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Contralateral Breast Carcinoma

MedGen UID:
476342
•Concept ID:
C3274709
•
Neoplastic Process

Definition

Breast carcinoma that develops in the opposite breast of a patient with an already diagnosed primary breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVContralateral Breast Carcinoma

Professional guidelines

PubMed

Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning.
Yi M, Buchholz TA, Meric-Bernstam F, Bedrosian I, Hwang RF, Ross MI, Kuerer HM, Luo S, Gonzalez-Angulo AM, Buzdar AU, Symmans WF, Feig BW, Lucci A, Huang EH, Hunt KK
Ann Surg 2011 Mar;253(3):572-9. doi: 10.1097/SLA.0b013e318208fc2a. PMID: 21209588Free PMC Article
Appropriateness of breast-conserving treatment of breast carcinoma in women with germline mutations in BRCA1 or BRCA2: a clinic-based series.
Robson M, Svahn T, McCormick B, Borgen P, Hudis CA, Norton L, Offit K
Cancer 2005 Jan 1;103(1):44-51. doi: 10.1002/cncr.20728. PMID: 15558796
Contralateral breast carcinoma: an assessment of risk and prognosis in stage I (T1N0M0) and stage II (T1N1M0) patients with 20-year follow-up.
Rosen PP, Groshen S, Kinne DW, Hellman S
Surgery 1989 Nov;106(5):904-10. PMID: 2814824

Recent clinical studies

Etiology

Bilateral breast carcinoma: clinical characteristics and its impact on survival.
Vuoto HD, García AM, Candás GB, Zimmermann AG, Uriburu JL, Isetta JA, Cogorno L, Khoury M, Bernabó OL
Breast J 2010 Nov-Dec;16(6):625-32. doi: 10.1111/j.1524-4741.2010.00976.x. PMID: 21070440
Tubular carcinoma of the breast: mammographic, sonographic, clinical and pathologic findings.
Günhan-Bilgen I, Oktay A
Eur J Radiol 2007 Jan;61(1):158-62. Epub 2006 Sep 20 doi: 10.1016/j.ejrad.2006.08.021. PMID: 16987629
High risk of contralateral breast carcinoma in women with hereditary/familial non-BRCA1/BRCA2 breast carcinoma.
Shahedi K, Emanuelsson M, Wiklund F, Gronberg H
Cancer 2006 Mar 15;106(6):1237-42. doi: 10.1002/cncr.21753. PMID: 16475207
MRI of the breast: state of the art.
Friedrich M
Eur Radiol 1998;8(5):707-25. doi: 10.1007/s003300050463. PMID: 9601956
Contralateral breast carcinoma: an assessment of risk and prognosis in stage I (T1N0M0) and stage II (T1N1M0) patients with 20-year follow-up.
Rosen PP, Groshen S, Kinne DW, Hellman S
Surgery 1989 Nov;106(5):904-10. PMID: 2814824

Diagnosis

Bilateral breast carcinoma: clinical characteristics and its impact on survival.
Vuoto HD, García AM, Candás GB, Zimmermann AG, Uriburu JL, Isetta JA, Cogorno L, Khoury M, Bernabó OL
Breast J 2010 Nov-Dec;16(6):625-32. doi: 10.1111/j.1524-4741.2010.00976.x. PMID: 21070440
Tubular carcinoma of the breast: mammographic, sonographic, clinical and pathologic findings.
Günhan-Bilgen I, Oktay A
Eur J Radiol 2007 Jan;61(1):158-62. Epub 2006 Sep 20 doi: 10.1016/j.ejrad.2006.08.021. PMID: 16987629
High risk of contralateral breast carcinoma in women with hereditary/familial non-BRCA1/BRCA2 breast carcinoma.
Shahedi K, Emanuelsson M, Wiklund F, Gronberg H
Cancer 2006 Mar 15;106(6):1237-42. doi: 10.1002/cncr.21753. PMID: 16475207
Occult contralateral breast carcinoma incidentally detected by breast magnetic resonance imaging.
Slanetz PJ, Edmister WB, Yeh ED, Talele AC, Kopans DB
Breast J 2002 May-Jun;8(3):145-8. doi: 10.1046/j.1524-4741.2002.08304.x. PMID: 12047470
MRI of the breast: state of the art.
Friedrich M
Eur Radiol 1998;8(5):707-25. doi: 10.1007/s003300050463. PMID: 9601956

Therapy

Critical Appraisal of the Risk of Secondary Cancer Induction From Breast Radiation Therapy With Volumetric Modulated Arc Therapy Relative to 3D Conformal Therapy.
Fogliata A, De Rose F, Franceschini D, Stravato A, Seppälä J, Scorsetti M, Cozzi L
Int J Radiat Oncol Biol Phys 2018 Mar 1;100(3):785-793. Epub 2017 Oct 31 doi: 10.1016/j.ijrobp.2017.10.040. PMID: 29249528
Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery: experience with 590 cases.
Veronesi U, Orecchia R, Luini A, Galimberti V, Gatti G, Intra M, Veronesi P, Leonardi MC, Ciocca M, Lazzari R, Caldarella P, Simsek S, Silva LS, Sances D
Ann Surg 2005 Jul;242(1):101-6. doi: 10.1097/01.sla.0000167927.82353.bc. PMID: 15973107Free PMC Article
Similar long-term results of breast-conservation treatment for Stage I and II invasive lobular carcinoma compared with invasive ductal carcinoma of the breast: The University of Pennsylvania experience.
Santiago RJ, Harris EE, Qin L, Hwang WT, Solin LJ
Cancer 2005 Jun 15;103(12):2447-54. doi: 10.1002/cncr.21071. PMID: 15887223
Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomized Trial.
Poggi MM, Danforth DN, Sciuto LC, Smith SL, Steinberg SM, Liewehr DJ, Menard C, Lippman ME, Lichter AS, Altemus RM
Cancer 2003 Aug 15;98(4):697-702. doi: 10.1002/cncr.11580. PMID: 12910512
Breast conservation therapy as a treatment option for the elderly. The M. D. Anderson experience.
Vlastos G, Mirza NQ, Meric F, Hunt KK, Kuerer HM, Ames FC, Ross MI, Buchholz TA, Hortobagyi GN, Singletary SE
Cancer 2001 Sep 1;92(5):1092-100. doi: 10.1002/1097-0142(20010901)92:5<1092::aid-cncr1425>3.0.co;2-p. PMID: 11571720

Prognosis

Tubular carcinoma of the breast: mammographic, sonographic, clinical and pathologic findings.
Günhan-Bilgen I, Oktay A
Eur J Radiol 2007 Jan;61(1):158-62. Epub 2006 Sep 20 doi: 10.1016/j.ejrad.2006.08.021. PMID: 16987629
High risk of contralateral breast carcinoma in women with hereditary/familial non-BRCA1/BRCA2 breast carcinoma.
Shahedi K, Emanuelsson M, Wiklund F, Gronberg H
Cancer 2006 Mar 15;106(6):1237-42. doi: 10.1002/cncr.21753. PMID: 16475207
Appropriateness of breast-conserving treatment of breast carcinoma in women with germline mutations in BRCA1 or BRCA2: a clinic-based series.
Robson M, Svahn T, McCormick B, Borgen P, Hudis CA, Norton L, Offit K
Cancer 2005 Jan 1;103(1):44-51. doi: 10.1002/cncr.20728. PMID: 15558796
Prognosis in T2N0M0 stage I breast carcinoma: a 20-year follow-up study.
Rosen PP, Groshen S, Kinne DW
J Clin Oncol 1991 Sep;9(9):1650-61. doi: 10.1200/JCO.1991.9.9.1650. PMID: 1875222
Contralateral breast carcinoma: an assessment of risk and prognosis in stage I (T1N0M0) and stage II (T1N1M0) patients with 20-year follow-up.
Rosen PP, Groshen S, Kinne DW, Hellman S
Surgery 1989 Nov;106(5):904-10. PMID: 2814824

Clinical prediction guides

Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning.
Yi M, Buchholz TA, Meric-Bernstam F, Bedrosian I, Hwang RF, Ross MI, Kuerer HM, Luo S, Gonzalez-Angulo AM, Buzdar AU, Symmans WF, Feig BW, Lucci A, Huang EH, Hunt KK
Ann Surg 2011 Mar;253(3):572-9. doi: 10.1097/SLA.0b013e318208fc2a. PMID: 21209588Free PMC Article
High risk of contralateral breast carcinoma in women with hereditary/familial non-BRCA1/BRCA2 breast carcinoma.
Shahedi K, Emanuelsson M, Wiklund F, Gronberg H
Cancer 2006 Mar 15;106(6):1237-42. doi: 10.1002/cncr.21753. PMID: 16475207
Contralateral prophylactic mastectomy. Predictors of significant histologic findings.
Goldflam K, Hunt KK, Gershenwald JE, Singletary SE, Mirza N, Kuerer HM, Babiera GV, Ames FC, Ross MI, Feig BW, Sahin AA, Arun B, Meric-Bernstam F
Cancer 2004 Nov 1;101(9):1977-86. doi: 10.1002/cncr.20617. PMID: 15389473
Nonmammary malignant neoplasms in patients with stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma. A long-term follow-up study.
Rosen PP, Groshen S, Kinne DW, Hellman S
Am J Clin Oncol 1989 Oct;12(5):369-74. doi: 10.1097/00000421-198910000-00001. PMID: 2801596
Lobular carcinoma in situ of the breast: preliminary results of treatment by ipsilateral mastectomy and contralateral breast biopsy.
Rosen PP, Braun DW Jr, Lyngholm B, Urban JA, Kinne DW
Cancer 1981 Feb 15;47(4):813-9. doi: 10.1002/1097-0142(19810215)47:4<813::aid-cncr2820470431>3.0.co;2-j. PMID: 7226031

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