U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Iatrogenic Cushing disease

MedGen UID:
543520
•Concept ID:
C0271725
•
Disease or Syndrome
Synonyms: Drug-induced Cushing's syndrome; Exogenous Cushing Syndrome; Iatrogenic Cushing Syndrome; Iatrogenic Cushing's disease; Iatrogenic Cushing's syndrome; Iatrogenic syndrome of excess cortisol
SNOMED CT: Drug-induced Cushing's syndrome (41299009); Iatrogenic Cushing's syndrome (41299009); Iatrogenic Cushing disease (41299009); Iatrogenic Cushing's disease (41299009); Iatrogenic syndrome of excess cortisol (41299009)

Definition

Cushing syndrome as a result of increased glucocorticoids due to medical therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIatrogenic Cushing disease

Professional guidelines

PubMed

Headliner in Physiology and Management of Childhood Asthma: Hypothalamic-Pituitary-Adrenal Axis.
Akcan N, Bahceciler NN
Curr Pediatr Rev 2020;16(1):43-52. doi: 10.2174/1573396315666191026100643. PMID: 31738144
Congenital nasal pyriform aperture stenosis: conservative management.
Collins B, Powitzky R, Enix J, Digoy GP
Ann Otol Rhinol Laryngol 2013 Oct;122(10):601-4. PMID: 24294681
Medical treatment in Cushing's syndrome: dopamine agonists and cabergoline.
Petrossians P, Thonnard AS, Beckers A
Neuroendocrinology 2010;92 Suppl 1:116-9. Epub 2010 Sep 10 doi: 10.1159/000317716. PMID: 20829631

Recent clinical studies

Etiology

COVID-19 pandemic and adrenals: deep insights and implications in patients with glucocorticoid disorders.
Cozzolino A, Hasenmajer V, Newell-Price J, Isidori AM
Endocrine 2023 Oct;82(1):1-14. Epub 2023 Jun 20 doi: 10.1007/s12020-023-03411-w. PMID: 37338722Free PMC Article
Endocrine Hypertension: A Practical Approach.
Pappachan JM, Buch HN
Adv Exp Med Biol 2017;956:215-237. doi: 10.1007/5584_2016_26. PMID: 27864805
Anesthesia for transsphenoidal pituitary surgery.
Dunn LK, Nemergut EC
Curr Opin Anaesthesiol 2013 Oct;26(5):549-54. doi: 10.1097/01.aco.0000432521.01339.ab. PMID: 23963232
Hyponatremia and antidiuresis syndrome.
Vantyghem MC, Balavoine AS, Wémeau JL, Douillard C
Ann Endocrinol (Paris) 2011 Dec;72(6):500-12. Epub 2011 Nov 25 doi: 10.1016/j.ando.2011.10.001. PMID: 22119069
Glucocorticoid therapy.
Axelrod L
Medicine (Baltimore) 1976 Jan;55(1):39-65. doi: 10.1097/00005792-197601000-00003. PMID: 173974

Diagnosis

Factitious, or iatrogenic but unexpected Cushing's syndrome.
Cristante J, Chabre O
Ann Endocrinol (Paris) 2023 May;84(3):370-372. Epub 2023 Mar 22 doi: 10.1016/j.ando.2023.03.007. PMID: 36963757
Postmenopausal hyperandrogenism.
Yoldemir T
Climacteric 2022 Apr;25(2):109-117. Epub 2021 May 14 doi: 10.1080/13697137.2021.1915273. PMID: 33988479
Old Problem, New Concerns: Hypercortisolemia in the Time of COVID-19.
Berlińska A, Świątkowska-Stodulska R, Sworczak K
Front Endocrinol (Lausanne) 2021;12:711612. Epub 2021 Oct 5 doi: 10.3389/fendo.2021.711612. PMID: 34675878Free PMC Article
Adrenal function in cystic fibrosis.
Rayas MS, Kelly A, Hughan KS, Daley T, Zangen D
J Cyst Fibros 2019 Oct;18 Suppl 2:S74-S81. doi: 10.1016/j.jcf.2019.08.023. PMID: 31679732
Endocrine Hypertension: A Practical Approach.
Pappachan JM, Buch HN
Adv Exp Med Biol 2017;956:215-237. doi: 10.1007/5584_2016_26. PMID: 27864805

Therapy

Factitious, or iatrogenic but unexpected Cushing's syndrome.
Cristante J, Chabre O
Ann Endocrinol (Paris) 2023 May;84(3):370-372. Epub 2023 Mar 22 doi: 10.1016/j.ando.2023.03.007. PMID: 36963757
Old Problem, New Concerns: Hypercortisolemia in the Time of COVID-19.
Berlińska A, Świątkowska-Stodulska R, Sworczak K
Front Endocrinol (Lausanne) 2021;12:711612. Epub 2021 Oct 5 doi: 10.3389/fendo.2021.711612. PMID: 34675878Free PMC Article
Adrenal function in cystic fibrosis.
Rayas MS, Kelly A, Hughan KS, Daley T, Zangen D
J Cyst Fibros 2019 Oct;18 Suppl 2:S74-S81. doi: 10.1016/j.jcf.2019.08.023. PMID: 31679732
Exogenous Cushing's syndrome and glucocorticoid withdrawal.
Hopkins RL, Leinung MC
Endocrinol Metab Clin North Am 2005 Jun;34(2):371-84, ix. doi: 10.1016/j.ecl.2005.01.013. PMID: 15850848
Glucocorticoid therapy.
Axelrod L
Medicine (Baltimore) 1976 Jan;55(1):39-65. doi: 10.1097/00005792-197601000-00003. PMID: 173974

Prognosis

COVID-19 pandemic and adrenals: deep insights and implications in patients with glucocorticoid disorders.
Cozzolino A, Hasenmajer V, Newell-Price J, Isidori AM
Endocrine 2023 Oct;82(1):1-14. Epub 2023 Jun 20 doi: 10.1007/s12020-023-03411-w. PMID: 37338722Free PMC Article
Cross-species Association Between Telomere Length and Glucocorticoid Exposure.
Lee RS, Zandi PP, Santos A, Aulinas A, Carey JL, Webb SM, McCaul ME, Resmini E, Wand GS
J Clin Endocrinol Metab 2021 Nov 19;106(12):e5124-e5135. doi: 10.1210/clinem/dgab519. PMID: 34265046Free PMC Article
Different Potent Glucocorticoids, Different Routes of Exposure but the Same Result: Iatrogenic Cushing’s Syndrome and Adrenal Insufficiency.
Güven A
J Clin Res Pediatr Endocrinol 2020 Nov 25;12(4):383-392. Epub 2020 May 20 doi: 10.4274/jcrpe.galenos.2020.2019.0220. PMID: 32431136Free PMC Article
Endocrine Hypertension: A Practical Approach.
Pappachan JM, Buch HN
Adv Exp Med Biol 2017;956:215-237. doi: 10.1007/5584_2016_26. PMID: 27864805
Hyponatremia and antidiuresis syndrome.
Vantyghem MC, Balavoine AS, Wémeau JL, Douillard C
Ann Endocrinol (Paris) 2011 Dec;72(6):500-12. Epub 2011 Nov 25 doi: 10.1016/j.ando.2011.10.001. PMID: 22119069

Clinical prediction guides

Topical Steroid-Induced Cushing's Syndrome in a Newborn Following Goniotomy for Glaucoma.
Choudhary S, Singh AK, Gupta K, Pandav SS, Kaushik S
J Glaucoma 2023 Jan 1;32(1):65-67. Epub 2022 Aug 22 doi: 10.1097/IJG.0000000000002116. PMID: 36001506
Off-Label Use of Ciprofloxacin/Dexamethasone Drops in the Pediatric Upper Airway: Case Presentation and Review of Adverse Effects.
Ben-Dov T, Yang J, April MM
Ann Otol Rhinol Laryngol 2023 May;132(5):589-595. Epub 2022 Jun 15 doi: 10.1177/00034894221104461. PMID: 35703381
Incretin Response to Mixed Meal Challenge in Active Cushing's Disease and after Pasireotide Therapy.
Barbot M, Mondin A, Regazzo D, Guarnotta V, Basso D, Giordano C, Scaroni C, Ceccato F
Int J Mol Sci 2022 May 6;23(9) doi: 10.3390/ijms23095217. PMID: 35563608Free PMC Article
Cross-species Association Between Telomere Length and Glucocorticoid Exposure.
Lee RS, Zandi PP, Santos A, Aulinas A, Carey JL, Webb SM, McCaul ME, Resmini E, Wand GS
J Clin Endocrinol Metab 2021 Nov 19;106(12):e5124-e5135. doi: 10.1210/clinem/dgab519. PMID: 34265046Free PMC Article
Endocrine Hypertension: A Practical Approach.
Pappachan JM, Buch HN
Adv Exp Med Biol 2017;956:215-237. doi: 10.1007/5584_2016_26. PMID: 27864805

Recent systematic reviews

Intranasal Corticosteroid Therapy: Systematic Review and Meta-analysis of Reported Safety and Adverse Effects in Children.
Donaldson AM, Choby G, Kim DH, Marks LA, Lal D
Otolaryngol Head Neck Surg 2020 Dec;163(6):1087-1096. Epub 2020 Jul 14 doi: 10.1177/0194599820931454. PMID: 32660332

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...