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Rheumatic Fever

MedGen UID:
48448
Concept ID:
C0035436
Disease or Syndrome
Synonyms: Acute Rheumatic Fever; Inflammatory Rheumatism
SNOMED CT: Acute rheumatic arthritis (81077008); Acute rheumatic fever (195528001); ARF - acute rheumatic fever (195528001); Acute arthritis due to acute rheumatic fever (81077008); Acute rheumatic fever with acute arthritis (81077008); RhF - Rheumatic fever (58718002); Rheumatic fever (58718002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017767
Orphanet: ORPHA3099

Definition

Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRheumatic Fever
Follow this link to review classifications for Rheumatic Fever in Orphanet.

Professional guidelines

PubMed

Sykes EA, Wu V, Beyea MM, Simpson MTW, Beyea JA
Can Fam Physician 2020 Apr;66(4):251-257. PMID: 32273409Free PMC Article
Wunderlich NC, Dalvi B, Ho SY, Küx H, Siegel RJ
Curr Cardiol Rep 2019 Feb 28;21(3):14. doi: 10.1007/s11886-019-1099-7. PMID: 30815750
Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Tleyjeh IM, Rybak MJ, Barsic B, Lockhart PB, Gewitz MH, Levison ME, Bolger AF, Steckelberg JM, Baltimore RS, Fink AM, O'Gara P, Taubert KA; American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council
Circulation 2015 Oct 13;132(15):1435-86. Epub 2015 Sep 15 doi: 10.1161/CIR.0000000000000296. PMID: 26373316

Recent clinical studies

Etiology

de Loizaga SR, Beaton AZ
Pediatr Ann 2021 Mar;50(3):e98-e104. Epub 2021 Mar 1 doi: 10.3928/19382359-20210221-01. PMID: 34038651
Lahiri S, Sanyahumbi A
Pediatr Rev 2021 May;42(5):221-232. doi: 10.1542/pir.2019-0288. PMID: 33931507
Arvind B, Ramakrishnan S
Indian J Pediatr 2020 Apr;87(4):305-311. Epub 2020 Jan 11 doi: 10.1007/s12098-019-03128-7. PMID: 31925717
Risavi BL, Iszkula E, Yost B
J Emerg Med 2019 Jun;56(6):e119-e121. Epub 2019 Apr 16 doi: 10.1016/j.jemermed.2019.02.012. PMID: 31003820
Gewitz MH, Baltimore RS, Tani LY, Sable CA, Shulman ST, Carapetis J, Remenyi B, Taubert KA, Bolger AF, Beerman L, Mayosi BM, Beaton A, Pandian NG, Kaplan EL; American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young
Circulation 2015 May 19;131(20):1806-18. Epub 2015 Apr 23 doi: 10.1161/CIR.0000000000000205. PMID: 25908771

Diagnosis

Holloway AR
Pediatr Ann 2022 Dec;51(12):e457-e460. Epub 2022 Dec 1 doi: 10.3928/19382359-20221006-03. PMID: 36476197
de Loizaga SR, Beaton AZ
Pediatr Ann 2021 Mar;50(3):e98-e104. Epub 2021 Mar 1 doi: 10.3928/19382359-20210221-01. PMID: 34038651
Lahiri S, Sanyahumbi A
Pediatr Rev 2021 May;42(5):221-232. doi: 10.1542/pir.2019-0288. PMID: 33931507
Arvind B, Ramakrishnan S
Indian J Pediatr 2020 Apr;87(4):305-311. Epub 2020 Jan 11 doi: 10.1007/s12098-019-03128-7. PMID: 31925717
Webb RH, Grant C, Harnden A
BMJ 2015 Jul 14;351:h3443. doi: 10.1136/bmj.h3443. PMID: 26175053

Therapy

Spinks A, Glasziou PP, Del Mar CB
Cochrane Database Syst Rev 2021 Dec 9;12(12):CD000023. doi: 10.1002/14651858.CD000023.pub5. PMID: 34881426Free PMC Article
van Driel ML, De Sutter AI, Thorning S, Christiaens T
Cochrane Database Syst Rev 2021 Mar 17;3(3):CD004406. doi: 10.1002/14651858.CD004406.pub5. PMID: 33728634Free PMC Article
Chun C, Kingsbury DJ
Perm J 2019;23 Epub 2019 Oct 18 doi: 10.7812/TPP/18.304. PMID: 31926573Free PMC Article
Schödel F, Moreland NJ, Wittes JT, Mulholland K, Frazer I, Steer AC, Fraser JD, Carapetis J
Vaccine 2017 Apr 11;35(16):2007-2014. Epub 2017 Mar 16 doi: 10.1016/j.vaccine.2017.02.060. PMID: 28318768
Webb RH, Grant C, Harnden A
BMJ 2015 Jul 14;351:h3443. doi: 10.1136/bmj.h3443. PMID: 26175053

Prognosis

Lahiri S, Sanyahumbi A
Pediatr Rev 2021 May;42(5):221-232. doi: 10.1542/pir.2019-0288. PMID: 33931507
Muhamed B, Mutithu D, Aremu O, Zühlke L, Sliwa K
Int J Cardiol 2019 Nov 15;295:48-55. Epub 2019 Jul 29 doi: 10.1016/j.ijcard.2019.07.079. PMID: 31405583
Berkley J
Circulation 2018 Oct 30;138(18):1920-1922. doi: 10.1161/CIRCULATIONAHA.118.035900. PMID: 30372134
Islam AK, Majumder AA
Indian Heart J 2016 Jan-Feb;68(1):88-98. Epub 2016 Jan 14 doi: 10.1016/j.ihj.2015.07.039. PMID: 26896274Free PMC Article
Carapetis JR, Steer AC, Mulholland EK, Weber M
Lancet Infect Dis 2005 Nov;5(11):685-94. doi: 10.1016/S1473-3099(05)70267-X. PMID: 16253886

Clinical prediction guides

Smith KL, Hughes R, Myrex P
Am Fam Physician 2023 Jan;107(1):35-41. PMID: 36689967
Hippisley-Cox J, Coupland C, Brindle P
BMJ 2017 May 23;357:j2099. doi: 10.1136/bmj.j2099. PMID: 28536104Free PMC Article
McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, Baker AL, Jackson MA, Takahashi M, Shah PB, Kobayashi T, Wu MH, Saji TT, Pahl E; American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Council on Epidemiology and Prevention
Circulation 2017 Apr 25;135(17):e927-e999. Epub 2017 Mar 29 doi: 10.1161/CIR.0000000000000484. PMID: 28356445
Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP
Rev Soc Bras Med Trop 2014 Jul;47(4):409-13. doi: 10.1590/0037-8682-0265-2013. PMID: 25229278
Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Bolger AF, Levison ME, Ferrieri P, Gerber MA, Tani LY, Gewitz MH, Tong DC, Steckelberg JM, Baltimore RS, Shulman ST, Burns JC, Falace DA, Newburger JW, Pallasch TJ, Takahashi M, Taubert KA; Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease; Council on Cardiovascular Disease in the Young; Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia; American Heart Association; Infectious Diseases Society of America
Circulation 2005 Jun 14;111(23):e394-434. doi: 10.1161/CIRCULATIONAHA.105.165564. PMID: 15956145

Recent systematic reviews

Kulik E, Stuart B, Willcox M
Trans R Soc Trop Med Hyg 2022 Apr 4;116(4):286-297. doi: 10.1093/trstmh/trab156. PMID: 34636404Free PMC Article
Spinks A, Glasziou PP, Del Mar CB
Cochrane Database Syst Rev 2021 Dec 9;12(12):CD000023. doi: 10.1002/14651858.CD000023.pub5. PMID: 34881426Free PMC Article
van Driel ML, De Sutter AI, Thorning S, Christiaens T
Cochrane Database Syst Rev 2021 Mar 17;3(3):CD004406. doi: 10.1002/14651858.CD004406.pub5. PMID: 33728634Free PMC Article
Opara CC, Aghassibake N, Watkins DA
Int J Cardiol 2021 Jan 15;323:235-241. Epub 2020 Sep 10 doi: 10.1016/j.ijcard.2020.09.020. PMID: 32920073
da Silva F, de Carvalho J
J Immunol Res 2014;2014:614591. Epub 2014 Apr 22 doi: 10.1155/2014/614591. PMID: 24860836Free PMC Article

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