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Pituitary resistance to thyroid hormone

MedGen UID:
574887
•Concept ID:
C0342198
•
Disease or Syndrome
Synonyms: PitRTH; Pituitary Resistance to Thyroid Hormone; Pituitary thyroid hormone resistance; Thyrotoxicosis due to pituitary thyroid hormone resistance
SNOMED CT: Pituitary thyroid hormone resistance (360348000); Thyrotoxicosis due to pituitary thyroid hormone resistance (360353005)
 
HPO: HP:0008227

Definition

A condition in which the pituitary gland is partially resistant to thyroid hormone, so that it continues to secrete thyroid-stimulating hormone (TSH) until the blood level of thyroid hormone rises higher than normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary resistance to thyroid hormone

Professional guidelines

PubMed

Medical management of thyrotropin-secreting pituitary adenomas.
Beck-Peccoz P, Persani L
Pituitary 2002;5(2):83-8. doi: 10.1023/a:1022360414062. PMID: 12675505
Diagnosis and management of thyrotoxicosis.
Hennessey JV
Am Fam Physician 1996 Sep 15;54(4):1315-24. PMID: 8816575
Treatment of hyperthyroidism due to inappropriate secretion of thyrotropin with the somatostatin analog SMS 201-995.
Beck-Peccoz P, Mariotti S, Guillausseau PJ, Medri G, Piscitelli G, Bertoli A, Barbarino A, Rondena M, Chanson P, Pinchera A
J Clin Endocrinol Metab 1989 Jan;68(1):208-14. doi: 10.1210/jcem-68-1-208. PMID: 2491862

Recent clinical studies

Etiology

A child with resistance to thyroid hormone without thyroid hormone receptor gene mutation: a 20-year follow-up.
Hamon B, Hamon P, Bovier-Lapierre M, Pugeat M, Savagner F, Rodien P, Orgiazzi J
Thyroid 2008 Jan;18(1):35-44. doi: 10.1089/thy.2007.0079. PMID: 18302516
Hyperthyroidism due to inappropriate secretion of thyrotropin in 10 patients.
Wynne AG, Gharib H, Scheithauer BW, Davis DH, Freeman SL, Horvath E
Am J Med 1992 Jan;92(1):15-24. doi: 10.1016/0002-9343(92)90009-z. PMID: 1346235
Sex hormone-binding globulin measurement in patients with inappropriate secretion of thyrotropin (IST): evidence against selective pituitary thyroid hormone resistance in nonneoplastic IST.
Beck-Peccoz P, Roncoroni R, Mariotti S, Medri G, Marcocci C, Brabant G, Forloni F, Pinchera A, Faglia G
J Clin Endocrinol Metab 1990 Jul;71(1):19-25. doi: 10.1210/jcem-71-1-19. PMID: 2370293
Familial partial peripheral and pituitary resistance to thyroid hormone: a frequently missed diagnosis?
Hopwood NJ, Saunder SE, Shapiro B, Sisson JC
Pediatrics 1986 Dec;78(6):1114-22. PMID: 3097618
Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism.
Cavaliere H, Medeiros-Neto GA, Rosner W, Kourides IA
J Endocrinol Invest 1985 Dec;8(6):527-32. doi: 10.1007/BF03348554. PMID: 3938790

Diagnosis

Thyroid hormone resistance syndrome caused by heterozygous A317T mutation in thyroid hormone receptor β gene: Report of one Chinese pedigree and review of the literature.
Guo QH, Wang BA, Wang CZ, Wang M, Lu JM, Lv ZH, Mu YM
Medicine (Baltimore) 2016 Aug;95(33):e4415. doi: 10.1097/MD.0000000000004415. PMID: 27537566Free PMC Article
Medical management of thyrotropin-secreting pituitary adenomas.
Beck-Peccoz P, Persani L
Pituitary 2002;5(2):83-8. doi: 10.1023/a:1022360414062. PMID: 12675505
Diagnosis and management of thyrotoxicosis.
Hennessey JV
Am Fam Physician 1996 Sep 15;54(4):1315-24. PMID: 8816575
Thyroid hormone resistance syndromes.
McDermott MT, Ridgway EC
Am J Med 1993 Apr;94(4):424-32. doi: 10.1016/0002-9343(93)90155-i. PMID: 8475937
Central hypothyroidism and hyperthyroidism.
Emerson CH
Med Clin North Am 1985 Sep;69(5):1019-34. doi: 10.1016/s0025-7125(16)31003-3. PMID: 3932791

Therapy

Pituitary resistance to thyroid hormone caused by a novel mutation (H435A) in the thyroid hormone receptor beta: A case report.
Yu C, Zhao J, Yao J, Wang H, Shang H, Zhang R, Cui Y, Wang L, Dong J, Liao L
Medicine (Baltimore) 2018 May;97(21):e10544. doi: 10.1097/MD.0000000000010544. PMID: 29794730Free PMC Article
Pituitary resistance to thyroid hormones: pathophysiology and therapeutic options.
Suzuki S, Shigematsu S, Inaba H, Takei M, Takeda T, Komatsu M
Endocrine 2011 Dec;40(3):366-71. Epub 2011 Sep 29 doi: 10.1007/s12020-011-9538-2. PMID: 21956518
Thyroid hormone resistance syndromes.
McDermott MT, Ridgway EC
Am J Med 1993 Apr;94(4):424-32. doi: 10.1016/0002-9343(93)90155-i. PMID: 8475937
Bromocriptine and Triac therapy for hyperthyroidism due to pituitary resistance to thyroid hormone.
Dulgeroff AJ, Geffner ME, Koyal SN, Wong M, Hershman JM
J Clin Endocrinol Metab 1992 Oct;75(4):1071-5. doi: 10.1210/jcem.75.4.1400873. PMID: 1400873
Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism.
Cavaliere H, Medeiros-Neto GA, Rosner W, Kourides IA
J Endocrinol Invest 1985 Dec;8(6):527-32. doi: 10.1007/BF03348554. PMID: 3938790

Prognosis

A child with resistance to thyroid hormone without thyroid hormone receptor gene mutation: a 20-year follow-up.
Hamon B, Hamon P, Bovier-Lapierre M, Pugeat M, Savagner F, Rodien P, Orgiazzi J
Thyroid 2008 Jan;18(1):35-44. doi: 10.1089/thy.2007.0079. PMID: 18302516
Hyperthyroidism due to inappropriate secretion of thyrotropin in 10 patients.
Wynne AG, Gharib H, Scheithauer BW, Davis DH, Freeman SL, Horvath E
Am J Med 1992 Jan;92(1):15-24. doi: 10.1016/0002-9343(92)90009-z. PMID: 1346235

Clinical prediction guides

Selective pituitary resistance to thyroid hormone produced by expression of a mutant thyroid hormone receptor beta gene in the pituitary gland of transgenic mice.
Hayashi Y, Xie J, Weiss RE, Pohlenz J, Refetoff S
Biochem Biophys Res Commun 1998 Apr 7;245(1):204-10. doi: 10.1006/bbrc.1998.8396. PMID: 9535809
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene.
Adams M, Matthews C, Collingwood TN, Tone Y, Beck-Peccoz P, Chatterjee KK
J Clin Invest 1994 Aug;94(2):506-15. doi: 10.1172/JCI117362. PMID: 8040303Free PMC Article
Sex hormone-binding globulin measurement in patients with inappropriate secretion of thyrotropin (IST): evidence against selective pituitary thyroid hormone resistance in nonneoplastic IST.
Beck-Peccoz P, Roncoroni R, Mariotti S, Medri G, Marcocci C, Brabant G, Forloni F, Pinchera A, Faglia G
J Clin Endocrinol Metab 1990 Jul;71(1):19-25. doi: 10.1210/jcem-71-1-19. PMID: 2370293
Syndrome of generalized (peripheral tissue and pituitary) resistance to thyroid hormone.
Aritaki S, Shimazaki T, Ogihara M, Matsuno T, Honda T, Izumizawa A
Acta Paediatr Jpn 1989 Dec;31(6):712-20. doi: 10.1111/j.1442-200x.1989.tb01385.x. PMID: 2516399
Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH".
Gershengorn MC, Weintraub BD
J Clin Invest 1975 Sep;56(3):633-42. doi: 10.1172/JCI108133. PMID: 1159077Free PMC Article

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