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Gallbladder Intracholecystic Papillary Neoplasm, High Grade

MedGen UID:
474728
•Concept ID:
C3273095
•
Neoplastic Process
Synonyms: Gallbladder ICPN with High Grade Intraepithelial Neoplasia; Gallbladder Intracholecystic Papillary (Tubular) Neoplasm with High Grade Intraepithelial Neoplasia; Gallbladder Intracholecystic Papillary Neoplasm with High Grade Intraepithelial Neoplasia; Gallbladder Intracholecystic Papillary Neoplasm, High-Grade; Gallbladder Intracystic/Intaductal Papillary Neoplasm with High Grade Intraepithelial Neoplasia; Intracystic Papillary Neoplasm with High Grade Intraepithelial Neoplasia

Definition

An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. It is characterized by the presence of severe epithelial atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Intracholecystic Papillary Neoplasm, High Grade

Recent clinical studies

Etiology

Contrast-Enhanced CT and Ultrasonography Features of Intracholecystic Papillary Neoplasm with or without associated Invasive Carcinoma.
Kim JH, Kim JH, Kang HJ, Bae JS
Korean J Radiol 2023 Jan;24(1):39-50. doi: 10.3348/kjr.2022.0577. PMID: 36606619Free PMC Article
Intracholecystic tubular non-mucinous neoplasm (ICTN) of the gallbladder: a clinicopathologically distinct, invasion-resistant entity.
Pehlivanoglu B, Balci S, Basturk O, Bagci P, Erbarut Seven I, Memis B, Dursun N, Jang KT, Saka B, Ohike N, Tajiri T, Roa JC, Sarmiento JM, Reid MD, Adsay V
Virchows Arch 2021 Mar;478(3):435-447. Epub 2020 Jul 20 doi: 10.1007/s00428-020-02877-7. PMID: 32691142
Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder: A Short Review of Literature.
Saei Hamedani F, Garcia-Buitrago M
Appl Immunohistochem Mol Morphol 2020 Jan;28(1):57-61. doi: 10.1097/PAI.0000000000000711. PMID: 31815746
Intracholecystic papillary-tubular neoplasm of gallbladder: A 5-year retrospective pathological study.
Hazarika P, Sharma MK
Indian J Pathol Microbiol 2018 Oct-Dec;61(4):516-519. doi: 10.4103/IJPM.IJPM_489_17. PMID: 30303140
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder.
Argon A, Barbet FY, Nart D
Int J Surg Pathol 2016 Sep;24(6):504-11. Epub 2016 Apr 27 doi: 10.1177/1066896916644781. PMID: 27122163

Diagnosis

Contrast-Enhanced CT and Ultrasonography Features of Intracholecystic Papillary Neoplasm with or without associated Invasive Carcinoma.
Kim JH, Kim JH, Kang HJ, Bae JS
Korean J Radiol 2023 Jan;24(1):39-50. doi: 10.3348/kjr.2022.0577. PMID: 36606619Free PMC Article
Characterization of high-grade biliary intraepithelial neoplasm of the gallbladder in comparison with intracholecystic papillary neoplasm.
Nakanuma Y, Sugino T, Okamura Y, Nomura Y, Watanabe H, Terada T, Sato Y
Hum Pathol 2021 Oct;116:22-30. Epub 2021 Jul 12 doi: 10.1016/j.humpath.2021.06.007. PMID: 34265338
Pathological characterization of intracholecystic papillary neoplasm: A recently proposed preinvasive neoplasm of gallbladder.
Nakanuma Y, Nomura Y, Watanabe H, Terada T, Sato Y, Kakuda Y, Sugino T, Ohnishi Y, Okamura Y
Ann Diagn Pathol 2021 Jun;52:151723. Epub 2021 Mar 3 doi: 10.1016/j.anndiagpath.2021.151723. PMID: 33725666
Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder: A Short Review of Literature.
Saei Hamedani F, Garcia-Buitrago M
Appl Immunohistochem Mol Morphol 2020 Jan;28(1):57-61. doi: 10.1097/PAI.0000000000000711. PMID: 31815746
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Prognosis

Contrast-Enhanced CT and Ultrasonography Features of Intracholecystic Papillary Neoplasm with or without associated Invasive Carcinoma.
Kim JH, Kim JH, Kang HJ, Bae JS
Korean J Radiol 2023 Jan;24(1):39-50. doi: 10.3348/kjr.2022.0577. PMID: 36606619Free PMC Article
Low-Grade Dysplastic Intracholecystic Papillary Neoplasia: A Case Report.
Logrado A, Constantino J, Daniel C, Pereira J, Carvalho MT, Casimiro C
Am J Case Rep 2021 Mar 3;22:e929788. doi: 10.12659/AJCR.929788. PMID: 33654049Free PMC Article
Intracholecystic papillary-tubular neoplasms of the gallbladder - A clinicopathological study of 36 cases.
Kiruthiga KG, Kodiatte TA, Burad D, Kurian R, Raju RS, Rymbai ML, Jagannathan AM, Vyas FL
Ann Diagn Pathol 2019 Jun;40:88-93. Epub 2019 Apr 30 doi: 10.1016/j.anndiagpath.2019.04.014. PMID: 31077876
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder.
Argon A, Barbet FY, Nart D
Int J Surg Pathol 2016 Sep;24(6):504-11. Epub 2016 Apr 27 doi: 10.1177/1066896916644781. PMID: 27122163
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Clinical prediction guides

Diagnostic usefulness of SpyGlass in intracholecystic papillary neoplasm with pancreaticobiliary maljunction: a case report and comparison with conventional gallbladder cancer with pancreaticobiliary maljunction.
Akita M, Yanagimoto H, Tsugawa D, Ajiki T, Masuda A, Komatsu M, Goto T, Kido M, Toyama H, Fukumoto T
Clin J Gastroenterol 2023 Jun;16(3):476-481. Epub 2023 Mar 3 doi: 10.1007/s12328-023-01778-x. PMID: 36867354
Contrast-Enhanced CT and Ultrasonography Features of Intracholecystic Papillary Neoplasm with or without associated Invasive Carcinoma.
Kim JH, Kim JH, Kang HJ, Bae JS
Korean J Radiol 2023 Jan;24(1):39-50. doi: 10.3348/kjr.2022.0577. PMID: 36606619Free PMC Article
Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound.
Koike D, Kato H, Asano Y, Ito M, Arakawa S, Kawabe N, Shimura M, Hayashi C, Ochi T, Kamio K, Kawai T, Yasuoka H, Higashiguchi T, Horiguchi A
BMC Gastroenterol 2022 Aug 8;22(1):377. doi: 10.1186/s12876-022-02454-z. PMID: 35941538Free PMC Article
Intracholecystic tubular non-mucinous neoplasm (ICTN) of the gallbladder: a clinicopathologically distinct, invasion-resistant entity.
Pehlivanoglu B, Balci S, Basturk O, Bagci P, Erbarut Seven I, Memis B, Dursun N, Jang KT, Saka B, Ohike N, Tajiri T, Roa JC, Sarmiento JM, Reid MD, Adsay V
Virchows Arch 2021 Mar;478(3):435-447. Epub 2020 Jul 20 doi: 10.1007/s00428-020-02877-7. PMID: 32691142
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder.
Argon A, Barbet FY, Nart D
Int J Surg Pathol 2016 Sep;24(6):504-11. Epub 2016 Apr 27 doi: 10.1177/1066896916644781. PMID: 27122163

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