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Dengue hemorrhagic fever

MedGen UID:
5506
•Concept ID:
C0019100
•
Disease or Syndrome
Synonyms: Hemorrhagic dengue; Philippine hemorrhagic fever; Singapore hemorrhagic fever; Thai hemorrhagic fever
SNOMED CT: DHF - Dengue hemorrhagic fever (20927009); Severe dengue (20927009); Dengue hemorrhagic fever (20927009)
 
Monarch Initiative: MONDO:0005358

Definition

A serious condition caused by Dengue virus infection. Patients present with an acute febrile illness followed by restlessness, irritability, and bleeding. It may lead to hemorrhagic shock and death. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDengue hemorrhagic fever

Professional guidelines

PubMed

Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?
Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425
Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment.
Halstead SB, Cohen SN
Microbiol Mol Biol Rev 2015 Sep;79(3):281-91. doi: 10.1128/MMBR.00009-15. PMID: 26085471Free PMC Article
Dengue hemorrhagic fever: clinical manifestations and management.
Kabra SK, Jain Y, Singhal T, Ratageri VH
Indian J Pediatr 1999 Jan-Feb;66(1):93-101. doi: 10.1007/BF02752362. PMID: 10798041

Recent clinical studies

Etiology

Dengue overview: An updated systemic review.
Khan MB, Yang ZS, Lin CY, Hsu MC, Urbina AN, Assavalapsakul W, Wang WH, Chen YH, Wang SF
J Infect Public Health 2023 Oct;16(10):1625-1642. Epub 2023 Aug 3 doi: 10.1016/j.jiph.2023.08.001. PMID: 37595484
Immune-Mediated Pathogenesis in Dengue Virus Infection.
Khanam A, Gutiérrez-Barbosa H, Lyke KE, Chua JV
Viruses 2022 Nov 21;14(11) doi: 10.3390/v14112575. PMID: 36423184Free PMC Article
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?
Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425
Dengue virus pathogenesis: an integrated view.
Martina BE, Koraka P, Osterhaus AD
Clin Microbiol Rev 2009 Oct;22(4):564-81. doi: 10.1128/CMR.00035-09. PMID: 19822889Free PMC Article

Diagnosis

Dengue hemorrhagic fever: a growing global menace.
Parveen S, Riaz Z, Saeed S, Ishaque U, Sultana M, Faiz Z, Shafqat Z, Shabbir S, Ashraf S, Marium A
J Water Health 2023 Nov;21(11):1632-1650. doi: 10.2166/wh.2023.114. PMID: 38017595
Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Dengue Fever: Causes, Complications, and Vaccine Strategies.
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article
Dengue and dengue hemorrhagic fever.
Gubler DJ
Clin Microbiol Rev 1998 Jul;11(3):480-96. doi: 10.1128/CMR.11.3.480. PMID: 9665979Free PMC Article

Therapy

Dengue overview: An updated systemic review.
Khan MB, Yang ZS, Lin CY, Hsu MC, Urbina AN, Assavalapsakul W, Wang WH, Chen YH, Wang SF
J Infect Public Health 2023 Oct;16(10):1625-1642. Epub 2023 Aug 3 doi: 10.1016/j.jiph.2023.08.001. PMID: 37595484
Clinical Safety Experience of TAK-003 for Dengue Fever: A New Tetravalent Live Attenuated Vaccine Candidate.
Patel SS, Rauscher M, Kudela M, Pang H
Clin Infect Dis 2023 Feb 8;76(3):e1350-e1359. doi: 10.1093/cid/ciac418. PMID: 35639602Free PMC Article
Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?
Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425
Dengue Fever: Causes, Complications, and Vaccine Strategies.
Khetarpal N, Khanna I
J Immunol Res 2016;2016:6803098. Epub 2016 Jul 20 doi: 10.1155/2016/6803098. PMID: 27525287Free PMC Article
Dengue and dengue hemorrhagic fever.
Gubler DJ
Clin Microbiol Rev 1998 Jul;11(3):480-96. doi: 10.1128/CMR.11.3.480. PMID: 9665979Free PMC Article

Prognosis

Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review.
Al-Tawfiq JA, Memish ZA
Vector Borne Zoonotic Dis 2018 Feb;18(2):75-81. Epub 2018 Jan 10 doi: 10.1089/vbz.2017.2209. PMID: 29319426
Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections.
Soo KM, Khalid B, Ching SM, Chee HY
PLoS One 2016;11(5):e0154760. Epub 2016 May 23 doi: 10.1371/journal.pone.0154760. PMID: 27213782Free PMC Article
Dengue.
Halstead SB
Curr Opin Infect Dis 2002 Oct;15(5):471-6. doi: 10.1097/00001432-200210000-00003. PMID: 12686878
Dengue and dengue hemorrhagic fever.
Gubler DJ
Clin Microbiol Rev 1998 Jul;11(3):480-96. doi: 10.1128/CMR.11.3.480. PMID: 9665979Free PMC Article

Clinical prediction guides

Neurological Complications of Dengue Fever.
Trivedi S, Chakravarty A
Curr Neurol Neurosci Rep 2022 Aug;22(8):515-529. Epub 2022 Jun 21 doi: 10.1007/s11910-022-01213-7. PMID: 35727463Free PMC Article
Dengue Hemorrhagic Fever: A State-of-the-Art Review Focused in Pulmonary Involvement.
de Almeida RR, Paim B, de Oliveira SA, Souza AS Jr, Gomes ACP, Escuissato DL, Zanetti G, Marchiori E
Lung 2017 Aug;195(4):389-395. Epub 2017 Jun 13 doi: 10.1007/s00408-017-0021-6. PMID: 28612239Free PMC Article
Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections.
Soo KM, Khalid B, Ching SM, Chee HY
PLoS One 2016;11(5):e0154760. Epub 2016 May 23 doi: 10.1371/journal.pone.0154760. PMID: 27213782Free PMC Article
Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment.
Halstead SB, Cohen SN
Microbiol Mol Biol Rev 2015 Sep;79(3):281-91. doi: 10.1128/MMBR.00009-15. PMID: 26085471Free PMC Article
Dengue.
Halstead SB
Curr Opin Infect Dis 2002 Oct;15(5):471-6. doi: 10.1097/00001432-200210000-00003. PMID: 12686878

Recent systematic reviews

Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis.
Kanan M, Naffaa M, Alanazi A, Nasser F, Alsaiari AA, Almehmadi M, Assiry A, Muzafar H, Katam H, Arar A, Asdaq SMB, Abida, Imran M, Dzinamarira T
J Infect Public Health 2024 Apr;17(4):579-587. Epub 2024 Feb 3 doi: 10.1016/j.jiph.2024.02.001. PMID: 38368646
Dengue overview: An updated systemic review.
Khan MB, Yang ZS, Lin CY, Hsu MC, Urbina AN, Assavalapsakul W, Wang WH, Chen YH, Wang SF
J Infect Public Health 2023 Oct;16(10):1625-1642. Epub 2023 Aug 3 doi: 10.1016/j.jiph.2023.08.001. PMID: 37595484
Association of dengue disease severity and blood group: A systematic review and meta-analysis.
Hashan MR, Ghozy S, El-Qushayri AE, Pial RH, Hossain MA, Al Kibria GM
Rev Med Virol 2021 Jan;31(1):1-9. Epub 2020 Aug 10 doi: 10.1002/rmv.2147. PMID: 32776660
Dengue hemorrhagic fever - A systemic literature review of current perspectives on pathogenesis, prevention and control.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, Wang SF
J Microbiol Immunol Infect 2020 Dec;53(6):963-978. Epub 2020 Mar 26 doi: 10.1016/j.jmii.2020.03.007. PMID: 32265181
Meta-Analysis of Dengue Severity during Infection by Different Dengue Virus Serotypes in Primary and Secondary Infections.
Soo KM, Khalid B, Ching SM, Chee HY
PLoS One 2016;11(5):e0154760. Epub 2016 May 23 doi: 10.1371/journal.pone.0154760. PMID: 27213782Free PMC Article

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