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Amelanotic melanoma

MedGen UID:
64644
•Concept ID:
C0206735
•
Neoplastic Process
Synonyms: Amelanotic Melanoma; Amelanotic Melanomas; Melanoma, Amelanotic; Melanomas, Amelanotic
SNOMED CT: Amelanotic melanoma (70594002)
 
Monarch Initiative: MONDO:0002971

Definition

A melanoma characterized by the complete absence of melanin pigment in the melanoma cells. It occurs more frequently on the face and it is often associated with desmoplastic reaction. [from NCI]

Professional guidelines

PubMed

Circumscribed choroidal hemangioma: An overview of clinical manifestation, diagnosis and management.
Sen M, Honavar SG
Indian J Ophthalmol 2019 Dec;67(12):1965-1973. doi: 10.4103/ijo.IJO_2036_19. PMID: 31755430Free PMC Article
Genital melanoma: prognosis factors and treatment modality.
Ferraioli D, Lamblin G, Mathevet P, Hetu J, Berakdar I, Beurrier F, Chopin N
Arch Gynecol Obstet 2016 Nov;294(5):1037-1045. Epub 2016 Jun 30 doi: 10.1007/s00404-016-4144-4. PMID: 27365105
Surgical management of primary anorectal melanoma.
Pessaux P, Pocard M, Elias D, Duvillard P, Avril MF, Zimmerman P, Lasser P
Br J Surg 2004 Sep;91(9):1183-7. doi: 10.1002/bjs.4592. PMID: 15449271

Recent clinical studies

Etiology

Amelanotic melanoma of the head and neck: analysis of tumor characteristics from the National Cancer Database.
Huayllani MT, Boczar D, Saleem HY, Spaulding AC, Bagaria SP, Lu X, Kassis S, Perdikis G, Forte AJ
Int J Dermatol 2021 Mar;60(3):347-351. Epub 2020 Oct 11 doi: 10.1111/ijd.15243. PMID: 33040374
Clinicopathological and dermoscopic features of amelanotic and hypomelanotic melanoma: a retrospective multicentric study.
Paolino G, Bearzi P, Pampena R, Longo C, Frascione P, Rizzo N, Raucci M, Carbone A, Cantisani C, Ricci F, Didona D, Frattini F, Bulotta A, Gregorc V, Mercuri SR
Int J Dermatol 2020 Nov;59(11):1371-1380. Epub 2020 Jul 29 doi: 10.1111/ijd.15064. PMID: 32726478
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck.
Guo W, Yin G, Liu H, Duan H, Huang Z, Chen X
Acta Otolaryngol 2020 Sep;140(9):785-788. Epub 2020 May 23 doi: 10.1080/00016489.2020.1763456. PMID: 32449432
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients.
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790

Diagnosis

Acral Amelanotic Melanoma.
Bouceiro-Mendes R, Soares-de-Almeida L
Acta Med Port 2021 Jun 1;34(6):468. Epub 2021 Apr 13 doi: 10.20344/amp.13044. PMID: 33861192
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Amelanotic melanoma.
Muinonen-Martin AJ, O'Shea SJ, Newton-Bishop J
BMJ 2018 Mar 15;360:k826. doi: 10.1136/bmj.k826. PMID: 29545447
Intrasclera schwannoma.
Hosseini H, Eghtedari M, Roozitalab M, Ashraf M, Shahrzad S
BMJ Case Rep 2011 Mar 3;2011 doi: 10.1136/bcr.07.2010.3158. PMID: 22707621Free PMC Article

Therapy

Pterostilbene-Mediated Inhibition of Cell Proliferation and Cell Death Induction in Amelanotic and Melanotic Melanoma.
Wawszczyk J, Jesse K, Kapral M
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021115. PMID: 36674631Free PMC Article
Mechanisms of curcumin-based photodynamic therapy and its effects in combination with electroporation: An in vitro and molecular dynamics study.
Szlasa W, Szewczyk A, Drąg-Zalesińska M, Czapor-Irzabek H, Michel O, Kiełbik A, Cierluk K, Zalesińska A, Novickij V, Tarek M, Saczko J, Kulbacka J
Bioelectrochemistry 2021 Aug;140:107806. Epub 2021 Mar 26 doi: 10.1016/j.bioelechem.2021.107806. PMID: 33819839
Amelanotic Melanoma Concealed by Psoriasis.
Curman P, Lapins J, Radros N, Krynitz B, Wikström JD
Acta Derm Venereol 2020 Mar 12;100(6):adv00082. doi: 10.2340/00015555-3397. PMID: 31930427Free PMC Article
The diagnostic accuracy of dermoscopy and reflectance confocal microscopy for amelanotic/hypomelanotic melanoma: a systematic review and meta-analysis.
Lan J, Wen J, Cao S, Yin T, Jiang B, Lou Y, Zhu J, An X, Suo H, Li D, Zhang Y, Tao J
Br J Dermatol 2020 Aug;183(2):210-219. Epub 2019 Dec 22 doi: 10.1111/bjd.18722. PMID: 31747045
AUSTRALIAN AND NEW ZEALAND STUDY OF PHOTODYNAMIC THERAPY IN CHOROIDAL AMELANOTIC MELANOMA.
O'Day RF, Pejnovic TM, Isaacs T, Muecke JS, Glasson WJ, Campbell WG
Retina 2020 May;40(5):972-976. doi: 10.1097/IAE.0000000000002520. PMID: 30908472

Prognosis

Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck.
Guo W, Yin G, Liu H, Duan H, Huang Z, Chen X
Acta Otolaryngol 2020 Sep;140(9):785-788. Epub 2020 May 23 doi: 10.1080/00016489.2020.1763456. PMID: 32449432
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients.
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Amelanotic melanoma.
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Human mycetoma.
Samaila MO, Mbibu HN, Oluwole OP
Surg Infect (Larchmt) 2007 Oct;8(5):519-22. doi: 10.1089/sur.2006.052. PMID: 17999585
Amelanotic malignant melanoma.
Adler MJ, White CR Jr
Semin Cutan Med Surg 1997 Jun;16(2):122-30. doi: 10.1016/s1085-5629(97)80006-5. PMID: 9220551

Clinical prediction guides

Oral Amelanotic Melanomas: Clinicopathologic Features of 8 Cases and Review of the Literature.
Soares CD, Carlos R, Andrade BAB, Cunha JLS, Agostini M, Romañach MJ, Hernandez-Guerrero JC, Mosqueda-Taylor A, Almeida OP, Jorge J
Int J Surg Pathol 2021 May;29(3):263-272. Epub 2020 Jul 31 doi: 10.1177/1066896920946435. PMID: 32734791
Dermoscopic patterns of intradermal naevi.
Greco V, Cappello M, Megna M, Costa C, Villani A, Fabbrocini G, Marino V, Scalvenzi M
Australas J Dermatol 2020 Nov;61(4):337-341. Epub 2020 Jul 27 doi: 10.1111/ajd.13366. PMID: 32715462
Phenotypic and genotypic analysis of amelanotic and hypomelanotic melanoma patients.
Rayner JE, McMeniman EK, Duffy DL, De'Ambrosis B, Smithers BM, Jagirdar K, Lee KJ, Soyer HP, Sturm RA
J Eur Acad Dermatol Venereol 2019 Jun;33(6):1076-1083. Epub 2019 Mar 15 doi: 10.1111/jdv.15446. PMID: 30680790
Melanoma masquerading as nonmelanocytic lesions.
Detrixhe A, Libon F, Mansuy M, Nikkels-Tassoudji N, Rorive A, Arrese JE, Quatresooz P, Reginster MA, Nikkels AF
Melanoma Res 2016 Dec;26(6):631-634. doi: 10.1097/CMR.0000000000000294. PMID: 27537773
Hereditary sensory neuropathy type I.
Auer-Grumbach M
Orphanet J Rare Dis 2008 Mar 18;3:7. doi: 10.1186/1750-1172-3-7. PMID: 18348718Free PMC Article

Recent systematic reviews

Oral Amelanotic Melanoma: A Systematic Review of Case Reports and Case Series.
Bansal SP, Dhanawade SS, Arvandekar AS, Mehta V, Desai RS
Head Neck Pathol 2022 Jun;16(2):513-524. Epub 2021 Jul 26 doi: 10.1007/s12105-021-01366-w. PMID: 34309791Free PMC Article
The diagnostic accuracy of dermoscopy and reflectance confocal microscopy for amelanotic/hypomelanotic melanoma: a systematic review and meta-analysis.
Lan J, Wen J, Cao S, Yin T, Jiang B, Lou Y, Zhu J, An X, Suo H, Li D, Zhang Y, Tao J
Br J Dermatol 2020 Aug;183(2):210-219. Epub 2019 Dec 22 doi: 10.1111/bjd.18722. PMID: 31747045
Amelanotic Meningeal Melanoma with Leptomeningeal Dissemination: A Case Report and Systematic Literature Review.
Zhang S, Wang W, Su X, Tan Q, Sun H, Liu Z, Chen N, Gong Q, Yue Q
World Neurosurg 2019 Feb;122:229-239. Epub 2018 Nov 4 doi: 10.1016/j.wneu.2018.10.199. PMID: 30404049

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