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Pain threshold

MedGen UID:
58158
•Concept ID:
C0162703
•
Finding
Synonyms: Pain Threshold; Pain Thresholds; Threshold, Pain; Thresholds, Pain
SNOMED CT: Quality of pain sense (251586001); Sensitivity to pain (251586001); Pain tolerance level (225781004); Pain threshold (251586001); Pain tolerance (363835005)

Definition

The minimum level of stimulation of a body part that a person will perceive as being noxious or unpleasant. (Taber''s) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPain threshold

Professional guidelines

PubMed

Antipsychotic-Induced Constipation: A Review of the Pathogenesis, Clinical Diagnosis, and Treatment.
Xu Y, Amdanee N, Zhang X
CNS Drugs 2021 Dec;35(12):1265-1274. Epub 2021 Aug 24 doi: 10.1007/s40263-021-00859-0. PMID: 34427901
Depression, anxiety and acute pain: links and management challenges.
Michaelides A, Zis P
Postgrad Med 2019 Sep;131(7):438-444. Epub 2019 Sep 12 doi: 10.1080/00325481.2019.1663705. PMID: 31482756
Manual therapy for the management of pain and limited range of motion in subjects with signs and symptoms of temporomandibular disorder: a systematic review of randomised controlled trials.
Calixtre LB, Moreira RF, Franchini GH, Alburquerque-Sendín F, Oliveira AB
J Oral Rehabil 2015 Nov;42(11):847-61. Epub 2015 Jun 7 doi: 10.1111/joor.12321. PMID: 26059857

Recent clinical studies

Etiology

Self-Reported Pain Tolerance and Opioid Pain Medication Use After Foot and Ankle Surgery.
Sokil LE, Rogero RG, McDonald EL, Corr D, Fuchs D, Winters BS, Pedowitz DI, Daniel JN, Raikin SM, Shakked RJ
Foot Ankle Spec 2022 Oct;15(5):438-447. Epub 2020 Nov 6 doi: 10.1177/1938640020970371. PMID: 33158380
Effect of manual therapy with exercise in patients with chronic cervical radiculopathy: a randomized clinical trial.
Alshami AM, Bamhair DA
Trials 2021 Oct 18;22(1):716. doi: 10.1186/s13063-021-05690-y. PMID: 34663421Free PMC Article
Bell's Palsy-Retroauricular Pain Threshold.
Kopitović A, Katanić F, Kalember S, Simić S, Vico N, Sekulić S
Medicina (Kaunas) 2021 Mar 13;57(3) doi: 10.3390/medicina57030263. PMID: 33805591Free PMC Article
Efficacy of a proprioceptive exercise program in patients with nonspecific neck pain: a randomized controlled trial.
Espí-López GV, Aguilar-Rodríguez M, Zarzoso M, Serra-Añó P, Martínez DE LA Fuente JM, Inglés M, Marques-Sule E
Eur J Phys Rehabil Med 2021 Jun;57(3):397-405. Epub 2020 Oct 13 doi: 10.23736/S1973-9087.20.06302-9. PMID: 33047944
Pain-Free Versus Pain-Threshold Rehabilitation Following Acute Hamstring Strain Injury: A Randomized Controlled Trial.
Hickey JT, Timmins RG, Maniar N, Rio E, Hickey PF, Pitcher CA, Williams MD, Opar DA
J Orthop Sports Phys Ther 2020 Feb;50(2):91-103. doi: 10.2519/jospt.2020.8895. PMID: 32005093

Diagnosis

Training-induced hypoalgesia and its potential underlying mechanisms.
Song JS, Yamada Y, Kataoka R, Wong V, Spitz RW, Bell ZW, Loenneke JP
Neurosci Biobehav Rev 2022 Oct;141:104858. Epub 2022 Sep 9 doi: 10.1016/j.neubiorev.2022.104858. PMID: 36096206
Effect of manual therapy with exercise in patients with chronic cervical radiculopathy: a randomized clinical trial.
Alshami AM, Bamhair DA
Trials 2021 Oct 18;22(1):716. doi: 10.1186/s13063-021-05690-y. PMID: 34663421Free PMC Article
Bell's Palsy-Retroauricular Pain Threshold.
Kopitović A, Katanić F, Kalember S, Simić S, Vico N, Sekulić S
Medicina (Kaunas) 2021 Mar 13;57(3) doi: 10.3390/medicina57030263. PMID: 33805591Free PMC Article
Efficacy of a proprioceptive exercise program in patients with nonspecific neck pain: a randomized controlled trial.
Espí-López GV, Aguilar-Rodríguez M, Zarzoso M, Serra-Añó P, Martínez DE LA Fuente JM, Inglés M, Marques-Sule E
Eur J Phys Rehabil Med 2021 Jun;57(3):397-405. Epub 2020 Oct 13 doi: 10.23736/S1973-9087.20.06302-9. PMID: 33047944
Pain and sex hormones: a review of current understanding.
Maurer AJ, Lissounov A, Knezevic I, Candido KD, Knezevic NN
Pain Manag 2016;6(3):285-96. Epub 2016 Mar 17 doi: 10.2217/pmt-2015-0002. PMID: 26983893

Therapy

Effect of manual therapy with exercise in patients with chronic cervical radiculopathy: a randomized clinical trial.
Alshami AM, Bamhair DA
Trials 2021 Oct 18;22(1):716. doi: 10.1186/s13063-021-05690-y. PMID: 34663421Free PMC Article
Transcutaneous electrical nerve stimulation and heat to reduce pain in a chronic low back pain population: a randomized controlled clinical trial.
Leemans L, Elma Ö, Nijs J, Wideman TH, Siffain C, den Bandt H, Van Laere S, Beckwée D
Braz J Phys Ther 2021 Jan-Feb;25(1):86-96. Epub 2020 May 12 doi: 10.1016/j.bjpt.2020.04.001. PMID: 32434666Free PMC Article
Manual therapy versus therapeutic exercise in non-specific chronic neck pain: a randomized controlled trial.
Bernal-Utrera C, Gonzalez-Gerez JJ, Anarte-Lazo E, Rodriguez-Blanco C
Trials 2020 Jul 28;21(1):682. doi: 10.1186/s13063-020-04610-w. PMID: 32723399Free PMC Article
Nonsuicidal Self-Injury in Adolescents.
Plener PL, Kaess M, Schmahl C, Pollak S, Fegert JM, Brown RC
Dtsch Arztebl Int 2018 Jan 19;115(3):23-30. doi: 10.3238/arztebl.2018.0023. PMID: 29366448Free PMC Article
The Effectiveness of Trigger Point Dry Needling for Musculoskeletal Conditions by Physical Therapists: A Systematic Review and Meta-analysis.
Gattie E, Cleland JA, Snodgrass S
J Orthop Sports Phys Ther 2017 Mar;47(3):133-149. Epub 2017 Feb 3 doi: 10.2519/jospt.2017.7096. PMID: 28158962

Prognosis

Pain-Free Versus Pain-Threshold Rehabilitation Following Acute Hamstring Strain Injury: A Randomized Controlled Trial.
Hickey JT, Timmins RG, Maniar N, Rio E, Hickey PF, Pitcher CA, Williams MD, Opar DA
J Orthop Sports Phys Ther 2020 Feb;50(2):91-103. doi: 10.2519/jospt.2020.8895. PMID: 32005093
Effectiveness of mobilisation of the upper cervical region and craniocervical flexor training on orofacial pain, mandibular function and headache in women with TMD. A randomised, controlled trial.
Calixtre LB, Oliveira AB, de Sena Rosa LR, Armijo-Olivo S, Visscher CM, Alburquerque-Sendín F
J Oral Rehabil 2019 Feb;46(2):109-119. Epub 2018 Oct 26 doi: 10.1111/joor.12733. PMID: 30307636
Effects of aquatic training and detraining on women with fibromyalgia: controlled randomized clinical trial.
Andrade CP, Zamunér AR, Forti M, Tamburús NY, Silva E
Eur J Phys Rehabil Med 2019 Feb;55(1):79-88. Epub 2018 Jul 6 doi: 10.23736/S1973-9087.18.05041-4. PMID: 29984564
Sensitization and pain.
Aguggia M, Saracco MG, Cavallini M, Bussone G, Cortelli P
Neurol Sci 2013 May;34 Suppl 1:S37-40. doi: 10.1007/s10072-013-1382-0. PMID: 23695043
Randomized controlled trial on physical therapy for TMJ closed lock.
Craane B, Dijkstra PU, Stappaerts K, De Laat A
J Dent Res 2012 Apr;91(4):364-9. Epub 2012 Feb 8 doi: 10.1177/0022034512438275. PMID: 22318373

Clinical prediction guides

Personal Pain Sensitivity Prediction from Ultra-short-term Resting Heart Rate Variability.
Jiang M, Wu W, Wang Y, Rahmani AM, Salanera S, Liljeberg P
Annu Int Conf IEEE Eng Med Biol Soc 2022 Jul;2022:1137-1140. doi: 10.1109/EMBC48229.2022.9871427. PMID: 36086385
Intra-rater and inter-rater reliability of pressure pain threshold assessment in stroke patients.
Zhang YH, Wang YC, Hu GW, Ding XQ, Shen XH, Yang H, Rong JF, Wang XQ
Eur J Phys Rehabil Med 2022 Aug;58(4):549-557. Epub 2022 Apr 1 doi: 10.23736/S1973-9087.22.07378-6. PMID: 35362718Free PMC Article
Self-Reported Pain Tolerance and Opioid Pain Medication Use After Foot and Ankle Surgery.
Sokil LE, Rogero RG, McDonald EL, Corr D, Fuchs D, Winters BS, Pedowitz DI, Daniel JN, Raikin SM, Shakked RJ
Foot Ankle Spec 2022 Oct;15(5):438-447. Epub 2020 Nov 6 doi: 10.1177/1938640020970371. PMID: 33158380
Immediate analgesic effect of two modes of transcutaneous electrical nerve stimulation on patients with chronic low back pain: a randomized controlled trial.
Pivovarsky MLF, Gaideski F, Macedo RM, Korelo RIG, Guarita-Souza LC, Liebano RE, Macedo ACB
Einstein (Sao Paulo) 2021;19:eAO6027. Epub 2021 Dec 17 doi: 10.31744/einstein_journal/2021AO6027. PMID: 34932756Free PMC Article
Burning mouth syndrome.
Gurvits GE, Tan A
World J Gastroenterol 2013 Feb 7;19(5):665-72. doi: 10.3748/wjg.v19.i5.665. PMID: 23429751Free PMC Article

Recent systematic reviews

Effect of ischemic compression on myofascial pain syndrome: a systematic review and meta-analysis.
Lu W, Li J, Tian Y, Lu X
Chiropr Man Therap 2022 Sep 1;30(1):34. doi: 10.1186/s12998-022-00441-5. PMID: 36050701Free PMC Article
The Biology of BDSM: A Systematic Review.
Wuyts E, Morrens M
J Sex Med 2022 Jan;19(1):144-157. Epub 2021 Dec 6 doi: 10.1016/j.jsxm.2021.11.002. PMID: 34876387
Pain sensitivity is reduced by exercise training: Evidence from a systematic review and meta-analysis.
Belavy DL, Van Oosterwijck J, Clarkson M, Dhondt E, Mundell NL, Miller CT, Owen PJ
Neurosci Biobehav Rev 2021 Jan;120:100-108. Epub 2020 Nov 27 doi: 10.1016/j.neubiorev.2020.11.012. PMID: 33253748
Comparison of dry needling and trigger point manual therapy in patients with neck and upper back myofascial pain syndrome: a systematic review and meta-analysis.
Lew J, Kim J, Nair P
J Man Manip Ther 2021 Jun;29(3):136-146. Epub 2020 Sep 22 doi: 10.1080/10669817.2020.1822618. PMID: 32962567Free PMC Article
The Effectiveness of Trigger Point Dry Needling for Musculoskeletal Conditions by Physical Therapists: A Systematic Review and Meta-analysis.
Gattie E, Cleland JA, Snodgrass S
J Orthop Sports Phys Ther 2017 Mar;47(3):133-149. Epub 2017 Feb 3 doi: 10.2519/jospt.2017.7096. PMID: 28158962

Supplemental Content

Table of contents

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