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Disorganized schizophrenia

MedGen UID:
48577
•Concept ID:
C0036347
•
Mental or Behavioral Dysfunction
Synonyms: Disorganized Schizophrenia; Disorganized Schizophrenias; Hebephrenic Schizophrenia; Hebephrenic Schizophrenias; Schizophrenia, Disorganized; Schizophrenia, Hebephrenic; Schizophrenias, Disorganized; Schizophrenias, Hebephrenic
SNOMED CT: Hebephrenic schizophrenia (35252006); Disorganized schizophrenia (35252006)

Definition

A subtype of schizophrenia characterized by disorganized speech, disorganized behavior, and a flat or inappropriate affect; associated features include grimacing, mannerisms, and other oddities of behavior. Criteria for the catatonic type of schizophrenia are not met. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorganized schizophrenia

Professional guidelines

PubMed

Pharmacological Treatment for Social Cognition: Current Evidence.
Riccardi C, Montemagni C, Del Favero E, Bellino S, Brasso C, Rocca P
Int J Mol Sci 2021 Jul 12;22(14) doi: 10.3390/ijms22147457. PMID: 34299076Free PMC Article
Lumateperone for the Treatment of Schizophrenia.
Edinoff A, Wu N, deBoisblanc C, Feltner CO, Norder M, Tzoneva V, Kaye AM, Cornett EM, Kaye AD, Viswanath O, Urits I
Psychopharmacol Bull 2020 Sep 14;50(4):32-59. PMID: 33012872Free PMC Article
Attachment in schizophrenia--implications for research, prevention, and treatment.
Harder S
Schizophr Bull 2014 Nov;40(6):1189-93. Epub 2014 Sep 16 doi: 10.1093/schbul/sbu133. PMID: 25232144Free PMC Article

Recent clinical studies

Etiology

Parietal lobe and disorganisation syndrome in schizophrenia and psychotic bipolar disorder: A bimodal connectivity study.
Das TK, Kumar J, Francis S, Liddle PF, Palaniyappan L
Psychiatry Res Neuroimaging 2020 Sep 30;303:111139. Epub 2020 Jul 15 doi: 10.1016/j.pscychresns.2020.111139. PMID: 32707490
Heboidophrenia and Pseudo-Psychopathic Schizophrenia: Current Knowledge and Critical Perspective.
De Page L, Englebert J
Psychopathology 2018;51(4):227-233. Epub 2018 Jun 26 doi: 10.1159/000488768. PMID: 29945141
Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs?
Corves C, Engel RR, Davis J, Leucht S
Acta Psychiatr Scand 2014 Jul;130(1):40-5. Epub 2013 Dec 2 doi: 10.1111/acps.12231. PMID: 24299424
Acute hebephrenia.
Paus S, Urbach H, Klockgether T, Hartmann A
Arch Neurol 2005 Aug;62(8):1312-3. doi: 10.1001/archneur.62.8.1312. PMID: 16087776
The genetics and biochemistry of paranoid schizophrenia and other paranoid psychoses.
Kendler KS, Davis KL
Schizophr Bull 1981;7(4):689-709. doi: 10.1093/schbul/7.4.689. PMID: 7034192

Diagnosis

One hundred and fifty years of hebephrenia. A review.
Martínez DR
Rev Colomb Psiquiatr (Engl Ed) 2023 Apr-Jun;52(2):139-145. Epub 2023 Jul 13 doi: 10.1016/j.rcpeng.2021.07.004. PMID: 37453821
Heboidophrenia and Pseudo-Psychopathic Schizophrenia: Current Knowledge and Critical Perspective.
De Page L, Englebert J
Psychopathology 2018;51(4):227-233. Epub 2018 Jun 26 doi: 10.1159/000488768. PMID: 29945141
The core symptoms of schizophrenia.
Flaum M, Schultz SK
Ann Med 1996 Dec;28(6):525-31. doi: 10.3109/07853899608999116. PMID: 9017111
The diagnosis of schizophrenia: a review of recent developments.
Haier RJ
Schizophr Bull 1980;6(3):417-28. doi: 10.1093/schbul/6.3.417. PMID: 6996081
Heterogeneity of schizophrenia.
Tsuang MT
Biol Psychiatry 1975 Aug;10(4):465-74. PMID: 1100126

Therapy

A Case of Olanzapine-Induced Cutaneous Eruption.
Sohi MK, Towne D, Mogallapu R, Chalia A, Ang-Rabanes M
Am J Case Rep 2023 Oct 1;24:e941379. doi: 10.12659/AJCR.941379. PMID: 37777823Free PMC Article
Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs?
Corves C, Engel RR, Davis J, Leucht S
Acta Psychiatr Scand 2014 Jul;130(1):40-5. Epub 2013 Dec 2 doi: 10.1111/acps.12231. PMID: 24299424
Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study.
Ortiz BB, Araújo Filho GM, Araripe Neto AG, Medeiros D, Bressan RA
Braz J Psychiatry 2013 Oct-Dec;35(4):432-4. Epub 2013 Dec 23 doi: 10.1590/1516-4446-2013-1190. PMID: 24402218
Perceptual grouping in disorganized schizophrenia.
Uhlhaas PJ, Phillips WA, Mitchell G, Silverstein SM
Psychiatry Res 2006 Dec 7;145(2-3):105-17. Epub 2006 Nov 1 doi: 10.1016/j.psychres.2005.10.016. PMID: 17081620
Acute hebephrenia.
Paus S, Urbach H, Klockgether T, Hartmann A
Arch Neurol 2005 Aug;62(8):1312-3. doi: 10.1001/archneur.62.8.1312. PMID: 16087776

Prognosis

Parietal lobe and disorganisation syndrome in schizophrenia and psychotic bipolar disorder: A bimodal connectivity study.
Das TK, Kumar J, Francis S, Liddle PF, Palaniyappan L
Psychiatry Res Neuroimaging 2020 Sep 30;303:111139. Epub 2020 Jul 15 doi: 10.1016/j.pscychresns.2020.111139. PMID: 32707490
Heboidophrenia and Pseudo-Psychopathic Schizophrenia: Current Knowledge and Critical Perspective.
De Page L, Englebert J
Psychopathology 2018;51(4):227-233. Epub 2018 Jun 26 doi: 10.1159/000488768. PMID: 29945141
Long-term prognosis and followup in schizophrenia.
Stephens JH
Schizophr Bull 1978;4(1):25-47. doi: 10.1093/schbul/4.1.25. PMID: 34208
Culture and schizophrenia.
Jablensky A, Sartorius N
Psychol Med 1975 May;5(2):113-24. doi: 10.1017/s003329170005635x. PMID: 1161950
Heterogeneity of schizophrenia.
Tsuang MT
Biol Psychiatry 1975 Aug;10(4):465-74. PMID: 1100126

Clinical prediction guides

Parietal lobe and disorganisation syndrome in schizophrenia and psychotic bipolar disorder: A bimodal connectivity study.
Das TK, Kumar J, Francis S, Liddle PF, Palaniyappan L
Psychiatry Res Neuroimaging 2020 Sep 30;303:111139. Epub 2020 Jul 15 doi: 10.1016/j.pscychresns.2020.111139. PMID: 32707490
Disorganized Symptoms Predicted Worse Functioning Outcome in Schizophrenia Patients with Established Illness.
Ortiz BB, Gadelha A, Higuchi CH, Noto C, Medeiros D, Pitta JCDN, de Araújo Filho GM, Hallak JEC, Bressan RA
Clin Schizophr Relat Psychoses 2017 Fall;11(3):151-155. Epub 2015 Feb 24 doi: 10.3371/CSRP.ORGA.022015. PMID: 25711508
Prevalence of aggression in hospitalized patients with schizophrenia in China: A meta-analysis.
Zhou JS, Zhong BL, Xiang YT, Chen Q, Cao XL, Correll CU, Ungvari GS, Chiu HF, Lai KY, Wang XP
Asia Pac Psychiatry 2016 Mar;8(1):60-9. Epub 2015 Sep 7 doi: 10.1111/appy.12209. PMID: 26346165
Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs?
Corves C, Engel RR, Davis J, Leucht S
Acta Psychiatr Scand 2014 Jul;130(1):40-5. Epub 2013 Dec 2 doi: 10.1111/acps.12231. PMID: 24299424
Perceptual grouping in disorganized schizophrenia.
Uhlhaas PJ, Phillips WA, Mitchell G, Silverstein SM
Psychiatry Res 2006 Dec 7;145(2-3):105-17. Epub 2006 Nov 1 doi: 10.1016/j.psychres.2005.10.016. PMID: 17081620

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