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Hyperandrogenization syndrome

MedGen UID:
64509
Concept ID:
C0206081
Disease or Syndrome
Synonym: Hyperandrogenism
SNOMED CT: Hyperandrogenism (237793004); Hyperandrogenization syndrome (237793004)

Definition

A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperandrogenization syndrome

Professional guidelines

PubMed

Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM
Reprod Biol Endocrinol 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z. PMID: 36703143Free PMC Article
Sadeghi HM, Adeli I, Calina D, Docea AO, Mousavi T, Daniali M, Nikfar S, Tsatsakis A, Abdollahi M
Int J Mol Sci 2022 Jan 6;23(2) doi: 10.3390/ijms23020583. PMID: 35054768Free PMC Article
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621

Recent clinical studies

Etiology

Zeng X, Xie YJ, Liu YT, Long SL, Mo ZC
Clin Chim Acta 2020 Mar;502:214-221. Epub 2019 Nov 13 doi: 10.1016/j.cca.2019.11.003. PMID: 31733195
Matheson E, Bain J
Am Fam Physician 2019 Aug 1;100(3):168-175. PMID: 31361105
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Jun;131(6):e157-e171. doi: 10.1097/AOG.0000000000002656. PMID: 29794677
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621
Adv Clin Exp Med 2017 May-Jun;26(3):555-558. doi: 10.17219/acem/61987. PMID: 28791833

Diagnosis

Siddiqui S, Mateen S, Ahmad R, Moin S
J Assist Reprod Genet 2022 Nov;39(11):2439-2473. Epub 2022 Oct 3 doi: 10.1007/s10815-022-02625-7. PMID: 36190593Free PMC Article
Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, Boyle J, Teede HJ
Lancet Diabetes Endocrinol 2022 Sep;10(9):668-680. Epub 2022 Aug 4 doi: 10.1016/S2213-8587(22)00163-2. PMID: 35934017
Armanini D, Boscaro M, Bordin L, Sabbadin C
Int J Mol Sci 2022 Apr 8;23(8) doi: 10.3390/ijms23084110. PMID: 35456928Free PMC Article
Matheson E, Bain J
Am Fam Physician 2019 Aug 1;100(3):168-175. PMID: 31361105
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621

Therapy

Siddiqui S, Mateen S, Ahmad R, Moin S
J Assist Reprod Genet 2022 Nov;39(11):2439-2473. Epub 2022 Oct 3 doi: 10.1007/s10815-022-02625-7. PMID: 36190593Free PMC Article
Rashid R, Mir SA, Kareem O, Ali T, Ara R, Malik A, Amin F, Bader GN
Taiwan J Obstet Gynecol 2022 Jan;61(1):40-50. doi: 10.1016/j.tjog.2021.11.009. PMID: 35181044
Starace M, Orlando G, Alessandrini A, Piraccini BM
Am J Clin Dermatol 2020 Feb;21(1):69-84. doi: 10.1007/s40257-019-00479-x. PMID: 31677111
Matheson E, Bain J
Am Fam Physician 2019 Aug 1;100(3):168-175. PMID: 31361105
Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Hum Reprod 2004 Jan;19(1):41-7. doi: 10.1093/humrep/deh098. PMID: 14688154

Prognosis

Pkhaladze L, Russo M, Unfer V, Nordio M, Basciani S, Khomasuridze A
Eur Rev Med Pharmacol Sci 2021 Dec;25(23):7476-7485. doi: 10.26355/eurrev_202112_27447. PMID: 34919250
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Mubki T, Rudnicka L, Olszewska M, Shapiro J
J Am Acad Dermatol 2014 Sep;71(3):415.e1-415.e15. doi: 10.1016/j.jaad.2014.04.070. PMID: 25128118
Piraccini BM, Alessandrini A
G Ital Dermatol Venereol 2014 Feb;149(1):15-24. PMID: 24566563
Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF; Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Fertil Steril 2009 Feb;91(2):456-88. Epub 2008 Oct 23 doi: 10.1016/j.fertnstert.2008.06.035. PMID: 18950759

Clinical prediction guides

Guan C, Zahid S, Minhas AS, Ouyang P, Vaught A, Baker VL, Michos ED
Fertil Steril 2022 May;117(5):924-935. doi: 10.1016/j.fertnstert.2022.03.009. PMID: 35512976
Krentowska A, Kowalska I
Diabetes Metab Res Rev 2022 Jan;38(1):e3464. Epub 2021 May 14 doi: 10.1002/dmrr.3464. PMID: 33988288
Matheson E, Bain J
Am Fam Physician 2019 Aug 1;100(3):168-175. PMID: 31361105
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF; Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Fertil Steril 2009 Feb;91(2):456-88. Epub 2008 Oct 23 doi: 10.1016/j.fertnstert.2008.06.035. PMID: 18950759

Recent systematic reviews

Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM
Reprod Biol Endocrinol 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z. PMID: 36703143Free PMC Article
Gu Y, Zhou G, Zhou F, Wu Q, Ma C, Zhang Y, Ding J, Hua K
Front Endocrinol (Lausanne) 2022;13:808898. Epub 2022 Apr 13 doi: 10.3389/fendo.2022.808898. PMID: 35498415Free PMC Article
Shang Y, Zhou H, He R, Lu W
Front Endocrinol (Lausanne) 2021;12:735954. Epub 2021 Nov 1 doi: 10.3389/fendo.2021.735954. PMID: 34790167Free PMC Article
Lim SS, Kakoly NS, Tan JWJ, Fitzgerald G, Bahri Khomami M, Joham AE, Cooray SD, Misso ML, Norman RJ, Harrison CL, Ranasinha S, Teede HJ, Moran LJ
Obes Rev 2019 Feb;20(2):339-352. Epub 2018 Oct 19 doi: 10.1111/obr.12762. PMID: 30339316
Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF; Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Fertil Steril 2009 Feb;91(2):456-88. Epub 2008 Oct 23 doi: 10.1016/j.fertnstert.2008.06.035. PMID: 18950759

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