U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Extrahepatic Bile Duct Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
474775
•Concept ID:
C3273142
•
Neoplastic Process
Synonym: Extrahepatic Bile Duct MANEC

Definition

A carcinoma that arises from the extrahepatic bile ducts and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic Bile Duct Mixed Adenoneuroendocrine Carcinoma

Professional guidelines

PubMed

Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Recent clinical studies

Etiology

Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series.
Yang S, Lu J, Cai Y, Li B, Xiong X
BMC Gastroenterol 2021 Aug 25;21(1):329. doi: 10.1186/s12876-021-01909-z. PMID: 34433421Free PMC Article
Comparison of Clinicopathological Features of Biliary Neuroendocrine Carcinoma with Adenocarcinoma.
Shiihara M, Higuchi R, Furukawa T, Yazawa T, Uemura S, Izumo W, Yamamoto M
Dig Surg 2021;38(1):30-37. Epub 2020 Jun 22 doi: 10.1159/000508443. PMID: 32570243
Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report.
Li X, Li D, Sun X, Lv G
J Int Med Res 2020 Aug;48(8):300060520947918. doi: 10.1177/0300060520947918. PMID: 32833541Free PMC Article
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Neuroendocrine neoplasms of the extrahepatic bile duct: radiologic and clinical characteristics.
Hong N, Kim HJ, Byun JH, Kim SY, Kim KW, Kim JH, Hong SM
Abdom Imaging 2015 Jan;40(1):181-91. doi: 10.1007/s00261-014-0191-0. PMID: 25008023

Diagnosis

Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series.
Yang S, Lu J, Cai Y, Li B, Xiong X
BMC Gastroenterol 2021 Aug 25;21(1):329. doi: 10.1186/s12876-021-01909-z. PMID: 34433421Free PMC Article
Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Mixed adenoneuroendocrine carcinoma of the extrahepatic bile duct: a case report.
Zhang HW, Kou K, Qi J, Xie EB, Wang M, Li Y, Lv GY, Wang GY
J Int Med Res 2019 Jul;47(7):3421-3426. Epub 2019 Jun 3 doi: 10.1177/0300060519850391. PMID: 31154920Free PMC Article
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Intrahepatic bile duct mixed adenoneuroendocrine carcinoma: a case report and review of the literature.
Zheng SL, Yip VS, Pedica F, Prachalias A, Quaglia A
Diagn Pathol 2015 Nov 20;10:204. doi: 10.1186/s13000-015-0439-1. PMID: 26589730Free PMC Article

Prognosis

Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series.
Yang S, Lu J, Cai Y, Li B, Xiong X
BMC Gastroenterol 2021 Aug 25;21(1):329. doi: 10.1186/s12876-021-01909-z. PMID: 34433421Free PMC Article
Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report.
Li X, Li D, Sun X, Lv G
J Int Med Res 2020 Aug;48(8):300060520947918. doi: 10.1177/0300060520947918. PMID: 32833541Free PMC Article
Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Mixed adenoneuroendocrine carcinoma of the extrahepatic bile duct: a case report.
Zhang HW, Kou K, Qi J, Xie EB, Wang M, Li Y, Lv GY, Wang GY
J Int Med Res 2019 Jul;47(7):3421-3426. Epub 2019 Jun 3 doi: 10.1177/0300060519850391. PMID: 31154920Free PMC Article
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Clinical prediction guides

Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series.
Yang S, Lu J, Cai Y, Li B, Xiong X
BMC Gastroenterol 2021 Aug 25;21(1):329. doi: 10.1186/s12876-021-01909-z. PMID: 34433421Free PMC Article
Neuroendocrine Neoplasms of the Major Duodenal Papilla With Focus on Histopathological Features and Prognosis.
Zhang Q, Lu CJ, Zhang X, Ma Z, Xin Q, Zhang CS
Int J Surg Pathol 2015 Sep;23(6):433-8. Epub 2015 May 18 doi: 10.1177/1066896915586808. PMID: 25987105
Neuroendocrine neoplasms of the extrahepatic bile duct: radiologic and clinical characteristics.
Hong N, Kim HJ, Byun JH, Kim SY, Kim KW, Kim JH, Hong SM
Abdom Imaging 2015 Jan;40(1):181-91. doi: 10.1007/s00261-014-0191-0. PMID: 25008023

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...