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Mastalgia

MedGen UID:
6239
•Concept ID:
C0024902
•
Sign or Symptom
Synonyms: Breast Pain; Breast Pains; Mammalgia; Mammalgias; Mastalgias; Mastodynia; Mastodynias; Pain, Breast; Pains, Breast
SNOMED CT: Pain of breast (53430007); Pain in the breast (53430007); Breast painful (53430007); Mastodynia (53430007); Painful breasts (53430007); Mastalgia (53430007); Breast pain (53430007)
 
HPO: HP:0034265

Definition

Pain in the breast. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMastalgia

Professional guidelines

PubMed

Management of Mastalgia.
ElSherif A, Valente SA
Surg Clin North Am 2022 Dec;102(6):929-946. doi: 10.1016/j.suc.2022.06.001. PMID: 36335929
Management of breast complaints and high-risk lesions.
Pleasant V
Best Pract Res Clin Obstet Gynaecol 2022 Sep;83:46-59. Epub 2022 Apr 4 doi: 10.1016/j.bpobgyn.2022.03.017. PMID: 35570155
Evaluation and management of breast pain.
Smith RL, Pruthi S, Fitzpatrick LA
Mayo Clin Proc 2004 Mar;79(3):353-72. doi: 10.4065/79.3.353. PMID: 15008609

Recent clinical studies

Etiology

Management of Mastalgia.
ElSherif A, Valente SA
Surg Clin North Am 2022 Dec;102(6):929-946. doi: 10.1016/j.suc.2022.06.001. PMID: 36335929
Benign Breast Disorders.
Weaver M, Stuckey A
Obstet Gynecol Clin North Am 2022 Mar;49(1):57-72. doi: 10.1016/j.ogc.2021.11.003. PMID: 35168773
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Common Breast Problems.
Salzman B, Collins E, Hersh L
Am Fam Physician 2019 Apr 15;99(8):505-514. PMID: 30990294
Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.
van Die MD, Burger HG, Teede HJ, Bone KM
Planta Med 2013 May;79(7):562-75. Epub 2012 Nov 7 doi: 10.1055/s-0032-1327831. PMID: 23136064

Diagnosis

Fibrocystic Change.
Bennett DL, Buckley A, Lee MV
Radiol Clin North Am 2024 Jul;62(4):581-592. Epub 2024 Mar 7 doi: 10.1016/j.rcl.2023.12.008. PMID: 38777535
Management of Mastalgia.
ElSherif A, Valente SA
Surg Clin North Am 2022 Dec;102(6):929-946. doi: 10.1016/j.suc.2022.06.001. PMID: 36335929
Benign Breast Disorders.
Weaver M, Stuckey A
Obstet Gynecol Clin North Am 2022 Mar;49(1):57-72. doi: 10.1016/j.ogc.2021.11.003. PMID: 35168773
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article
Common Breast Problems.
Salzman B, Collins E, Hersh L
Am Fam Physician 2019 Apr 15;99(8):505-514. PMID: 30990294

Therapy

Management of Mastalgia.
ElSherif A, Valente SA
Surg Clin North Am 2022 Dec;102(6):929-946. doi: 10.1016/j.suc.2022.06.001. PMID: 36335929
Tamoxifen in Mastalgia: A Meta-Analysis.
Sinha MK, Barman A, Sahu S, Jha AK, Asharaf AA
J Obstet Gynaecol Can 2022 Oct;44(10):1084-1094. Epub 2022 Jun 22 doi: 10.1016/j.jogc.2022.06.006. PMID: 35752405
Mastalgia.
Iddon J, Dixon JM
BMJ 2013 Dec 13;347:f3288. doi: 10.1136/bmj.f3288. PMID: 24336097
Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.
van Die MD, Burger HG, Teede HJ, Bone KM
Planta Med 2013 May;79(7):562-75. Epub 2012 Nov 7 doi: 10.1055/s-0032-1327831. PMID: 23136064
Mastodynia.
BeLieu RM
Obstet Gynecol Clin North Am 1994 Sep;21(3):461-77. PMID: 7816407

Prognosis

Factors associated with delay in seeking care for breast symptoms.
Soh JY, Yahya MM, Bachok N, Wan Zain WZ, Wong MP, Zakaria Z, Hashim Isa Merican SR, Md Hashim MN, Wan Mokhter WM, Ramely R, Zakaria AD, Mohamad IS
BMC Womens Health 2022 Jul 27;22(1):316. doi: 10.1186/s12905-022-01898-5. PMID: 35897099Free PMC Article
Fiftieth anniversary of aldosterone: from discovery to cardiovascular therapy.
Tan LB, Schlosshan D, Barker D
Int J Cardiol 2004 Sep;96(3):321-33. doi: 10.1016/j.ijcard.2004.05.004. PMID: 15310530
Evidence for the management of mastalgia.
Gumm R, Cunnick GH, Mokbel K
Curr Med Res Opin 2004 May;20(5):681-4. doi: 10.1185/030079904125003377. PMID: 15140333
Mastodynia.
BeLieu RM
Obstet Gynecol Clin North Am 1994 Sep;21(3):461-77. PMID: 7816407
Dydrogesterone and endometriosis.
Johnston WI
Br J Obstet Gynaecol 1976 Jan;83(1):77-80. doi: 10.1111/j.1471-0528.1976.tb00734.x. PMID: 1252380

Clinical prediction guides

Vitex agnus castus effects on hyperprolactinaemia.
Puglia LT, Lowry J, Tamagno G
Front Endocrinol (Lausanne) 2023;14:1269781. Epub 2023 Nov 21 doi: 10.3389/fendo.2023.1269781. PMID: 38075075Free PMC Article
The Efficacy and Safety of Medical and Surgical Therapy in Patients With Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ye Z, Silverberg SJ, Sreekanta A, Tong K, Wang Y, Chang Y, Zhang M, Guyatt G, Tangamornsuksun W, Zhang Y, Manja V, Bakaa L, Couban RJ, Brandi ML, Clarke B, Khan AA, Mannstadt M, Bilezikian JP
J Bone Miner Res 2022 Nov;37(11):2351-2372. Epub 2022 Oct 17 doi: 10.1002/jbmr.4685. PMID: 36053960
The effects of exercise on mastalgia.
Genç A, Çelebi MM, Çelik SU, Atman ED, Kocaay AF, Zergeroğlu AM, Elhan AH, Genç V
Phys Sportsmed 2017 Feb;45(1):17-21. Epub 2016 Nov 3 doi: 10.1080/00913847.2017.1252702. PMID: 27776458
Estradiol valerate/dienogest.
Wellington K, Perry CM
Drugs 2002;62(3):491-504; discussion 505-6. doi: 10.2165/00003495-200262030-00006. PMID: 11827562
Mastodynia.
BeLieu RM
Obstet Gynecol Clin North Am 1994 Sep;21(3):461-77. PMID: 7816407

Recent systematic reviews

The Efficacy and Safety of Medical and Surgical Therapy in Patients With Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ye Z, Silverberg SJ, Sreekanta A, Tong K, Wang Y, Chang Y, Zhang M, Guyatt G, Tangamornsuksun W, Zhang Y, Manja V, Bakaa L, Couban RJ, Brandi ML, Clarke B, Khan AA, Mannstadt M, Bilezikian JP
J Bone Miner Res 2022 Nov;37(11):2351-2372. Epub 2022 Oct 17 doi: 10.1002/jbmr.4685. PMID: 36053960
A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment.
Ahmad Adni LL, Norhayati MN, Mohd Rosli RR, Muhammad J
Int J Environ Res Public Health 2021 Jun 10;18(12) doi: 10.3390/ijerph18126295. PMID: 34200727Free PMC Article
Cyclic and non-cyclic breast-pain: A systematic review on pain reduction, side effects, and quality of life for various treatments.
Groen JW, Grosfeld S, Wilschut JA, Bramer WM, Ernst MF, Mullender MM
Eur J Obstet Gynecol Reprod Biol 2017 Dec;219:74-93. Epub 2017 Oct 18 doi: 10.1016/j.ejogrb.2017.10.018. PMID: 29059585
To image or not in noncyclic breast pain? A systematic review.
Martín-Díaz M, Maes-Carballo M, Khan KS, Bueno-Cavanillas A
Curr Opin Obstet Gynecol 2017 Dec;29(6):404-412. doi: 10.1097/GCO.0000000000000407. PMID: 28961632
Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.
van Die MD, Burger HG, Teede HJ, Bone KM
Planta Med 2013 May;79(7):562-75. Epub 2012 Nov 7 doi: 10.1055/s-0032-1327831. PMID: 23136064

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