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Metastatic Carcinoma in the Liver

MedGen UID:
482989
•Concept ID:
C3282903
•
Neoplastic Process
Synonyms: Metastatic carcinoma of liver; Metastatic carcinoma to liver; Metastatic Carcinoma to the Liver; Secondary carcinoma of liver
SNOMED CT: Secondary carcinoma of liver (1251486007); Metastatic carcinoma to liver (1251486007); Metastatic carcinoma of liver (1251486007)

Definition

A carcinoma that has spread to the liver from another primary anatomic site. Representative examples include metastatic carcinomas from the colon, breast, and lung. [from NCI]

Professional guidelines

PubMed

Pathologic differential diagnosis of metastatic carcinoma in the liver.
Park JH, Kim JH
Clin Mol Hepatol 2019 Mar;25(1):12-20. Epub 2018 Oct 5 doi: 10.3350/cmh.2018.0067. PMID: 30300991Free PMC Article

Recent clinical studies

Etiology

Imaging of Fontan-Associated Liver Disease.
Brown MJ, Kolbe AB, Hull NC, Hilscher M, Kamath PS, Yalon M, Gu CN, Amawi ADT, Venkatesh SK, Wells ML
J Comput Assist Tomogr 2024 Jan-Feb 01;48(1):1-11. Epub 2023 Aug 10 doi: 10.1097/RCT.0000000000001533. PMID: 37574655
Hepatic tumours and radiotherapy.
Rio E, Mornex F, Maingon P, Peiffert D, Parent L
Cancer Radiother 2022 Feb-Apr;26(1-2):266-271. Epub 2021 Dec 23 doi: 10.1016/j.canrad.2021.08.013. PMID: 34953707
Liver Resection Versus Local Ablation Therapies for Hepatocellular Carcinoma Within the Milan Criteria: A Systematic Review and Meta-analysis.
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
Inflammation in Primary and Metastatic Liver Tumorigenesis-Under the Influence of Alcohol and High-Fat Diets.
Strathearn LS, Stepanov AI, Font-Burgada J
Nutrients 2020 Mar 27;12(4) doi: 10.3390/nu12040933. PMID: 32230953Free PMC Article
The ins and outs of liver imaging.
O'Neill EK, Cogley JR, Miller FH
Clin Liver Dis 2015 Feb;19(1):99-121. Epub 2014 Oct 29 doi: 10.1016/j.cld.2014.09.006. PMID: 25454299

Diagnosis

Pathologic differential diagnosis of metastatic carcinoma in the liver.
Park JH, Kim JH
Clin Mol Hepatol 2019 Mar;25(1):12-20. Epub 2018 Oct 5 doi: 10.3350/cmh.2018.0067. PMID: 30300991Free PMC Article
Frozen Sections of the Liver.
Pittman ME, Yantiss RK
Surg Pathol Clin 2018 Jun;11(2):453-466. Epub 2018 Mar 26 doi: 10.1016/j.path.2018.02.012. PMID: 29751885
A practical diagnostic approach to hepatic masses.
Vyas M, Jain D
Indian J Pathol Microbiol 2018 Jan-Mar;61(1):2-17. doi: 10.4103/IJPM.IJPM_578_17. PMID: 29567877
Space Occupying Lesions in the Liver.
Thyagarajan MS, Sharif K
Indian J Pediatr 2016 Nov;83(11):1291-1302. Epub 2016 Oct 25 doi: 10.1007/s12098-016-2240-x. PMID: 27783314
The ins and outs of liver imaging.
O'Neill EK, Cogley JR, Miller FH
Clin Liver Dis 2015 Feb;19(1):99-121. Epub 2014 Oct 29 doi: 10.1016/j.cld.2014.09.006. PMID: 25454299

Therapy

Aspirin for Metabolic Dysfunction-Associated Steatotic Liver Disease Without Cirrhosis: A Randomized Clinical Trial.
Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study.
Shi GM, Huang XY, Wu D, Sun HC, Liang F, Ji Y, Chen Y, Yang GH, Lu JC, Meng XL, Wang XY, Sun L, Ge NL, Huang XW, Qiu SJ, Yang XR, Gao Q, He YF, Xu Y, Sun J, Ren ZG, Fan J, Zhou J
Signal Transduct Target Ther 2023 Mar 17;8(1):106. doi: 10.1038/s41392-023-01317-7. PMID: 36928584Free PMC Article
Immunotherapy in cholangiocarcinoma.
Al-Rajabi R, Sun W
Curr Opin Gastroenterol 2021 Mar 1;37(2):105-111. doi: 10.1097/MOG.0000000000000715. PMID: 33507028
Liver Resection Versus Local Ablation Therapies for Hepatocellular Carcinoma Within the Milan Criteria: A Systematic Review and Meta-analysis.
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
The hepatic bridge.
Sugarbaker PH
Eur J Surg Oncol 2018 Jul;44(7):1083-1086. Epub 2018 Apr 11 doi: 10.1016/j.ejso.2018.03.031. PMID: 29699839

Prognosis

Metastasis patterns and prognosis of octogenarians with metastatic breast cancer: A large-cohort retrospective study.
Lv Z, Zhang W, Zhang Y, Zhong G, Zhang X, Yang Q, Li Y
PLoS One 2022;17(2):e0263104. Epub 2022 Feb 17 doi: 10.1371/journal.pone.0263104. PMID: 35176034Free PMC Article
Management of Recurrent HCC After Liver Transplantation.
Sarici B, Isik B, Yilmaz S
J Gastrointest Cancer 2020 Dec;51(4):1197-1199. doi: 10.1007/s12029-020-00498-6. PMID: 32839944
The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis.
Zhou K, Wang A, Ao S, Chen J, Ji K, He Q, Ji X, Wu X, Zhang J, Li Z, Bu Z, Ji J
BMC Cancer 2020 Jul 17;20(1):671. doi: 10.1186/s12885-020-07031-9. PMID: 32680468Free PMC Article
Anatomy of the Right Anterior Sector of the Liver and Its Clinical Implications in Surgery.
Cazauran JB, Pâris L, Rousset P, Mercier F, Kepenekian V, Viste A, Passot G
J Gastrointest Surg 2018 Oct;22(10):1819-1831. Epub 2018 Jun 18 doi: 10.1007/s11605-018-3831-9. PMID: 29916108
Cholangiocarcinoma: has there been any progress?
Meza-Junco J, Montano-Loza AJ, Ma M, Wong W, Sawyer MB, Bain VG
Can J Gastroenterol 2010 Jan;24(1):52-7. doi: 10.1155/2010/704759. PMID: 20186357Free PMC Article

Clinical prediction guides

Hepatic tumours and radiotherapy.
Rio E, Mornex F, Maingon P, Peiffert D, Parent L
Cancer Radiother 2022 Feb-Apr;26(1-2):266-271. Epub 2021 Dec 23 doi: 10.1016/j.canrad.2021.08.013. PMID: 34953707
Robotic ALPPS.
Machado MAC, Surjan RC, Makdissi F
Ann Surg Oncol 2020 Apr;27(4):1174-1179. Epub 2019 Nov 4 doi: 10.1245/s10434-019-08027-x. PMID: 31686346
The hepatic bridge.
Sugarbaker PH
Eur J Surg Oncol 2018 Jul;44(7):1083-1086. Epub 2018 Apr 11 doi: 10.1016/j.ejso.2018.03.031. PMID: 29699839
Radiation-Induced Liver Toxicity.
Munoz-Schuffenegger P, Ng S, Dawson LA
Semin Radiat Oncol 2017 Oct;27(4):350-357. doi: 10.1016/j.semradonc.2017.04.002. PMID: 28865518
Liver surgery in cirrhosis and portal hypertension.
Hackl C, Schlitt HJ, Renner P, Lang SA
World J Gastroenterol 2016 Mar 7;22(9):2725-35. doi: 10.3748/wjg.v22.i9.2725. PMID: 26973411Free PMC Article

Recent systematic reviews

Clinical characteristics, surveillance, treatment allocation, and outcomes of non-alcoholic fatty liver disease-related hepatocellular carcinoma: a systematic review and meta-analysis.
Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
Liver Resection Versus Local Ablation Therapies for Hepatocellular Carcinoma Within the Milan Criteria: A Systematic Review and Meta-analysis.
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
Hepatotoxicity From Immune Checkpoint Inhibitors: A Systematic Review and Management Recommendation.
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR
Hepatology 2020 Jul;72(1):315-329. doi: 10.1002/hep.31227. PMID: 32167613
Immune checkpoint inhibitors, alone or in combination with chemotherapy, as first-line treatment for advanced non-small cell lung cancer. A systematic review and network meta-analysis.
Dafni U, Tsourti Z, Vervita K, Peters S
Lung Cancer 2019 Aug;134:127-140. Epub 2019 May 30 doi: 10.1016/j.lungcan.2019.05.029. PMID: 31319971
Non-hepatocellular carcinoma spinal metastases.
Goodwin CR, Abu-Bonsrah N, Boone C, Ruiz-Valls A, Sankey EW, Sarabia-Estrada R, Elder BD, Kosztowski T, Sciubba DM
J Clin Neurosci 2016 May;27:22-7. Epub 2016 Jan 8 doi: 10.1016/j.jocn.2015.11.003. PMID: 26778049

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