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Small placenta

MedGen UID:
488920
•Concept ID:
C0566694
•
Finding
HPO: HP:0006266

Definition

Reduced size of the placenta. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall placenta

Conditions with this feature

Fetal akinesia deformation sequence 1
MedGen UID:
220903
•Concept ID:
C1276035
•
Disease or Syndrome
Decreased fetal activity associated with multiple joint contractures, facial anomalies and pulmonary hypoplasia. Ultrasound examination may reveal polyhydramnios, ankylosis, scalp edema, and decreased chest movements (reflecting pulmonary hypoplasia).
See: Condition Record
Neu-Laxova syndrome 1
MedGen UID:
1633287
•Concept ID:
C4551478
•
Disease or Syndrome
Any Neu-Laxova syndrome in which the cause of the disease is a mutation in the PHGDH gene.
See: Condition Record
Fetal akinesia deformation sequence 1
Neu-Laxova syndrome 1

Professional guidelines

PubMed

Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction.
Lees CC, Stampalija T, Baschat A, da Silva Costa F, Ferrazzi E, Figueras F, Hecher K, Kingdom J, Poon LC, Salomon LJ, Unterscheider J
Ultrasound Obstet Gynecol 2020 Aug;56(2):298-312. doi: 10.1002/uog.22134. PMID: 32738107
Isthmocele: an overview of diagnosis and treatment.
Kremer TG, Ghiorzi IB, Dibi RP
Rev Assoc Med Bras (1992) 2019 Jun 3;65(5):714-721. doi: 10.1590/1806-9282.65.5.714. PMID: 31166450

Recent clinical studies

Etiology

Fetal growth restriction and a single umbilical artery are independent predictors of hypospadias during pregnancy.
Endo T, Iida M, Ichihashi Y, Oishi M, Ikenoue S, Kasuga Y, Sato T, Hida M, Ishii T, Asanuma H, Hasegawa T, Tanaka M, Ochiai D
Placenta 2022 Dec;130:53-59. Epub 2022 Nov 5 doi: 10.1016/j.placenta.2022.11.001. PMID: 36401899
Intrauterine Fetal and Neonatal Death between Small for Date and Non-Small for Date in Small for Gestational Age Infants.
Itoh T, Matsuda Y, Itoh H, Ogawa M, Sasaki K, Kanayama N
Int J Med Sci 2019;16(4):501-506. Epub 2019 Mar 9 doi: 10.7150/ijms.31153. PMID: 31171900Free PMC Article
Independent risk factors for a small placenta and a small-for-gestational-age infant at 35-41 weeks of gestation: An association with circulating angiogenesis-related factor levels at 19-31 weeks of gestation.
Hirashima C, Ohkuchi A, Takahashi K, Suzuki H, Shirasuna K, Matsubara S
J Obstet Gynaecol Res 2017 Aug;43(8):1285-1292. Epub 2017 Jun 14 doi: 10.1111/jog.13360. PMID: 28613009
How to build a healthy heart from scratch.
Thornburg KL, Challis JR
Adv Exp Med Biol 2014;814:205-16. doi: 10.1007/978-1-4939-1031-1_18. PMID: 25015813Free PMC Article
The placenta in leprosy.
Duncan ME, Fox H, Harkness RA, Rees RJ
Placenta 1984 May-Jun;5(3):189-98. doi: 10.1016/s0143-4004(84)80028-4. PMID: 6390420

Diagnosis

Placental Pathology Findings in Unexplained Pregnancy Losses.
Thompson BB, Holzer PH, Kliman HJ
Reprod Sci 2024 Feb;31(2):488-504. Epub 2023 Sep 19 doi: 10.1007/s43032-023-01344-3. PMID: 37725247Free PMC Article
Placental Area in the Lower Uterine Segment, Cervical Length, and Clinical Outcome in Pregnancies With Complete Placenta Previa.
Zhou L, Zhao X, Xu D, Pang S, Mao X, Feng S, Yue Y
J Magn Reson Imaging 2023 Oct;58(4):1047-1054. Epub 2023 Feb 27 doi: 10.1002/jmri.28617. PMID: 36847772
Fetal growth restriction and a single umbilical artery are independent predictors of hypospadias during pregnancy.
Endo T, Iida M, Ichihashi Y, Oishi M, Ikenoue S, Kasuga Y, Sato T, Hida M, Ishii T, Asanuma H, Hasegawa T, Tanaka M, Ochiai D
Placenta 2022 Dec;130:53-59. Epub 2022 Nov 5 doi: 10.1016/j.placenta.2022.11.001. PMID: 36401899
Three-dimensional sonographic volumetry of the placenta and the fetus between weeks 15 and 17 of gestation.
Hafner E, Schuchter K, van Leeuwen M, Metzenbauer M, Dillinger-Paller B, Philipp K
Ultrasound Obstet Gynecol 2001 Aug;18(2):116-20. doi: 10.1046/j.1469-0705.2001.00489.x. PMID: 11529989
Risk of retained placenta: multivariate approach.
Adelusi B, Soltan MH, Chowdhury N, Kangave D
Acta Obstet Gynecol Scand 1997 May;76(5):414-8. doi: 10.3109/00016349709047821. PMID: 9197442

Therapy

Three-dimensional sonographic volumetry of the placenta and the fetus between weeks 15 and 17 of gestation.
Hafner E, Schuchter K, van Leeuwen M, Metzenbauer M, Dillinger-Paller B, Philipp K
Ultrasound Obstet Gynecol 2001 Aug;18(2):116-20. doi: 10.1046/j.1469-0705.2001.00489.x. PMID: 11529989
Fatal fetal outcome with the combined use of valsartan and atenolol.
Briggs GG, Nageotte MP
Ann Pharmacother 2001 Jul-Aug;35(7-8):859-61. doi: 10.1345/aph.1A013. PMID: 11485133
Risk of retained placenta: multivariate approach.
Adelusi B, Soltan MH, Chowdhury N, Kangave D
Acta Obstet Gynecol Scand 1997 May;76(5):414-8. doi: 10.3109/00016349709047821. PMID: 9197442

Prognosis

Fetal growth restriction and a single umbilical artery are independent predictors of hypospadias during pregnancy.
Endo T, Iida M, Ichihashi Y, Oishi M, Ikenoue S, Kasuga Y, Sato T, Hida M, Ishii T, Asanuma H, Hasegawa T, Tanaka M, Ochiai D
Placenta 2022 Dec;130:53-59. Epub 2022 Nov 5 doi: 10.1016/j.placenta.2022.11.001. PMID: 36401899
Identification of neurodevelopmental trajectories in infancy and of risk factors affecting deviant development: a longitudinal birth cohort study.
Nishimura T, Takei N, Tsuchiya KJ, Asano R, Mori N
Int J Epidemiol 2016 Apr;45(2):543-53. Epub 2016 Feb 13 doi: 10.1093/ije/dyv363. PMID: 26874928
Pathologic basis of improving the screening utility of 2-dimensional placental morphology ultrasound.
Costantini D, Walker M, Milligan N, Keating S, Kingdom J
Placenta 2012 Oct;33(10):845-9. Epub 2012 Jul 28 doi: 10.1016/j.placenta.2012.07.010. PMID: 22841938
Risk of retained placenta: multivariate approach.
Adelusi B, Soltan MH, Chowdhury N, Kangave D
Acta Obstet Gynecol Scand 1997 May;76(5):414-8. doi: 10.3109/00016349709047821. PMID: 9197442
Comparative aspects of placental exchange functions.
Schröder HJ
Eur J Obstet Gynecol Reprod Biol 1995 Nov;63(1):81-90. doi: 10.1016/0301-2115(95)02206-m. PMID: 8674572

Clinical prediction guides

Placental Pathology Findings in Unexplained Pregnancy Losses.
Thompson BB, Holzer PH, Kliman HJ
Reprod Sci 2024 Feb;31(2):488-504. Epub 2023 Sep 19 doi: 10.1007/s43032-023-01344-3. PMID: 37725247Free PMC Article
Fetal growth restriction and a single umbilical artery are independent predictors of hypospadias during pregnancy.
Endo T, Iida M, Ichihashi Y, Oishi M, Ikenoue S, Kasuga Y, Sato T, Hida M, Ishii T, Asanuma H, Hasegawa T, Tanaka M, Ochiai D
Placenta 2022 Dec;130:53-59. Epub 2022 Nov 5 doi: 10.1016/j.placenta.2022.11.001. PMID: 36401899
Intrauterine Fetal and Neonatal Death between Small for Date and Non-Small for Date in Small for Gestational Age Infants.
Itoh T, Matsuda Y, Itoh H, Ogawa M, Sasaki K, Kanayama N
Int J Med Sci 2019;16(4):501-506. Epub 2019 Mar 9 doi: 10.7150/ijms.31153. PMID: 31171900Free PMC Article
Comparative aspects of placental exchange functions.
Schröder HJ
Eur J Obstet Gynecol Reprod Biol 1995 Nov;63(1):81-90. doi: 10.1016/0301-2115(95)02206-m. PMID: 8674572
The placenta in leprosy.
Duncan ME, Fox H, Harkness RA, Rees RJ
Placenta 1984 May-Jun;5(3):189-98. doi: 10.1016/s0143-4004(84)80028-4. PMID: 6390420

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