U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plantar verrucous skin carcinoma

MedGen UID:
578859
•Concept ID:
C0349657
•
Neoplastic Process
Synonyms: Carcinoma cuniculatum; Epithelioma cuniculatum; plantar part of pes verrucous carcinoma; Plantar verrucous carcinoma; Plantar Verrucous Carcinoma; Plantar Verrucous Carcinoma of Skin; plantar verrucous carcinoma of skin; Plantar Verrucous Carcinoma of the Skin; plantar verrucous carcinoma of the skin; Plantar Verrucous Skin Carcinoma; plantar verrucous skin carcinoma
SNOMED CT: Plantar verrucous carcinoma (254655003); Epithelioma cuniculatum (254655003); Carcinoma cuniculatum (254655003)
 
Monarch Initiative: MONDO:0002765

Definition

A verrucous carcinoma that arises from the plantar aspect of the foot. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlantar verrucous skin carcinoma

Professional guidelines

PubMed

Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options.
Shwe Daniel S, Cox SV, Kraus CN, Elsensohn AN
Cutis 2023 Feb;111(2):E19-E24. doi: 10.12788/cutis.0720. PMID: 37075193

Recent clinical studies

Etiology

Verrucous carcinoma presenting as recalcitrant verruca plantaris.
Hornback CJ, Weinberger CH
Dermatol Online J 2024 Mar 15;30(1) doi: 10.5070/D330163293. PMID: 38762863
An Unusual Presentation of Verrucous Carcinoma of the Foot with Bone Invasion.
Lee HM, Kim YS, Kim JP, Lee JI, Uhm KS
J Am Podiatr Med Assoc 2016 Nov;106(6):427-429. doi: 10.7547/15-046. PMID: 28033059
Cutaneous Toxic Effects of BRAF Inhibitors Alone and in Combination With MEK Inhibitors for Metastatic Melanoma.
Carlos G, Anforth R, Clements A, Menzies AM, Carlino MS, Chou S, Fernandez-Peñas P
JAMA Dermatol 2015 Oct;151(10):1103-9. doi: 10.1001/jamadermatol.2015.1745. PMID: 26200476
Cutaneous adverse events in patients treated with BRAF inhibitor-based therapies for metastatic melanoma for longer than 52 weeks.
Anforth R, Carlos G, Clements A, Kefford R, Fernandez-Peñas P
Br J Dermatol 2015 Jan;172(1):239-43. Epub 2014 Nov 21 doi: 10.1111/bjd.13200. PMID: 25040674
Squamous cell carcinomas are associated with verrucokeratotic cutaneous lesions but not with common warts in organ-transplant patients. A case-control study.
Joly P, Bastuji-Garin S, Frances C, Lebbe C, Aubin F, Penso-Assathiany D, D'incan M, Avril MF, Lair G, Barete S, Euvrard S
Transplantation 2010 May 27;89(10):1224-30. doi: 10.1097/TP.0b013e3181d7598b. PMID: 20559031

Diagnosis

An Unusual Presentation of Verrucous Carcinoma of the Foot with Bone Invasion.
Lee HM, Kim YS, Kim JP, Lee JI, Uhm KS
J Am Podiatr Med Assoc 2016 Nov;106(6):427-429. doi: 10.7547/15-046. PMID: 28033059
Verrucous carcinoma of the foot, not your typical plantar wart: a case study.
Gordon DK, Ponder EN, Berrey BH, Kubik MJ, Sindone J
Foot (Edinb) 2014 Jun;24(2):94-8. Epub 2014 Apr 3 doi: 10.1016/j.foot.2014.03.009. PMID: 24810296
Plantar verrucous carcinoma treated with Mohs micrographic surgery: a case report and literature review.
Alkalay R, Alcalay J, Shiri J
J Drugs Dermatol 2006 Jan;5(1):68-73. PMID: 16468296
Dermatologic disorders of the foot.
Omura EF, Rye B
Clin Sports Med 1994 Oct;13(4):825-41. PMID: 7805109
Plantar verrucous carcinoma. Literature review and treatment by the Mohs' chemosurgery technique.
Swanson NA, Taylor WB
Arch Dermatol 1980 Jul;116(7):794-7. doi: 10.1001/archderm.116.7.794. PMID: 7396544

Therapy

Cutaneous toxicities of new treatments for melanoma.
Boada A, Carrera C, Segura S, Collgros H, Pasquali P, Bodet D, Puig S, Malvehy J
Clin Transl Oncol 2018 Nov;20(11):1373-1384. Epub 2018 May 24 doi: 10.1007/s12094-018-1891-7. PMID: 29799097
Vitiligo of the Face in a Patient Treated With Vemurafenib for Metastatic Melanoma.
Nasca MR, Lacarrubba F, Ferraù F, Micali G
J Drugs Dermatol 2016 Jun 1;15(6):766-8. PMID: 27272087
Cutaneous Toxic Effects of BRAF Inhibitors Alone and in Combination With MEK Inhibitors for Metastatic Melanoma.
Carlos G, Anforth R, Clements A, Menzies AM, Carlino MS, Chou S, Fernandez-Peñas P
JAMA Dermatol 2015 Oct;151(10):1103-9. doi: 10.1001/jamadermatol.2015.1745. PMID: 26200476
Cutaneous adverse events in patients treated with BRAF inhibitor-based therapies for metastatic melanoma for longer than 52 weeks.
Anforth R, Carlos G, Clements A, Kefford R, Fernandez-Peñas P
Br J Dermatol 2015 Jan;172(1):239-43. Epub 2014 Nov 21 doi: 10.1111/bjd.13200. PMID: 25040674
Recalcitrant verrucous lesion: verrucous hyperplasia or epithelioma cuniculatum (verrucous carcinoma).
Kelishadi SS, Wirth GA, Evans GR
J Am Podiatr Med Assoc 2006 Mar-Apr;96(2):148-53. doi: 10.7547/0960148. PMID: 16546953

Prognosis

Squamous cell carcinomas are associated with verrucokeratotic cutaneous lesions but not with common warts in organ-transplant patients. A case-control study.
Joly P, Bastuji-Garin S, Frances C, Lebbe C, Aubin F, Penso-Assathiany D, D'incan M, Avril MF, Lair G, Barete S, Euvrard S
Transplantation 2010 May 27;89(10):1224-30. doi: 10.1097/TP.0b013e3181d7598b. PMID: 20559031
Plantar verrucous carcinoma: report of a case treated with Boyd amputation followed by reconstruction with a free forearm flap.
Yoshitatsu S, Takagi T, Ohata C, Kozuka T
J Dermatol 2001 Apr;28(4):226-30. doi: 10.1111/j.1346-8138.2001.tb00122.x. PMID: 11449675
Verrucous squamous cell carcinoma.
Frankel AH, Warren AM
J Foot Surg 1986 Jul-Aug;25(4):307-10. PMID: 3734335

Clinical prediction guides

Pachyonychia congenita: a clinical study of 12 cases and review of the literature.
Su WP, Chun SI, Hammond DE, Gordon H
Pediatr Dermatol 1990 Mar;7(1):33-8. doi: 10.1111/j.1525-1470.1990.tb01070.x. PMID: 2140447

Recent systematic reviews

Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options.
Shwe Daniel S, Cox SV, Kraus CN, Elsensohn AN
Cutis 2023 Feb;111(2):E19-E24. doi: 10.12788/cutis.0720. PMID: 37075193

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...