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Autoimmune Cytopenia

MedGen UID:
476339
•Concept ID:
C3274706
•
Pathologic Function
Synonyms: Autoimmune cytopenia; Autoimmune cytopenias

Definition

Cytopenia caused by autoantibodies against the red blood cells, neutrophils, and/or platelets. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAutoimmune Cytopenia

Professional guidelines

PubMed

Autoimmunity in Primary Immunodeficiencies (PID).
Padron GT, Hernandez-Trujillo VP
Clin Rev Allergy Immunol 2023 Aug;65(1):1-18. Epub 2022 Jun 1 doi: 10.1007/s12016-022-08942-0. PMID: 35648371
Targeted treatment of autoimmune cytopenias in primary immunodeficiencies.
Pacillo L, Giardino G, Amodio D, Giancotta C, Rivalta B, Rotulo GA, Manno EC, Cifaldi C, Palumbo G, Pignata C, Palma P, Rossi P, Finocchi A, Cancrini C
Front Immunol 2022;13:911385. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.911385. PMID: 36052091Free PMC Article
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
Schwab C, Gabrysch A, Olbrich P, Patiño V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Sumnik Z, Sediva A, Slatter M, Arkwright PD, Cant A, Lorenz HM, Giese T, Lougaris V, Plebani A, Price C, Sullivan KE, Moutschen M, Litzman J, Freiberger T, van de Veerdonk FL, Recher M, Albert MH, Hauck F, Seneviratne S, Pachlopnik Schmid J, Kolios A, Unglik G, Klemann C, Speckmann C, Ehl S, Leichtner A, Blumberg R, Franke A, Snapper S, Zeissig S, Cunningham-Rundles C, Giulino-Roth L, Elemento O, Dückers G, Niehues T, Fronkova E, Kanderová V, Platt CD, Chou J, Chatila TA, Geha R, McDermott E, Bunn S, Kurzai M, Schulz A, Alsina L, Casals F, Deyà-Martinez A, Hambleton S, Kanegane H, Taskén K, Neth O, Grimbacher B
J Allergy Clin Immunol 2018 Dec;142(6):1932-1946. Epub 2018 May 4 doi: 10.1016/j.jaci.2018.02.055. PMID: 29729943Free PMC Article

Recent clinical studies

Etiology

Targeted treatment of autoimmune cytopenias in primary immunodeficiencies.
Pacillo L, Giardino G, Amodio D, Giancotta C, Rivalta B, Rotulo GA, Manno EC, Cifaldi C, Palumbo G, Pignata C, Palma P, Rossi P, Finocchi A, Cancrini C
Front Immunol 2022;13:911385. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.911385. PMID: 36052091Free PMC Article
Autoimmune Cytopenias in Common Variable Immunodeficiency Are a Diagnostic and Therapeutic Conundrum: An Update.
Chawla S, Barman P, Tyagi R, Jindal AK, Sharma S, Rawat A, Singh S
Front Immunol 2022;13:869466. Epub 2022 Jun 20 doi: 10.3389/fimmu.2022.869466. PMID: 35795667Free PMC Article
Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD).
Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, Van Damme A, Brichard B
J Clin Immunol 2021 Jan;41(1):51-58. Epub 2020 Oct 4 doi: 10.1007/s10875-020-00883-7. PMID: 33011939
Autoimmunity Following Allogeneic Hematopoietic Stem Cell Transplantation.
Buxbaum NP, Pavletic SZ
Front Immunol 2020;11:2017. Epub 2020 Aug 25 doi: 10.3389/fimmu.2020.02017. PMID: 32983144Free PMC Article
Autoinflammatory and autoimmune conditions at the crossroad of COVID-19.
Rodríguez Y, Novelli L, Rojas M, De Santis M, Acosta-Ampudia Y, Monsalve DM, Ramírez-Santana C, Costanzo A, Ridgway WM, Ansari AA, Gershwin ME, Selmi C, Anaya JM
J Autoimmun 2020 Nov;114:102506. Epub 2020 Jun 16 doi: 10.1016/j.jaut.2020.102506. PMID: 32563547Free PMC Article

Diagnosis

Autoimmunity in Primary Immunodeficiencies (PID).
Padron GT, Hernandez-Trujillo VP
Clin Rev Allergy Immunol 2023 Aug;65(1):1-18. Epub 2022 Jun 1 doi: 10.1007/s12016-022-08942-0. PMID: 35648371
Adult Evans' Syndrome.
Michel M
Hematol Oncol Clin North Am 2022 Apr;36(2):381-392. Epub 2022 Mar 11 doi: 10.1016/j.hoc.2021.12.004. PMID: 35282950
Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD).
Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, Van Damme A, Brichard B
J Clin Immunol 2021 Jan;41(1):51-58. Epub 2020 Oct 4 doi: 10.1007/s10875-020-00883-7. PMID: 33011939
What's up in the ALPS.
Rieux-Laucat F
Curr Opin Immunol 2017 Dec;49:79-86. Epub 2017 Oct 23 doi: 10.1016/j.coi.2017.10.001. PMID: 29073495
Autoimmune cytopenia in chronic lymphocytic leukaemia: diagnosis and treatment.
Hodgson K, Ferrer G, Pereira A, Moreno C, Montserrat E
Br J Haematol 2011 Jul;154(1):14-22. Epub 2011 May 1 doi: 10.1111/j.1365-2141.2011.08707.x. PMID: 21534942

Therapy

Autoimmune cytopenia and Kabuki syndrome in paediatrics: Insights in 11 patients.
Bianchi C, Margot H, Fernandes H, Pasquet M, Priqueler L, Roy-Peaud F, Bauduer F, Bayart S, Garnier N, Fain O, Van Gils J, Joly SB, Rialland F, Paillard C, Deparis M, Lambilliotte A, Leblanc T, Fahd M, Leverger G, Héritier S, Geneviève D, Rieux-Laucat F, Picard C, Neyraud C, Aladjidi N
Br J Haematol 2024 May;204(5):1899-1907. Epub 2024 Mar 3 doi: 10.1111/bjh.19387. PMID: 38432067
Markers of refractory primary immune thrombocytopenia.
Moulis G, Garabet L
Br J Haematol 2023 Oct;203(1):112-118. Epub 2023 Aug 30 doi: 10.1111/bjh.19076. PMID: 38019080
Maintenence rituximab following induction in autoimmune cytopenias.
Rai MP, Lee EJ, Bussel JB
Br J Haematol 2023 Jul;202(1):153-158. Epub 2023 Apr 22 doi: 10.1111/bjh.18814. PMID: 37086173
Efficacy and steroid-sparing effect of tacrolimus in patients with autoimmune cytopenia.
Zhang R, Chen M, Yang C, Han B
Ann Hematol 2022 Nov;101(11):2421-2431. Epub 2022 Sep 6 doi: 10.1007/s00277-022-04967-9. PMID: 36066607
Autoimmune Cytopenia in CLL: Prognosis and Management in the Era of Targeted Therapies.
Albiol N, Moreno C
Cancer J 2021 Jul-Aug 01;27(4):286-296. doi: 10.1097/PPO.0000000000000537. PMID: 34398555

Prognosis

Targeted treatment of autoimmune cytopenias in primary immunodeficiencies.
Pacillo L, Giardino G, Amodio D, Giancotta C, Rivalta B, Rotulo GA, Manno EC, Cifaldi C, Palumbo G, Pignata C, Palma P, Rossi P, Finocchi A, Cancrini C
Front Immunol 2022;13:911385. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.911385. PMID: 36052091Free PMC Article
Autoimmune Cytopenia in CLL: Prognosis and Management in the Era of Targeted Therapies.
Albiol N, Moreno C
Cancer J 2021 Jul-Aug 01;27(4):286-296. doi: 10.1097/PPO.0000000000000537. PMID: 34398555
Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD).
Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, Van Damme A, Brichard B
J Clin Immunol 2021 Jan;41(1):51-58. Epub 2020 Oct 4 doi: 10.1007/s10875-020-00883-7. PMID: 33011939
Autoimmunity Following Allogeneic Hematopoietic Stem Cell Transplantation.
Buxbaum NP, Pavletic SZ
Front Immunol 2020;11:2017. Epub 2020 Aug 25 doi: 10.3389/fimmu.2020.02017. PMID: 32983144Free PMC Article
Autoimmune cytopenia in chronic lymphocytic leukaemia: diagnosis and treatment.
Hodgson K, Ferrer G, Pereira A, Moreno C, Montserrat E
Br J Haematol 2011 Jul;154(1):14-22. Epub 2011 May 1 doi: 10.1111/j.1365-2141.2011.08707.x. PMID: 21534942

Clinical prediction guides

Efficacy and steroid-sparing effect of tacrolimus in patients with autoimmune cytopenia.
Zhang R, Chen M, Yang C, Han B
Ann Hematol 2022 Nov;101(11):2421-2431. Epub 2022 Sep 6 doi: 10.1007/s00277-022-04967-9. PMID: 36066607
Targeted treatment of autoimmune cytopenias in primary immunodeficiencies.
Pacillo L, Giardino G, Amodio D, Giancotta C, Rivalta B, Rotulo GA, Manno EC, Cifaldi C, Palumbo G, Pignata C, Palma P, Rossi P, Finocchi A, Cancrini C
Front Immunol 2022;13:911385. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.911385. PMID: 36052091Free PMC Article
Autoimmune Cytopenias in Common Variable Immunodeficiency Are a Diagnostic and Therapeutic Conundrum: An Update.
Chawla S, Barman P, Tyagi R, Jindal AK, Sharma S, Rawat A, Singh S
Front Immunol 2022;13:869466. Epub 2022 Jun 20 doi: 10.3389/fimmu.2022.869466. PMID: 35795667Free PMC Article
Autoimmunity Following Allogeneic Hematopoietic Stem Cell Transplantation.
Buxbaum NP, Pavletic SZ
Front Immunol 2020;11:2017. Epub 2020 Aug 25 doi: 10.3389/fimmu.2020.02017. PMID: 32983144Free PMC Article
Autoinflammatory and autoimmune conditions at the crossroad of COVID-19.
Rodríguez Y, Novelli L, Rojas M, De Santis M, Acosta-Ampudia Y, Monsalve DM, Ramírez-Santana C, Costanzo A, Ridgway WM, Ansari AA, Gershwin ME, Selmi C, Anaya JM
J Autoimmun 2020 Nov;114:102506. Epub 2020 Jun 16 doi: 10.1016/j.jaut.2020.102506. PMID: 32563547Free PMC Article

Recent systematic reviews

Lessons Learned From the Clinical Presentation of Common Variable Immunodeficiency Disorders: A Systematic Review and Meta-Analysis.
Janssen LMA, van der Flier M, de Vries E
Front Immunol 2021;12:620709. Epub 2021 Mar 23 doi: 10.3389/fimmu.2021.620709. PMID: 33833753Free PMC Article
Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review.
Tang KT, Hsu BC, Chen DY
Front Immunol 2021;12:645013. Epub 2021 Mar 12 doi: 10.3389/fimmu.2021.645013. PMID: 33777042Free PMC Article
Autoimmunity in common variable immunodeficiency: a systematic review and meta-analysis.
Rizvi FS, Zainaldain H, Rafiemanesh H, Jamee M, Hossein-Khannazer N, Hamedifar H, Sabzevari A, Yazdani R, Abolhassani H, Aghamohammadi A, Azizi G
Expert Rev Clin Immunol 2020 Dec;16(12):1227-1235. Epub 2020 Dec 7 doi: 10.1080/1744666X.2021.1850272. PMID: 33203275
Are RASopathies new monogenic predisposing conditions to the development of systemic lupus erythematosus? Case report and systematic review of the literature.
Bader-Meunier B, Cavé H, Jeremiah N, Magerus A, Lanzarotti N, Rieux-Laucat F, Cormier-Daire V
Semin Arthritis Rheum 2013 Oct;43(2):217-9. Epub 2013 Jun 17 doi: 10.1016/j.semarthrit.2013.04.009. PMID: 23786871
Chronic lymphocytic leukemia and autoimmunity: a systematic review.
Hodgson K, Ferrer G, Montserrat E, Moreno C
Haematologica 2011 May;96(5):752-61. Epub 2011 Jan 17 doi: 10.3324/haematol.2010.036152. PMID: 21242190Free PMC Article

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