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Generalized atherosclerosis

MedGen UID:
4866
•Concept ID:
C0017327
•
Disease or Syndrome
Synonyms: generalised and unspecified atherosclerosis; generalized and unspecified atherosclerosis; Generalized Atherosclerosis; generalized atherosclerosis
SNOMED CT: Generalized atherosclerosis (39823006)
 
Monarch Initiative: MONDO:0002275

Definition

Atherosclerosis that is not localized. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGeneralized atherosclerosis

Professional guidelines

PubMed

Selection of Patients for Angioplasty for Treatment of Atherosclerotic Renovascular Disease: Predicting Responsive Patients.
Mishima E, Suzuki T, Ito S
Am J Hypertens 2020 Apr 29;33(5):391-401. doi: 10.1093/ajh/hpaa016. PMID: 31996895
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Evidence for maximal treatment of atherosclerosis: drastic reduction of cholesterol and fibrinogen restores vascular homeostasis.
Jaeger BR
Ther Apher 2001 Jun;5(3):207-11. PMID: 11467757

Recent clinical studies

Etiology

Non-invasive ultrasound-based imaging of atherosclerosis.
Kaspar M, Baumgartner I, Staub D, Drexel H, Thalhammer C
Vasa 2019 Mar;48(2):126-133. Epub 2018 Oct 16 doi: 10.1024/0301-1526/a000747. PMID: 30324866
Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study.
Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovás JM, Sanz G, Jiménez-Borreguero LJ, Fuster V
Circulation 2015 Jun 16;131(24):2104-13. Epub 2015 Apr 16 doi: 10.1161/CIRCULATIONAHA.114.014310. PMID: 25882487
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Peripheral arterial disease: implications beyond the peripheral circulation.
Paraskevas KI, Mukherjee D, Whayne TF Jr
Angiology 2013 Nov;64(8):569-71. Epub 2012 Dec 4 doi: 10.1177/0003319712466730. PMID: 23221278
Exercise and carotid atherosclerosis.
Kadoglou NP, Iliadis F, Liapis CD
Eur J Vasc Endovasc Surg 2008 Mar;35(3):264-72. Epub 2007 Nov 7 doi: 10.1016/j.ejvs.2007.08.022. PMID: 17988901

Diagnosis

Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study.
Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovás JM, Sanz G, Jiménez-Borreguero LJ, Fuster V
Circulation 2015 Jun 16;131(24):2104-13. Epub 2015 Apr 16 doi: 10.1161/CIRCULATIONAHA.114.014310. PMID: 25882487
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Peripheral arterial disease: implications beyond the peripheral circulation.
Paraskevas KI, Mukherjee D, Whayne TF Jr
Angiology 2013 Nov;64(8):569-71. Epub 2012 Dec 4 doi: 10.1177/0003319712466730. PMID: 23221278
Diabetes and peripheral vascular disease.
Huysman E, Mathieu C
Acta Chir Belg 2009 Oct;109(5):587-94. doi: 10.1080/00015458.2009.11680493. PMID: 19994800
Treatment of chronic peripheral arterial disease.
Antignani PL
Curr Vasc Pharmacol 2003 Jun;1(2):205-16. doi: 10.2174/1570161033476691. PMID: 15320844

Therapy

Molecular and Cellular Mechanisms Driving Cardiovascular Disease in Hutchinson-Gilford Progeria Syndrome: Lessons Learned from Animal Models.
Benedicto I, Dorado B, Andrés V
Cells 2021 May 11;10(5) doi: 10.3390/cells10051157. PMID: 34064612Free PMC Article
Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study.
Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovás JM, Sanz G, Jiménez-Borreguero LJ, Fuster V
Circulation 2015 Jun 16;131(24):2104-13. Epub 2015 Apr 16 doi: 10.1161/CIRCULATIONAHA.114.014310. PMID: 25882487
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Diabetes and peripheral vascular disease.
Huysman E, Mathieu C
Acta Chir Belg 2009 Oct;109(5):587-94. doi: 10.1080/00015458.2009.11680493. PMID: 19994800
Treatment of chronic peripheral arterial disease.
Antignani PL
Curr Vasc Pharmacol 2003 Jun;1(2):205-16. doi: 10.2174/1570161033476691. PMID: 15320844

Prognosis

Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study.
Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, Ibañez B, López-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martínez de Vega V, García L, Molina J, Sánchez-González J, Guzmán G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovás JM, Sanz G, Jiménez-Borreguero LJ, Fuster V
Circulation 2015 Jun 16;131(24):2104-13. Epub 2015 Apr 16 doi: 10.1161/CIRCULATIONAHA.114.014310. PMID: 25882487
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Aortic sclerosis and mitral annulus calcification: a window to vascular atherosclerosis?
Lazaros G, Toutouzas K, Drakopoulou M, Boudoulas H, Stefanadis C, Rajamannan N
Expert Rev Cardiovasc Ther 2013 Jul;11(7):863-77. doi: 10.1586/14779072.2013.811978. PMID: 23895030
Peripheral arterial disease: implications beyond the peripheral circulation.
Paraskevas KI, Mukherjee D, Whayne TF Jr
Angiology 2013 Nov;64(8):569-71. Epub 2012 Dec 4 doi: 10.1177/0003319712466730. PMID: 23221278
Asymptomatic carotid bruit.
Fareleira F, Julião M, Roque A, Carneiro AV
Rev Port Cardiol 2005 Feb;24(2):285-94. PMID: 15861909

Clinical prediction guides

International Union of Angiology (IUA) consensus paper on imaging strategies in atherosclerotic carotid artery imaging: From basic strategies to advanced approaches.
Saba L, Antignani PL, Gupta A, Cau R, Paraskevas KI, Poredos P, Wasserman B, Kamel H, Avgerinos ED, Salgado R, Caobelli F, Aluigi L, Savastano L, Brown M, Hatsukami T, Hussein E, Suri JS, Mansilha A, Wintermark M, Staub D, Montequin JF, Rodriguez RTT, Balu N, Pitha J, Kooi ME, Lal BK, Spence JD, Lanzino G, Marcus HS, Mancini M, Chaturvedi S, Blinc A
Atherosclerosis 2022 Aug;354:23-40. Epub 2022 Jun 28 doi: 10.1016/j.atherosclerosis.2022.06.1014. PMID: 35816927
Asymptomatic peripheral artery disease and antiplatelet management.
Raparelli V, Proietti M, Napoleone L, Bucci T, Talerico G, Pignataro FS, Basili S
Vasa 2014 Sep;43(5):309-25. doi: 10.1024/0301-1526/a000369. PMID: 25147008
Aortic sclerosis and mitral annulus calcification: a window to vascular atherosclerosis?
Lazaros G, Toutouzas K, Drakopoulou M, Boudoulas H, Stefanadis C, Rajamannan N
Expert Rev Cardiovasc Ther 2013 Jul;11(7):863-77. doi: 10.1586/14779072.2013.811978. PMID: 23895030
Peripheral arterial disease: implications beyond the peripheral circulation.
Paraskevas KI, Mukherjee D, Whayne TF Jr
Angiology 2013 Nov;64(8):569-71. Epub 2012 Dec 4 doi: 10.1177/0003319712466730. PMID: 23221278
Asymptomatic carotid bruit.
Fareleira F, Julião M, Roque A, Carneiro AV
Rev Port Cardiol 2005 Feb;24(2):285-94. PMID: 15861909

Recent systematic reviews

Complex atheromatous plaques in the descending aorta and the risk of stroke: a systematic review and meta-analysis.
Katsanos AH, Giannopoulos S, Kosmidou M, Voumvourakis K, Parissis JT, Kyritsis AP, Tsivgoulis G
Stroke 2014 Jun;45(6):1764-70. Epub 2014 May 1 doi: 10.1161/STROKEAHA.114.005190. PMID: 24788969
Exercise and carotid atherosclerosis.
Kadoglou NP, Iliadis F, Liapis CD
Eur J Vasc Endovasc Surg 2008 Mar;35(3):264-72. Epub 2007 Nov 7 doi: 10.1016/j.ejvs.2007.08.022. PMID: 17988901

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