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Nephropathy induced by heavy metals

MedGen UID:
625180
•Concept ID:
C0451769
•
Disease or Syndrome
Synonyms: Heavy-Metal-Induced Nephropathy; Nephropathy caused by heavy metals; Nephropathy due to heavy metals
SNOMED CT: Nephropathy due to heavy metals (197753000); Nephropathy induced by heavy metals (197753000); Nephropathy caused by heavy metals (197753000)

Definition

Damage to the kidney and renal tubules resulting from heavy metal exposure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephropathy induced by heavy metals

Professional guidelines

PubMed

Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylase Inhibitors.
Locatelli F, Minutolo R, De Nicola L, Del Vecchio L
Drugs 2022 Nov;82(16):1565-1589. Epub 2022 Nov 9 doi: 10.1007/s40265-022-01783-3. PMID: 36350500Free PMC Article
Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.
Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB; Conference Participants
Kidney Int 2021 Jun;99(6):1280-1295. Epub 2021 Apr 8 doi: 10.1016/j.kint.2021.03.020. PMID: 33839163
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article

Recent clinical studies

Etiology

Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease.
Natale P, Palmer SC, Jaure A, Hodson EM, Ruospo M, Cooper TE, Hahn D, Saglimbene VM, Craig JC, Strippoli GF
Cochrane Database Syst Rev 2022 Aug 25;8(8):CD013751. doi: 10.1002/14651858.CD013751.pub2. PMID: 36005278Free PMC Article
Recent and Emerging Therapies for Iron Deficiency in Anemia of CKD: A Review.
Bazeley JW, Wish JB
Am J Kidney Dis 2022 Jun;79(6):868-876. Epub 2021 Nov 7 doi: 10.1053/j.ajkd.2021.09.017. PMID: 34758368
The Effects of Cadmium Toxicity.
Genchi G, Sinicropi MS, Lauria G, Carocci A, Catalano A
Int J Environ Res Public Health 2020 May 26;17(11) doi: 10.3390/ijerph17113782. PMID: 32466586Free PMC Article
Nephrotoxicity and Chinese Herbal Medicine.
Yang B, Xie Y, Guo M, Rosner MH, Yang H, Ronco C
Clin J Am Soc Nephrol 2018 Oct 8;13(10):1605-1611. Epub 2018 Apr 3 doi: 10.2215/CJN.11571017. PMID: 29615394Free PMC Article
Hazards of heavy metal contamination.
Järup L
Br Med Bull 2003;68:167-82. doi: 10.1093/bmb/ldg032. PMID: 14757716

Diagnosis

The Effect of Oxidative Stress-Induced Autophagy by Cadmium Exposure in Kidney, Liver, and Bone Damage, and Neurotoxicity.
Ma Y, Su Q, Yue C, Zou H, Zhu J, Zhao H, Song R, Liu Z
Int J Mol Sci 2022 Nov 4;23(21) doi: 10.3390/ijms232113491. PMID: 36362277Free PMC Article
Recent and Emerging Therapies for Iron Deficiency in Anemia of CKD: A Review.
Bazeley JW, Wish JB
Am J Kidney Dis 2022 Jun;79(6):868-876. Epub 2021 Nov 7 doi: 10.1053/j.ajkd.2021.09.017. PMID: 34758368
Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.
Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB; Conference Participants
Kidney Int 2021 Jun;99(6):1280-1295. Epub 2021 Apr 8 doi: 10.1016/j.kint.2021.03.020. PMID: 33839163
The Effects of Cadmium Toxicity.
Genchi G, Sinicropi MS, Lauria G, Carocci A, Catalano A
Int J Environ Res Public Health 2020 May 26;17(11) doi: 10.3390/ijerph17113782. PMID: 32466586Free PMC Article
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL
Nat Commun 2019 Apr 8;10(1):1617. doi: 10.1038/s41467-019-09277-9. PMID: 30962421Free PMC Article

Therapy

Roxadustat: Do we know all the answers?
Li QY, Xiong QW, Yao X, Liu F, Tang X, Fu H, Tong T, Mao J, Peng WX
Biomol Biomed 2023 May 1;23(3):354-363. doi: 10.17305/bb.2022.8437. PMID: 36724056Free PMC Article
Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease.
Natale P, Palmer SC, Jaure A, Hodson EM, Ruospo M, Cooper TE, Hahn D, Saglimbene VM, Craig JC, Strippoli GF
Cochrane Database Syst Rev 2022 Aug 25;8(8):CD013751. doi: 10.1002/14651858.CD013751.pub2. PMID: 36005278Free PMC Article
Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.
Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB; Conference Participants
Kidney Int 2021 Jun;99(6):1280-1295. Epub 2021 Apr 8 doi: 10.1016/j.kint.2021.03.020. PMID: 33839163
Nephrotoxicity and Chinese Herbal Medicine.
Yang B, Xie Y, Guo M, Rosner MH, Yang H, Ronco C
Clin J Am Soc Nephrol 2018 Oct 8;13(10):1605-1611. Epub 2018 Apr 3 doi: 10.2215/CJN.11571017. PMID: 29615394Free PMC Article
Hazards of heavy metal contamination.
Järup L
Br Med Bull 2003;68:167-82. doi: 10.1093/bmb/ldg032. PMID: 14757716

Prognosis

Iron metabolism and chronic inflammation in IgA nephropathy.
Tian ZY, Li Z, Chu L, Liu Y, He JR, Xin Y, Li AM, Zhang H
Ren Fail 2023 Dec;45(1):2195012. doi: 10.1080/0886022X.2023.2195012. PMID: 37013479Free PMC Article
Effects of hypoxia-inducible factor-prolyl hydroxylase inhibitors vs. erythropoiesis-stimulating agents on iron metabolism in non-dialysis-dependent anemic patients with CKD: A network meta-analysis.
Yang J, Xing J, Zhu X, Xie X, Wang L, Zhang X
Front Endocrinol (Lausanne) 2023;14:1131516. Epub 2023 Mar 16 doi: 10.3389/fendo.2023.1131516. PMID: 37008953Free PMC Article
Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma.
Xu J, Hu Z, Cao H, Zhang H, Luo P, Zhang J, Wang X, Cheng Q, Li J
Front Immunol 2022;13:981764. Epub 2022 Dec 20 doi: 10.3389/fimmu.2022.981764. PMID: 36605188Free PMC Article
Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease.
Natale P, Palmer SC, Jaure A, Hodson EM, Ruospo M, Cooper TE, Hahn D, Saglimbene VM, Craig JC, Strippoli GF
Cochrane Database Syst Rev 2022 Aug 25;8(8):CD013751. doi: 10.1002/14651858.CD013751.pub2. PMID: 36005278Free PMC Article
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article

Clinical prediction guides

Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma.
Xu J, Hu Z, Cao H, Zhang H, Luo P, Zhang J, Wang X, Cheng Q, Li J
Front Immunol 2022;13:981764. Epub 2022 Dec 20 doi: 10.3389/fimmu.2022.981764. PMID: 36605188Free PMC Article
Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells.
Guo J, Wang R, Min F
J Leukoc Biol 2022 Nov;112(5):1065-1077. Epub 2022 Jun 30 doi: 10.1002/JLB.1A0422-211R. PMID: 35774015
Mercury-induced inflammation and autoimmunity.
Pollard KM, Cauvi DM, Toomey CB, Hultman P, Kono DH
Biochim Biophys Acta Gen Subj 2019 Dec;1863(12):129299. Epub 2019 Feb 10 doi: 10.1016/j.bbagen.2019.02.001. PMID: 30742953Free PMC Article
Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease.
Ueda N, Takasawa K
Nutrients 2018 Aug 27;10(9) doi: 10.3390/nu10091173. PMID: 30150549Free PMC Article
Hazards of heavy metal contamination.
Järup L
Br Med Bull 2003;68:167-82. doi: 10.1093/bmb/ldg032. PMID: 14757716

Recent systematic reviews

Effects of hypoxia-inducible factor-prolyl hydroxylase inhibitors vs. erythropoiesis-stimulating agents on iron metabolism in non-dialysis-dependent anemic patients with CKD: A network meta-analysis.
Yang J, Xing J, Zhu X, Xie X, Wang L, Zhang X
Front Endocrinol (Lausanne) 2023;14:1131516. Epub 2023 Mar 16 doi: 10.3389/fendo.2023.1131516. PMID: 37008953Free PMC Article
Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease.
Natale P, Palmer SC, Jaure A, Hodson EM, Ruospo M, Cooper TE, Hahn D, Saglimbene VM, Craig JC, Strippoli GF
Cochrane Database Syst Rev 2022 Aug 25;8(8):CD013751. doi: 10.1002/14651858.CD013751.pub2. PMID: 36005278Free PMC Article
Associations between exposure to heavy metals and the risk of chronic kidney disease: a systematic review and meta-analysis.
Jalili C, Kazemi M, Cheng H, Mohammadi H, Babaei A, Taheri E, Moradi S
Crit Rev Toxicol 2021 Feb;51(2):165-182. Epub 2021 May 7 doi: 10.1080/10408444.2021.1891196. PMID: 33960873
Drinking water heavy metal toxicity and chronic kidney diseases: a systematic review.
Farkhondeh T, Naseri K, Esform A, Aramjoo H, Naghizadeh A
Rev Environ Health 2021 Sep 27;36(3):359-366. Epub 2020 Nov 2 doi: 10.1515/reveh-2020-0110. PMID: 33128529
Cadmium and renal cancer.
Il'yasova D, Schwartz GG
Toxicol Appl Pharmacol 2005 Sep 1;207(2):179-86. doi: 10.1016/j.taap.2004.12.005. PMID: 16102569

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