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Squamous Papilloma

MedGen UID:
61470
•Concept ID:
C0205874
•
Neoplastic Process
Synonyms: Papilloma, Squamous Cell; Papillomas, Squamous Cell; Squamous Cell Papilloma; Squamous Cell Papillomas
SNOMED CT: Squamous cell papilloma (63451008); Squamous papilloma (63451008); Keratotic papilloma (63451008)
 
HPO: HP:0031021
Monarch Initiative: MONDO:0001825

Definition

A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy [NCI thesaurus]. [from HPO]

Professional guidelines

PubMed

Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma-An Update from the Pathologist's Point of View.
Cocuz IG, Popelea MC, Niculescu R, Manea A, Sabău AH, Tinca AC, Szoke AR, Budin CE, Stoian A, Morariu SH, Cotoi TC, Cocuz ME, Cotoi OS
Int J Mol Sci 2024 Feb 13;25(4) doi: 10.3390/ijms25042220. PMID: 38396897Free PMC Article
Systemic bevacizumab for treatment of recurrent respiratory papillomatosis.
Zhao X, Wang J, Chen Q, Wu X, Mao W, Ma J, Fang R, He P, Wei C
Eur Arch Otorhinolaryngol 2024 Apr;281(4):1865-1875. Epub 2024 Jan 5 doi: 10.1007/s00405-023-08430-x. PMID: 38180605
Implication and Management of Incidental Oropharyngeal Papillomas-A Retrospective Case Series Review.
Kim D, Siegel J, Chouake RJ, Geliebter J, Zalvan CH
Ear Nose Throat J 2021 Aug;100(7):546-551. Epub 2019 Oct 3 doi: 10.1177/0145561319871228. PMID: 31581834

Recent clinical studies

Etiology

Esophageal Squamous Papilloma in Children: A Single-center Case Series.
Tou AM, Al-Nimr AO
J Pediatr Gastroenterol Nutr 2021 May 1;72(5):690-692. doi: 10.1097/MPG.0000000000003066. PMID: 33847287
Clinical and pathological diagnosis and comparison of benign and malignant eyelid tumors.
Sendul SY, Akpolat C, Yilmaz Z, Eryilmaz OT, Guven D, Kabukcuoglu F
J Fr Ophtalmol 2021 Apr;44(4):537-543. Epub 2021 Feb 18 doi: 10.1016/j.jfo.2020.07.019. PMID: 33610396
Tentacular-Type Esophageal Squamous Papilloma.
Zimmer V
Mayo Clin Proc 2019 Aug;94(8):1551. doi: 10.1016/j.mayocp.2019.03.025. PMID: 31378230
HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
The role of human papillomavirus in oral disease.
Pringle GA
Dent Clin North Am 2014 Apr;58(2):385-99. doi: 10.1016/j.cden.2013.12.008. PMID: 24655529

Diagnosis

Clinical and pathological diagnosis and comparison of benign and malignant eyelid tumors.
Sendul SY, Akpolat C, Yilmaz Z, Eryilmaz OT, Guven D, Kabukcuoglu F
J Fr Ophtalmol 2021 Apr;44(4):537-543. Epub 2021 Feb 18 doi: 10.1016/j.jfo.2020.07.019. PMID: 33610396
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
The role of human papillomavirus in oral disease.
Pringle GA
Dent Clin North Am 2014 Apr;58(2):385-99. doi: 10.1016/j.cden.2013.12.008. PMID: 24655529

Therapy

Systemic bevacizumab for treatment of recurrent respiratory papillomatosis.
Zhao X, Wang J, Chen Q, Wu X, Mao W, Ma J, Fang R, He P, Wei C
Eur Arch Otorhinolaryngol 2024 Apr;281(4):1865-1875. Epub 2024 Jan 5 doi: 10.1007/s00405-023-08430-x. PMID: 38180605
Implication and Management of Incidental Oropharyngeal Papillomas-A Retrospective Case Series Review.
Kim D, Siegel J, Chouake RJ, Geliebter J, Zalvan CH
Ear Nose Throat J 2021 Aug;100(7):546-551. Epub 2019 Oct 3 doi: 10.1177/0145561319871228. PMID: 31581834
A rapidly regressive esophageal squamous papilloma.
Khan AT, Dhorajiya P, Lung E
Gastrointest Endosc 2019 Oct;90(4):684-685. Epub 2019 May 15 doi: 10.1016/j.gie.2019.05.015. PMID: 31102642
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
A solitary bronchial papilloma with malignant changes.
Inoue Y, Oka M, Ishii H, Kimino K, Kishikawa M, Ito M, Ito T, Nakashima M, Kohno S
Intern Med 2001 Jan;40(1):56-60. doi: 10.2169/internalmedicine.40.56. PMID: 11201373

Prognosis

Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Tentacular-Type Esophageal Squamous Papilloma.
Zimmer V
Mayo Clin Proc 2019 Aug;94(8):1551. doi: 10.1016/j.mayocp.2019.03.025. PMID: 31378230
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
Human papillomavirus in sinonasal papillomas and squamous cell carcinoma.
Kashima HK, Kessis T, Hruban RH, Wu TC, Zinreich SJ, Shah KV
Laryngoscope 1992 Sep;102(9):973-6. doi: 10.1288/00005537-199209000-00003. PMID: 1325585

Clinical prediction guides

Changing Trends in Benign Human Papillomavirus (HPV) Related Epithelial Neoplasms of the Oral Cavity: 1995-2015.
Alramadhan SA, Fitzpatrick SG, Bhattacharyya I, Islam MN, Cohen DM
Head Neck Pathol 2022 Sep;16(3):738-745. Epub 2022 Mar 7 doi: 10.1007/s12105-022-01426-9. PMID: 35257322Free PMC Article
HPV RNA in-situ hybridization as a diagnostic aid in papillary laryngeal lesions.
Garcia JA, Best SR, Rooper LM
Laryngoscope 2020 Apr;130(4):955-960. Epub 2019 Jul 8 doi: 10.1002/lary.28159. PMID: 31283030
Induction of esophageal cancers by nitenpyram (NIT) in rats.
Xing LG, Wu YL, Zheng HN, Jia YY, Wu GF, Yang C
Eur Rev Med Pharmacol Sci 2018 Dec;22(24):8698-8711. doi: 10.26355/eurrev_201812_16635. PMID: 30575910
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article

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