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Cystic, mucinous, and serous neoplasm

MedGen UID:
61678
•Concept ID:
C0206767
•
Neoplastic Process
Synonyms: Cystic, Mucinous, and Serous Neoplasms; Neoplasms, Cystic, Mucinous, and Serous
 
Monarch Initiative: MONDO:0006720

Definition

Neoplasms containing cyst-like formations or producing mucin or serum. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCystic, mucinous, and serous neoplasm

Professional guidelines

PubMed

Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines.
van Huijgevoort NCM, Del Chiaro M, Wolfgang CL, van Hooft JE, Besselink MG
Nat Rev Gastroenterol Hepatol 2019 Nov;16(11):676-689. Epub 2019 Sep 16 doi: 10.1038/s41575-019-0195-x. PMID: 31527862
European evidence-based guidelines on pancreatic cystic neoplasms.
European Study Group on Cystic Tumours of the Pancreas
Gut 2018 May;67(5):789-804. Epub 2018 Mar 24 doi: 10.1136/gutjnl-2018-316027. PMID: 29574408Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Recent clinical studies

Etiology

Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas.
Tanaka M, Fernández-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K; International Association of Pancreatology
Pancreatology 2012 May-Jun;12(3):183-97. Epub 2012 Apr 16 doi: 10.1016/j.pan.2012.04.004. PMID: 22687371
International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.
Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S; International Association of Pancreatology
Pancreatology 2006;6(1-2):17-32. doi: 10.1159/000090023. PMID: 16327281

Diagnosis

Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
Imaging of the Pancreas.
Xu MM, Sethi A
Gastroenterol Clin North Am 2016 Mar;45(1):101-16. doi: 10.1016/j.gtc.2015.10.010. PMID: 26895683
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.
Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S; International Association of Pancreatology
Pancreatology 2006;6(1-2):17-32. doi: 10.1159/000090023. PMID: 16327281

Therapy

Serous pancreatic neoplasia, data and review.
Dietrich CF, Dong Y, Jenssen C, Ciaravino V, Hocke M, Wang WP, Burmester E, Moeller K, Atkinson NS, Capelli P, D'Onofrio M
World J Gastroenterol 2017 Aug 14;23(30):5567-5578. doi: 10.3748/wjg.v23.i30.5567. PMID: 28852316Free PMC Article
Cervical cancer: A global health crisis.
Small W Jr, Bacon MA, Bajaj A, Chuang LT, Fisher BJ, Harkenrider MM, Jhingran A, Kitchener HC, Mileshkin LR, Viswanathan AN, Gaffney DK
Cancer 2017 Jul 1;123(13):2404-2412. Epub 2017 May 2 doi: 10.1002/cncr.30667. PMID: 28464289
Hormonal Maintenance Therapy for Women With Low-Grade Serous Cancer of the Ovary or Peritoneum.
Gershenson DM, Bodurka DC, Coleman RL, Lu KH, Malpica A, Sun CC
J Clin Oncol 2017 Apr 1;35(10):1103-1111. Epub 2017 Feb 21 doi: 10.1200/JCO.2016.71.0632. PMID: 28221866Free PMC Article
Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
Pancreatic cancer.
Kamisawa T, Wood LD, Itoi T, Takaori K
Lancet 2016 Jul 2;388(10039):73-85. Epub 2016 Jan 30 doi: 10.1016/S0140-6736(16)00141-0. PMID: 26830752

Prognosis

Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations.
Holloway RW, Abu-Rustum NR, Backes FJ, Boggess JF, Gotlieb WH, Jeffrey Lowery W, Rossi EC, Tanner EJ, Wolsky RJ
Gynecol Oncol 2017 Aug;146(2):405-415. Epub 2017 May 28 doi: 10.1016/j.ygyno.2017.05.027. PMID: 28566221Free PMC Article
Hormonal Maintenance Therapy for Women With Low-Grade Serous Cancer of the Ovary or Peritoneum.
Gershenson DM, Bodurka DC, Coleman RL, Lu KH, Malpica A, Sun CC
J Clin Oncol 2017 Apr 1;35(10):1103-1111. Epub 2017 Feb 21 doi: 10.1200/JCO.2016.71.0632. PMID: 28221866Free PMC Article
Management of borderline ovarian tumours.
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Clinical prediction guides

Management of Preinvasive Lesions.
Patrono MG, Corzo C, Iniesta M, Ramirez PT
Clin Obstet Gynecol 2017 Dec;60(4):771-779. doi: 10.1097/GRF.0000000000000316. PMID: 28957950
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Hormonal Maintenance Therapy for Women With Low-Grade Serous Cancer of the Ovary or Peritoneum.
Gershenson DM, Bodurka DC, Coleman RL, Lu KH, Malpica A, Sun CC
J Clin Oncol 2017 Apr 1;35(10):1103-1111. Epub 2017 Feb 21 doi: 10.1200/JCO.2016.71.0632. PMID: 28221866Free PMC Article
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent systematic reviews

It is not necessary to resect all mucinous cystic neoplasms of the pancreas: current guidelines do not reflect the actual risk of malignancy.
Pollini T, Marchegiani G, Facciorusso A, Balduzzi A, Biancotto M, Bassi C, Maker AV, Salvia R
HPB (Oxford) 2023 Jul;25(7):747-757. Epub 2023 Mar 9 doi: 10.1016/j.hpb.2023.03.001. PMID: 37003852
Pregnancy-associated mucinous cystic neoplasms of the pancreas - A systematic review.
Dhamor D, Irrinki S, Naik A, Kurdia KC, Rastogi P, Gupta P, Kapoor VK
Am J Surg 2023 Apr;225(4):630-638. Epub 2022 Nov 17 doi: 10.1016/j.amjsurg.2022.11.002. PMID: 36424200
Perineal Talc Use and Ovarian Cancer: A Systematic Review and Meta-Analysis.
Penninkilampi R, Eslick GD
Epidemiology 2018 Jan;29(1):41-49. doi: 10.1097/EDE.0000000000000745. PMID: 28863045
Nature and management of pancreatic mucinous cystic neoplasm (MCN): A systematic review of the literature.
Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A, Verdejo Gil C, Del Chiaro M, Laukkarinen J
Pancreatology 2016 Nov-Dec;16(6):1028-1036. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.011. PMID: 27681503
Serous and mucinous borderline ovarian tumours: differences in clinical presentation, high-risk histopathological features, and lethal recurrence rates.
Vasconcelos I, Darb-Esfahani S, Sehouli J
BJOG 2016 Mar;123(4):498-508. Epub 2015 Dec 25 doi: 10.1111/1471-0528.13840. PMID: 26705090

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