U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign neoplasm of small intestine

MedGen UID:
56324
•Concept ID:
C0153944
•
Neoplastic Process
Synonyms: Benign Neoplasm of Small Intestine; benign neoplasm of small intestine; Benign Neoplasm of the Small Intestine; benign neoplasm of the small intestine; Benign Small Intestinal Neoplasm; benign small intestinal neoplasm; Benign Small Intestinal Neoplasm NOS; Benign Small Intestinal Tumor; benign small intestinal tumor; benign small intestinal tumour; Benign Small Intestine Neoplasm; benign small intestine neoplasm; Benign Small Intestine Tumor; benign small intestine tumor; benign small intestine tumour; Benign tumor of small intestine; Benign Tumor of Small Intestine; benign tumor of small intestine; Benign Tumor of the Small Intestine; benign tumor of the small intestine; benign tumour of small intestine; benign tumour of the small intestine; small intestine benign neoplasm
SNOMED CT: Benign tumor of small intestine (92385005); Benign neoplasm of small intestine (92385005)
 
Monarch Initiative: MONDO:0021501

Definition

A neoplasm that arises from the small intestine and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of small intestine

Professional guidelines

PubMed

Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults.
Yamamoto H, Sakamoto H, Kumagai H, Abe T, Ishiguro S, Uchida K, Kawasaki Y, Saida Y, Sano Y, Takeuchi Y, Tajika M, Nakajima T, Banno K, Funasaka Y, Hori S, Yamaguchi T, Yoshida T, Ishikawa H, Iwama T, Okazaki Y, Saito Y, Matsuura N, Mutoh M, Tomita N, Akiyama T, Yamamoto T, Ishida H, Nakayama Y
Digestion 2023;104(5):335-347. Epub 2023 Apr 13 doi: 10.1159/000529799. PMID: 37054692
Management of Incidentalomas.
Reidelberger K, Fingeret A
Surg Clin North Am 2021 Dec;101(6):1081-1096. doi: 10.1016/j.suc.2021.06.006. PMID: 34774270
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

Recent clinical studies

Etiology

The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Imaging and Screening of Cancer of the Small Bowel.
Kim JS, Park SH, Hansel S, Fletcher JG
Radiol Clin North Am 2017 Nov;55(6):1273-1291. Epub 2017 Sep 13 doi: 10.1016/j.rcl.2017.06.008. PMID: 28991566
Small Bowel Neoplasms and Polyps.
Pourmand K, Itzkowitz SH
Curr Gastroenterol Rep 2016 May;18(5):23. doi: 10.1007/s11894-016-0497-x. PMID: 27086004
Malignant tumours of the small intestine.
Reynolds I, Healy P, Mcnamara DA
Surgeon 2014 Oct;12(5):263-70. Epub 2014 Mar 14 doi: 10.1016/j.surge.2014.02.003. PMID: 24637026

Diagnosis

Updates in the diagnosis and management of non-ampullary small-bowel polyposis.
Lucaciu L, Yano T, Saurin JC
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101852. Epub 2023 Jul 22 doi: 10.1016/j.bpg.2023.101852. PMID: 37652652
Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Management of small bowel polyps: from small to big.
Saurin JC, Benech N, Pioche M
Curr Opin Gastroenterol 2019 May;35(3):250-256. doi: 10.1097/MOG.0000000000000518. PMID: 30844897
Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix: 2018 Update.
Zhang Y, Zulfiqar M, Bluth MH, Bhalla A, Beydoun R
Clin Lab Med 2018 Jun;38(2):343-355. doi: 10.1016/j.cll.2018.03.002. PMID: 29776634

Therapy

Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Long-term survival of metastatic small intestine neuroendocrine tumors: a meta-analysis.
Van Den Heede K, Chidambaram S, Van Slycke S, Brusselaers N, Warfvinge CF, Ohlsson H, Gustafsson R, Nordenström E, Almquist M
Endocr Relat Cancer 2022 Feb 7;29(3):163-173. doi: 10.1530/ERC-21-0354. PMID: 34982042
Antiproliferative Systemic Therapies for Metastatic Small Bowel Neuroendocrine Tumours.
Dawod M, Gordoa TA, Cives M, De Mestier L, Crona J, Spada F, Oberg K, Pavel M, Lamarca A
Curr Treat Options Oncol 2021 Jun 29;22(8):73. doi: 10.1007/s11864-021-00863-y. PMID: 34185197
Small bowel adenocarcinoma.
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433

Prognosis

Gastric and Small Intestine Gist: Results of 156 Cases in 20 Years.
Lopez Gordo S, Bettonica C, Miró M, Estremiana F, Aranda H, Farran L
J Gastrointest Cancer 2022 Jun;53(2):451-459. Epub 2021 Apr 19 doi: 10.1007/s12029-021-00641-x. PMID: 33871798
Management of Small Bowel Neuroendocrine Tumors.
Scott AT, Howe JR
Surg Oncol Clin N Am 2020 Apr;29(2):223-241. doi: 10.1016/j.soc.2019.11.006. PMID: 32151357
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Malignant tumours of the small intestine.
Reynolds I, Healy P, Mcnamara DA
Surgeon 2014 Oct;12(5):263-70. Epub 2014 Mar 14 doi: 10.1016/j.surge.2014.02.003. PMID: 24637026
Risk stratification of patients diagnosed with gastrointestinal stromal tumor.
Joensuu H
Hum Pathol 2008 Oct;39(10):1411-9. doi: 10.1016/j.humpath.2008.06.025. PMID: 18774375

Clinical prediction guides

Metabolic programs of T cell tissue residency empower tumour immunity.
Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger SJ, Goldrath AW
Nature 2023 Sep;621(7977):179-187. Epub 2023 Aug 30 doi: 10.1038/s41586-023-06483-w. PMID: 37648857
Safety and Efficacy of Avelumab in Small Bowel Adenocarcinoma.
Cardin DB, Gilbert J, Whisenant JG, Ayers GD, Jalikis F, Dahlman KB, O'Neal JF, Revetta F, Shi C, Berlin J
Clin Colorectal Cancer 2022 Sep;21(3):236-243. Epub 2022 Mar 24 doi: 10.1016/j.clcc.2022.03.003. PMID: 35450836
Gastrointestinal Stromal Tumours of the Small Intestine.
Uzunoglu H, Tosun Y, Akinci O, Baris B
J Coll Physicians Surg Pak 2021 Dec;31(12):1487-1493. doi: 10.29271/jcpsp.2021.12.1487. PMID: 34794293
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433

Recent systematic reviews

Somatostatinoma of the Ampulla of Vater: A Systematic Review.
Giannakodimos I, Giannakodimos A, Ziogou A, Frountzas M, Kritikos N, Vlachos K, Toutouzas KG, Schizas D
J Gastrointestin Liver Dis 2022 Dec 17;31(4):459-466. doi: 10.15403/jgld-4383. PMID: 36535044
Risk of Cancer in Inflammatory Bowel Diseases: Umbrella Review and Reanalysis of Meta-analyses.
Piovani D, Hassan C, Repici A, Rimassa L, Carlo-Stella C, Nikolopoulos GK, Riboli E, Bonovas S
Gastroenterology 2022 Sep;163(3):671-684. Epub 2022 May 26 doi: 10.1053/j.gastro.2022.05.038. PMID: 35643170
A systematic review of symptomatic hamartomas of the jejunum and ileum.
Farkas N, Conroy M, Baig M
Ann R Coll Surg Engl 2022 Jan;104(1):18-23. Epub 2021 Sep 21 doi: 10.1308/rcsann.2021.0038. PMID: 34545759Free PMC Article
A systematic review of the possible carcinogenic role of the aristolochic acid.
Bara T Jr, Gurzu S, Sugimura H, Bara T, Beleaua MA, Jung I
Rom J Morphol Embryol 2017;58(1):41-44. PMID: 28523296
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...