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Microcystic adenoma

MedGen UID:
64420
•Concept ID:
C0205648
•
Neoplastic Process
Synonyms: Adenoma, Microcystic; Adenomas, Microcystic; Microcystic Adenoma; Microcystic Adenomas
SNOMED CT: Microcystic adenoma (79494009)
 
Monarch Initiative: MONDO:0003435

Definition

A benign epithelial neoplasm characterized by a microcystic pattern. The cystic spaces are lined by small cuboidal cells without evidence of significant cytologic atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrocystic adenoma

Professional guidelines

PubMed

Magnetic resonance imaging of cystic pancreatic lesions in adults: an update in current diagnostic features and management.
Barral M, Soyer P, Dohan A, Laurent V, Hoeffel C, Fishman EK, Boudiaf M
Abdom Imaging 2014 Feb;39(1):48-65. doi: 10.1007/s00261-013-0048-y. PMID: 24263208
Comments and illustrations regarding the guidelines and good clinical practice recommendations for contrast-enhanced ultrasound (CEUS)--update 2008.
Dietrich CF
Ultraschall Med 2008 Sep;29 Suppl 4:S188-202. Epub 2008 Oct 2 doi: 10.1055/s-2008-1027799. PMID: 18833497

Recent clinical studies

Etiology

Cystic tumors of the pancreas: ultrasound, computed tomography, and magnetic resonance imaging features.
Sidden CR, Mortele KJ
Semin Ultrasound CT MR 2007 Oct;28(5):339-56. doi: 10.1053/j.sult.2007.07.001. PMID: 17970551
A giant pancreatic serous microcystic adenoma with 20 years follow-up.
Schulz HU, Kellner U, Kahl S, Effenberger O, Asperger W, Lippert H, Röcken C
Langenbecks Arch Surg 2007 Mar;392(2):209-13. Epub 2007 Jan 19 doi: 10.1007/s00423-006-0146-1. PMID: 17235583
Microcystic adenoma of the pancreas: clinical, radiologic, and cytologic features.
Lal A, Bourtsos EP, DeFrias DV, Nemcek AA, Nayar R
Cancer 2004 Oct 25;102(5):288-94. doi: 10.1002/cncr.20487. PMID: 15559952
Microcystic features at US: a nonspecific sign for microcystic adenomas of the pancreas.
Yeh HC, Stancato-Pasik A, Shapiro RS
Radiographics 2001 Nov-Dec;21(6):1455-61. doi: 10.1148/radiographics.21.6.g01nv251455. PMID: 11706216
Pancreatic cystic neoplasms.
Mathieu D, Guigui B, Valette PJ, Dao TH, Bruneton JN, Bruel JM, Pringot J, Vasile N
Radiol Clin North Am 1989 Jan;27(1):163-76. PMID: 2642272

Diagnosis

Cystic tumors of the pancreas: imaging and management.
Dewhurst CE, Mortele KJ
Radiol Clin North Am 2012 May;50(3):467-86. Epub 2012 Mar 28 doi: 10.1016/j.rcl.2012.03.001. PMID: 22560692
Solid serous adenoma of the pancreas: an uncommon but important entity.
Machado MC, Machado MA
Eur J Surg Oncol 2008 Jul;34(7):730-3. Epub 2008 Apr 25 doi: 10.1016/j.ejso.2008.03.009. PMID: 18440191
Microcystic adenoma of the pancreas: clinical, radiologic, and cytologic features.
Lal A, Bourtsos EP, DeFrias DV, Nemcek AA, Nayar R
Cancer 2004 Oct 25;102(5):288-94. doi: 10.1002/cncr.20487. PMID: 15559952
Combined serous microcystic adenoma and well-differentiated endocrine pancreatic neoplasm: a case report and review of the literature.
Slukvin II, Hafez GR, Niederhuber JE, Warner TF
Arch Pathol Lab Med 2003 Oct;127(10):1369-72. doi: 10.5858/2003-127-1369-CSMAAW. PMID: 14521452
MR imaging of pancreatic diseases.
Ito K, Koike S, Matsunaga N
Eur J Radiol 2001 May;38(2):78-93. doi: 10.1016/s0720-048x(01)00293-5. PMID: 11335090

Therapy

Use of expandable metallic biliary stents in resectable pancreatic cancer.
Wasan SM, Ross WA, Staerkel GA, Lee JH
Am J Gastroenterol 2005 Sep;100(9):2056-61. doi: 10.1111/j.1572-0241.2005.42031.x. PMID: 16128952

Prognosis

Synchronous pancreatic cancer and pancreatic serous cystic neoplasm: A case report.
Zong Y, Xiao W, Ma Y, Wang B, Yu W
J Pak Med Assoc 2023 Apr;73(4):901-904. doi: 10.47391/JPMA.5496. PMID: 37052011
A disseminated variant of pancreatic serous cystadenoma causing obstructive jaundice, a very rare entity: a case report and review of the literature.
Al-Jiffry BO, Rayzah F, Khayat SH
BMC Res Notes 2014 Oct 22;7:749. doi: 10.1186/1756-0500-7-749. PMID: 25338636Free PMC Article
A giant pancreatic serous microcystic adenoma with 20 years follow-up.
Schulz HU, Kellner U, Kahl S, Effenberger O, Asperger W, Lippert H, Röcken C
Langenbecks Arch Surg 2007 Mar;392(2):209-13. Epub 2007 Jan 19 doi: 10.1007/s00423-006-0146-1. PMID: 17235583
Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects.
Adsay NV, Basturk O, Cheng JD, Andea AA
Semin Radiat Oncol 2005 Oct;15(4):254-64. doi: 10.1016/j.semradonc.2005.04.001. PMID: 16183479
Pancreatic cystic neoplasms.
Mathieu D, Guigui B, Valette PJ, Dao TH, Bruneton JN, Bruel JM, Pringot J, Vasile N
Radiol Clin North Am 1989 Jan;27(1):163-76. PMID: 2642272

Clinical prediction guides

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758
A disseminated variant of pancreatic serous cystadenoma causing obstructive jaundice, a very rare entity: a case report and review of the literature.
Al-Jiffry BO, Rayzah F, Khayat SH
BMC Res Notes 2014 Oct 22;7:749. doi: 10.1186/1756-0500-7-749. PMID: 25338636Free PMC Article
A von Hippel-Lindau disease-associated microcystic adenoma of the ethmoid sinus: case report.
Xu DS, Dirks MS, Quezado MM, Lubensky IA, Zhuang Z, Lonser RR, Asthagiri AR
Neurosurgery 2011 Oct;69(4):E1017-21; discussion E1021-2. doi: 10.1227/NEU.0b013e318223b7a7. PMID: 21572360Free PMC Article
Neuroendocrine tumours--analysis of own material--a nine--year retrospective study.
Kaliszewski K, Bednarz W, Łukieńczuk T, Balcerzak W, Kaliszewska M, Dawiskiba J
Hepatogastroenterology 2010 Mar-Apr;57(98):236-41. PMID: 20583420
From the Archives of the AFIP. Microcystic adenoma of the pancreas.
Buck JL, Hayes WS
Radiographics 1990 Mar;10(2):313-22. doi: 10.1148/radiographics.10.2.2183300. PMID: 2183300

Recent systematic reviews

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758

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