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Progressive massive fibrosis

MedGen UID:
573584
•Concept ID:
C0340170
•
Disease or Syndrome
Synonyms: Complicated pneumoconiosis; PMF - Progressive massive fibrosis
SNOMED CT: Complicated pneumoconiosis (233749003); Progressive massive fibrosis (233749003); PMF - Progressive massive fibrosis (233749003)
 
HPO: HP:0033706

Definition

This condition is caused by slow-growing conglomeration of dust particles and collagen deposition in individuals (mostly coal workers) heavily exposed to inorganic dust. Progressive massive fibrosis manifests as masslike lesions, usually bilateral and in the upper lobes. Background nodular opacities reflect accompanying pneumoconiosis, with or without emphysematous destruction adjacent to the massive fibrosis. Lesions similar to progressive massive fibrosis sometimes occur in other conditions, such as sarcoidosis and talcosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProgressive massive fibrosis

Professional guidelines

PubMed

Coal dust exposures in the longwall mines of New South Wales, Australia: a respiratory risk assessment.
Kizil GV, Donoghue AM
Occup Med (Lond) 2002 May;52(3):137-49. doi: 10.1093/occmed/52.3.137. PMID: 12063359

Recent clinical studies

Etiology

Progressive massive fibrosis: An overview of the recent literature.
Weissman DN
Pharmacol Ther 2022 Dec;240:108232. Epub 2022 Jun 19 doi: 10.1016/j.pharmthera.2022.108232. PMID: 35732247Free PMC Article
Progressive Massive Fibrosis Risk Factors: A Retrospective Cross-Sectional Study.
Sari G, Koyuncu A, Şimşek C
J Occup Environ Med 2022 Jul 1;64(7):557-561. Epub 2022 Jun 8 doi: 10.1097/JOM.0000000000002545. PMID: 35673264
Coal workers' pneumoconiosis: an Australian perspective.
Zosky GR, Hoy RF, Silverstone EJ, Brims FJ, Miles S, Johnson AR, Gibson PG, Yates DH
Med J Aust 2016 Jun 20;204(11):414-8. doi: 10.5694/mja16.00357. PMID: 27318401
Lung disease and coal mining: what pulmonologists need to know.
Go LH, Krefft SD, Cohen RA, Rose CS
Curr Opin Pulm Med 2016 Mar;22(2):170-8. doi: 10.1097/MCP.0000000000000251. PMID: 26761630
Genetic susceptibility in pneumoconiosis.
Yucesoy B, Luster MI
Toxicol Lett 2007 Feb 5;168(3):249-54. Epub 2006 Nov 16 doi: 10.1016/j.toxlet.2006.10.021. PMID: 17161563

Diagnosis

Update on Silicosis.
Churg A, Muller NL
Surg Pathol Clin 2024 Jun;17(2):193-202. Epub 2023 Dec 11 doi: 10.1016/j.path.2023.11.005. PMID: 38692804
Progressive massive fibrosis: An overview of the recent literature.
Weissman DN
Pharmacol Ther 2022 Dec;240:108232. Epub 2022 Jun 19 doi: 10.1016/j.pharmthera.2022.108232. PMID: 35732247Free PMC Article
Progressive Massive Fibrosis Risk Factors: A Retrospective Cross-Sectional Study.
Sari G, Koyuncu A, Şimşek C
J Occup Environ Med 2022 Jul 1;64(7):557-561. Epub 2022 Jun 8 doi: 10.1097/JOM.0000000000002545. PMID: 35673264
Occupational and environmental lung disease.
Seaman DM, Meyer CA, Kanne JP
Clin Chest Med 2015 Jun;36(2):249-68, viii-ix. Epub 2015 Apr 1 doi: 10.1016/j.ccm.2015.02.008. PMID: 26024603
Bronchiectasis.
Javidan-Nejad C, Bhalla S
Radiol Clin North Am 2009 Mar;47(2):289-306. doi: 10.1016/j.rcl.2008.11.006. PMID: 19249457

Therapy

Update on Silicosis.
Churg A, Muller NL
Surg Pathol Clin 2024 Jun;17(2):193-202. Epub 2023 Dec 11 doi: 10.1016/j.path.2023.11.005. PMID: 38692804
Patterns of progressive massive fibrosis on modern coal miner chest radiographs.
Halldin CN, Blackley DJ, Markle T, Cohen RA, Laney AS
Arch Environ Occup Health 2020;75(3):152-158. Epub 2019 May 20 doi: 10.1080/19338244.2019.1593099. PMID: 31107177Free PMC Article
Current Review of Pneumoconiosis Among US Coal Miners.
Hall NB, Blackley DJ, Halldin CN, Laney AS
Curr Environ Health Rep 2019 Sep;6(3):137-147. doi: 10.1007/s40572-019-00237-5. PMID: 31302880Free PMC Article
Occupational and environmental lung disease.
Seaman DM, Meyer CA, Kanne JP
Clin Chest Med 2015 Jun;36(2):249-68, viii-ix. Epub 2015 Apr 1 doi: 10.1016/j.ccm.2015.02.008. PMID: 26024603
Genetic susceptibility in pneumoconiosis.
Yucesoy B, Luster MI
Toxicol Lett 2007 Feb 5;168(3):249-54. Epub 2006 Nov 16 doi: 10.1016/j.toxlet.2006.10.021. PMID: 17161563

Prognosis

Prognostic Implication of Exfoliative Airway Pathology in Cancer-Free Coal Workers' Pneumoconiosis.
Cho U, Kim TE, Park CK, Yoon HK, Sa YJ, Kim HL, Kim TJ
Int J Environ Res Public Health 2022 Nov 14;19(22) doi: 10.3390/ijerph192214975. PMID: 36429692Free PMC Article
Burden of Silicosis among stone crushing workers in India.
Govindagoudar MB, Singh PK, Chaudhry D, Chaudhary R, Sachdeva A, Dhankhar S, Tyagi D
Occup Med (Lond) 2022 Aug 16;72(6):366-371. doi: 10.1093/occmed/kqab146. PMID: 34729596
The Burden of Silicosis in Michigan: 1988-2016.
Reilly MJ, Timmer SJ, Rosenman KD
Ann Am Thorac Soc 2018 Dec;15(12):1404-1410. doi: 10.1513/AnnalsATS.201802-117OC. PMID: 30188758Free PMC Article
Rheumatoid pneumoconiosis (Caplan's syndrome).
Schreiber J, Koschel D, Kekow J, Waldburg N, Goette A, Merget R
Eur J Intern Med 2010 Jun;21(3):168-72. Epub 2010 Mar 2 doi: 10.1016/j.ejim.2010.02.004. PMID: 20493416
Comparative pathology of environmental lung disease: an overview.
Green FH, Vallyathan V, Hahn FF
Toxicol Pathol 2007 Jan;35(1):136-47. doi: 10.1080/01926230601132055. PMID: 17325982

Clinical prediction guides

Prognostic Implication of Exfoliative Airway Pathology in Cancer-Free Coal Workers' Pneumoconiosis.
Cho U, Kim TE, Park CK, Yoon HK, Sa YJ, Kim HL, Kim TJ
Int J Environ Res Public Health 2022 Nov 14;19(22) doi: 10.3390/ijerph192214975. PMID: 36429692Free PMC Article
Progressive Massive Fibrosis Risk Factors: A Retrospective Cross-Sectional Study.
Sari G, Koyuncu A, Şimşek C
J Occup Environ Med 2022 Jul 1;64(7):557-561. Epub 2022 Jun 8 doi: 10.1097/JOM.0000000000002545. PMID: 35673264
Computed Tomography Findings in Progressive Massive Fibrosis: Analyses of 90 Cases.
Sarı G, Gökçek A, Koyuncu A, Şimşek C
Med Lav 2022 Feb 22;113(1):e2022002. doi: 10.23749/mdl.v113i1.12303. PMID: 35226653Free PMC Article
Patterns of progressive massive fibrosis on modern coal miner chest radiographs.
Halldin CN, Blackley DJ, Markle T, Cohen RA, Laney AS
Arch Environ Occup Health 2020;75(3):152-158. Epub 2019 May 20 doi: 10.1080/19338244.2019.1593099. PMID: 31107177Free PMC Article
Lung disease and coal mining: what pulmonologists need to know.
Go LH, Krefft SD, Cohen RA, Rose CS
Curr Opin Pulm Med 2016 Mar;22(2):170-8. doi: 10.1097/MCP.0000000000000251. PMID: 26761630

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