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Large for gestation age fetus

MedGen UID:
628980
•Concept ID:
C0456091
•
Finding
Synonyms: Accelerated fetal growth; Accelerated foetal growth; Fetal growth acceleration; Fetal Large for Gestational Age; Fetal LGA; Fetus Large for Gestational Age; Foetal growth acceleration; Large for gestation age foetus; Large for gestational dates; Large-for-dates fetus; Large-for-dates foetus; LFD - Fetus large for dates; LFD - Foetus large for dates; LGA - Large for gestational age fetus; LGA - Large for gestational age foetus
SNOMED CT: Accelerated foetal growth (199616008); Foetal growth acceleration (199616008); Large for gestation age foetus (199616008); LFD - Foetus large for dates (199616008); LGA - Large for gestational age foetus (199616008); Large-for-dates foetus (199616008); Large-for-dates fetus (199616008); Accelerated fetal growth (199616008); Large for gestation age fetus (199616008); LGA - Large for gestational age fetus (199616008); Fetal growth acceleration (199616008); LFD - Fetus large for dates (199616008); Large for gestational dates (199616008)

Definition

A fetus exceeding 90% of expected weight for gestational age. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge for gestation age fetus

Professional guidelines

PubMed

Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Diet and Healthy Lifestyle in the Management of Gestational Diabetes Mellitus.
Rasmussen L, Poulsen CW, Kampmann U, Smedegaard SB, Ovesen PG, Fuglsang J
Nutrients 2020 Oct 6;12(10) doi: 10.3390/nu12103050. PMID: 33036170Free PMC Article
ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth.
Salomon LJ, Alfirevic Z, Da Silva Costa F, Deter RL, Figueras F, Ghi T, Glanc P, Khalil A, Lee W, Napolitano R, Papageorghiou A, Sotiriadis A, Stirnemann J, Toi A, Yeo G
Ultrasound Obstet Gynecol 2019 Jun;53(6):715-723. doi: 10.1002/uog.20272. PMID: 31169958

Recent clinical studies

Etiology

Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study.
Schlaikjær Hartwig T, Ambye L, Gruhn JR, Petersen JF, Wrønding T, Amato L, Chi-Ho Chan A, Ji B, Bro-Jørgensen MH, Werge L, Petersen MMBS, Brinkmann C, Petersen JB, Dunø M, Bache I, Herrgård MJ, Jørgensen FS, Hoffmann ER, Nielsen HS; COPL consortium
Lancet 2023 Mar 4;401(10378):762-771. Epub 2023 Feb 2 doi: 10.1016/S0140-6736(22)02610-1. PMID: 36739882
Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Abnormal Fetal Growth: Small for Gestational Age, Fetal Growth Restriction, Large for Gestational Age: Definitions and Epidemiology.
Damhuis SE, Ganzevoort W, Gordijn SJ
Obstet Gynecol Clin North Am 2021 Jun;48(2):267-279. doi: 10.1016/j.ogc.2021.02.002. PMID: 33972065
Pregnancy-related listeriosis.
Wadhwa Desai R, Smith MA
Birth Defects Res 2017 Mar 15;109(5):324-335. doi: 10.1002/bdr2.1012. PMID: 28398675
Cell-free DNA analysis for noninvasive examination of trisomy.
Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ
N Engl J Med 2015 Apr 23;372(17):1589-97. Epub 2015 Apr 1 doi: 10.1056/NEJMoa1407349. PMID: 25830321

Diagnosis

Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study.
Schlaikjær Hartwig T, Ambye L, Gruhn JR, Petersen JF, Wrønding T, Amato L, Chi-Ho Chan A, Ji B, Bro-Jørgensen MH, Werge L, Petersen MMBS, Brinkmann C, Petersen JB, Dunø M, Bache I, Herrgård MJ, Jørgensen FS, Hoffmann ER, Nielsen HS; COPL consortium
Lancet 2023 Mar 4;401(10378):762-771. Epub 2023 Feb 2 doi: 10.1016/S0140-6736(22)02610-1. PMID: 36739882
Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Pregnancy-related listeriosis.
Wadhwa Desai R, Smith MA
Birth Defects Res 2017 Mar 15;109(5):324-335. doi: 10.1002/bdr2.1012. PMID: 28398675
Systematic review of first-trimester ultrasound screening for detection of fetal structural anomalies and factors that affect screening performance.
Karim JN, Roberts NW, Salomon LJ, Papageorghiou AT
Ultrasound Obstet Gynecol 2017 Oct;50(4):429-441. Epub 2017 Sep 7 doi: 10.1002/uog.17246. PMID: 27546497
Cell-free DNA analysis for noninvasive examination of trisomy.
Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ
N Engl J Med 2015 Apr 23;372(17):1589-97. Epub 2015 Apr 1 doi: 10.1056/NEJMoa1407349. PMID: 25830321

Therapy

Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Nutritional influences on brain development.
Georgieff MK, Ramel SE, Cusick SE
Acta Paediatr 2018 Aug;107(8):1310-1321. Epub 2018 Mar 22 doi: 10.1111/apa.14287. PMID: 29468731Free PMC Article
Multiple-micronutrient supplementation for women during pregnancy.
Haider BA, Bhutta ZA
Cochrane Database Syst Rev 2017 Apr 13;4(4):CD004905. doi: 10.1002/14651858.CD004905.pub5. PMID: 28407219Free PMC Article
Management of Toxoplasma gondii infection during pregnancy.
Montoya JG, Remington JS
Clin Infect Dis 2008 Aug 15;47(4):554-66. doi: 10.1086/590149. PMID: 18624630

Prognosis

Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition.
Chang KJ, Seow KM, Chen KH
Int J Environ Res Public Health 2023 Feb 8;20(4) doi: 10.3390/ijerph20042994. PMID: 36833689Free PMC Article
Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study.
Schlaikjær Hartwig T, Ambye L, Gruhn JR, Petersen JF, Wrønding T, Amato L, Chi-Ho Chan A, Ji B, Bro-Jørgensen MH, Werge L, Petersen MMBS, Brinkmann C, Petersen JB, Dunø M, Bache I, Herrgård MJ, Jørgensen FS, Hoffmann ER, Nielsen HS; COPL consortium
Lancet 2023 Mar 4;401(10378):762-771. Epub 2023 Feb 2 doi: 10.1016/S0140-6736(22)02610-1. PMID: 36739882
Environmental factors affecting pregnancy outcomes.
Sakali AK, Papagianni M, Bargiota A, Rasic-Markovic A, Macut D, Mastorakos G
Endocrine 2023 Jun;80(3):459-469. Epub 2023 Feb 2 doi: 10.1007/s12020-023-03307-9. PMID: 36729371
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Cell-free DNA analysis for noninvasive examination of trisomy.
Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ
N Engl J Med 2015 Apr 23;372(17):1589-97. Epub 2015 Apr 1 doi: 10.1056/NEJMoa1407349. PMID: 25830321

Clinical prediction guides

The Born in Guangzhou Cohort Study enables generational genetic discoveries.
Huang S, Liu S, Huang M, He JR, Wang C, Wang T, Feng X, Kuang Y, Lu J, Gu Y, Xia X, Lin S; Born in Guangzhou Cohort Study (BIGCS) Group, Zhou W, Fu Q, Xia H, Qiu X
Nature 2024 Feb;626(7999):565-573. Epub 2024 Jan 31 doi: 10.1038/s41586-023-06988-4. PMID: 38297123
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study.
Schlaikjær Hartwig T, Ambye L, Gruhn JR, Petersen JF, Wrønding T, Amato L, Chi-Ho Chan A, Ji B, Bro-Jørgensen MH, Werge L, Petersen MMBS, Brinkmann C, Petersen JB, Dunø M, Bache I, Herrgård MJ, Jørgensen FS, Hoffmann ER, Nielsen HS; COPL consortium
Lancet 2023 Mar 4;401(10378):762-771. Epub 2023 Feb 2 doi: 10.1016/S0140-6736(22)02610-1. PMID: 36739882
Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Cell-free DNA analysis for noninvasive examination of trisomy.
Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ
N Engl J Med 2015 Apr 23;372(17):1589-97. Epub 2015 Apr 1 doi: 10.1056/NEJMoa1407349. PMID: 25830321

Recent systematic reviews

Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Impact of maternal pre-pregnancy body mass index on maternal, fetal and neonatal adverse outcomes in the worldwide populations: A systematic review and meta-analysis.
Vats H, Saxena R, Sachdeva MP, Walia GK, Gupta V
Obes Res Clin Pract 2021 Nov-Dec;15(6):536-545. Epub 2021 Nov 12 doi: 10.1016/j.orcp.2021.10.005. PMID: 34782256
Multiple-micronutrient supplementation for women during pregnancy.
Haider BA, Bhutta ZA
Cochrane Database Syst Rev 2017 Apr 13;4(4):CD004905. doi: 10.1002/14651858.CD004905.pub5. PMID: 28407219Free PMC Article
Systematic review of first-trimester ultrasound screening for detection of fetal structural anomalies and factors that affect screening performance.
Karim JN, Roberts NW, Salomon LJ, Papageorghiou AT
Ultrasound Obstet Gynecol 2017 Oct;50(4):429-441. Epub 2017 Sep 7 doi: 10.1002/uog.17246. PMID: 27546497
A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants.
Fenton TR, Kim JH
BMC Pediatr 2013 Apr 20;13:59. doi: 10.1186/1471-2431-13-59. PMID: 23601190Free PMC Article

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