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Sweat gland adenoma

MedGen UID:: 5551
•Concept ID:: C0019522
•: Neoplastic Process

Synonyms:	Adenoma, Sweat Gland; Adenomas, Sweat Gland; Sweat Gland Adenoma; Sweat Gland Adenomas; Syringadenoma; Syringadenomas
SNOMED CT:	Sweat gland adenoma (81393009); Hidradenoma (81393009); Syringadenoma (81393009); Acrospiradenoma (400099008); Acrospiroma (400099008); Hidradenoma of skin (253020008); Hidradenoma (253020008); Syringadenoma (253020008)

Monarch Initiative:	MONDO:0021110

Definition

A benign epithelial neoplasm arising from the sweat glands. Variants include the clear cell and nodular hidradenoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSweat gland adenoma

Phenotypic abnormality
- Neoplasm
  - Neoplasms by Histologic Type
    - Neoplasms, Glandular and Epithelial
      - Neoplasms, Adnexal and Skin Appendage
        Sweat gland adenoma
        Acrospiromas
        Tubular Sweat Gland Adenomas

Professional guidelines

PubMed

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.

Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696

See all (1)

Recent clinical studies

Etiology

Congenital syringocystadenoma papilliferum.

Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179

Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia.

Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D
Acta Dermatovenerol Croat 2007;15(3):148-51. PMID: 17868540

Multiple linear eccrine spiradenomas with eyelid involvement.

Gupta S, Radotra BD, Kaur I, Handa S, Kumar B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):163-6. doi: 10.1046/j.1468-3083.2001.00234.x. PMID: 11495528

Cytology of primary skin tumors.

Dey P, Das A, Radhika S, Nijhawan R
Acta Cytol 1996 Jul-Aug;40(4):708-13. doi: 10.1159/000333943. PMID: 8693890

Eccrine sweat gland carcinoma: an histologic and immunohistochemical study of 32 cases.

Swanson PE, Cherwitz DL, Neumann MP, Wick MR
J Cutan Pathol 1987 Apr;14(2):65-86. doi: 10.1111/j.1600-0560.1987.tb00477.x. PMID: 2439558

See all (66)

Diagnosis

Association of HPV42 with digital papillary adenocarcinoma and the use of in situ hybridization for its distinction from acral hidradenoma and diagnosis at non-acral sites.

Vanderbilt C, Brenn T, Moy AP, Harloe G, Ariyan C, Athanasian E, Busam KJ
Mod Pathol 2022 Oct;35(10):1405-1410. Epub 2022 May 10 doi: 10.1038/s41379-022-01094-8. PMID: 35538210

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.

Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696

Syringocystadenoma.

Mundi JP, Rose AE, Boyd KP, Patel RR, Lipkin G
Dermatol Online J 2013 Dec 16;19(12):20722. PMID: 24365013

Malignant acrospiroma.

Stagnone GJ, Kucan JO, Gross K, Mann JL, Zook EG
J Hand Surg Am 1990 Nov;15(6):987-90. doi: 10.1016/0363-5023(90)90029-q. PMID: 2176667

Eccrine porocarcinoma.

Gschnait F, Horn F, Lindlbauer R, Sponer D
J Cutan Pathol 1980 Dec;7(6):349-53. doi: 10.1111/j.1600-0560.1980.tb01208.x. PMID: 6256417

See all (304)

Therapy

Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib.

Bollée G, Patey N, Cazajous G, Robert C, Goujon JM, Fakhouri F, Bruneval P, Noël LH, Knebelmann B
Nephrol Dial Transplant 2009 Feb;24(2):682-5. Epub 2008 Dec 2 doi: 10.1093/ndt/gfn657. PMID: 19054798

New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma.

Langbein L, Cribier B, Schirmacher P, Praetzel-Wunder S, Peltre B, Schweizer J
Br J Dermatol 2008 Sep;159(3):633-45. Epub 2008 Jul 19 doi: 10.1111/j.1365-2133.2008.08746.x. PMID: 18647305

Parotid acinar cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia.

Cheuk DK, Shek TW, Chan GC, Lau YL, Ha SY, Chiang AK
Pediatr Blood Cancer 2008 Mar;50(3):636-9. doi: 10.1002/pbc.21002. PMID: 16865683

Malignant eccrine spiradenoma.

Mirza I, Kloss R, Sieber SC
Arch Pathol Lab Med 2002 May;126(5):591-4. doi: 10.5858/2002-126-0591-MES. PMID: 11958666

A reactive acrosyringeal proliferation in a patient with ectodermal dysplasia: eccrine syringofibroadenoma-like lesion.

Utani A, Hattori Y
J Dermatol 1999 Jan;26(1):36-43. doi: 10.1111/j.1346-8138.1999.tb03507.x. PMID: 10063211

See all (14)

Prognosis

Syringocystadenocarcinoma papilliferum of the eyelid.

Hoguet AS, Dolphin K, McCormick SA, Milman T
Ophthalmic Plast Reconstr Surg 2012 Jan-Feb;28(1):e27-9. doi: 10.1097/IOP.0b013e318216366a. PMID: 22266788

Hidradenocarcinomas: a brief review and future directions.

Gauerke S, Driscoll JJ
Arch Pathol Lab Med 2010 May;134(5):781-5. doi: 10.5858/134.5.781. PMID: 20441512

Congenital syringocystadenoma papilliferum.

Karg E, Korom I, Varga E, Ban G, Turi S
Pediatr Dermatol 2008 Jan-Feb;25(1):132-3. doi: 10.1111/j.1525-1470.2007.00607.x. PMID: 18304179

Oncocytic nodular hidradenoma.

Roth MJ, Stern JB, Hijazi Y, Haupt HM, Kumar A
Am J Dermatopathol 1996 Jun;18(3):314-6. doi: 10.1097/00000372-199606000-00013. PMID: 8806968

Syringadenocarcinoma papilliferum.

Numata M, Hosoe S, Itoh N, Munakata Y, Hayashi S, Maruyama Y
J Cutan Pathol 1985 Feb;12(1):3-7. doi: 10.1111/j.1600-0560.1985.tb00422.x. PMID: 2982933

See all (68)

Clinical prediction guides

Trichilemmal cysts with proteinaceous material: A potential diagnostic pitfall.

Mitsui Y, Ogawa K, Koga K, Goto K, Takai T, Anan T, Fukumoto T, Asada H
J Cutan Pathol 2022 Jun;49(6):515-524. Epub 2022 Feb 22 doi: 10.1111/cup.14214. PMID: 35166386

Oncocytic nodular hidradenoma.

Roth MJ, Stern JB, Hijazi Y, Haupt HM, Kumar A
Am J Dermatopathol 1996 Jun;18(3):314-6. doi: 10.1097/00000372-199606000-00013. PMID: 8806968

Mammary-like glands of the vulva and their disorders.

van der Putte SC
Int J Gynecol Pathol 1994 Apr;13(2):150-60. doi: 10.1097/00004347-199404000-00009. PMID: 8005737

Eccrine porocarcinoma.

Akiyoshi E, Nogita T, Yamaguchi R, Toyoda H, Kawashima M, Hidano A
Dermatologica 1991;182(4):239-42. doi: 10.1159/000247804. PMID: 1653154

Eruptive hidradenoma.

Bevilacqua P, Bolognia J
Cutis 1990 Jul;46(1):69-72. PMID: 2166651

See all (74)