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Radiation retinopathy

MedGen UID:
573183
•Concept ID:
C0339483
•
Pathologic Function
Synonym: Radiation Retinopathy
SNOMED CT: Radiation retinopathy (95221007)

Definition

Injury of the retina following exposure to radiation. The retinal injury results from occlusive microangiopathy caused by endothelial cell loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiation retinopathy

Professional guidelines

PubMed

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Laser treatment for choroidal melanoma: Current concepts.
Maheshwari A, Finger PT
Surv Ophthalmol 2023 Mar-Apr;68(2):211-224. Epub 2022 May 27 doi: 10.1016/j.survophthal.2022.05.002. PMID: 35644256
Treatment of radiation maculopathy and radiation-induced macular edema: A systematic review.
Fallico M, Chronopoulos A, Schutz JS, Reibaldi M
Surv Ophthalmol 2021 May-Jun;66(3):441-460. Epub 2020 Sep 10 doi: 10.1016/j.survophthal.2020.08.007. PMID: 32918934

Recent clinical studies

Etiology

Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect.
Akagunduz OO, Yilmaz SG, Tavlayan E, Baris ME, Afrashi F, Esassolak M
Cancer Res Treat 2022 Apr;54(2):417-423. Epub 2021 Jun 24 doi: 10.4143/crt.2021.575. PMID: 34176248Free PMC Article
Treatment of radiation maculopathy and radiation-induced macular edema: A systematic review.
Fallico M, Chronopoulos A, Schutz JS, Reibaldi M
Surv Ophthalmol 2021 May-Jun;66(3):441-460. Epub 2020 Sep 10 doi: 10.1016/j.survophthal.2020.08.007. PMID: 32918934
Therapy of uveal melanoma A Review.
Rusňák Š, Hecová L, Kasl Z, Sobotová M, Hauer L
Cesk Slov Oftalmol 2020 Fall;77(1):1-13. doi: 10.31348/2020/10. PMID: 33086849
Updates in imaging in ocular oncology.
Davila JR, Mruthyunjaya P
F1000Res 2019;8 Epub 2019 Oct 1 doi: 10.12688/f1000research.19979.1. PMID: 31602297Free PMC Article
Ionizing radiation and the retina.
Archer DB, Gardiner TA
Curr Opin Ophthalmol 1994 Jun;5(3):59-65. doi: 10.1097/00055735-199406000-00011. PMID: 10147458

Diagnosis

Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect.
Akagunduz OO, Yilmaz SG, Tavlayan E, Baris ME, Afrashi F, Esassolak M
Cancer Res Treat 2022 Apr;54(2):417-423. Epub 2021 Jun 24 doi: 10.4143/crt.2021.575. PMID: 34176248Free PMC Article
Treatment of radiation maculopathy and radiation-induced macular edema: A systematic review.
Fallico M, Chronopoulos A, Schutz JS, Reibaldi M
Surv Ophthalmol 2021 May-Jun;66(3):441-460. Epub 2020 Sep 10 doi: 10.1016/j.survophthal.2020.08.007. PMID: 32918934
Updates in imaging in ocular oncology.
Davila JR, Mruthyunjaya P
F1000Res 2019;8 Epub 2019 Oct 1 doi: 10.12688/f1000research.19979.1. PMID: 31602297Free PMC Article
Radiation retinopathy.
Zamber RW, Kinyoun JL
West J Med 1992 Nov;157(5):530-3. PMID: 1441494Free PMC Article
Radiation retinopathy.
Brown GC, Shields JA, Sanborn G, Augsburger JJ, Savino PJ, Schatz NJ
Ophthalmology 1982 Dec;89(12):1494-501. doi: 10.1016/s0161-6420(82)34611-4. PMID: 7162794

Therapy

Treatment of radiation maculopathy and radiation-induced macular edema: A systematic review.
Fallico M, Chronopoulos A, Schutz JS, Reibaldi M
Surv Ophthalmol 2021 May-Jun;66(3):441-460. Epub 2020 Sep 10 doi: 10.1016/j.survophthal.2020.08.007. PMID: 32918934
Anti-Vascular Endothelial Growth Factor Therapy for Radiation Retinopathy.
Rayess N, Mruthyunjaya P
Ophthalmic Surg Lasers Imaging Retina 2020 Apr 1;51(4):S44-S49. doi: 10.3928/23258160-20200401-06. PMID: 32348534
Current treatments and preventive strategies for radiation retinopathy.
Reichstein D
Curr Opin Ophthalmol 2015 May;26(3):157-66. doi: 10.1097/ICU.0000000000000141. PMID: 25730680
Radiation retinopathy.
Zamber RW, Kinyoun JL
West J Med 1992 Nov;157(5):530-3. PMID: 1441494Free PMC Article
Radiation retinopathy.
Brown GC, Shields JA, Sanborn G, Augsburger JJ, Savino PJ, Schatz NJ
Ophthalmology 1982 Dec;89(12):1494-501. doi: 10.1016/s0161-6420(82)34611-4. PMID: 7162794

Prognosis

Radiation optic neuropathy and retinopathy in patients with presumed benign intraorbital tumours treated with fractionated stereotactic radiotherapy.
Gishti O, de Keizer ROB, Detiger SE, van Rij C, Slagter C, Paridaens D
Eye (Lond) 2023 Aug;37(12):2470-2474. Epub 2022 Dec 13 doi: 10.1038/s41433-022-02356-0. PMID: 36513859Free PMC Article
Radiation retinopathy intricacies and advances in management.
García-O'Farrill N, Pugazhendhi S, Karth PA, Hunter AA
Semin Ophthalmol 2022 May 19;37(4):417-435. Epub 2021 Dec 7 doi: 10.1080/08820538.2021.2000623. PMID: 34874814
Treatment outcomes after definitive radio(chemo)therapy for 17 lacrimal sac squamous cell carcinoma.
Song X, He H, Zhu Y, Wang S, Wang J, Wang W, Li Y
Br J Radiol 2020 Nov 1;93(1115):20190633. Epub 2020 Oct 6 doi: 10.1259/bjr.20190633. PMID: 32970475Free PMC Article
Proliferative radiation retinopathy.
Kinyoun JL, Lawrence BS, Barlow WE
Arch Ophthalmol 1996 Sep;114(9):1097-100. doi: 10.1001/archopht.1996.01100140299007. PMID: 8790095
Ionizing radiation and the retina.
Archer DB, Gardiner TA
Curr Opin Ophthalmol 1994 Jun;5(3):59-65. doi: 10.1097/00055735-199406000-00011. PMID: 10147458

Clinical prediction guides

Choroidal metastasis: Radiation and bevacizumab at presentation.
Maheshwari A, Finger PT
Indian J Ophthalmol 2023 May;71(5):2014-2019. doi: 10.4103/ijo.IJO_1772_22. PMID: 37203075Free PMC Article
Radiation optic neuropathy and retinopathy in patients with presumed benign intraorbital tumours treated with fractionated stereotactic radiotherapy.
Gishti O, de Keizer ROB, Detiger SE, van Rij C, Slagter C, Paridaens D
Eye (Lond) 2023 Aug;37(12):2470-2474. Epub 2022 Dec 13 doi: 10.1038/s41433-022-02356-0. PMID: 36513859Free PMC Article
Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect.
Akagunduz OO, Yilmaz SG, Tavlayan E, Baris ME, Afrashi F, Esassolak M
Cancer Res Treat 2022 Apr;54(2):417-423. Epub 2021 Jun 24 doi: 10.4143/crt.2021.575. PMID: 34176248Free PMC Article
Early Detection of Radiation Retinopathy in Pediatric Patients Undergoing External Beam Radiation Using Optical Coherence Tomography Angiography.
Adeniran JF, Sophie R, Adhi M, Ramasubramanian A
Ophthalmic Surg Lasers Imaging Retina 2019 Mar 1;50(3):145-152. doi: 10.3928/23258160-20190301-03. PMID: 30893447
Treatment of radiation retinopathy following plaque brachytherapy for choroidal melanoma.
Wen JC, McCannel TA
Curr Opin Ophthalmol 2009 May;20(3):200-4. doi: 10.1097/ICU.0b013e328329b62d. PMID: 19349865

Recent systematic reviews

Radiotherapy and Radiosurgery in the Management of Optic Nerve Sheath Meningiomas: An International Systematic Review and Meta-Analysis of Twenty Studies.
Vaishnav YJ, Singh R, Didwania P, Lehrer EJ, Bakaeva T, Harris TJ, Migliori ME, Sheehan JP, Trifiletti DM
World Neurosurg 2022 Aug;164:e929-e944. Epub 2022 May 21 doi: 10.1016/j.wneu.2022.05.064. PMID: 35609728
Treatment of radiation maculopathy and radiation-induced macular edema: A systematic review.
Fallico M, Chronopoulos A, Schutz JS, Reibaldi M
Surv Ophthalmol 2021 May-Jun;66(3):441-460. Epub 2020 Sep 10 doi: 10.1016/j.survophthal.2020.08.007. PMID: 32918934
Radiotherapy for neovascular age-related macular degeneration.
Evans JR, Igwe C, Jackson TL, Chong V
Cochrane Database Syst Rev 2020 Aug 26;8(8):CD004004. doi: 10.1002/14651858.CD004004.pub4. PMID: 32844399Free PMC Article
Radiotherapy for neovascular age-related macular degeneration.
Evans JR, Sivagnanavel V, Chong V
Cochrane Database Syst Rev 2010 May 12;2010(5):CD004004. doi: 10.1002/14651858.CD004004.pub3. PMID: 20464726Free PMC Article
Orbital radiation for graves ophthalmopathy: a report by the American Academy of Ophthalmology.
Bradley EA, Gower EW, Bradley DJ, Meyer DR, Cahill KV, Custer PL, Holck DE, Woog JJ
Ophthalmology 2008 Feb;115(2):398-409. doi: 10.1016/j.ophtha.2007.10.028. PMID: 18082885

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