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Adenomyoma

MedGen UID:: 64617
•Concept ID:: C0206622
•: Neoplastic Process

Synonym:	Adenomyomas
SNOMED CT:	Adenomyoma (40293003)

Monarch Initiative:	MONDO:0005635

Definition

A benign neoplasm characterized by the presence of a glandular and a mesenchymal (fibromyomatous) component. It occurs in the uterine corpus, cervix, and uterine ligaments. A variant of adenomyoma associated with glandular architectural complexity is called atypical polypoid adenomyoma. Simple polypectomy is usually curative. Atypical polypoid adenomyoma may recur following polypectomy. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdenomyoma

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign Genitourinary System Neoplasm
      - Benign reproductive system neoplasm
        Benign female reproductive system neoplasm
        Adenomyoma
        Adenomyoma of uterine corpus
        Uterine corpus atypical polypoid adenomyoma
        Atypical polypoid adenomyoma
        Cervical atypical polypoid adenomyoma
        Cervical adenomyoma
        Cervical Adenomyoma, Mesonephric-Type
        Endocervical type cervical adenomyoma
        Uterine Ligament Adenomyoma

Professional guidelines

PubMed

Minimally invasive treatment of adenomyosis.

Dueholm M
Best Pract Res Clin Obstet Gynaecol 2018 Aug;51:119-137. Epub 2018 Feb 15 doi: 10.1016/j.bpobgyn.2018.01.016. PMID: 29555380

Treatment options and reproductive outcome for adenomyosis-associated infertility.

Soave I, Wenger JM, Pluchino N, Marci R
Curr Med Res Opin 2018 May;34(5):839-849. Epub 2017 Nov 10 doi: 10.1080/03007995.2017.1393404. PMID: 29046066

Medical treatment for adenomyosis and/or adenomyoma.

Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683

See all (26)

Recent clinical studies

Etiology

Mucinous Proliferations of the Uterine Corpus: Comprehensive Appraisal of an Evolving Spectrum of Neoplasms.

Fadare O
Adv Anat Pathol 2022 Sep 1;29(5):275-296. Epub 2022 May 3 doi: 10.1097/PAP.0000000000000348. PMID: 35499137

Cystic adenomyoma surgery.

Kerbage Y, Dericquebourg S, Collinet P, Verpillat P, Giraudet G, Rubod C
J Gynecol Obstet Hum Reprod 2022 Mar;51(3):102313. Epub 2022 Jan 11 doi: 10.1016/j.jogoh.2022.102313. PMID: 35031510

Uterine adenomyosis and adenomyoma: the surgical approach.

Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853

Gallbladder adenomyomatosis: Diagnosis and management.

Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704

Medical treatment for adenomyosis and/or adenomyoma.

Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683

See all (164)

Diagnosis

Cystic adenomyoma surgery.

Kerbage Y, Dericquebourg S, Collinet P, Verpillat P, Giraudet G, Rubod C
J Gynecol Obstet Hum Reprod 2022 Mar;51(3):102313. Epub 2022 Jan 11 doi: 10.1016/j.jogoh.2022.102313. PMID: 35031510

The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis.

Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458

Uterine adenomyosis and adenomyoma: the surgical approach.

Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853

Gallbladder adenomyomatosis: Diagnosis and management.

Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704

My approach to the interpretation of endometrial biopsies and curettings.

McCluggage WG
J Clin Pathol 2006 Aug;59(8):801-12. doi: 10.1136/jcp.2005.029702. PMID: 16873562 Free PMC Article

See all (384)

Therapy

Ultrasound-guided percutaneous microwave ablation of adenomyosis: a narrative review.

Zhang S, Wang K, Di A, Yu D, Yao T
Ann Palliat Med 2021 Nov;10(11):12003-12011. doi: 10.21037/apm-21-3133. PMID: 34872323

Alleviation of Symptoms and Improvement of Endometrial Receptivity Following Laparoscopic Adenomyoma Excision and Secondary Therapy with the Levonorgestrel-releasing Intrauterine System.

Wu Q, Lian Y, Chen L, Yu Y, Lin T
Reprod Sci 2020 Jun;27(6):1259-1265. Epub 2020 Jan 6 doi: 10.1007/s43032-019-00130-4. PMID: 32046429

Uterine adenomyosis and adenomyoma: the surgical approach.

Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853

Minimally invasive treatment of adenomyosis.

Dueholm M
Best Pract Res Clin Obstet Gynaecol 2018 Aug;51:119-137. Epub 2018 Feb 15 doi: 10.1016/j.bpobgyn.2018.01.016. PMID: 29555380

Medical treatment for adenomyosis and/or adenomyoma.

Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683

See all (63)

Prognosis

Gallbladder adenomyomatosis: Diagnosis and management.

Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704

Systematic review shows that pathological lead points are important and frequent in intussusception and are not limited to infants.

Fiegel H, Gfroerer S, Rolle U
Acta Paediatr 2016 Nov;105(11):1275-1279. doi: 10.1111/apa.13567. PMID: 27588829

A multiple perspectives on atypical polypoid adenomyoma of uterus.

Jiang QY, Wang L, Wu RJ
Gynecol Endocrinol 2013 Jul;29(7):623-5. Epub 2013 Mar 25 doi: 10.3109/09513590.2013.777418. PMID: 23527553

An update on adenomyosis.

Levy G, Dehaene A, Laurent N, Lernout M, Collinet P, Lucot JP, Lions C, Poncelet E
Diagn Interv Imaging 2013 Jan;94(1):3-25. Epub 2012 Dec 12 doi: 10.1016/j.diii.2012.10.012. PMID: 23246186

Pathology of mixed Müllerian tumours.

D'Angelo E, Prat J
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):705-18. Epub 2011 Jul 13 doi: 10.1016/j.bpobgyn.2011.05.010. PMID: 21742560

See all (94)

Clinical prediction guides

Atypical polypoid adenomyoma follow-up and management: Systematic review of case reports and series and meta-analysis.

Biasioli A, Londero AP, Orsaria M, Scrimin F, Mangino FP, Bertozzi S, Mariuzzi L, Cagnacci A
Medicine (Baltimore) 2020 Jun 26;99(26):e20491. doi: 10.1097/MD.0000000000020491. PMID: 32590732 Free PMC Article

Structural and molecular features of the endomyometrium in endometriosis and adenomyosis.

Benagiano G, Brosens I, Habiba M
Hum Reprod Update 2014 May-Jun;20(3):386-402. Epub 2013 Oct 18 doi: 10.1093/humupd/dmt052. PMID: 24140719

Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature.

Tahlan A, Nanda A, Mohan H
Int J Gynecol Pathol 2006 Oct;25(4):361-5. doi: 10.1097/01.pgp.0000209570.08716.b3. PMID: 16990713

Spectrum of MR features in adenomyosis.

Tamai K, Koyama T, Umeoka S, Saga T, Fujii S, Togashi K
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):583-602. Epub 2006 Mar 24 doi: 10.1016/j.bpobgyn.2006.01.009. PMID: 16564228

History of adenomyosis.

Benagiano G, Brosens I
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):449-63. Epub 2006 Mar 2 doi: 10.1016/j.bpobgyn.2006.01.007. PMID: 16515887

See all (109)

Recent systematic reviews

Extrauterine adenomyoma: A case report and systematic review of the literature.

Giorgi M, Labanca L, Centini G, Lazzeri L, Martire FG, Sorrentino E, Mancini V, Raimondo D, Raffone A, Neola D, Aru AC, Habib N, Casadio P, Seracchioli R, Zupi E
Int J Gynaecol Obstet 2024 Mar;164(3):869-901. Epub 2023 Sep 8 doi: 10.1002/ijgo.15049. PMID: 37688388

The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis.

Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458

Atypical polypoid adenomyoma follow-up and management: Systematic review of case reports and series and meta-analysis.

Systematic review shows that pathological lead points are important and frequent in intussusception and are not limited to infants.

Fiegel H, Gfroerer S, Rolle U
Acta Paediatr 2016 Nov;105(11):1275-1279. doi: 10.1111/apa.13567. PMID: 27588829

Uterus-sparing operative treatment for adenomyosis.

Grimbizis GF, Mikos T, Tarlatzis B
Fertil Steril 2014 Feb;101(2):472-87. Epub 2013 Nov 26 doi: 10.1016/j.fertnstert.2013.10.025. PMID: 24289992

See all (10)

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Adenomyoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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