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Leukemic infiltration

MedGen UID:
58150
•Concept ID:
C0162679
•
Neoplastic Process
Synonyms: Infiltration, Leukemic; Infiltrations, Leukemic; Leukemic Infiltration; Leukemic Infiltrations
SNOMED CT: Leukemic infiltration (446688004)

Definition

A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukemia show various degrees of infiltration, depending upon the type of leukemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukemia the skin is often infiltrated. The central nervous system too is a common site. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukemic infiltration

Professional guidelines

PubMed

Unmet needs in the treatment of mantle cell lymphoma.
Rosen ST, Link BK, Fowler NH
Clin Adv Hematol Oncol 2013 Nov;11(11 Suppl 18):1-19. PMID: 24893041
Acute leukemia: diagnosis and management of testicular involvement.
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Urology 1983 Jun;21(6):573-7. doi: 10.1016/0090-4295(83)90194-2. PMID: 6575491
Electrolyte and acid-base disturbances in the management of leukemia.
O'Regan S, Carson S, Chesney RW, Drummond KN
Blood 1977 Mar;49(3):345-53. PMID: 264790

Recent clinical studies

Etiology

Neuro-ophthalmic Complications in Pediatric Leukemia.
Rothfield L, Falcone MM, Gaier ED, Heidary G, Gise R
J Neuroophthalmol 2023 Dec 1;43(4):520-524. Epub 2023 May 29 doi: 10.1097/WNO.0000000000001879. PMID: 37247249
Imaging Features of Pulmonary Leukemic Infiltration With Comparison of Lymphoid and Myeloid Leukemias.
Gosangi B, Hatabu H, Hammer MM
Curr Probl Diagn Radiol 2021 Mar-Apr;50(2):164-167. Epub 2019 Sep 18 doi: 10.1067/j.cpradiol.2019.09.007. PMID: 31582265
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Seizures caused by brain tumors in children.
Sánchez Fernández I, Loddenkemper T
Seizure 2017 Jan;44:98-107. Epub 2016 Dec 7 doi: 10.1016/j.seizure.2016.11.028. PMID: 28017579
Intrathecal chemotherapy in lymphomatous meningitis.
Canova F, Marino D, Trentin C, Soldà C, Ghiotto C, Aversa SM
Crit Rev Oncol Hematol 2011 Aug;79(2):127-34. Epub 2010 Aug 8 doi: 10.1016/j.critrevonc.2010.07.005. PMID: 20696592

Diagnosis

Skin changes in hairy cell leukemia.
Robak E, Jesionek-Kupnicka D, Robak T
Ann Hematol 2021 Mar;100(3):615-625. Epub 2020 Nov 20 doi: 10.1007/s00277-020-04349-z. PMID: 33216198Free PMC Article
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
A lot of nerve.
Birnbaum FA, Meekins LC, Srinivasan A, Murchison AP
Surv Ophthalmol 2020 Mar-Apr;65(2):272-277. Epub 2019 Apr 25 doi: 10.1016/j.survophthal.2019.04.005. PMID: 31029580
Neurologic complications of leukemia.
Demopoulos A, DeAngelis LM
Curr Opin Neurol 2002 Dec;15(6):691-9. doi: 10.1097/01.wco.0000044765.39452.2d. PMID: 12447107
Testicular pseudolymphoma.
Algaba F, Santaularia JM, Garat JM, Cubells J
Eur Urol 1986;12(5):362-3. doi: 10.1159/000472658. PMID: 3780807

Therapy

Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions.
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
The Clinical Spectrum of Hepatic Manifestations in Chronic Lymphocytic Leukemia.
Kreiniz N, Beyar Katz O, Polliack A, Tadmor T
Clin Lymphoma Myeloma Leuk 2017 Dec;17(12):863-869. Epub 2017 Jul 23 doi: 10.1016/j.clml.2017.07.008. PMID: 28803824
CART attack.
Pillai V, Maude SL
Blood 2017 Jul 13;130(2):229. doi: 10.1182/blood-2017-04-779009. PMID: 28705860
Therapy-related leukaemia cutis: a review.
Weinel S, Malone J, Jain D, Callen JP
Australas J Dermatol 2008 Nov;49(4):187-90. doi: 10.1111/j.1440-0960.2008.00466.x. PMID: 18855778
Intrathecal chemotherapy.
Kerr JZ, Berg S, Blaney SM
Crit Rev Oncol Hematol 2001 Mar;37(3):227-36. doi: 10.1016/s1040-8428(00)00115-3. PMID: 11248578

Prognosis

Leukemic and Lymphomatous Optic Neuropathy: A Case Series.
Lee V, Farooq AV, Shah HA
J Neuroophthalmol 2021 Dec 1;41(4):e796-e802. doi: 10.1097/WNO.0000000000001365. PMID: 34629409
Cutaneous manifestations of B-cell chronic lymphocytic leukemia.
Morozova EA, Olisova OY, Nikitin EA
Int J Hematol 2020 Oct;112(4):459-465. Epub 2020 Sep 5 doi: 10.1007/s12185-020-02978-8. PMID: 32889697
Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions.
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
The leukemias.
Burke VP, Startzell JM
Oral Maxillofac Surg Clin North Am 2008 Nov;20(4):597-608. doi: 10.1016/j.coms.2008.06.011. PMID: 18940626
Leukemia cutis.
Ratnam KV, Khor CJ, Su WP
Dermatol Clin 1994 Apr;12(2):419-31. PMID: 8045053

Clinical prediction guides

Inflammatory recruitment of healthy hematopoietic stem and progenitor cells in the acute myeloid leukemia niche.
Chen DW, Fan JM, Schrey JM, Mitchell DV, Jung SK, Hurwitz SN, Perez EB, Muraro MJ, Carroll M, Taylor DM, Kurre P
Leukemia 2024 Apr;38(4):741-750. Epub 2024 Jan 16 doi: 10.1038/s41375-024-02136-7. PMID: 38228679Free PMC Article
Current challenges and opportunities in treating adult patients with Philadelphia-negative acute lymphoblastic leukaemia.
Wolach O, Amitai I, DeAngelo DJ
Br J Haematol 2017 Dec;179(5):705-723. Epub 2017 Oct 26 doi: 10.1111/bjh.14916. PMID: 29076138
Development and function of human innate immune cells in a humanized mouse model.
Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA
Nat Biotechnol 2014 Apr;32(4):364-72. Epub 2014 Mar 16 doi: 10.1038/nbt.2858. PMID: 24633240Free PMC Article
Skin lesions in chronic lymphocytic leukemia.
Robak E, Robak T
Leuk Lymphoma 2007 May;48(5):855-65. doi: 10.1080/10428190601137336. PMID: 17487727
HRCT findings of chest complications in patients with leukemia.
Tanaka N, Matsumoto T, Miura G, Emoto T, Matsunaga N
Eur Radiol 2002 Jun;12(6):1512-22. Epub 2002 Feb 2 doi: 10.1007/s003300101112. PMID: 12042962

Recent systematic reviews

Radiological aspects of lymphomas and leukaemias affecting the jaws: A systematic review.
Gomes NR, Lima LA, Morais-Perdigão AL, de Caceres CVBL, Sant'Ana MSP, Pontes HAR, Pontes FSC, Smit C, van Heerden WFP, Robinson L, Brasileiro CB, Brennan PA, Fonseca FP
J Oral Pathol Med 2023 Apr;52(4):315-323. Epub 2023 Mar 7 doi: 10.1111/jop.13422. PMID: 36852531
Purging of malignant cell contamination prior to spermatogonia stem cell autotransplantation to preserve fertility: progress & prospects.
Abdelaal O, Barber H, Atala A, Sadri-Ardekani H
Curr Opin Endocrinol Diabetes Obes 2019 Jun;26(3):166-174. doi: 10.1097/MED.0000000000000481. PMID: 30998603
Anterior segment infiltration of acute lymphoblastic leukemia: case report and systematic review.
Yu AM, Chan SC, Iordanous Y, Padmore RF, O'Connor MD
Can J Ophthalmol 2019 Feb;54(1):20-26. Epub 2018 Apr 22 doi: 10.1016/j.jcjo.2018.02.016. PMID: 30851770

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