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Malignant neoplasm of endocervix

MedGen UID:
56309
•Concept ID:
C0153569
•
Neoplastic Process
Synonyms: Cancer of endocervix; cancer of endocervix; endocervix cancer; Malignant Endocervical Neoplasm; malignant endocervical neoplasm; Malignant Endocervical Tumor; malignant endocervical tumor; malignant endocervical tumour; Malignant Endocervix Neoplasm; malignant endocervix neoplasm; Malignant Endocervix Tumor; malignant endocervix tumor; malignant endocervix tumour; Malignant neoplasm of endocervical canal; Malignant Neoplasm of Endocervix; malignant neoplasm of endocervix; Malignant Neoplasm of the Endocervix; malignant neoplasm of the endocervix; Malignant Neoplasm of the Uterine Endocervix; malignant neoplasm of the uterine endocervix; Malignant Neoplasm of Uterine Endocervix; malignant neoplasm of uterine endocervix; Malignant Tumor of Endocervix; malignant tumor of endocervix; Malignant Tumor of the Endocervix; malignant tumor of the endocervix; Malignant Tumor of the Uterine Endocervix; malignant tumor of the uterine endocervix; Malignant Tumor of Uterine Endocervix; malignant tumor of uterine endocervix; malignant tumour of endocervix; malignant tumour of the endocervix; malignant tumour of the uterine endocervix; malignant tumour of uterine endocervix; Malignant Uterine Endocervix Neoplasm; malignant uterine endocervix neoplasm; Malignant Uterine Endocervix Tumor; malignant uterine endocervix tumor; malignant uterine endocervix tumour
SNOMED CT: Malignant neoplasm of endocervix (372097009); Malignant neoplasm of endocervical canal (188176007); Cancer of endocervix (372097009)
 
Monarch Initiative: MONDO:0021309

Definition

A malignant neoplasm that affects the endocervix. [from NCI]

Professional guidelines

PubMed

Global challenges of radiotherapy for the treatment of locally advanced cervical cancer.
Mayadev JS, Ke G, Mahantshetty U, Pereira MD, Tarnawski R, Toita T
Int J Gynecol Cancer 2022 Mar;32(3):436-445. doi: 10.1136/ijgc-2021-003001. PMID: 35256434Free PMC Article
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer.
Lim K, Small W Jr, Portelance L, Creutzberg C, Jürgenliemk-Schulz IM, Mundt A, Mell LK, Mayr N, Viswanathan A, Jhingran A, Erickson B, De los Santos J, Gaffney D, Yashar C, Beriwal S, Wolfson A, Taylor A, Bosch W, El Naqa I, Fyles A; Gyn IMRT Consortium
Int J Radiat Oncol Biol Phys 2011 Feb 1;79(2):348-55. Epub 2010 May 14 doi: 10.1016/j.ijrobp.2009.10.075. PMID: 20472347

Recent clinical studies

Etiology

Reconstructive surgery for congenital atresia of the uterine cervix: a systematic review.
Fedele F, Parazzini F, Vercellini P, Bergamini V, Fedele L
Arch Gynecol Obstet 2023 Sep;308(3):685-700. Epub 2022 Oct 28 doi: 10.1007/s00404-022-06825-5. PMID: 36305896
The role of endocervical curettage in detection and treatment of cervical canal lesions.
Lang L, Jia Y, Duan Z, Wu J, Luo M, Tian P
Histol Histopathol 2022 Jan;37(1):63-68. Epub 2021 Nov 9 doi: 10.14670/HH-18-394. PMID: 34755328
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Early Cervical Cancer: Current Dilemmas of Staging and Surgery.
Zigras T, Lennox G, Willows K, Covens A
Curr Oncol Rep 2017 Aug;19(8):51. doi: 10.1007/s11912-017-0614-5. PMID: 28664470
Glassy cell carcinoma of the cervix: a literature review.
Zolciak-Siwinska A, Jonska-Gmyrek J
Eur J Obstet Gynecol Reprod Biol 2014 Aug;179:232-5. Epub 2014 Apr 13 doi: 10.1016/j.ejogrb.2014.03.035. PMID: 24792540

Diagnosis

Ultrasonographic features of uterine cervical lesions.
Oh H, Park SB, Park HJ, Lee ES, Hur J, Choi W, Choi BI
Br J Radiol 2021 May 1;94(1121):20201242. Epub 2021 Feb 9 doi: 10.1259/bjr.20201242. PMID: 33560888Free PMC Article
Cervicovaginal cellular angiofibroma.
Van Mulders S, Faes E, Broeckx G, Jacquemyn Y
BMJ Case Rep 2020 Jul 16;13(7) doi: 10.1136/bcr-2020-235241. PMID: 32675122Free PMC Article
Imaging and Staging of Cervical Cancer.
Devine C, Viswanathan C, Faria S, Marcal L, Sagebiel TL
Semin Ultrasound CT MR 2019 Aug;40(4):280-286. Epub 2019 Mar 5 doi: 10.1053/j.sult.2019.03.001. PMID: 31375168
Imaging and staging of neuroendocrine cervical cancer.
Elsherif S, Odisio EGLC, Faria S, Javadi S, Yedururi S, Frumovitz M, Ramalingam P, Bhosale P
Abdom Radiol (NY) 2018 Dec;43(12):3468-3478. doi: 10.1007/s00261-018-1667-0. PMID: 29974177
Cervical tumors.
Sahdev A
Semin Ultrasound CT MR 2010 Oct;31(5):399-413. doi: 10.1053/j.sult.2010.07.004. PMID: 20974359

Therapy

Cervicovaginal microbiome and natural history of HPV in a longitudinal study.
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis.
Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis E
BMJ 2016 Jul 28;354:i3633. doi: 10.1136/bmj.i3633. PMID: 27469988Free PMC Article
Classification of radical hysterectomy.
Querleu D, Morrow CP
Lancet Oncol 2008 Mar;9(3):297-303. doi: 10.1016/S1470-2045(08)70074-3. PMID: 18308255

Prognosis

Implications of the new FIGO staging and the role of imaging in cervical cancer.
Kido A, Nakamoto Y
Br J Radiol 2021 Sep 1;94(1125):20201342. Epub 2021 May 14 doi: 10.1259/bjr.20201342. PMID: 33989030Free PMC Article
Imaging and staging of neuroendocrine cervical cancer.
Elsherif S, Odisio EGLC, Faria S, Javadi S, Yedururi S, Frumovitz M, Ramalingam P, Bhosale P
Abdom Radiol (NY) 2018 Dec;43(12):3468-3478. doi: 10.1007/s00261-018-1667-0. PMID: 29974177
Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial.
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Perivascular epithelioid cell tumors of the uterine cervix.
Kudela E, Biringer K, Kasajova P, Nachajova M, Adamkov M
Pathol Res Pract 2016 Aug;212(8):667-71. Epub 2016 Mar 30 doi: 10.1016/j.prp.2016.03.010. PMID: 27083240

Clinical prediction guides

Squamous and Glandular Epithelial Tumors of the Cervix: A Pragmatical Review Emphasizing Emerging Issues in Classification, Diagnosis, and Staging.
Stolnicu S, Soslow RA
Surg Pathol Clin 2022 Jun;15(2):369-388. doi: 10.1016/j.path.2022.02.010. PMID: 35715166
Adequacy in Endocervical Curettage.
Alqabbani R, Chan J, Goldberg A
Am J Clin Pathol 2022 Sep 2;158(3):378-382. doi: 10.1093/ajcp/aqac058. PMID: 35568991
Implications of the new FIGO staging and the role of imaging in cervical cancer.
Kido A, Nakamoto Y
Br J Radiol 2021 Sep 1;94(1125):20201342. Epub 2021 May 14 doi: 10.1259/bjr.20201342. PMID: 33989030Free PMC Article
Optimisation and evaluation of the random forest model in the efficacy prediction of chemoradiotherapy for advanced cervical cancer based on radiomics signature from high-resolution T2 weighted images.
Liu D, Zhang X, Zheng T, Shi Q, Cui Y, Wang Y, Liu L
Arch Gynecol Obstet 2021 Mar;303(3):811-820. Epub 2021 Jan 4 doi: 10.1007/s00404-020-05908-5. PMID: 33394142Free PMC Article
The importance of cryosurgery in gynecological practice.
Wojciech R
Ginekol Pol 2011 Aug;82(8):618-22. PMID: 21957608

Recent systematic reviews

Proportions and incidence of locally advanced cervical cancer: a global systematic literature review.
Monk BJ, Tan DSP, Hernández Chagüi JD, Takyar J, Paskow MJ, Nunes AT, Pujade-Lauraine E
Int J Gynecol Cancer 2022 Dec 5;32(12):1531-1539. doi: 10.1136/ijgc-2022-003801. PMID: 36241221Free PMC Article
Integrating HPV vaccination programs with enhanced cervical cancer screening and treatment, a systematic review.
Wirtz C, Mohamed Y, Engel D, Sidibe A, Holloway M, Bloem P, Kumar S, Brotherton J, Reis V, Morgan C
Vaccine 2022 Mar 31;40 Suppl 1:A116-A123. Epub 2021 Dec 1 doi: 10.1016/j.vaccine.2021.11.013. PMID: 34863615
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis.
Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis E
BMJ 2016 Jul 28;354:i3633. doi: 10.1136/bmj.i3633. PMID: 27469988Free PMC Article
Evidence supporting see-and-treat management of cervical intraepithelial neoplasia: a systematic review and meta-analysis.
Ebisch RM, Rovers MM, Bosgraaf RP, van der Pluijm-Schouten HW, Melchers WJ, van den Akker PA, Massuger LF, Bekkers RL
BJOG 2016 Jan;123(1):59-66. Epub 2015 Jul 14 doi: 10.1111/1471-0528.13530. PMID: 26177672

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