U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Liver Infantile Hemangioma

MedGen UID:
474705
•Concept ID:
C3273072
•
Neoplastic Process
Synonyms: Hepatic Infantile Hemangioma; Infantile hemangioma of liver; Liver Infantile Hemangioendothelioma
SNOMED CT: Infantile hemangioma of liver (703271000)

Definition

A capillary hemangioma that arises from the liver. It occurs in infants and children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Infantile Hemangioma

Professional guidelines

PubMed

A Comprehensive Review of Hepatic Hemangioma Management.
Aziz H, Brown ZJ, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Sep;26(9):1998-2007. Epub 2022 Jun 15 doi: 10.1007/s11605-022-05382-1. PMID: 35705835
Diagnosis and Follow-up of Incidental Liver Lesions in Children.
Karmazyn B, Rao GS, Johnstone LS, Severance TS, Ferguson MJ, Marshalleck FE, Molleston JP
J Pediatr Gastroenterol Nutr 2022 Mar 1;74(3):320-327. doi: 10.1097/MPG.0000000000003377. PMID: 34984985
Primary mesenchymal liver tumors: radiological spectrum, differential diagnosis, and pathologic correlation.
Harman M, Nart D, Acar T, Elmas N
Abdom Imaging 2015 Jun;40(5):1316-30. doi: 10.1007/s00261-014-0268-9. PMID: 25311993

Recent clinical studies

Etiology

Diagnosis and Follow-up of Incidental Liver Lesions in Children.
Karmazyn B, Rao GS, Johnstone LS, Severance TS, Ferguson MJ, Marshalleck FE, Molleston JP
J Pediatr Gastroenterol Nutr 2022 Mar 1;74(3):320-327. doi: 10.1097/MPG.0000000000003377. PMID: 34984985
Liver Tumors in Pediatric Patients.
Meyers R, Hiyama E, Czauderna P, Tiao GM
Surg Oncol Clin N Am 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006. PMID: 33706899
Hemangioma-related syndromes.
Valdebran M, Wine Lee L
Curr Opin Pediatr 2020 Aug;32(4):498-505. doi: 10.1097/MOP.0000000000000925. PMID: 32692048
Congenital hepatic shunts.
Gallego C, Miralles M, Marín C, Muyor P, González G, García-Hidalgo E
Radiographics 2004 May-Jun;24(3):755-72. doi: 10.1148/rg.243035046. PMID: 15143226
Hepatic hemangiomas.
Hobbs KE
World J Surg 1990 Jul-Aug;14(4):468-71. doi: 10.1007/BF01658669. PMID: 2200208

Diagnosis

A Comprehensive Review of Hepatic Hemangioma Management.
Aziz H, Brown ZJ, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Sep;26(9):1998-2007. Epub 2022 Jun 15 doi: 10.1007/s11605-022-05382-1. PMID: 35705835
Emergencies in paediatric hepatology.
Jagadisan B, Dhawan A
J Hepatol 2022 May;76(5):1199-1214. Epub 2022 Jan 3 doi: 10.1016/j.jhep.2021.12.027. PMID: 34990749
Liver Tumors in Pediatric Patients.
Meyers R, Hiyama E, Czauderna P, Tiao GM
Surg Oncol Clin N Am 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006. PMID: 33706899
Hemangioma-related syndromes.
Valdebran M, Wine Lee L
Curr Opin Pediatr 2020 Aug;32(4):498-505. doi: 10.1097/MOP.0000000000000925. PMID: 32692048
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring.
Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, Hammill A, Masand PM, Fishman SJ
J Pediatr 2018 Dec;203:294-300.e2. Epub 2018 Sep 21 doi: 10.1016/j.jpeds.2018.08.012. PMID: 30244993

Therapy

Clinical features of cutaneous infantile hemangioma combined with asymptomatic infantile hepatic hemangioma and efficacy of propranolol treatment.
Li L, Yu L, Xu Z, Wei L, Zhang B, Han X, Sun Y, Ma L
J Cosmet Dermatol 2023 Dec;22(12):3369-3374. Epub 2023 Jun 14 doi: 10.1111/jocd.15823. PMID: 37313653
Historical and Contemporary Management of Infantile Hepatic Hemangioma: A 30-year Single-center Experience.
Macdonald A, Durkin N, Deganello A, Sellars ME, Makin E, Davenport M
Ann Surg 2022 Jan 1;275(1):e250-e255. doi: 10.1097/SLA.0000000000003881. PMID: 33064395
Clinical and economic impact of surgery for treating infantile hemangiomas in the era of propranolol: overview of single-center experience from La Paz Hospital, Madrid.
López-Gutiérrez JC
Eur J Pediatr 2019 Jan;178(1):1-6. Epub 2018 Nov 12 doi: 10.1007/s00431-018-3290-z. PMID: 30421264
Individualized Treatment for Infantile Hemangioma.
Xu MN, Zhang M, Xu Y, Wang M, Yuan SM
J Craniofac Surg 2018 Oct;29(7):1876-1879. doi: 10.1097/SCS.0000000000004745. PMID: 30052610
Consumptive hypothyroidism associated with parotid infantile hemangioma.
De Corti F, Crivellaro C, Zanon GF, Luzzatto C
J Pediatr Endocrinol Metab 2015 Mar;28(3-4):467-9. doi: 10.1515/jpem-2013-0420. PMID: 25153570

Prognosis

Diagnosis and Follow-up of Incidental Liver Lesions in Children.
Karmazyn B, Rao GS, Johnstone LS, Severance TS, Ferguson MJ, Marshalleck FE, Molleston JP
J Pediatr Gastroenterol Nutr 2022 Mar 1;74(3):320-327. doi: 10.1097/MPG.0000000000003377. PMID: 34984985
Infantile hepatic hemangioma: current state of the art, controversies, and perspectives.
Zavras N, Dimopoulou A, Machairas N, Paspala A, Vaos G
Eur J Pediatr 2020 Jan;179(1):1-8. Epub 2019 Nov 22 doi: 10.1007/s00431-019-03504-7. PMID: 31758313
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring.
Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, Hammill A, Masand PM, Fishman SJ
J Pediatr 2018 Dec;203:294-300.e2. Epub 2018 Sep 21 doi: 10.1016/j.jpeds.2018.08.012. PMID: 30244993
Congenital hepatic shunts.
Gallego C, Miralles M, Marín C, Muyor P, González G, García-Hidalgo E
Radiographics 2004 May-Jun;24(3):755-72. doi: 10.1148/rg.243035046. PMID: 15143226
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128

Clinical prediction guides

Coexisting Infantile Hepatic Hemangioma and Hepatoblastoma in a Neonate: A Case Report.
Zhang SH, Chen GY, Wei L
Int J Surg Pathol 2023 Jun;31(4):485-490. Epub 2023 Apr 25 doi: 10.1177/10668969231171127. PMID: 37097887
Clinical evaluation of transcatheter arterial embolization combined with propranolol orally treatment of infantile hepatic hemangioma.
Wang L, Li J, Song D, Guo L
Pediatr Surg Int 2022 Aug;38(8):1149-1155. Epub 2022 Jun 16 doi: 10.1007/s00383-022-05143-w. PMID: 35708761
Infantile hepatic hemangioma: current state of the art, controversies, and perspectives.
Zavras N, Dimopoulou A, Machairas N, Paspala A, Vaos G
Eur J Pediatr 2020 Jan;179(1):1-8. Epub 2019 Nov 22 doi: 10.1007/s00431-019-03504-7. PMID: 31758313
Critical hepatic hemangioma in infants: recent nationwide survey in Japan.
Kuroda T, Hoshino K, Nosaka S, Shiota Y, Nakazawa A, Takimoto T
Pediatr Int 2014 Jun;56(3):304-8. doi: 10.1111/ped.12347. PMID: 24689756
Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy.
Kassarjian A, Zurakowski D, Dubois J, Paltiel HJ, Fishman SJ, Burrows PE
AJR Am J Roentgenol 2004 Mar;182(3):785-95. doi: 10.2214/ajr.182.3.1820785. PMID: 14975986

Recent systematic reviews

A Comprehensive Review of Hepatic Hemangioma Management.
Aziz H, Brown ZJ, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Sep;26(9):1998-2007. Epub 2022 Jun 15 doi: 10.1007/s11605-022-05382-1. PMID: 35705835

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...