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Seropositive rheumatoid arthritis

MedGen UID:
592547
Concept ID:
C0409651
Disease or Syndrome
Synonyms: Rheumatoid factor positive rheumatoid arthritis; Seropositive Rheumatoid Arthritis
SNOMED CT: Rheumatoid factor positive rheumatoid arthritis (239791005); Seropositive rheumatoid arthritis (239791005)

Definition

Rheumatoid arthritis in which a patient''s serum is positive for certain disease-related antibodies including anti-cyclic citrullinated peptides (anti-CCPs), also called anti-citrullinated protein antibodies (ACPAs),and rheumatoid factor (RF). Screening for anti-CCPs is more specific than RF which can be found in other pathologic conditions. The production of these disease-associated antibodies may precede the development of clinical symptoms by several years. Seropositive patients have a greater likelihood of developing extra-articular complications and a more severe course of disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSeropositive rheumatoid arthritis

Professional guidelines

PubMed

Kim HW, Han M, Jung I, Ahn SS
Rheumatology (Oxford) 2024 Mar 1;63(3):630-638. doi: 10.1093/rheumatology/kead336. PMID: 37421392
Choi S, Lee KH
PLoS One 2018;13(4):e0195550. Epub 2018 Apr 6 doi: 10.1371/journal.pone.0195550. PMID: 29624625Free PMC Article
Csuka ME, McCarty DJ
Rheum Dis Clin North Am 1989 Aug;15(3):439-54. PMID: 2672131

Recent clinical studies

Etiology

Cho MH, Cho JH, Eun Y, Han K, Jung J, Cho IY, Yoo JE, Lee H, Kim H, Park SY, Shin DW
J Thorac Oncol 2024 Feb;19(2):216-226. Epub 2023 Oct 12 doi: 10.1016/j.jtho.2023.10.006. PMID: 37838085
Joshua V, Loberg Haarhaus M, Hensvold A, Wähämaa H, Gerstner C, Hansson M, Israelsson L, Stålesen R, Sköld M, Grunewald J, Klareskog L, Grönwall C, Réthi B, Catrina A, Malmström V
Arthritis Rheumatol 2023 Nov;75(11):1910-1922. Epub 2023 Aug 3 doi: 10.1002/art.42549. PMID: 37192126
Ahn SS, Han M, Jung I, Kim HW
Clin Exp Rheumatol 2023 Sep;41(9):1908-1916. Epub 2023 Mar 27 doi: 10.55563/clinexprheumatol/ins2z2. PMID: 36995320
Min YS, Kim MG, Ahn YS
Int J Environ Res Public Health 2021 Dec 3;18(23) doi: 10.3390/ijerph182312776. PMID: 34886499Free PMC Article
Rantapää Dahlqvist S, Andrade F
J Intern Med 2019 Dec;286(6):627-643. Epub 2019 Oct 21 doi: 10.1111/joim.12980. PMID: 31562671Free PMC Article

Diagnosis

Cho MH, Cho JH, Eun Y, Han K, Jung J, Cho IY, Yoo JE, Lee H, Kim H, Park SY, Shin DW
J Thorac Oncol 2024 Feb;19(2):216-226. Epub 2023 Oct 12 doi: 10.1016/j.jtho.2023.10.006. PMID: 37838085
Joshua V, Loberg Haarhaus M, Hensvold A, Wähämaa H, Gerstner C, Hansson M, Israelsson L, Stålesen R, Sköld M, Grunewald J, Klareskog L, Grönwall C, Réthi B, Catrina A, Malmström V
Arthritis Rheumatol 2023 Nov;75(11):1910-1922. Epub 2023 Aug 3 doi: 10.1002/art.42549. PMID: 37192126
Ahn SS, Han M, Jung I, Kim HW
Clin Exp Rheumatol 2023 Sep;41(9):1908-1916. Epub 2023 Mar 27 doi: 10.55563/clinexprheumatol/ins2z2. PMID: 36995320
Ro J, Kim SH, Kim HR, Lee SH, Min HK
Sci Rep 2022 Feb 9;12(1):2201. doi: 10.1038/s41598-022-06194-8. PMID: 35140294Free PMC Article
Min YS, Kim MG, Ahn YS
Int J Environ Res Public Health 2021 Dec 3;18(23) doi: 10.3390/ijerph182312776. PMID: 34886499Free PMC Article

Therapy

Ahn SS, Han M, Jung I, Kim HW
Clin Exp Rheumatol 2023 Sep;41(9):1908-1916. Epub 2023 Mar 27 doi: 10.55563/clinexprheumatol/ins2z2. PMID: 36995320
Sonigra A, Nel HJ, Wehr P, Ramnoruth N, Patel S, van Schie KA, Bladen MW, Mehdi AM, Tesiram J, Talekar M, Rossjohn J, Reid HH, Stuurman FE, Roberts H, Vecchio P, Gourley I, Rigby M, Becart S, Toes RE, Scherer HU, Lê Cao KA, Campbell K, Thomas R
JCI Insight 2022 Oct 24;7(20) doi: 10.1172/jci.insight.160964. PMID: 36278483Free PMC Article
Magorivska I, Döncző B, Dumych T, Karmash A, Boichuk M, Hychka K, Mihalj M, Szabó M, Csánky E, Rech J, Guttman A, Vari SG, Bilyy R
Autoimmunity 2018 May;51(3):111-117. Epub 2018 May 7 doi: 10.1080/08916934.2018.1468886. PMID: 29733234
Choi S, Lee KH
PLoS One 2018;13(4):e0195550. Epub 2018 Apr 6 doi: 10.1371/journal.pone.0195550. PMID: 29624625Free PMC Article
Langevitz P, Livneh A, Bank I, Pras M
Drug Saf 2000 May;22(5):405-14. doi: 10.2165/00002018-200022050-00007. PMID: 10830256

Prognosis

Chung MK, Lee CH, Park JS, Lim HS, Lee J
Korean J Intern Med 2023 Jan;38(1):125-133. Epub 2022 May 19 doi: 10.3904/kjim.2021.339. PMID: 35581954Free PMC Article
Gadeholt O, Hausotter K, Eberle H, Klink T, Pfeil A
Clin Rheumatol 2019 Sep;38(9):2403-2410. Epub 2019 May 23 doi: 10.1007/s10067-019-04602-5. PMID: 31123977
Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD
Nat Rev Rheumatol 2018 Sep;14(9):542-557. doi: 10.1038/s41584-018-0070-0. PMID: 30111803Free PMC Article
Choi S, Lee KH
PLoS One 2018;13(4):e0195550. Epub 2018 Apr 6 doi: 10.1371/journal.pone.0195550. PMID: 29624625Free PMC Article
Malmström V, Catrina AI, Klareskog L
Nat Rev Immunol 2017 Jan;17(1):60-75. Epub 2016 Dec 5 doi: 10.1038/nri.2016.124. PMID: 27916980

Clinical prediction guides

Min YS, Kim MG, Ahn YS
Int J Environ Res Public Health 2021 Dec 3;18(23) doi: 10.3390/ijerph182312776. PMID: 34886499Free PMC Article
Bouzit L, Malspeis S, Sparks JA, Cui J, Karlson EW, Yoshida K, Costenbader KH
Semin Arthritis Rheum 2021 Oct;51(5):1016-1022. Epub 2021 Jul 10 doi: 10.1016/j.semarthrit.2021.07.006. PMID: 34416623Free PMC Article
Rincón-Arévalo H, Rojas M, Vanegas-García A, Muñoz-Vahos C, Orejuela-Erazo J, Vásquez G, Castaño D
Clin Exp Immunol 2021 May;204(2):221-238. Epub 2021 Mar 2 doi: 10.1111/cei.13576. PMID: 33459349Free PMC Article
Gadeholt O, Hausotter K, Eberle H, Klink T, Pfeil A
Clin Rheumatol 2019 Sep;38(9):2403-2410. Epub 2019 May 23 doi: 10.1007/s10067-019-04602-5. PMID: 31123977
Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD
Nat Rev Rheumatol 2018 Sep;14(9):542-557. doi: 10.1038/s41584-018-0070-0. PMID: 30111803Free PMC Article

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