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Rosenthal fibers

MedGen UID:
569336
•Concept ID:
C0333731
•
Cell Component
Synonyms: Rosenthal fiber; Rosenthal fibres
SNOMED CT: Rosenthal fiber (84605001)
 
HPO: HP:0100320

Definition

Thick, elongated, worm-like or corkscrew eosinophilic bundle that are found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders. [from HPO]

Professional guidelines

PubMed

Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease.
Hagemann TL, Powers B, Mazur C, Kim A, Wheeler S, Hung G, Swayze E, Messing A
Ann Neurol 2018 Jan;83(1):27-39. Epub 2018 Jan 14 doi: 10.1002/ana.25118. PMID: 29226998Free PMC Article
A clinicopathologic study of 81 patients with ependymomas and proposal of diagnostic criteria for anaplastic ependymoma.
Ho DM, Hsu CY, Wong TT, Chiang H
J Neurooncol 2001 Aug;54(1):77-85. doi: 10.1023/a:1012590505236. PMID: 11763426

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