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Proliferative Inflammatory Atrophy

MedGen UID:
474872
•Concept ID:
C3273239
•
Disease or Syndrome
Synonym: Prostate Proliferative Inflammatory Atrophy

Definition

A lesion in the prostate gland characterized by glandular atrophy, chronic inflammation, and epithelial hyperplasia. It has been suggested that it is a precancerous lesion and it may lead to the development of prostatic intraepithelial neoplasia and prostatic carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProliferative Inflammatory Atrophy

Professional guidelines

PubMed

Sinensetin regulates age-related sarcopenia in cultured primary thigh and calf muscle cells.
Kim JA, Kim SM, Ha SE, Vetrivel P, Saralamma VVG, Kim EH, Kim GS
BMC Complement Altern Med 2019 Oct 28;19(1):287. doi: 10.1186/s12906-019-2714-2. PMID: 31660942Free PMC Article

Recent clinical studies

Etiology

Clinical Significance of Proliferative Inflammatory Atrophy in Negative Prostatic Biopsies.
Servian P, Celma A, Planas J, Placer J, de Torres IM, Morote J
Prostate 2016 Dec;76(16):1501-1506. Epub 2016 Jul 12 doi: 10.1002/pros.23234. PMID: 27404228
Clinical significance of proliferative inflammatory atrophy in prostate biopsy.
Celma A, Servián P, Planas J, Placer J, Quilez MT, Arbós MA, de Torres I, Morote J
Actas Urol Esp 2014 Mar;38(2):122-6. Epub 2013 Oct 13 doi: 10.1016/j.acuro.2013.04.008. PMID: 24129226
Prostate cancer and inflammation: the evidence.
Sfanos KS, De Marzo AM
Histopathology 2012 Jan;60(1):199-215. doi: 10.1111/j.1365-2559.2011.04033.x. PMID: 22212087Free PMC Article
Inflammation, atrophy, and prostate carcinogenesis.
De Marzo AM, Nakai Y, Nelson WG
Urol Oncol 2007 Sep-Oct;25(5):398-400. doi: 10.1016/j.urolonc.2007.05.007. PMID: 17826659
Cyclooxygenase-2 and prostate carcinogenesis.
Hussain T, Gupta S, Mukhtar H
Cancer Lett 2003 Mar 10;191(2):125-35. doi: 10.1016/s0304-3835(02)00524-4. PMID: 12618325

Diagnosis

Club-like cells in proliferative inflammatory atrophy of the prostate.
Huang FW, Song H, Weinstein HN, Xie J, Cooperberg MR, Hicks J, Mummert L, De Marzo AM, Sfanos KS
J Pathol 2023 Sep;261(1):85-95. Epub 2023 Aug 7 doi: 10.1002/path.6149. PMID: 37550827Free PMC Article
Inflammation and focal atrophy in prostate needle biopsy cores and association to prostatic adenocarcinoma.
Benedetti I, Bettin A, Reyes N
Ann Diagn Pathol 2016 Oct;24:55-61. Epub 2016 Jul 21 doi: 10.1016/j.anndiagpath.2016.04.010. PMID: 27649956
The molecular and cellular origin of human prostate cancer.
Packer JR, Maitland NJ
Biochim Biophys Acta 2016 Jun;1863(6 Pt A):1238-60. Epub 2016 Feb 26 doi: 10.1016/j.bbamcr.2016.02.016. PMID: 26921821
Prostate growth and inflammation.
Sciarra A, Mariotti G, Salciccia S, Autran Gomez A, Monti S, Toscano V, Di Silverio F
J Steroid Biochem Mol Biol 2008 Feb;108(3-5):254-60. Epub 2007 Sep 7 doi: 10.1016/j.jsbmb.2007.09.013. PMID: 17935971
Human prostate cancer precursors and pathobiology.
De Marzo AM, Meeker AK, Zha S, Luo J, Nakayama M, Platz EA, Isaacs WB, Nelson WG
Urology 2003 Nov;62(5 Suppl 1):55-62. doi: 10.1016/j.urology.2003.09.053. PMID: 14607218

Therapy

The diet as a cause of human prostate cancer.
Nelson WG, Demarzo AM, Yegnasubramanian S
Cancer Treat Res 2014;159:51-68. doi: 10.1007/978-3-642-38007-5_4. PMID: 24114474Free PMC Article
Anti-inflammatory drugs, antioxidants, and prostate cancer prevention.
Bardia A, Platz EA, Yegnasubramanian S, De Marzo AM, Nelson WG
Curr Opin Pharmacol 2009 Aug;9(4):419-26. Epub 2009 Jul 1 doi: 10.1016/j.coph.2009.06.002. PMID: 19574101Free PMC Article
Inflammation, atrophy, and prostate carcinogenesis.
De Marzo AM, Nakai Y, Nelson WG
Urol Oncol 2007 Sep-Oct;25(5):398-400. doi: 10.1016/j.urolonc.2007.05.007. PMID: 17826659
The role of inflammation in the pathogenesis of prostate cancer.
Nelson WG, De Marzo AM, DeWeese TL, Isaacs WB
J Urol 2004 Nov;172(5 Pt 2):S6-11; discussion S11-2. doi: 10.1097/01.ju.0000142058.99614.ff. PMID: 15535435
Preneoplastic prostate lesions: an opportunity for prostate cancer prevention.
Nelson WG, De Marzo AM, Deweese TL, Lin X, Brooks JD, Putzi MJ, Nelson CP, Groopman JD, Kensler TW
Ann N Y Acad Sci 2001 Dec;952:135-44. doi: 10.1111/j.1749-6632.2001.tb02734.x. PMID: 11795433

Prognosis

Metabolic syndrome is not associated with greater evidences of proliferative inflammatory atrophy and inflammation in patients with suspected prostate cancer.
Russo GI, Cimino S, Giranio G, Regis F, Favilla V, Privitera S, Motta F, Caltabiano R, Stenzl A, Todenhöfer T, Morgia G
Urol Oncol 2018 May;36(5):240.e21-240.e26. Epub 2018 Feb 9 doi: 10.1016/j.urolonc.2018.01.012. PMID: 29429896
CXXC5 expression in prostate cancer: implications for cancer progression.
Benedetti I, De Marzo AM, Geliebter J, Reyes N
Int J Exp Pathol 2017 Aug;98(4):234-243. doi: 10.1111/iep.12241. PMID: 29027288Free PMC Article
Clinical Significance of Proliferative Inflammatory Atrophy in Negative Prostatic Biopsies.
Servian P, Celma A, Planas J, Placer J, de Torres IM, Morote J
Prostate 2016 Dec;76(16):1501-1506. Epub 2016 Jul 12 doi: 10.1002/pros.23234. PMID: 27404228
Polyomavirus BK and prostate cancer: a complex interaction of potential clinical relevance.
Keller EX, Delbue S, Tognon M, Provenzano M
Rev Med Virol 2015 Nov;25(6):366-78. Epub 2015 Aug 26 doi: 10.1002/rmv.1851. PMID: 26308483
The controversial relationship between benign prostatic hyperplasia and prostate cancer: the role of inflammation.
De Nunzio C, Kramer G, Marberger M, Montironi R, Nelson W, Schröder F, Sciarra A, Tubaro A
Eur Urol 2011 Jul;60(1):106-17. Epub 2011 Apr 9 doi: 10.1016/j.eururo.2011.03.055. PMID: 21497433

Clinical prediction guides

The inflammatory microenvironment and microbiome in prostate cancer development.
Sfanos KS, Yegnasubramanian S, Nelson WG, De Marzo AM
Nat Rev Urol 2018 Jan;15(1):11-24. Epub 2017 Oct 31 doi: 10.1038/nrurol.2017.167. PMID: 29089606
Clinical Significance of Proliferative Inflammatory Atrophy in Negative Prostatic Biopsies.
Servian P, Celma A, Planas J, Placer J, de Torres IM, Morote J
Prostate 2016 Dec;76(16):1501-1506. Epub 2016 Jul 12 doi: 10.1002/pros.23234. PMID: 27404228
Clinical significance of proliferative inflammatory atrophy finding in prostatic biopsies.
Servian P, Celma A, Planas J, Placer J, de Torres IM, Olivan M, Morote J
Prostate 2015 Oct;75(14):1669-75. Epub 2015 Jul 17 doi: 10.1002/pros.23047. PMID: 26184870
Clinical significance of proliferative inflammatory atrophy in prostate biopsy.
Celma A, Servián P, Planas J, Placer J, Quilez MT, Arbós MA, de Torres I, Morote J
Actas Urol Esp 2014 Mar;38(2):122-6. Epub 2013 Oct 13 doi: 10.1016/j.acuro.2013.04.008. PMID: 24129226
Cyclooxygenase-2 and prostate carcinogenesis.
Hussain T, Gupta S, Mukhtar H
Cancer Lett 2003 Mar 10;191(2):125-35. doi: 10.1016/s0304-3835(02)00524-4. PMID: 12618325

Recent systematic reviews

In Search for risk predictors at the microscopic scenario of a negative biopsy. A systematic review.
Schwartzmann I, Celma A, Gallardo I, Moreno O, Regis L, Placer J, Planas J, Trilla Herrero E, Morote Robles J
Actas Urol Esp (Engl Ed) 2019 Sep;43(7):337-347. Epub 2019 May 17 doi: 10.1016/j.acuro.2019.01.010. PMID: 31109736
Polyomavirus BK and prostate cancer: a complex interaction of potential clinical relevance.
Keller EX, Delbue S, Tognon M, Provenzano M
Rev Med Virol 2015 Nov;25(6):366-78. Epub 2015 Aug 26 doi: 10.1002/rmv.1851. PMID: 26308483
Clinical significance of proliferative inflammatory atrophy in prostate biopsy.
Celma A, Servián P, Planas J, Placer J, Quilez MT, Arbós MA, de Torres I, Morote J
Actas Urol Esp 2014 Mar;38(2):122-6. Epub 2013 Oct 13 doi: 10.1016/j.acuro.2013.04.008. PMID: 24129226

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