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Cholesteatoma of middle ear

MedGen UID:
57836
•Concept ID:
C0155490
•
Disease or Syndrome
Synonyms: Aural Cholesteatoma; Aural Cholesteatomas; Cholesteatoma, Aural; Cholesteatoma, Middle Ear; Cholesteatomas, Aural; Cholesteatomas, Middle Ear; Middle Ear Cholesteatoma; Middle Ear Cholesteatomas
SNOMED CT: Cholesteatoma of middle ear (87688009); Epidermosis of middle ear (87688009)
 
Monarch Initiative: MONDO:0006533

Definition

A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Cholesteatoma of middle ear

Professional guidelines

PubMed

Staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society.
Tono T, Sakagami M, Kojima H, Yamamoto Y, Matsuda K, Komori M, Hato N, Morita Y, Hashimoto S
Auris Nasus Larynx 2017 Apr;44(2):135-140. Epub 2016 Sep 9 doi: 10.1016/j.anl.2016.06.012. PMID: 27616746
The results of surgical treatment of middle ear cholesteatoma by using open and closed techniques.
Khujadze M, Vashakidze N, Gogniashvili G, Khelashvili B
Georgian Med News 2008 Oct;(163):21-4. PMID: 18997248
Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study.
Gyo K, Sasaki Y
J Laryngol Otol 1994 Feb;108(2):113-5. doi: 10.1017/s0022215100126040. PMID: 7513006

Recent clinical studies

Etiology

Chronic rhinosinusitis could increase the risk of cholesteatoma of middle ear.
Son DS, Cho MS, Kim DK
Int Forum Allergy Rhinol 2023 Feb;13(2):168-171. Epub 2022 Sep 8 doi: 10.1002/alr.23065. PMID: 35900051
Improved assessment of middle ear recurrent/residual cholesteatomas using temporal subtraction CT.
Baba A, Matsushima S, Fukuda T, Yamauchi H, Fujioka H, Hasumi J, Yoshimoto S, Shoji T, Kurihara S, Yamamoto Y, Kojima H, Kurokawa R, Kurokawa M, Ota Y, Ojiri H
Jpn J Radiol 2022 Mar;40(3):271-278. Epub 2021 Oct 24 doi: 10.1007/s11604-021-01209-2. PMID: 34689305Free PMC Article
Endoscopic myringoplasty: comparison of double layer cartilage-perichondrium graft and single fascia grafting.
Lou ZC
J Otolaryngol Head Neck Surg 2020 Jun 22;49(1):40. doi: 10.1186/s40463-020-00440-7. PMID: 32571414Free PMC Article

Diagnosis

Improved assessment of middle ear recurrent/residual cholesteatomas using temporal subtraction CT.
Baba A, Matsushima S, Fukuda T, Yamauchi H, Fujioka H, Hasumi J, Yoshimoto S, Shoji T, Kurihara S, Yamamoto Y, Kojima H, Kurokawa R, Kurokawa M, Ota Y, Ojiri H
Jpn J Radiol 2022 Mar;40(3):271-278. Epub 2021 Oct 24 doi: 10.1007/s11604-021-01209-2. PMID: 34689305Free PMC Article

Therapy

Endoscopic myringoplasty: comparison of double layer cartilage-perichondrium graft and single fascia grafting.
Lou ZC
J Otolaryngol Head Neck Surg 2020 Jun 22;49(1):40. doi: 10.1186/s40463-020-00440-7. PMID: 32571414Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

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    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
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