Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Cutaneous syphilis

MedGen UID:: 52623
•Concept ID:: C0039132
•: Disease or Syndrome

Synonyms:	Cutaneous Syphilis; Skin Syphilis; Syphilis, Cutaneous; Syphilis, Skin
SNOMED CT:	Syphilitic skin disorder (371237000)

Monarch Initiative:	MONDO:0006718

Definition

Cutaneous lesions arising from infection with Treponema pallidum. In the primary stage, 18-21 days following infection, one or more chancres appear. If untreated, the subsequent stages of the disease appear as syphilids. These eruptions are superficial, nondestructive, exanthematic, transient, macular roseolas that may later be maculopapular or papular polymorphous or scaly, pustular, pigmented eruptions.(Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p409) [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCutaneous syphilis

Clinical finding
- Finding by Cause
  - Infection
    - Bacterial Infections and Mycoses
      - Bacterial infectious disease
        Bacterial infection of skin
        Cutaneous syphilis

Professional guidelines

PubMed

Relevance in biology and mechanisms of immune and treatment evasion of Treponema pallidum.

Drago F, Javor S, Parodi A
G Ital Dermatol Venereol 2019 Oct;154(5):573-580. Epub 2017 Dec 1 doi: 10.23736/S0392-0488.17.05830-8. PMID: 29199801

Update on the diagnosis and treatment of syphilis.

Morales-Múnera CE, Fuentes-Finkelstein PA, Vall Mayans M
Actas Dermosifiliogr 2015 Jan-Feb;106(1):68-9. Epub 2014 Sep 20 doi: 10.1016/j.ad.2014.06.007. PMID: 25245171

The differential diagnosis of scaling eruptions.

FLIEGELMAN MT
Skin (Los Angeles) 1963 Apr;2:113-8. PMID: 13945550

See all (3)

Recent clinical studies

Etiology

Sexually acquired syphilis: Historical aspects, microbiology, epidemiology, and clinical manifestations.

Forrestel AK, Kovarik CL, Katz KA
J Am Acad Dermatol 2020 Jan;82(1):1-14. Epub 2019 Apr 12 doi: 10.1016/j.jaad.2019.02.073. PMID: 30986477

Atypical Cutaneous Manifestations in Syphilis.

Ivars Lleó M, Clavo Escribano P, Menéndez Prieto B
Actas Dermosifiliogr 2016 May;107(4):275-83. Epub 2015 Dec 23 doi: 10.1016/j.ad.2015.11.002. PMID: 26708562

Sexually transmitted diseases.

Bechtel MA, Trout W
Clin Obstet Gynecol 2015 Mar;58(1):172-84. doi: 10.1097/GRF.0000000000000078. PMID: 25565081

Syphilis: uncommon presentations in adults.

Dourmishev LA, Dourmishev AL
Clin Dermatol 2005 Nov-Dec;23(6):555-64. doi: 10.1016/j.clindermatol.2005.01.015. PMID: 16325063

Testing for syphilis.

Johnson PC, Farnie MA
Dermatol Clin 1994 Jan;12(1):9-17. PMID: 8143388

See all (53)

Diagnosis

Corymbose Syphilis.

Gisondi P, Bellinato F
Sex Transm Dis 2022 Jul 1;49(7):e85-e86. Epub 2022 Mar 17 doi: 10.1097/OLQ.0000000000001630. PMID: 35312665

Sexually acquired syphilis: Historical aspects, microbiology, epidemiology, and clinical manifestations.

Forrestel AK, Kovarik CL, Katz KA
J Am Acad Dermatol 2020 Jan;82(1):1-14. Epub 2019 Apr 12 doi: 10.1016/j.jaad.2019.02.073. PMID: 30986477

HIV-Associated Psoriasis.

Queirós N, Torres T
Actas Dermosifiliogr (Engl Ed) 2018 May;109(4):303-311. Epub 2018 Feb 1 doi: 10.1016/j.ad.2017.09.014. PMID: 29361272

Sexually transmitted diseases.

Bechtel MA, Trout W
Clin Obstet Gynecol 2015 Mar;58(1):172-84. doi: 10.1097/GRF.0000000000000078. PMID: 25565081

Syphilis--diagnosis and treatment.

Rudolph AH, Duncan WC
Clin Obstet Gynecol 1975 Mar;18(1):163-82. doi: 10.1097/00003081-197503000-00015. PMID: 1091382

See all (384)

Therapy

Syphilitic Alopecia.

Sebaratnam DF, Wong XL
Sex Transm Dis 2018 Jul;45(7):e49. doi: 10.1097/OLQ.0000000000000850. PMID: 29624564

HIV-Associated Psoriasis.

Queirós N, Torres T
Actas Dermosifiliogr (Engl Ed) 2018 May;109(4):303-311. Epub 2018 Feb 1 doi: 10.1016/j.ad.2017.09.014. PMID: 29361272

Sexually transmitted diseases.

Bechtel MA, Trout W
Clin Obstet Gynecol 2015 Mar;58(1):172-84. doi: 10.1097/GRF.0000000000000078. PMID: 25565081

Syphilis: uncommon presentations in adults.

Dourmishev LA, Dourmishev AL
Clin Dermatol 2005 Nov-Dec;23(6):555-64. doi: 10.1016/j.clindermatol.2005.01.015. PMID: 16325063

Syphilis--diagnosis and treatment.

Rudolph AH, Duncan WC
Clin Obstet Gynecol 1975 Mar;18(1):163-82. doi: 10.1097/00003081-197503000-00015. PMID: 1091382

See all (171)

Prognosis

Syphilis: uncommon presentations in adults.

Dourmishev LA, Dourmishev AL
Clin Dermatol 2005 Nov-Dec;23(6):555-64. doi: 10.1016/j.clindermatol.2005.01.015. PMID: 16325063

Secondary syphilitic lesions.

Baughn RE, Musher DM
Clin Microbiol Rev 2005 Jan;18(1):205-16. doi: 10.1128/CMR.18.1.205-216.2005. PMID: 15653827 Free PMC Article

Testing for syphilis.

Johnson PC, Farnie MA
Dermatol Clin 1994 Jan;12(1):9-17. PMID: 8143388

Dermatologic and systemic manifestations of syphilis.

Goens JL, Janniger CK, De Wolf K
Am Fam Physician 1994 Oct;50(5):1013-20. PMID: 7942400

Nonvenereal treponematoses: yaws, endemic syphilis, and pinta.

Koff AB, Rosen T
J Am Acad Dermatol 1993 Oct;29(4):519-35; quiz 536-8. doi: 10.1016/0190-9622(93)70217-h. PMID: 8408787

See all (52)

Clinical prediction guides

Secondary syphilis with extra-genital condyloma lata: A case report and review of the literature.

Barei F, Murgia G, Ramoni S, Cusini M, Marzano AV
Int J STD AIDS 2022 Oct;33(12):1022-1028. Epub 2022 Sep 14 doi: 10.1177/09564624221124710. PMID: 36113077

Syphilis: A Contemporary Clinicopathologic Assessment.

Taxy JB, Cibull T
Am J Surg Pathol 2020 Sep;44(9):1274-1281. doi: 10.1097/PAS.0000000000001523. PMID: 32568824

Cutaneous manifestations of syphilis : recognition and management.

Lautenschlager S
Am J Clin Dermatol 2006;7(5):291-304. doi: 10.2165/00128071-200607050-00003. PMID: 17007540

Secondary syphilitic lesions.

Baughn RE, Musher DM
Clin Microbiol Rev 2005 Jan;18(1):205-16. doi: 10.1128/CMR.18.1.205-216.2005. PMID: 15653827 Free PMC Article

Testing for syphilis.

Johnson PC, Farnie MA
Dermatol Clin 1994 Jan;12(1):9-17. PMID: 8143388

See all (40)