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Hyperdynamic Ventricular Ejection Fraction

MedGen UID:
476412
•Concept ID:
C3274779
•
Finding

Definition

A pathologically high percentage of blood that is forced from the heart ventricle to produce cardiac output. This is often the result of ventricular dilation due to hypertrophic cardiomyopathy. Quantitatively, the ejection fraction is considered higher than 70%. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperdynamic Ventricular Ejection Fraction

Professional guidelines

PubMed

The "Preeclampsia and Hypertension Target Treatment" study: a multicenter prospective study to evaluate the effectiveness of the antihypertensive therapy based on maternal hemodynamic findings.
di Pasquo E, Giannubilo SR, Valentini B, Salvi S, Rullo R, Fruci S, Filippi E, Ornaghi S, Zullino S, Rossi F, Farsetti D, Di Martino DD, Vasapollo B, Locatelli A, De Santis M, Ciavattini A, Lanzone A, Mecacci F, Ferrazzi E, Valensise H, Ghi T
Am J Obstet Gynecol MFM 2024 May;6(5):101368. Epub 2024 Apr 3 doi: 10.1016/j.ajogmf.2024.101368. PMID: 38574856
Intraoperative management of liver transplantation in patients with hypertrophic cardiomyopathy: a review.
Robertson A
Transplant Proc 2010 Jun;42(5):1721-3. doi: 10.1016/j.transproceed.2010.02.091. PMID: 20620509
Patent ductus arteriosus in micropreemies and full-term infants: the relative merits of surgical ligation versus indomethacin treatment.
Little DC, Pratt TC, Blalock SE, Krauss DR, Cooney DR, Custer MD
J Pediatr Surg 2003 Mar;38(3):492-6. doi: 10.1053/jpsu.2003.50086. PMID: 12632374

Recent clinical studies

Etiology

Is Left Ventricular Systolic Dysfunction Associated With Increased Mortality Among Patients With Sepsis and Septic Shock?
Dugar S, Sato R, Chawla S, You JY, Wang X, Grimm R, Collier P, Lanspa M, Duggal A
Chest 2023 Jun;163(6):1437-1447. Epub 2023 Jan 14 doi: 10.1016/j.chest.2023.01.010. PMID: 36646415
Echocardiographic Characteristics and Clinical Outcomes of the Hyperdynamic Heart: A 'Super-Normal' Heart is not a Normal Heart.
Gotsman I, Leibowitz D, Keren A, Amir O, Zwas DR
Am J Cardiol 2023 Jan 15;187:119-126. Epub 2022 Nov 29 doi: 10.1016/j.amjcard.2022.10.029. PMID: 36459734
Hyperdynamic Left Ventricular Ejection Fraction in ICU Patients With Sepsis.
Chotalia M, Ali M, Hebballi R, Singh H, Parekh D, Bangash MN, Patel JM
Crit Care Med 2022 May 1;50(5):770-779. Epub 2021 Oct 4 doi: 10.1097/CCM.0000000000005315. PMID: 34605779
Deep Learning-Based Automated Echocardiographic Quantification of Left Ventricular Ejection Fraction: A Point-of-Care Solution.
Asch FM, Mor-Avi V, Rubenson D, Goldstein S, Saric M, Mikati I, Surette S, Chaudhry A, Poilvert N, Hong H, Horowitz R, Park D, Diaz-Gomez JL, Boesch B, Nikravan S, Liu RB, Philips C, Thomas JD, Martin RP, Lang RM
Circ Cardiovasc Imaging 2021 Jun;14(6):e012293. Epub 2021 Jun 15 doi: 10.1161/CIRCIMAGING.120.012293. PMID: 34126754
Hyperdynamic left ventricular ejection fraction in the intensive care unit.
Paonessa JR, Brennan T, Pimentel M, Steinhaus D, Feng M, Celi LA
Crit Care 2015 Aug 7;19(1):288. doi: 10.1186/s13054-015-1012-8. PMID: 26250903Free PMC Article

Diagnosis

Comparison of visual estimation and quantitative measurement of left ventricular ejection fraction in untrained perioperative echocardiographers.
Raksamani K, Noirit A, Chaikittisilpa N
BMC Anesthesiol 2023 Apr 1;23(1):106. doi: 10.1186/s12871-023-02067-3. PMID: 37005582Free PMC Article
Echocardiographic Characteristics and Clinical Outcomes of the Hyperdynamic Heart: A 'Super-Normal' Heart is not a Normal Heart.
Gotsman I, Leibowitz D, Keren A, Amir O, Zwas DR
Am J Cardiol 2023 Jan 15;187:119-126. Epub 2022 Nov 29 doi: 10.1016/j.amjcard.2022.10.029. PMID: 36459734
Magnetic Resonance Imaging of Normal Pressure Hydrocephalus.
Bradley WG Jr
Semin Ultrasound CT MR 2016 Apr;37(2):120-8. Epub 2016 Jan 20 doi: 10.1053/j.sult.2016.01.005. PMID: 27063662
Hyperdynamic left ventricular ejection fraction in the intensive care unit.
Paonessa JR, Brennan T, Pimentel M, Steinhaus D, Feng M, Celi LA
Crit Care 2015 Aug 7;19(1):288. doi: 10.1186/s13054-015-1012-8. PMID: 26250903Free PMC Article
Chemotherapy-induced takotsubo cardiomyopathy.
Smith SA, Auseon AJ
Heart Fail Clin 2013 Apr;9(2):233-42, x. Epub 2013 Jan 23 doi: 10.1016/j.hfc.2012.12.009. PMID: 23562124

Therapy

Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-β-Blocking R-Enantiomer Carvedilol.
Seo K, Yamamoto Y, Kirillova A, Kawana M, Yadav S, Huang Y, Wang Q, Lane KV, Pruitt BL, Perez MV, Bernstein D, Wu JC, Wheeler MT, Parikh VN, Ashley EA
Circulation 2023 Nov 21;148(21):1691-1704. Epub 2023 Oct 18 doi: 10.1161/CIRCULATIONAHA.123.065017. PMID: 37850394
Comparison of visual estimation and quantitative measurement of left ventricular ejection fraction in untrained perioperative echocardiographers.
Raksamani K, Noirit A, Chaikittisilpa N
BMC Anesthesiol 2023 Apr 1;23(1):106. doi: 10.1186/s12871-023-02067-3. PMID: 37005582Free PMC Article
Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry.
Gebhard C, Maredziak M, Messerli M, Buechel RR, Lin F, Gransar H, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kim YJ, Leipsic J, Maffei E, Marques H, Gonçalves PA, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Lu Y, Jones EC, Peña JM, Min JK, Kaufmann PA
Eur Heart J Cardiovasc Imaging 2020 Apr 1;21(4):363-374. doi: 10.1093/ehjci/jez321. PMID: 31985803Free PMC Article
Hyperdynamic left ventricular ejection fraction in the intensive care unit.
Paonessa JR, Brennan T, Pimentel M, Steinhaus D, Feng M, Celi LA
Crit Care 2015 Aug 7;19(1):288. doi: 10.1186/s13054-015-1012-8. PMID: 26250903Free PMC Article
Chemotherapy-induced takotsubo cardiomyopathy.
Smith SA, Auseon AJ
Heart Fail Clin 2013 Apr;9(2):233-42, x. Epub 2013 Jan 23 doi: 10.1016/j.hfc.2012.12.009. PMID: 23562124

Prognosis

Ventricular Changes in Patients with Acute COVID-19 Infection: Follow-up of the World Alliance Societies of Echocardiography (WASE-COVID) Study.
Karagodin I, Singulane CC, Descamps T, Woodward GM, Xie M, Tucay ES, Sarwar R, Vasquez-Ortiz ZY, Alizadehasl A, Monaghan MJ, Ordonez Salazar BA, Soulat-Dufour L, Mostafavi A, Moreo A, Citro R, Narang A, Wu C, Addetia K, Tude Rodrigues AC, Lang RM, Asch FM; WASE-COVID Investigators
J Am Soc Echocardiogr 2022 Mar;35(3):295-304. Epub 2021 Nov 6 doi: 10.1016/j.echo.2021.10.015. PMID: 34752928Free PMC Article
Hyperdynamic Left Ventricular Ejection Fraction in ICU Patients With Sepsis.
Chotalia M, Ali M, Hebballi R, Singh H, Parekh D, Bangash MN, Patel JM
Crit Care Med 2022 May 1;50(5):770-779. Epub 2021 Oct 4 doi: 10.1097/CCM.0000000000005315. PMID: 34605779
Magnetic Resonance Imaging of Normal Pressure Hydrocephalus.
Bradley WG Jr
Semin Ultrasound CT MR 2016 Apr;37(2):120-8. Epub 2016 Jan 20 doi: 10.1053/j.sult.2016.01.005. PMID: 27063662
Hyperdynamic left ventricular ejection fraction in the intensive care unit.
Paonessa JR, Brennan T, Pimentel M, Steinhaus D, Feng M, Celi LA
Crit Care 2015 Aug 7;19(1):288. doi: 10.1186/s13054-015-1012-8. PMID: 26250903Free PMC Article
Myocardial dysfunction in the patient with sepsis.
Krishnagopalan S, Kumar A, Parrillo JE, Kumar A
Curr Opin Crit Care 2002 Oct;8(5):376-88. doi: 10.1097/00075198-200210000-00003. PMID: 12357104

Clinical prediction guides

Ventricular Changes in Patients with Acute COVID-19 Infection: Follow-up of the World Alliance Societies of Echocardiography (WASE-COVID) Study.
Karagodin I, Singulane CC, Descamps T, Woodward GM, Xie M, Tucay ES, Sarwar R, Vasquez-Ortiz ZY, Alizadehasl A, Monaghan MJ, Ordonez Salazar BA, Soulat-Dufour L, Mostafavi A, Moreo A, Citro R, Narang A, Wu C, Addetia K, Tude Rodrigues AC, Lang RM, Asch FM; WASE-COVID Investigators
J Am Soc Echocardiogr 2022 Mar;35(3):295-304. Epub 2021 Nov 6 doi: 10.1016/j.echo.2021.10.015. PMID: 34752928Free PMC Article
Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry.
Gebhard C, Maredziak M, Messerli M, Buechel RR, Lin F, Gransar H, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kim YJ, Leipsic J, Maffei E, Marques H, Gonçalves PA, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Lu Y, Jones EC, Peña JM, Min JK, Kaufmann PA
Eur Heart J Cardiovasc Imaging 2020 Apr 1;21(4):363-374. doi: 10.1093/ehjci/jez321. PMID: 31985803Free PMC Article
Sex-specific cardiac phenotype and clinical outcomes in patients with hypertrophic cardiomyopathy.
Lu DY, Ventoulis I, Liu H, Kudchadkar SM, Greenland GV, Yalcin H, Kontari E, Goyal S, Corona-Villalobos CP, Vakrou S, Zimmerman SL, Abraham TP, Abraham MR
Am Heart J 2020 Jan;219:58-69. Epub 2019 Oct 20 doi: 10.1016/j.ahj.2019.10.004. PMID: 31726421
Magnetic Resonance Imaging of Normal Pressure Hydrocephalus.
Bradley WG Jr
Semin Ultrasound CT MR 2016 Apr;37(2):120-8. Epub 2016 Jan 20 doi: 10.1053/j.sult.2016.01.005. PMID: 27063662
Hyperdynamic left ventricular ejection fraction in the intensive care unit.
Paonessa JR, Brennan T, Pimentel M, Steinhaus D, Feng M, Celi LA
Crit Care 2015 Aug 7;19(1):288. doi: 10.1186/s13054-015-1012-8. PMID: 26250903Free PMC Article

Recent systematic reviews

Systematic review of uncalibrated arterial pressure waveform analysis to determine cardiac output and stroke volume variation.
Slagt C, Malagon I, Groeneveld AB
Br J Anaesth 2014 Apr;112(4):626-37. Epub 2014 Jan 14 doi: 10.1093/bja/aet429. PMID: 24431387

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