U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Paraseptal emphysema

MedGen UID:
538541
Concept ID:
C0264394
Disease or Syndrome
Synonyms: Distal acinar emphysema; Peripheral lobular emphysema; Subpleural emphysema
SNOMED CT: Paraseptal emphysema (31898008); Peripheral lobular emphysema (31898008); Subpleural emphysema (31898008)
 
HPO: HP:0033649

Definition

Paraseptal emphysema is characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa. This emphysema is characterized by subpleural and peribronchovascular regions of low attenuation separated by intact interlobular septa, sometimes associated with bullae. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaseptal emphysema

Conditions with this feature

Interstitial lung disease due to ABCA3 deficiency
MedGen UID:
410074
Concept ID:
C1970456
Disease or Syndrome
For a general phenotypic description and a discussion of genetic heterogeneity of pulmonary surfactant metabolism dysfunction, see SMDP1 (265120).

Professional guidelines

PubMed

Hochhegger B, Patel PP, Zanon M, Müller E, Ferreira Correa L, Verma N, Mohammed TL, Quinto Dos Reis Hochhegger D, Irion K, Marchiori E
Lung 2022 Dec;200(6):817-820. Epub 2022 Oct 22 doi: 10.1007/s00408-022-00576-5. PMID: 36271930
Slebos DJ, Ten Hacken NH, Hetzel M, Herth FJF, Shah PL
Respiration 2018;96(1):1-11. Epub 2018 Jul 10 doi: 10.1159/000490193. PMID: 29991060Free PMC Article

Recent clinical studies

Etiology

Marciano BE, Olivier KN, Folio LR, Zerbe CS, Hsu AP, Freeman AF, Filie AC, Spinner MA, Sanchez LA, Lovell JP, Parta M, Cuellar-Rodriguez JM, Hickstein DD, Holland SM
Chest 2021 Oct;160(4):1350-1359. Epub 2021 Jun 3 doi: 10.1016/j.chest.2021.05.046. PMID: 34089740Free PMC Article
González J, Henschke CI, Yankelevitz DF, Seijo LM, Reeves AP, Yip R, Xie Y, Chung M, Sánchez-Salcedo P, Alcaide AB, Campo A, Bertó J, Del Mar Ocón M, Pueyo J, Bastarrika G, de-Torres JP, Zulueta JJ
PLoS One 2019;14(7):e0219187. Epub 2019 Jul 25 doi: 10.1371/journal.pone.0219187. PMID: 31344121Free PMC Article
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Copeland CR, Nath H, Terry NLJ, Wilson CG, Kim YI, Lynch DA, Bodduluri S, Wells JM, Dransfield MT, Díaz AA, Washko GR, Foreman MG, Bhatt SP; Genetic Epidemiology of COPD (COPDGene) Investigators
Ann Am Thorac Soc 2018 Apr;15(4):479-484. doi: 10.1513/AnnalsATS.201709-713OC. PMID: 29298081Free PMC Article
Leung JM, Malagoli A, Santoro A, Besutti G, Ligabue G, Scaglioni R, Dai D, Hague C, Leipsic J, Sin DD, Man SP, Guaraldi G
PLoS One 2016;11(11):e0167247. Epub 2016 Nov 30 doi: 10.1371/journal.pone.0167247. PMID: 27902753Free PMC Article

Diagnosis

Wu Y, Qi S, Sun Y, Xia S, Yao Y, Qian W
Phys Med Biol 2021 Dec 15;66(24) doi: 10.1088/1361-6560/ac3dc8. PMID: 34826824
Marciano BE, Olivier KN, Folio LR, Zerbe CS, Hsu AP, Freeman AF, Filie AC, Spinner MA, Sanchez LA, Lovell JP, Parta M, Cuellar-Rodriguez JM, Hickstein DD, Holland SM
Chest 2021 Oct;160(4):1350-1359. Epub 2021 Jun 3 doi: 10.1016/j.chest.2021.05.046. PMID: 34089740Free PMC Article
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Raoof S, Bondalapati P, Vydyula R, Ryu JH, Gupta N, Raoof S, Galvin J, Rosen MJ, Lynch D, Travis W, Mehta S, Lazzaro R, Naidich D
Chest 2016 Oct;150(4):945-965. Epub 2016 May 13 doi: 10.1016/j.chest.2016.04.026. PMID: 27180915Free PMC Article
Takahashi M, Fukuoka J, Nitta N, Takazakura R, Nagatani Y, Murakami Y, Otani H, Murata K
Int J Chron Obstruct Pulmon Dis 2008;3(2):193-204. doi: 10.2147/copd.s2639. PMID: 18686729Free PMC Article

Therapy

Lee HJ, Jin KN, Lee HW, Lee JK, Park TY, Heo EY, Kim DK
Int J Chron Obstruct Pulmon Dis 2022;17:2301-2315. Epub 2022 Sep 18 doi: 10.2147/COPD.S372735. PMID: 36159655Free PMC Article
Yang X, Dorrius MD, Jiang W, Nie Z, Vliegenthart R, Groen HJM, Heuvelmans MA, Sidorenkov G, Vonder M, Ye Z, de Bock GH
Eur Radiol 2022 Dec;32(12):8162-8170. Epub 2022 Jun 9 doi: 10.1007/s00330-022-08884-3. PMID: 35678862Free PMC Article
Franconeri A, Marasco E, Dore R, Codullo V, Calliada F, Disabella E, Meloni F, Zanframundo G, Montecucco C, Valentini A, Cavagna L
Respir Med 2019 Nov-Dec;160:105816. Epub 2019 Nov 9 doi: 10.1016/j.rmed.2019.105816. PMID: 31739247
Janssen R, Piscaer I, Franssen FME, Wouters EFM
Expert Rev Respir Med 2019 Apr;13(4):381-397. Epub 2019 Feb 22 doi: 10.1080/17476348.2019.1580575. PMID: 30761929
Copeland CR, Nath H, Terry NLJ, Wilson CG, Kim YI, Lynch DA, Bodduluri S, Wells JM, Dransfield MT, Díaz AA, Washko GR, Foreman MG, Bhatt SP; Genetic Epidemiology of COPD (COPDGene) Investigators
Ann Am Thorac Soc 2018 Apr;15(4):479-484. doi: 10.1513/AnnalsATS.201709-713OC. PMID: 29298081Free PMC Article

Prognosis

Lee HJ, Jin KN, Lee HW, Lee JK, Park TY, Heo EY, Kim DK
Int J Chron Obstruct Pulmon Dis 2022;17:2301-2315. Epub 2022 Sep 18 doi: 10.2147/COPD.S372735. PMID: 36159655Free PMC Article
Klont F, Horvatovich P, Bowler RP, van Rikxoort E, Charbonnier JP, Kwiatkowski M, Lynch DA, Humphries S, Bischoff R, Ten Hacken NHT, Pouwels SD
Respir Res 2022 Jan 24;23(1):15. doi: 10.1186/s12931-022-01934-w. PMID: 35073932Free PMC Article
Tanabe N, Hirai T
Korean J Intern Med 2021 Nov;36(6):1294-1304. Epub 2021 Oct 6 doi: 10.3904/kjim.2021.124. PMID: 34607419Free PMC Article
González J, Henschke CI, Yankelevitz DF, Seijo LM, Reeves AP, Yip R, Xie Y, Chung M, Sánchez-Salcedo P, Alcaide AB, Campo A, Bertó J, Del Mar Ocón M, Pueyo J, Bastarrika G, de-Torres JP, Zulueta JJ
PLoS One 2019;14(7):e0219187. Epub 2019 Jul 25 doi: 10.1371/journal.pone.0219187. PMID: 31344121Free PMC Article
Leung JM, Malagoli A, Santoro A, Besutti G, Ligabue G, Scaglioni R, Dai D, Hague C, Leipsic J, Sin DD, Man SP, Guaraldi G
PLoS One 2016;11(11):e0167247. Epub 2016 Nov 30 doi: 10.1371/journal.pone.0167247. PMID: 27902753Free PMC Article

Clinical prediction guides

Shiraishi Y, Tanabe N, Shimizu K, Oguma A, Shima H, Sakamoto R, Yamazaki H, Oguma T, Sato A, Suzuki M, Makita H, Muro S, Nishimura M, Sato S, Konno S, Hirai T
Chest 2023 Aug;164(2):327-338. Epub 2023 Jan 31 doi: 10.1016/j.chest.2023.01.034. PMID: 36736486
Marciano BE, Olivier KN, Folio LR, Zerbe CS, Hsu AP, Freeman AF, Filie AC, Spinner MA, Sanchez LA, Lovell JP, Parta M, Cuellar-Rodriguez JM, Hickstein DD, Holland SM
Chest 2021 Oct;160(4):1350-1359. Epub 2021 Jun 3 doi: 10.1016/j.chest.2021.05.046. PMID: 34089740Free PMC Article
González J, Henschke CI, Yankelevitz DF, Seijo LM, Reeves AP, Yip R, Xie Y, Chung M, Sánchez-Salcedo P, Alcaide AB, Campo A, Bertó J, Del Mar Ocón M, Pueyo J, Bastarrika G, de-Torres JP, Zulueta JJ
PLoS One 2019;14(7):e0219187. Epub 2019 Jul 25 doi: 10.1371/journal.pone.0219187. PMID: 31344121Free PMC Article
Leung JM, Malagoli A, Santoro A, Besutti G, Ligabue G, Scaglioni R, Dai D, Hague C, Leipsic J, Sin DD, Man SP, Guaraldi G
PLoS One 2016;11(11):e0167247. Epub 2016 Nov 30 doi: 10.1371/journal.pone.0167247. PMID: 27902753Free PMC Article
Araki T, Nishino M, Zazueta OE, Gao W, Dupuis J, Okajima Y, Latourelle JC, Rosas IO, Murakami T, O'Connor GT, Washko GR, Hunninghake GM, Hatabu H
Eur J Radiol 2015 Jul;84(7):1413-8. Epub 2015 Mar 18 doi: 10.1016/j.ejrad.2015.03.010. PMID: 25868675Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...