Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Melanoma Arising in Giant Congenital Nevus

MedGen UID:: 569664
•Concept ID:: C0334441
•: Neoplastic Process

Synonyms:	Malignant melanoma in congenital melanocytic nevus; Malignant melanoma in giant pigmented nevus
SNOMED CT:	Malignant melanoma in giant pigmented nevus (75931002); Malignant melanoma in congenital melanocytic nevus (75931002)

Definition

A melanoma arising in a giant congenital melanocytic nevus. The risk of developing a melanoma in a giant congenital melanocytic nevus has been reported to be between 5% and 50%. The incidence of developing melanoma is higher before the age of 10 and in adult life. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMelanoma Arising in Giant Congenital Nevus

Disease
- Neoplasm
  - Malignant neoplastic disease
    - Malignant neoplasm of skin
      - Malignant melanoma of skin
        Melanoma in congenital melanocytic nevus
        Melanoma Arising in Giant Congenital Nevus

Recent clinical studies

Etiology

Melanoma on congenital melanocytic nevi.

Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732

Malignant Melanoma Arising From a Giant Congenital Melanocytic Nevus in a 3-Year Old: Review of Diagnosis and Management.

Kugar M, Akhavan A, Ndem I, Ollila D, Googe P, Blatt J, Wood J
J Craniofac Surg 2021 Jun 1;32(4):e342-e345. doi: 10.1097/SCS.0000000000007115. PMID: 33170823

Cutaneous Melanoma Arising in Congenital Melanocytic Nevus: A Retrospective Observational Study.

Caccavale S, Calabrese G, Mattiello E, Broganelli P, Ramondetta A, Pieretti G, Alfano R, Argenziano G
Dermatology 2021;237(3):473-478. Epub 2020 Oct 14 doi: 10.1159/000510221. PMID: 33053549

Paediatric melanoma: clinical update, genetic basis, and advances in diagnosis.

Merkel EA, Mohan LS, Shi K, Panah E, Zhang B, Gerami P
Lancet Child Adolesc Health 2019 Sep;3(9):646-654. Epub 2019 Jun 13 doi: 10.1016/S2352-4642(19)30116-6. PMID: 31204309

Common Skin Conditions in Children: Congenital Melanocytic Nevi and Infantile Hemangiomas.

Rayala BZ, Morrell DS
FP Essent 2017 Feb;453:33-37. PMID: 28196319

See all (35)

Diagnosis

Giant Congenital Melanocytic Nevus with Congenital Neurofibroma: A Case Report.

Sarkar A, Karmakar D, Saha JK, Saha Basu K, Chatterjee U, Saha K, Mishra DK
Fetal Pediatr Pathol 2023 Dec;42(6):972-978. Epub 2023 Aug 16 doi: 10.1080/15513815.2023.2244582. PMID: 37584237

Germline genomic findings in children and young adults with melanocytic tumors.

Nagel MB, Perrino MR, Nuccio R, Blake AK, Harrison L, Nichols KE, Pappo AS
Pediatr Blood Cancer 2023 Jul;70(7):e30361. Epub 2023 Apr 19 doi: 10.1002/pbc.30361. PMID: 37073685

NRAS mutant melanoma arising in a giant congenital melanocytic nevus in an infant.

Bansal N, Das M, Chatterjee U, Mallick MG, Arora N, Mishra DK
Indian J Pathol Microbiol 2021 Apr-Jun;64(2):402-405. doi: 10.4103/IJPM.IJPM_38_20. PMID: 33851646

Malignant Melanoma Arising From a Giant Congenital Melanocytic Nevus in a 3-Year Old: Review of Diagnosis and Management.

Kugar M, Akhavan A, Ndem I, Ollila D, Googe P, Blatt J, Wood J
J Craniofac Surg 2021 Jun 1;32(4):e342-e345. doi: 10.1097/SCS.0000000000007115. PMID: 33170823

Paediatric melanoma: clinical update, genetic basis, and advances in diagnosis.

Merkel EA, Mohan LS, Shi K, Panah E, Zhang B, Gerami P
Lancet Child Adolesc Health 2019 Sep;3(9):646-654. Epub 2019 Jun 13 doi: 10.1016/S2352-4642(19)30116-6. PMID: 31204309

See all (37)

Therapy

Rhabdomyosarcoma arising in a giant congenital melanocytic nevus.

Christman MP, Kerner JK, Cheng C, Piris A, Nepo AG, Sepehr A, Kroshinsky D
Pediatr Dermatol 2014 Sep-Oct;31(5):584-7. Epub 2014 Jun 9 doi: 10.1111/pde.12359. PMID: 24913904

Dermabrasion of congenital nevocellular nevi: experience in 215 patients.

Rompel R, Möser M, Petres J
Dermatology 1997;194(3):261-7. doi: 10.1159/000246115. PMID: 9187845

Precursors to skin cancer.

Sober AJ, Burstein JM
Cancer 1995 Jan 15;75(2 Suppl):645-50. doi: 10.1002/1097-0142(19950115)75:2+<645::aid-cncr2820751405>3.0.co;2-1. PMID: 7804989

See all (3)

Prognosis

Melanoma on congenital melanocytic nevi.

Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732

Risk of Malignant Transformation Arising From Giant Congenital Melanocytic Nevi: A 20-year Single-center Study.

Kim JY, Jeon JH, Choi TH, Kim BJ
Dermatol Surg 2022 Feb 1;48(2):171-175. doi: 10.1097/DSS.0000000000003341. PMID: 34935754

Paediatric melanoma: clinical update, genetic basis, and advances in diagnosis.

Merkel EA, Mohan LS, Shi K, Panah E, Zhang B, Gerami P
Lancet Child Adolesc Health 2019 Sep;3(9):646-654. Epub 2019 Jun 13 doi: 10.1016/S2352-4642(19)30116-6. PMID: 31204309

Melanoma arising in a Giant congenital melanocytic nevus: two case reports.

Belysheva TS, Vishnevskaya YV, Nasedkina TV, Emelyanova MA, Abramov IS, Orlova KV, Lubchenko LN, Utyashev IA, Doroshenko MB, Demidov LV, Aliev MD
Diagn Pathol 2019 Feb 19;14(1):21. doi: 10.1186/s13000-019-0797-1. PMID: 30782194 Free PMC Article

Proliferative Nodules vs Melanoma Arising in Giant Congenital Melanocytic Nevi During Childhood.

Vergier B, Laharanne E, Prochazkova-Carlotti M, de la Fouchardière A, Merlio JP, Kadlub N, Avril MF, Bodemer C, Lacoste C, Boralevi F, Taieb A, Ezzedine K, Fraitag S
JAMA Dermatol 2016 Oct 1;152(10):1147-1151. doi: 10.1001/jamadermatol.2016.2667. PMID: 27486690

See all (24)

Clinical prediction guides

Cutaneous Melanoma Arising in Congenital Melanocytic Nevus: A Retrospective Observational Study.

Caccavale S, Calabrese G, Mattiello E, Broganelli P, Ramondetta A, Pieretti G, Alfano R, Argenziano G
Dermatology 2021;237(3):473-478. Epub 2020 Oct 14 doi: 10.1159/000510221. PMID: 33053549

Malignant melanoma with areas of rhabdomyosarcomatous differentiation arising in a giant congenital nevus with RAF1 gene fusion.

Baltres A, Salhi A, Houlier A, Pissaloux D, Tirode F, Haddad V, Karanian M, Ysmail-Dahlouk S, Boukendakdji F, Dahlouk D, Allaoua F, Metref M, Djeridane A, Fraitag S, de la Fouchardière A
Pigment Cell Melanoma Res 2019 Sep;32(5):708-713. Epub 2019 Apr 21 doi: 10.1111/pcmr.12785. PMID: 30945443

Proliferative Nodules vs Melanoma Arising in Giant Congenital Melanocytic Nevi During Childhood.

5-Hydroxymethylcytosine Expression in Proliferative Nodules Arising within Congenital Nevi Allows Differentiation from Malignant Melanoma.

Pavlova O, Fraitag S, Hohl D
J Invest Dermatol 2016 Dec;136(12):2453-2461. Epub 2016 Jul 22 doi: 10.1016/j.jid.2016.07.015. PMID: 27456754

Precursors to skin cancer.

Sober AJ, Burstein JM
Cancer 1995 Jan 15;75(2 Suppl):645-50. doi: 10.1002/1097-0142(19950115)75:2+<645::aid-cncr2820751405>3.0.co;2-1. PMID: 7804989

See all (16)