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Extrahepatic Bile Duct Neuroendocrine Tumor G2

MedGen UID:
474774
•Concept ID:
C3273141
•
Neoplastic Process
Synonym: Extrahepatic Bile Duct NET G2

Definition

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic Bile Duct Neuroendocrine Tumor G2

Professional guidelines

PubMed

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article

Recent clinical studies

Etiology

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article
Ampullary neuroendocrine neoplasms: surgical experience of a rare and challenging entity.
Milanetto AC, Pasquali C, Da Broi M, Brambilla T, Capretti G, Zerbi A
Langenbecks Arch Surg 2018 Aug;403(5):581-589. Epub 2018 Jul 24 doi: 10.1007/s00423-018-1695-9. PMID: 30043166
Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis.
Dumitrascu T, Dima S, Herlea V, Tomulescu V, Ionescu M, Popescu I
Langenbecks Arch Surg 2012 Aug;397(6):933-43. Epub 2012 Apr 3 doi: 10.1007/s00423-012-0951-7. PMID: 22476195Free PMC Article
Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy.
Bogoevski D, Chayeb H, Cataldegirmen G, Schurr PG, Kaifi JT, Mann O, Yekebas EF, Izbicki JR
J Gastrointest Surg 2008 Nov;12(11):1830-7; discussion 1837-8. Epub 2008 Sep 13 doi: 10.1007/s11605-008-0683-8. PMID: 18791769

Diagnosis

A rare case of neuroendocrine cell tumor mixed with a mucinous component in the ampulla of Vater.
Sugai T, Uesugi N, Suzuki M, Suzuki N, Honda M, Abe T, Yanagawa N
Diagn Pathol 2024 Apr 27;19(1):64. doi: 10.1186/s13000-024-01488-z. PMID: 38678248Free PMC Article
Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article
A rare cause of biliary obstruction - intraductal neuroendocrine tumor of the right hepatic biliary duct: a case report.
Danila M, Sirli R, Popescu A, Iacob N, Ghiuchici AM
Med Ultrason 2021 May 20;23(2):235-237. Epub 2020 Apr 23 doi: 10.11152/mu-2503. PMID: 32399544
Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy.
Bogoevski D, Chayeb H, Cataldegirmen G, Schurr PG, Kaifi JT, Mann O, Yekebas EF, Izbicki JR
J Gastrointest Surg 2008 Nov;12(11):1830-7; discussion 1837-8. Epub 2008 Sep 13 doi: 10.1007/s11605-008-0683-8. PMID: 18791769

Prognosis

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article
Ampullary neuroendocrine neoplasms: surgical experience of a rare and challenging entity.
Milanetto AC, Pasquali C, Da Broi M, Brambilla T, Capretti G, Zerbi A
Langenbecks Arch Surg 2018 Aug;403(5):581-589. Epub 2018 Jul 24 doi: 10.1007/s00423-018-1695-9. PMID: 30043166
Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis.
Dumitrascu T, Dima S, Herlea V, Tomulescu V, Ionescu M, Popescu I
Langenbecks Arch Surg 2012 Aug;397(6):933-43. Epub 2012 Apr 3 doi: 10.1007/s00423-012-0951-7. PMID: 22476195Free PMC Article
Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs.
Harada K, Sato Y, Ikeda H, Maylee H, Igarashi S, Okamura A, Masuda S, Nakanuma Y
Virchows Arch 2012 Mar;460(3):281-9. Epub 2012 Feb 23 doi: 10.1007/s00428-012-1212-4. PMID: 22358181
Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy.
Bogoevski D, Chayeb H, Cataldegirmen G, Schurr PG, Kaifi JT, Mann O, Yekebas EF, Izbicki JR
J Gastrointest Surg 2008 Nov;12(11):1830-7; discussion 1837-8. Epub 2008 Sep 13 doi: 10.1007/s11605-008-0683-8. PMID: 18791769

Clinical prediction guides

Clinicopathological Findings and Treatment Outcomes of Patients with Primary Hepatobiliary Neuroendocrine Neoplasms: A Retrospective Single-institution Analysis.
Komiyama S, Okusaka T, Maruki Y, Ohba A, Nagashio Y, Kondo S, Hijioka S, Morizane C, Ueno H, Sukeda A, Mizui T, Takamoto T, Nara S, Ban D, Esaki M, Hiraoka N, Shimada K
Intern Med 2024 Apr 1;63(7):891-901. Epub 2023 Aug 23 doi: 10.2169/internalmedicine.2016-23. PMID: 37612088Free PMC Article
Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis.
Dumitrascu T, Dima S, Herlea V, Tomulescu V, Ionescu M, Popescu I
Langenbecks Arch Surg 2012 Aug;397(6):933-43. Epub 2012 Apr 3 doi: 10.1007/s00423-012-0951-7. PMID: 22476195Free PMC Article

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