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Drug-induced methemoglobinemia

MedGen UID:
632786
•Concept ID:
C0472781
•
Pathologic Function
Synonyms: Acquired methemoglobinemia; Drug Induced Methemoglobinemia; drug induced methemoglobinemia; drug-induced methemoglobinemia
SNOMED CT: Drug-induced methemoglobinemia (191390009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018740
Orphanet: ORPHA464453

Definition

A rare hematologic disease characterized by increased levels of methemoglobin in the blood due to exposure to oxidizing agents like nitrates or nitrites, a variety of medications (most commonly local anesthetics), or aniline dyes, among others. Clinical manifestations include cyanosis, dizziness, headache, dyspnea, confusion, and coma. The severity of symptoms ranges from mild to life-threatening, depending on the percentage of methemoglobin. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug-induced methemoglobinemia

Professional guidelines

PubMed

Health risk assessment for exposure to nitrate in drinking water from village wells in Semarang, Indonesia.
Sadler R, Maetam B, Edokpolo B, Connell D, Yu J, Stewart D, Park MJ, Gray D, Laksono B
Environ Pollut 2016 Sep;216:738-745. Epub 2016 Jul 8 doi: 10.1016/j.envpol.2016.06.041. PMID: 27400904
Drug-induced methaemoglobinaemia. Treatment issues.
Coleman MD, Coleman NA
Drug Saf 1996 Jun;14(6):394-405. doi: 10.2165/00002018-199614060-00005. PMID: 8828017

Recent clinical studies

Etiology

Effect of organo-selenium anticancer drugs on nitrite induced methemoglobinemia: A spectroscopic study.
Das D, Sen K
Spectrochim Acta A Mol Biomol Spectrosc 2021 Jan 15;245:118946. Epub 2020 Sep 12 doi: 10.1016/j.saa.2020.118946. PMID: 32979808
Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought.
Mitsides N, Green D, Middleton R, New D, Lamerton E, Allen J, Redshaw J, Chadwick PR, Subudhi CP, Wood G
Transpl Infect Dis 2014 Feb;16(1):37-43. Epub 2013 Nov 12 doi: 10.1111/tid.12161. PMID: 24215452
Protracted methemoglobinemia after phenazopyridine overdose in an infant.
Christensen CM, Farrar HC, Kearns GL
J Clin Pharmacol 1996 Feb;36(2):112-6. doi: 10.1002/j.1552-4604.1996.tb04175.x. PMID: 8852386

Diagnosis

A Curious Case of Methemoglobinemia Complicating a Pediatric Live Donor Liver Transplantation Surgery.
Somasundaram S, Motati H, Ahuja A, Vijai A
Transplant Proc 2023 Jun;55(5):1319-1323. Epub 2023 Mar 30 doi: 10.1016/j.transproceed.2023.02.044. PMID: 37002147
Anesthetic management of a patient with methemoglobinemia.
Groeper K, Katcher K, Tobias JD
South Med J 2003 May;96(5):504-9. doi: 10.1097/01.smj.0000051342.99317.99. PMID: 12911193
Drug-induced methemoglobinemia during thoracoscopic lung biopsy.
Lorelli DR, Morris DE, Lewis JW Jr
Ann Thorac Surg 2001 Feb;71(2):703-5. doi: 10.1016/s0003-4975(00)02175-5. PMID: 11235734
Drug-induced methemoglobinemia in a healthy 20-year-old soldier undergoing shoulder surgery.
Chalfa R, Elliott CG, Mathewson HS
Nurse Anesth 1993 Dec;4(4):202-4. PMID: 8136402
The importance of direct measurements of arterial blood gases in drug-induced methemoglobinemia.
Kolkmeier L
Heart Lung 1978 Jan-Feb;7(1):120-2. PMID: 244478

Therapy

A Curious Case of Methemoglobinemia Complicating a Pediatric Live Donor Liver Transplantation Surgery.
Somasundaram S, Motati H, Ahuja A, Vijai A
Transplant Proc 2023 Jun;55(5):1319-1323. Epub 2023 Mar 30 doi: 10.1016/j.transproceed.2023.02.044. PMID: 37002147
Troponin leak associated with drug-induced methemoglobinemia.
Cannon RD, Wagner M, Jacoby JL
Am J Emerg Med 2014 Oct;32(10):1295.e3-4. Epub 2014 Mar 19 doi: 10.1016/j.ajem.2014.03.015. PMID: 24686024
Protracted methemoglobinemia after phenazopyridine overdose in an infant.
Christensen CM, Farrar HC, Kearns GL
J Clin Pharmacol 1996 Feb;36(2):112-6. doi: 10.1002/j.1552-4604.1996.tb04175.x. PMID: 8852386
Phenazopyridine hydrochloride toxicity: a cause of drug-induced methemoglobinemia.
Green ED, Zimmerman RC, Ghurabi WH, Colohan DP
JACEP 1979 Oct;8(10):426-31. doi: 10.1016/s0361-1124(79)80409-8. PMID: 385954
Drug-induced methemoglobinemia.
Smith RP, Olson MV
Semin Hematol 1973 Jul;10(3):253-68. PMID: 4577648

Prognosis

Drug-induced methemoglobinemia in a healthy 20-year-old soldier undergoing shoulder surgery.
Chalfa R, Elliott CG, Mathewson HS
Nurse Anesth 1993 Dec;4(4):202-4. PMID: 8136402

Clinical prediction guides

A Curious Case of Methemoglobinemia Complicating a Pediatric Live Donor Liver Transplantation Surgery.
Somasundaram S, Motati H, Ahuja A, Vijai A
Transplant Proc 2023 Jun;55(5):1319-1323. Epub 2023 Mar 30 doi: 10.1016/j.transproceed.2023.02.044. PMID: 37002147
Protracted methemoglobinemia after phenazopyridine overdose in an infant.
Christensen CM, Farrar HC, Kearns GL
J Clin Pharmacol 1996 Feb;36(2):112-6. doi: 10.1002/j.1552-4604.1996.tb04175.x. PMID: 8852386

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