathological study of eight cases.
Murata K, Shiraki K, Kawakita T, Yamamoto N, Okano H, Sakai T, Ohmori S, Deguchi M, Shimizu A, Nakano T
Hepatogastroenterology 2003 Nov-Dec;50(54):2057-60. PMID: 14696464
Pathological characteristics, PCNA labeling index and DNA index in prognostic evaluation of patients with moderately differentiated hepatocellular carcinoma.
Zeng WJ, Liu GY, Xu J, Zhou XD, Zhang YE, Zhang N
World J Gastroenterol 2002 Dec;8(6):1040-4. doi: 10.3748/wjg.v8.i6.1040. PMID: 12439921Free PMC Article

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