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Inverted papilloma

MedGen UID:
61668
•Concept ID:
C0206721
•
Neoplastic Process
Synonyms: Inverted Papilloma; Inverted Papillomas; Papilloma, Inverted; Papillomas, Inverted
SNOMED CT: Benign inverted papilloma (104081000119103)
 
Monarch Initiative: MONDO:0002537

Definition

An endophytic benign papillary epithelial neoplasm that results from the invagination and proliferation of epithelial cells in the underlying stroma. Representative examples are the inverted urothelial papilloma that arises from the urinary tract and inverted Schneiderian papilloma that arises from the nasal cavity or paranasal sinuses. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Sinonasal inverted papilloma: From diagnosis to treatment.
Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431

Recent clinical studies

Etiology

Association between human papillomavirus infection and malignant transformation of sinonasal inverted papilloma: A systematic review and meta-analysis.
Ferreli F, Di Bari M, Moya-Plana A, Canzano F, Morenghi E, De Virgilio A, Mercante G, Spriano G, Colombo G
Am J Otolaryngol 2022 Nov-Dec;43(6):103614. Epub 2022 Sep 11 doi: 10.1016/j.amjoto.2022.103614. PMID: 36113312
Sinonasal inverted papilloma: From diagnosis to treatment.
Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431
Inverted papilloma: The stubbornly persistent tumor of the sinonasal cavity.
Rotenberg BW
Am J Rhinol Allergy 2016 Mar-Apr;30(2):77-8. doi: 10.2500/ajra.2016.30.4309. PMID: 26980387Free PMC Article
Inverted papilloma.
Yu LH, Ho CY, Lin CZ
Zhonghua Yi Xue Za Zhi (Taipei) 2000 May;63(5):349-54. PMID: 10862443
Inverted papilloma.
Weissler MC, Montgomery WW, Turner PA, Montgomery SK, Joseph MP
Ann Otol Rhinol Laryngol 1986 May-Jun;95(3 Pt 1):215-21. doi: 10.1177/000348948609500301. PMID: 3717844

Diagnosis

Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Editorial.
Kennedy DW
Int Forum Allergy Rhinol 2016 Dec;6(12):1219-1220. doi: 10.1002/alr.21888. PMID: 27922223
Sinonasal inverted papilloma: From diagnosis to treatment.
Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431
EDITORIAL.
Kennedy DW
Int Forum Allergy Rhinol 2015 Dec;5(12):1083-4. doi: 10.1002/alr.21692. PMID: 26769189
Inverted papilloma.
Yu LH, Ho CY, Lin CZ
Zhonghua Yi Xue Za Zhi (Taipei) 2000 May;63(5):349-54. PMID: 10862443

Therapy

Prognostic significance of p16, VEGF, and p53 expression patterns, Krouse stage, and smoking status in sinonasal inverted papillomas.
Cengiz BP
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):750-754. doi: 10.4103/ijpm.ijpm_159_21. PMID: 36308175
Surgical management of inverted papilloma; a single-center analysis of 247 patients with long follow-up.
Bugter O, Monserez DA, van Zijl FVWJ, Baatenburg de Jong RJ, Hardillo JA
J Otolaryngol Head Neck Surg 2017 Dec 20;46(1):67. doi: 10.1186/s40463-017-0246-7. PMID: 29262865Free PMC Article
Association of Krouse Classification for Sinonasal Inverted Papilloma With Recurrence: A Systematic Review and Meta-analysis.
Lisan Q, Moya-Plana A, Bonfils P
JAMA Otolaryngol Head Neck Surg 2017 Nov 1;143(11):1104-1110. doi: 10.1001/jamaoto.2017.1686. PMID: 28973390Free PMC Article
Management of inverted papilloma: review.
Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032
EDITORIAL.
Kennedy DW
Int Forum Allergy Rhinol 2015 Dec;5(12):1083-4. doi: 10.1002/alr.21692. PMID: 26769189

Prognosis

IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma.
Hakim SA, Abd Raboh NM, Shash LS
Anal Cell Pathol (Amst) 2021;2021:6639834. Epub 2021 Feb 16 doi: 10.1155/2021/6639834. PMID: 33680717Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
EGFR mutation and HPV infection in sinonasal inverted papilloma and squamous cell carcinoma.
Cabal VN, Menendez M, Vivanco B, Potes-Ares S, Riobello C, Suarez-Fernandez L, Garcia-Marin R, Blanco-Lorenzo V, Lopez F, Alvarez-Marcos C, Llorente JL, Hermsen MA
Rhinology 2020 Aug 1;58(4):368-376. doi: 10.4193/Rhin19.371. PMID: 32199023
The papillomas of the sinonasal tract. A comprehensive review.
Leoncini G, Zanetti L
Pathologica 2017 Mar;109(1):31-34. PMID: 28635991
Inverted papilloma of paranasal sinuses.
Eggers G, Mühling J, Hassfeld S
J Craniomaxillofac Surg 2007 Jan;35(1):21-9. Epub 2007 Jan 30 doi: 10.1016/j.jcms.2006.10.003. PMID: 17267229

Clinical prediction guides

IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma.
Hakim SA, Abd Raboh NM, Shash LS
Anal Cell Pathol (Amst) 2021;2021:6639834. Epub 2021 Feb 16 doi: 10.1155/2021/6639834. PMID: 33680717Free PMC Article
Benign Tumors of the Anterior Cranial Base.
Snyderman CH, Lavigne P
Adv Otorhinolaryngol 2020;84:106-113. Epub 2020 Jul 30 doi: 10.1159/000457930. PMID: 32731223
EGFR mutation and HPV infection in sinonasal inverted papilloma and squamous cell carcinoma.
Cabal VN, Menendez M, Vivanco B, Potes-Ares S, Riobello C, Suarez-Fernandez L, Garcia-Marin R, Blanco-Lorenzo V, Lopez F, Alvarez-Marcos C, Llorente JL, Hermsen MA
Rhinology 2020 Aug 1;58(4):368-376. doi: 10.4193/Rhin19.371. PMID: 32199023
Clinical features of nasal and sinonasal inverted papilloma associated with malignancy.
Miyazaki T, Haku Y, Yoshizawa A, Iwanaga K, Fujiwara T, Mizuta M, Yoshida A, Satou S, Tamaki H
Auris Nasus Larynx 2018 Oct;45(5):1014-1019. Epub 2018 Mar 13 doi: 10.1016/j.anl.2018.02.009. PMID: 29548524
Inverted papilloma.
Yu LH, Ho CY, Lin CZ
Zhonghua Yi Xue Za Zhi (Taipei) 2000 May;63(5):349-54. PMID: 10862443

Recent systematic reviews

Association between human papillomavirus infection and malignant transformation of sinonasal inverted papilloma: A systematic review and meta-analysis.
Ferreli F, Di Bari M, Moya-Plana A, Canzano F, Morenghi E, De Virgilio A, Mercante G, Spriano G, Colombo G
Am J Otolaryngol 2022 Nov-Dec;43(6):103614. Epub 2022 Sep 11 doi: 10.1016/j.amjoto.2022.103614. PMID: 36113312
A Systematic Review of Definitive Treatment for Inverted Papilloma Attachment Site and Associations With Recurrence.
Trent MS, Goshtasbi K, Hui L, Stuyt JAG, Adappa ND, Palmer JN, Kuan EC
Otolaryngol Head Neck Surg 2022 Sep;167(3):425-433. Epub 2021 Oct 12 doi: 10.1177/01945998211051975. PMID: 34637363
Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis.
Goudakos JK, Blioskas S, Nikolaou A, Vlachtsis K, Karkos P, Markou KD
Am J Rhinol Allergy 2018 May;32(3):167-174. Epub 2018 Apr 12 doi: 10.1177/1945892418765004. PMID: 29649889
Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.
Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, Bertini A, Magliulo G, Pasquini E
Eur Arch Otorhinolaryngol 2017 Aug;274(8):2991-3000. Epub 2017 Apr 21 doi: 10.1007/s00405-017-4571-2. PMID: 28432463
Management of inverted papilloma: review.
Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032

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