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Thyrotoxicosis with toxic single thyroid nodule

MedGen UID:
488786
•Concept ID:
C0154141
•
Disease or Syndrome; Finding
Synonyms: Thyrotoxicosis due to uninodular goiter; Toxic thyroid nodule; Toxic uninodular goiter; Toxic uninodular goiter with thyrotoxic crisis; Toxic uninodular goiter with thyrotoxic storm; Toxic uninodular thyroid goiter
SNOMED CT: Toxic uninodular goiter with thyrotoxic crisis (69329005); Toxic uninodular goiter with thyrotoxic storm (69329005); Toxic uninodular goiter (73869005); Toxic thyroid nodule (73869005); Toxic uninodular thyroid goiter (73869005); Thyrotoxicosis with toxic single thyroid nodule (73869005); Thyrotoxicosis due to uninodular goiter (73869005)
 
HPO: HP:0011786

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyrotoxicosis with toxic single thyroid nodule

Professional guidelines

PubMed

Radioactive Iodine for the Treatment of Subclinical Thyrotoxicosis Grade 1 and 2: Outcome of up to 18-Year Follow Up.
Phowira J, Coffey KL, Bartholomew PH, Vennart N, Moreira M, Emerson H, Kennedy D, Weaver JU
Front Endocrinol (Lausanne) 2022;13:843857. Epub 2022 Mar 9 doi: 10.3389/fendo.2022.843857. PMID: 35370990Free PMC Article
Treatment of autonomously functioning thyroid nodules at a single institution: radioiodine therapy, surgery, and ethanol injection therapy.
Yano Y, Sugino K, Akaishi J, Uruno T, Okuwa K, Shibuya H, Kitagawa W, Nagahama M, Ito K, Ito K
Ann Nucl Med 2011 Dec;25(10):749-54. Epub 2011 Oct 5 doi: 10.1007/s12149-011-0526-7. PMID: 21971604
The treatment of autonomous functioning thyroid nodules.
Eyre-Brook IA, Talbot CH
Br J Surg 1982 Oct;69(10):577-9. doi: 10.1002/bjs.1800691006. PMID: 7127035

Curated

UK NICE Guideline NG145, Thyroid disease: assessment and management, 2023

Recent clinical studies

Etiology

Borderline personality disorder and thyroid diseases: a Mendelian randomization study.
Wang Q, Li P, Qi S, Yuan J, Ding Z
Front Endocrinol (Lausanne) 2023;14:1259520. Epub 2023 Oct 3 doi: 10.3389/fendo.2023.1259520. PMID: 37854187Free PMC Article
Radioactive Iodine for the Treatment of Subclinical Thyrotoxicosis Grade 1 and 2: Outcome of up to 18-Year Follow Up.
Phowira J, Coffey KL, Bartholomew PH, Vennart N, Moreira M, Emerson H, Kennedy D, Weaver JU
Front Endocrinol (Lausanne) 2022;13:843857. Epub 2022 Mar 9 doi: 10.3389/fendo.2022.843857. PMID: 35370990Free PMC Article
High Rates of Underlying Thyroid Cancer in Patients Undergoing Thyroidectomy for Hyperthyroidism.
Alvarez AL, Mulder M, Handelsman RS, Lew JI, Farra JC
J Surg Res 2020 Jan;245:523-528. Epub 2019 Aug 23 doi: 10.1016/j.jss.2019.07.048. PMID: 31450040
Thyroid cancer in patients with hyperthyroidism.
Pazaitou-Panayiotou K, Michalakis K, Paschke R
Horm Metab Res 2012 Apr;44(4):255-62. Epub 2012 Feb 14 doi: 10.1055/s-0031-1299741. PMID: 22334393
Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations.
Krohn K, Führer D, Holzapfel HP, Paschke R
J Clin Endocrinol Metab 1998 Jan;83(1):130-4. doi: 10.1210/jcem.83.1.4477. PMID: 9435429

Diagnosis

Factors predicting remission in hyperthyroid patients after low-dose I-131 therapy: 20 years retrospective study from a tertiary care hospital.
S SY, Padma S, Sundaram PS
Ann Nucl Med 2024 Mar;38(3):231-237. Epub 2024 Jan 26 doi: 10.1007/s12149-023-01891-4. PMID: 38277114
High Rates of Underlying Thyroid Cancer in Patients Undergoing Thyroidectomy for Hyperthyroidism.
Alvarez AL, Mulder M, Handelsman RS, Lew JI, Farra JC
J Surg Res 2020 Jan;245:523-528. Epub 2019 Aug 23 doi: 10.1016/j.jss.2019.07.048. PMID: 31450040
Outcome of surgery for toxic goitres in Maiduguri: a single teaching hospital's perspective.
Ali N, Madziga AG, Dogo D, Gali BM, Gadzama AA
Niger J Clin Pract 2012 Jul-Sep;15(3):280-4. doi: 10.4103/1119-3077.100621. PMID: 22960961
Thyroid cancer in patients with hyperthyroidism.
Pazaitou-Panayiotou K, Michalakis K, Paschke R
Horm Metab Res 2012 Apr;44(4):255-62. Epub 2012 Feb 14 doi: 10.1055/s-0031-1299741. PMID: 22334393
Effect of radioiodine therapy on thyroid nodule size and function in patients with toxic adenomas.
Erdoğan MF, Küçük NO, Anil C, Aras S, Ozer D, Aras G, Kamel N
Nucl Med Commun 2004 Nov;25(11):1083-7. doi: 10.1097/00006231-200411000-00003. PMID: 15577585

Therapy

Borderline personality disorder and thyroid diseases: a Mendelian randomization study.
Wang Q, Li P, Qi S, Yuan J, Ding Z
Front Endocrinol (Lausanne) 2023;14:1259520. Epub 2023 Oct 3 doi: 10.3389/fendo.2023.1259520. PMID: 37854187Free PMC Article
Radioactive Iodine for the Treatment of Subclinical Thyrotoxicosis Grade 1 and 2: Outcome of up to 18-Year Follow Up.
Phowira J, Coffey KL, Bartholomew PH, Vennart N, Moreira M, Emerson H, Kennedy D, Weaver JU
Front Endocrinol (Lausanne) 2022;13:843857. Epub 2022 Mar 9 doi: 10.3389/fendo.2022.843857. PMID: 35370990Free PMC Article
Radioiodine therapy in benign thyroid disorders. Evaluation of French nuclear medicine practices.
Bernard D, Desruet MD, Wolf M, Roux J, Boin C, Mazet R, Gallazzini C, Calizzano A, Vuillez JP, Allenet B, Fagret D
Ann Endocrinol (Paris) 2014 Sep;75(4):241-6. Epub 2014 Aug 22 doi: 10.1016/j.ando.2014.07.863. PMID: 25156133
Treatment of autonomously functioning thyroid nodules at a single institution: radioiodine therapy, surgery, and ethanol injection therapy.
Yano Y, Sugino K, Akaishi J, Uruno T, Okuwa K, Shibuya H, Kitagawa W, Nagahama M, Ito K, Ito K
Ann Nucl Med 2011 Dec;25(10):749-54. Epub 2011 Oct 5 doi: 10.1007/s12149-011-0526-7. PMID: 21971604
Effect of radioiodine therapy on thyroid nodule size and function in patients with toxic adenomas.
Erdoğan MF, Küçük NO, Anil C, Aras S, Ozer D, Aras G, Kamel N
Nucl Med Commun 2004 Nov;25(11):1083-7. doi: 10.1097/00006231-200411000-00003. PMID: 15577585

Prognosis

Factors predicting remission in hyperthyroid patients after low-dose I-131 therapy: 20 years retrospective study from a tertiary care hospital.
S SY, Padma S, Sundaram PS
Ann Nucl Med 2024 Mar;38(3):231-237. Epub 2024 Jan 26 doi: 10.1007/s12149-023-01891-4. PMID: 38277114
Radioactive Iodine for the Treatment of Subclinical Thyrotoxicosis Grade 1 and 2: Outcome of up to 18-Year Follow Up.
Phowira J, Coffey KL, Bartholomew PH, Vennart N, Moreira M, Emerson H, Kennedy D, Weaver JU
Front Endocrinol (Lausanne) 2022;13:843857. Epub 2022 Mar 9 doi: 10.3389/fendo.2022.843857. PMID: 35370990Free PMC Article
High Rates of Underlying Thyroid Cancer in Patients Undergoing Thyroidectomy for Hyperthyroidism.
Alvarez AL, Mulder M, Handelsman RS, Lew JI, Farra JC
J Surg Res 2020 Jan;245:523-528. Epub 2019 Aug 23 doi: 10.1016/j.jss.2019.07.048. PMID: 31450040
Thyroid cancer in patients with hyperthyroidism.
Pazaitou-Panayiotou K, Michalakis K, Paschke R
Horm Metab Res 2012 Apr;44(4):255-62. Epub 2012 Feb 14 doi: 10.1055/s-0031-1299741. PMID: 22334393
Effect of radioiodine therapy on thyroid nodule size and function in patients with toxic adenomas.
Erdoğan MF, Küçük NO, Anil C, Aras S, Ozer D, Aras G, Kamel N
Nucl Med Commun 2004 Nov;25(11):1083-7. doi: 10.1097/00006231-200411000-00003. PMID: 15577585

Clinical prediction guides

Factors predicting remission in hyperthyroid patients after low-dose I-131 therapy: 20 years retrospective study from a tertiary care hospital.
S SY, Padma S, Sundaram PS
Ann Nucl Med 2024 Mar;38(3):231-237. Epub 2024 Jan 26 doi: 10.1007/s12149-023-01891-4. PMID: 38277114
Radioactive Iodine for the Treatment of Subclinical Thyrotoxicosis Grade 1 and 2: Outcome of up to 18-Year Follow Up.
Phowira J, Coffey KL, Bartholomew PH, Vennart N, Moreira M, Emerson H, Kennedy D, Weaver JU
Front Endocrinol (Lausanne) 2022;13:843857. Epub 2022 Mar 9 doi: 10.3389/fendo.2022.843857. PMID: 35370990Free PMC Article
Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter.
Chianelli M, Bizzarri G, Todino V, Misischi I, Bianchini A, Graziano F, Guglielmi R, Pacella CM, Gharib H, Papini E
J Clin Endocrinol Metab 2014 Jul;99(7):E1283-6. Epub 2014 Mar 31 doi: 10.1210/jc.2013-2967. PMID: 24684455
Treatment of autonomously functioning thyroid nodules at a single institution: radioiodine therapy, surgery, and ethanol injection therapy.
Yano Y, Sugino K, Akaishi J, Uruno T, Okuwa K, Shibuya H, Kitagawa W, Nagahama M, Ito K, Ito K
Ann Nucl Med 2011 Dec;25(10):749-54. Epub 2011 Oct 5 doi: 10.1007/s12149-011-0526-7. PMID: 21971604
Morphologic and functional substrate of thyrotoxicosis caused by nodular goiters.
Studer H, Hunziker HR, Ruchti C
Am J Med 1978 Aug;65(2):227-34. doi: 10.1016/0002-9343(78)90813-6. PMID: 686008

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG145, Thyroid disease: assessment and management, 2023

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    Reviews

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      Related literature resources in PubMed

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