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Cleft upper lip, upper jaw AND palate

MedGen UID:
539673
Concept ID:
C0266090
Congenital Abnormality
Synonyms: Cheilognathopalatoschisis; Cheilognathouranoschisis
SNOMED CT: Cheilognathopalatoschisis (337471007); Cleft upper lip, upper jaw AND palate (337471007); Cheilognathouranoschisis (338486003)

Definition

A congenital abnormality consisting of a fissure in the midline of the lip, hard and/or soft palate and upper jaw. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCleft upper lip, upper jaw AND palate

Professional guidelines

PubMed

Saele PK, Nordrehaug Aastrøm AK, Gjengedal H, Nasir EF, Mustafa M
Cleft Palate Craniofac J 2022 Jul;59(7):859-866. Epub 2021 Jul 20 doi: 10.1177/10556656211028509. PMID: 34282635Free PMC Article
Fariña R, Lolas J, Moreno E, Alister JP, Uribe MF, Pantoja R, Valladares S, Arrué C
J Craniofac Surg 2022 Mar-Apr 01;33(2):496-501. doi: 10.1097/SCS.0000000000007973. PMID: 34261964
Morris L
Curr Opin Otolaryngol Head Neck Surg 2019 Aug;27(4):302-309. doi: 10.1097/MOO.0000000000000558. PMID: 31219831

Recent clinical studies

Etiology

Viñas MJ, Galiotto-Barba F, Cortez-Lede MG, Rodríguez-González MÁ, Moral I, Delso E, González-Meli B, Lobo F, López-Cedrún JL, Neagu D, Garatea J, Garatea A, Berenguer B, Lorca-García C, Delgado MD, Martí E, Gutiérrez JM, Hernández C, Murillo-González J, Martínez-Álvarez C, Martínez-Sanz E
Sci Rep 2022 Nov 6;12(1):18837. doi: 10.1038/s41598-022-23584-0. PMID: 36336749Free PMC Article
Fariña R, Lolas J, Moreno E, Alister JP, Uribe MF, Pantoja R, Valladares S, Arrué C
J Craniofac Surg 2022 Mar-Apr 01;33(2):496-501. doi: 10.1097/SCS.0000000000007973. PMID: 34261964
Zhai J, Lv Y, Zheng Y, Wang B, Tong H, Yin N, Song T
J Craniofac Surg 2021 Mar-Apr 01;32(2):492-495. doi: 10.1097/SCS.0000000000006932. PMID: 33704967
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Manna F, Pensiero S, Clarich G, Guarneri GF, Parodi PC
J Craniofac Surg 2009 Sep;20(5):1383-7. doi: 10.1097/SCS.0b013e3181b0daa3. PMID: 19816262

Diagnosis

Minor K, Chueh J
Curr Opin Obstet Gynecol 2023 Apr 1;35(2):113-126. Epub 2023 Jan 24 doi: 10.1097/GCO.0000000000000852. PMID: 36912278
Jaruga A, Ksiazkiewicz J, Kuzniarz K, Tylzanowski P
Int J Mol Sci 2022 Jan 16;23(2) doi: 10.3390/ijms23020953. PMID: 35055138Free PMC Article
Lee CC, Peacock ZS
J Oral Maxillofac Surg 2022 Feb;80(2):276-284. Epub 2021 Sep 17 doi: 10.1016/j.joms.2021.09.008. PMID: 34648754
Tremont TJ, Posnick JC
Oral Maxillofac Surg Clin North Am 2020 May;32(2):321-338. Epub 2020 Mar 5 doi: 10.1016/j.coms.2020.01.006. PMID: 32146029
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938

Therapy

Dallaserra M, Pantoja T, Salazar J, Araya I, Yanine N, Villanueva J
J Stomatol Oral Maxillofac Surg 2022 Oct;123(5):e506-e520. Epub 2022 Feb 10 doi: 10.1016/j.jormas.2022.02.004. PMID: 35151895
Lin Y, Fu Z, Guo R, Ma L, Li W
Cleft Palate Craniofac J 2021 Apr;58(4):429-437. Epub 2020 Sep 28 doi: 10.1177/1055665620954058. PMID: 32985240
Allareddy V, Shusterman S, Ross E, Palermo V, Ricalde P
Oral Maxillofac Surg Clin North Am 2020 May;32(2):187-196. Epub 2020 Feb 17 doi: 10.1016/j.coms.2020.01.002. PMID: 32081579
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Mølsted K
Crit Rev Oral Biol Med 1999;10(2):225-39. doi: 10.1177/10454411990100020801. PMID: 10759424

Prognosis

Antonarakis GS, Huanca Ghislanzoni L, Fisher DM
J Stomatol Oral Maxillofac Surg 2022 Nov;123(6):e916-e921. Epub 2022 Jun 10 doi: 10.1016/j.jormas.2022.06.008. PMID: 35697253
Lee CC, Peacock ZS
J Oral Maxillofac Surg 2022 Feb;80(2):276-284. Epub 2021 Sep 17 doi: 10.1016/j.joms.2021.09.008. PMID: 34648754
Figueroa AA, Figueroa AD, Burton RG, Tragos C
Clin Plast Surg 2021 Jul;48(3):391-405. Epub 2021 May 8 doi: 10.1016/j.cps.2021.02.002. PMID: 34051893
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938
Smahel Z, Müllerová Z
Acta Chir Plast 1995;37(1):29-32. PMID: 7653173

Clinical prediction guides

Lee CC, Peacock ZS
J Oral Maxillofac Surg 2022 Feb;80(2):276-284. Epub 2021 Sep 17 doi: 10.1016/j.joms.2021.09.008. PMID: 34648754
Figueroa AA, Figueroa AD, Burton RG, Tragos C
Clin Plast Surg 2021 Jul;48(3):391-405. Epub 2021 May 8 doi: 10.1016/j.cps.2021.02.002. PMID: 34051893
Akay G, Eren İ, Karadag Ö, Güngör K
Oral Radiol 2021 Oct;37(4):567-572. Epub 2020 Nov 12 doi: 10.1007/s11282-020-00491-6. PMID: 33180266
Smahel Z, Müllerová Z
Acta Chir Plast 1995;37(1):29-32. PMID: 7653173
Precious DS, Delaire J
Oral Surg Oral Med Oral Pathol 1993 Feb;75(2):141-51. doi: 10.1016/0030-4220(93)90084-h. PMID: 8426712

Recent systematic reviews

Dallaserra M, Pantoja T, Salazar J, Araya I, Yanine N, Villanueva J
J Stomatol Oral Maxillofac Surg 2022 Oct;123(5):e506-e520. Epub 2022 Feb 10 doi: 10.1016/j.jormas.2022.02.004. PMID: 35151895
Valls-Ontañón A, Fernandes-Ciaccia L, Haas-Junior OL, Hernández-Alfaro F
J Craniomaxillofac Surg 2021 Oct;49(10):879-890. Epub 2021 Sep 10 doi: 10.1016/j.jcms.2021.09.002. PMID: 34538538
Velasques BD, Moura LB, Martins JR, Damian MF, Xavier CB
Oral Maxillofac Surg 2021 Jun;25(2):139-148. Epub 2020 Sep 17 doi: 10.1007/s10006-020-00906-y. PMID: 32940776
Reddy RR, Gosla Reddy S, Vaidhyanathan A, Bergé SJ, Kuijpers-Jagtman AM
J Craniomaxillofac Surg 2017 Jun;45(6):995-1003. Epub 2017 Mar 22 doi: 10.1016/j.jcms.2017.03.006. PMID: 28427835
Thierens L, Brusselaers N, De Roo N, De Pauw G
Oral Dis 2017 Oct;23(7):889-896. Epub 2017 Jan 24 doi: 10.1111/odi.12613. PMID: 27878905

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