U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Moderately Abnormal Ejection Fraction

MedGen UID:
476409
•Concept ID:
C3274776
•
Finding

Definition

Moderately less than normal amount of blood that is forced from the heart ventricle to produce cardiac output. Quantitatively, the ejection fraction is considered between 30% to 39%. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerately Abnormal Ejection Fraction

Professional guidelines

PubMed

Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
Neonatal Myocardial Infarction: A Proposed Algorithm for Coronary Arterial Thrombus Management.
El-Sabrout H, Ganta S, Guyon P, Ratnayaka K, Vaughn G, Perry J, Kimball A, Ryan J, Thornburg CD, Tucker S, Mo J, Hegde S, Nigro J, El-Said H
Circ Cardiovasc Interv 2022 May;15(5):e011664. Epub 2022 Apr 29 doi: 10.1161/CIRCINTERVENTIONS.121.011664. PMID: 35485231
Management and outcomes of heart failure patients with CKD: experience from an inter-disciplinary clinic.
Nguyen M, Rumjaun S, Lowe-Jones R, Ster IC, Rosano G, Anderson L, Banerjee D
ESC Heart Fail 2020 Oct;7(5):3225-3230. Epub 2020 Jul 11 doi: 10.1002/ehf2.12796. PMID: 32652822Free PMC Article

Recent clinical studies

Etiology

Haemodynamic and metabolic phenotyping of patients with aortic stenosis and preserved ejection fraction: A specific phenotype of heart failure with preserved ejection fraction?
De Biase N, Mazzola M, Del Punta L, Di Fiore V, De Carlo M, Giannini C, Costa G, Paneni F, Mengozzi A, Nesti L, Gargani L, Masi S, Pugliese NR
Eur J Heart Fail 2023 Nov;25(11):1947-1958. Epub 2023 Sep 14 doi: 10.1002/ejhf.3018. PMID: 37655676
Prevalence and incidence of diastolic dysfunction in atrial fibrillation: clinical implications.
Naser JA, Lee E, Scott CG, Kennedy AM, Pellikka PA, Lin G, Pislaru SV, Borlaug BA
Eur Heart J 2023 Dec 21;44(48):5049-5060. doi: 10.1093/eurheartj/ehad592. PMID: 37639219
Relation of Myocardial Perfusion Reserve and Left Ventricular Ejection Fraction in Ischemic and Nonischemic Cardiomyopathy.
Wang S, Patel H, Miller T, Ameyaw K, Miller P, Narang A, Kawaji K, Singh A, Landeras L, Liu XP, Mor-Avi V, Patel AR
Am J Cardiol 2022 Jul 1;174:143-150. Epub 2022 Apr 26 doi: 10.1016/j.amjcard.2022.02.022. PMID: 35487776Free PMC Article
Electrocardiographic changes in non-hospitalised children with COVID-19.
Heching HJ, Goyal A, Harvey B, Malloy-Walton L, Follansbee C, Mcintosh A, Forsha D
Cardiol Young 2022 Dec;32(12):1910-1916. Epub 2022 Jan 6 doi: 10.1017/S1047951121005138. PMID: 34986922
Review of Echocardiographic Findings in Patients with Obstructive Sleep Apnea.
Sascău R, Zota IM, Stătescu C, Boișteanu D, Roca M, Maștaleru A, Leon Constantin MM, Vasilcu TF, Gavril RS, Mitu F
Can Respir J 2018;2018:1206217. Epub 2018 Nov 18 doi: 10.1155/2018/1206217. PMID: 30581512Free PMC Article

Diagnosis

Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
Neonatal Myocardial Infarction: A Proposed Algorithm for Coronary Arterial Thrombus Management.
El-Sabrout H, Ganta S, Guyon P, Ratnayaka K, Vaughn G, Perry J, Kimball A, Ryan J, Thornburg CD, Tucker S, Mo J, Hegde S, Nigro J, El-Said H
Circ Cardiovasc Interv 2022 May;15(5):e011664. Epub 2022 Apr 29 doi: 10.1161/CIRCINTERVENTIONS.121.011664. PMID: 35485231
Presentation and Outcome of Arrhythmic Mitral Valve Prolapse.
Essayagh B, Sabbag A, Antoine C, Benfari G, Yang LT, Maalouf J, Asirvatham S, Michelena H, Enriquez-Sarano M
J Am Coll Cardiol 2020 Aug 11;76(6):637-649. doi: 10.1016/j.jacc.2020.06.029. PMID: 32762897
Review of Echocardiographic Findings in Patients with Obstructive Sleep Apnea.
Sascău R, Zota IM, Stătescu C, Boișteanu D, Roca M, Maștaleru A, Leon Constantin MM, Vasilcu TF, Gavril RS, Mitu F
Can Respir J 2018;2018:1206217. Epub 2018 Nov 18 doi: 10.1155/2018/1206217. PMID: 30581512Free PMC Article
Heart Failure with Preserved Ejection Fraction: Entresto a Possible Option.
Bramblett T, Teleb M, Albaghdadi A, Agrawal H, Mukherjee D
Cardiovasc Hematol Disord Drug Targets 2017;17(2):80-85. doi: 10.2174/1871529X17666170703120237. PMID: 28676030

Therapy

Effect of Training on Vascular Function and Repair in Heart Failure With Preserved Ejection Fraction.
Gevaert AB, Böhm B, Hartmann H, Goovaerts I, Stoop T, Van De Heyning CM, Beckers PJ, Baldassarri F, Mueller S, Oberhoffer R, Duvinage A, Haykowsky MJ, Wisløff U, Adams V, Pieske B, Halle M, Van Craenenbroeck EM
JACC Heart Fail 2023 Apr;11(4):454-464. Epub 2023 Mar 1 doi: 10.1016/j.jchf.2022.12.011. PMID: 36892488
Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial.
Heitner SB, Jacoby D, Lester SJ, Owens A, Wang A, Zhang D, Lambing J, Lee J, Semigran M, Sehnert AJ
Ann Intern Med 2019 Jun 4;170(11):741-748. Epub 2019 Apr 30 doi: 10.7326/M18-3016. PMID: 31035291
Heart Failure with Preserved Ejection Fraction: Entresto a Possible Option.
Bramblett T, Teleb M, Albaghdadi A, Agrawal H, Mukherjee D
Cardiovasc Hematol Disord Drug Targets 2017;17(2):80-85. doi: 10.2174/1871529X17666170703120237. PMID: 28676030
The Problem of Atrial Fibrillation in Patients with Chronic Kidney Disease.
Franczyk B, Gluba-Brzózka A, Ciałkowska-Rysz A, Banach M, Rysz J
Curr Vasc Pharmacol 2016;14(3):260-5. doi: 10.2174/1570161114666160115130836. PMID: 26769703

Prognosis

Haemodynamic and metabolic phenotyping of patients with aortic stenosis and preserved ejection fraction: A specific phenotype of heart failure with preserved ejection fraction?
De Biase N, Mazzola M, Del Punta L, Di Fiore V, De Carlo M, Giannini C, Costa G, Paneni F, Mengozzi A, Nesti L, Gargani L, Masi S, Pugliese NR
Eur J Heart Fail 2023 Nov;25(11):1947-1958. Epub 2023 Sep 14 doi: 10.1002/ejhf.3018. PMID: 37655676
Prevalence and incidence of diastolic dysfunction in atrial fibrillation: clinical implications.
Naser JA, Lee E, Scott CG, Kennedy AM, Pellikka PA, Lin G, Pislaru SV, Borlaug BA
Eur Heart J 2023 Dec 21;44(48):5049-5060. doi: 10.1093/eurheartj/ehad592. PMID: 37639219
Determining Which Hospitalized Coronavirus Disease 2019 Patients Require Urgent Echocardiography.
Yuan N, Wu S, Rader F, Siegel RJ
J Am Soc Echocardiogr 2021 Aug;34(8):831-838. Epub 2021 Apr 1 doi: 10.1016/j.echo.2021.03.010. PMID: 33812952Free PMC Article
Non-invasive cardiac mapping for non-response in cardiac resynchronization therapy.
Strik M, Ploux S, Jankelson L, Bordachar P
Ann Med 2019 Mar;51(2):109-117. Epub 2019 May 23 doi: 10.1080/07853890.2019.1616109. PMID: 31094217Free PMC Article
Technology Advances to Improve Response to Cardiac Resynchronization Therapy: What Clinicians Should Know.
Auricchio A, Heggermont WA
Rev Esp Cardiol (Engl Ed) 2018 Jun;71(6):477-484. Epub 2018 Feb 14 doi: 10.1016/j.rec.2018.01.006. PMID: 29454549

Clinical prediction guides

Prevalence and incidence of diastolic dysfunction in atrial fibrillation: clinical implications.
Naser JA, Lee E, Scott CG, Kennedy AM, Pellikka PA, Lin G, Pislaru SV, Borlaug BA
Eur Heart J 2023 Dec 21;44(48):5049-5060. doi: 10.1093/eurheartj/ehad592. PMID: 37639219
Effect of Training on Vascular Function and Repair in Heart Failure With Preserved Ejection Fraction.
Gevaert AB, Böhm B, Hartmann H, Goovaerts I, Stoop T, Van De Heyning CM, Beckers PJ, Baldassarri F, Mueller S, Oberhoffer R, Duvinage A, Haykowsky MJ, Wisløff U, Adams V, Pieske B, Halle M, Van Craenenbroeck EM
JACC Heart Fail 2023 Apr;11(4):454-464. Epub 2023 Mar 1 doi: 10.1016/j.jchf.2022.12.011. PMID: 36892488
Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial.
Heitner SB, Jacoby D, Lester SJ, Owens A, Wang A, Zhang D, Lambing J, Lee J, Semigran M, Sehnert AJ
Ann Intern Med 2019 Jun 4;170(11):741-748. Epub 2019 Apr 30 doi: 10.7326/M18-3016. PMID: 31035291
Review of Echocardiographic Findings in Patients with Obstructive Sleep Apnea.
Sascău R, Zota IM, Stătescu C, Boișteanu D, Roca M, Maștaleru A, Leon Constantin MM, Vasilcu TF, Gavril RS, Mitu F
Can Respir J 2018;2018:1206217. Epub 2018 Nov 18 doi: 10.1155/2018/1206217. PMID: 30581512Free PMC Article

Recent systematic reviews

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion-dependent beta thalassaemia.
Padhani ZA, Gangwani MK, Sadaf A, Hasan B, Colan S, Alvi N, Das JK
Cochrane Database Syst Rev 2023 Nov 17;11(11):CD011626. doi: 10.1002/14651858.CD011626.pub3. PMID: 37975597Free PMC Article
Parathyroidectomy for adults with primary hyperparathyroidism.
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
Diagnostic accuracy of handheld cardiac ultrasound device for assessment of left ventricular structure and function: systematic review and meta-analysis.
Jenkins S, Alabed S, Swift A, Marques G, Ryding A, Sawh C, Wardley J, Shah BN, Swoboda P, Senior R, Nijveldt R, Vassiliou VS, Garg P
Heart 2021 Nov;107(22):1826-1834. Epub 2021 Aug 6 doi: 10.1136/heartjnl-2021-319561. PMID: 34362772Free PMC Article
Risk Factors for Mortality and Ventricular Tachycardia in Patients With Repaired Tetralogy of Fallot: A Systematic Review and Meta-analysis.
Possner M, Tseng SY, Alahdab F, Bokma JP, Lubert AM, Khairy P, Murad MH, Ben Ali W, Prokop LJ, Czosek RJ, Veldtman GR, Alsaied T
Can J Cardiol 2020 Nov;36(11):1815-1825. Epub 2020 Feb 4 doi: 10.1016/j.cjca.2020.01.023. PMID: 32416063
Detection of Obstructive Coronary Artery Disease Using Peak Systolic Global Longitudinal Strain Derived by Two-Dimensional Speckle-Tracking: A Systematic Review and Meta-Analysis.
Liou K, Negishi K, Ho S, Russell EA, Cranney G, Ooi SY
J Am Soc Echocardiogr 2016 Aug;29(8):724-735.e4. Epub 2016 May 4 doi: 10.1016/j.echo.2016.03.002. PMID: 27155815

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...