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Nabothian cyst

MedGen UID:
6510
•Concept ID:
C0027269
•
Disease or Syndrome
Synonyms: Mucous retention cyst of cervix uteri; Naboth follicles; Nabothian Cyst; nabothian cyst; Nabothian cyst of cervix; Nabothian follicle
SNOMED CT: Nabothian cyst of cervix (767356009); Mucous retention cyst of cervix uteri (767356009); Naboth follicles (767356009); Nabothian cyst (767356009); Nabothian follicle (767356009)
 
Monarch Initiative: MONDO:0006313

Definition

A benign, mucus-filled cervical cyst that occurs when mucus-secreting columnar epithelial cells are covered with squamous epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNabothian cyst

Professional guidelines

PubMed

Nabothian cyst associated with high false-positive incidence of iodine-131 uptake in whole-body scans after treatment for differentiated thyroid cancer.
Liu S, Zhang M, Pan Y, Qu Q, Wu H, Lv J, Zhang Y
Nucl Med Commun 2013 Dec;34(12):1204-7. doi: 10.1097/MNM.0b013e328365911a. PMID: 24077637Free PMC Article
Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings.
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I
Int J Gynecol Cancer 2011 Oct;21(7):1287-96. doi: 10.1097/IGC.0b013e31821f746c. PMID: 21685796
Treatment of the Nabothian cyst.
Stepto RC
Am Fam Physician 1971 Oct;4(4):82-4. PMID: 5113876

Recent clinical studies

Etiology

Detection of high-risk human papillomavirus infected cervical biopsies samples by immunohistochemical expression of the p16 tumor marker.
Shafique M, Shoaib I, Aslam B, Khalid R, Tanvir I, Rasool MH, Shah TA, Almaary KS, Bourhia M, Qamar MU
Arch Microbiol 2023 Dec 12;206(1):17. doi: 10.1007/s00203-023-03736-0. PMID: 38085340
Limited frequency of malignant change in lobular endocervical glandular hyperplasia.
Kobara H, Miyamoto T, Ando H, Asaka R, Takatsu A, Ohya A, Asaka S, Shiozawa T
Int J Gynecol Cancer 2020 Oct;30(10):1480-1487. Epub 2020 Sep 3 doi: 10.1136/ijgc-2020-001612. PMID: 32883699Free PMC Article
Usefulness of a management protocol for patients with cervical multicystic lesions: A retrospective analysis of 94 cases and the significance of GNAS mutation.
Ando H, Miyamoto T, Kashima H, Takatsu A, Ishii K, Fujinaga Y, Shiozawa T
J Obstet Gynaecol Res 2016 Nov;42(11):1588-1598. Epub 2016 Oct 8 doi: 10.1111/jog.13083. PMID: 27718288Free PMC Article
Nabothian cyst a predominant cause of false-positive iodine uptake in uterus: comparison of SPECT/CT and pelvic MRI.
Isoda T, BaBa S, Maruoka Y, Kitamura Y, Nishie A, Sasaki M, Honda H
Clin Nucl Med 2014 Aug;39(8):680-4. doi: 10.1097/RLU.0000000000000504. PMID: 24978344
Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings.
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I
Int J Gynecol Cancer 2011 Oct;21(7):1287-96. doi: 10.1097/IGC.0b013e31821f746c. PMID: 21685796

Diagnosis

Biology and management of lobular endocervical glandular hyperplasia.
Miyamoto T, Kobara H, Shiozawa T
J Obstet Gynaecol Res 2022 Dec;48(12):3056-3067. Epub 2022 Sep 30 doi: 10.1111/jog.15441. PMID: 36177810Free PMC Article
Interpreting body MRI cases: classic findings in pelvic MRI.
Kania LM, Guglielmo F, Mitchell D
Abdom Radiol (NY) 2020 Sep;45(9):2916-2930. Epub 2020 Jun 30 doi: 10.1007/s00261-020-02615-2. PMID: 32607649
Nabothian cyst content: A potential pitfall for the diagnosis of invasive cancer on Pap test cytology.
Barrigón A, Ziadi S, Jacot-Guillarmod M, Da Silva S, Dumont M, Raineri I, Bongiovanni M
Diagn Cytopathol 2019 Feb;47(2):127-129. Epub 2018 Oct 24 doi: 10.1002/dc.24098. PMID: 30353714
Laparoscopic Excision of an Unusual Presentation of a Nabothian Cyst: Case Report and Review of the Literature.
Nassif J, Nahouli H, Mourad A, Yammine R, Khoury S, Khalil A
Surg Technol Int 2017 Dec 22;31:140-143. PMID: 29313317
A giant cervical nabothian cyst compressing the rectum, differential diagnosis and literature review.
Temur I, Ulker K, Sulu B, Karaca M, Aydin A, Gurcu B
Clin Exp Obstet Gynecol 2011;38(3):276-9. PMID: 21995165

Therapy

Feasibility of office CO2 laser surgery in patients affected by benign pathologies and congenital malformations of female lower genital tract.
Frega A, Verrone A, Schimberni M, Manzara F, Ralli E, Catalano A, Schimberni M, Torcia F, Cozza G, Bianchi P, Marziani R, Lukic A
Eur Rev Med Pharmacol Sci 2015;19(14):2528-36. PMID: 26221878
Treatment of the Nabothian cyst.
Stepto RC
Am Fam Physician 1971 Oct;4(4):82-4. PMID: 5113876

Prognosis

Usefulness of the 'cosmos pattern' for differentiating between cervical gastric-type mucin-positive lesions and other benign cervical cystic lesions in magnetic resonance images.
Ohya A, Kobara H, Miyamoto T, Komatsu M, Shiozawa T, Fujinaga Y
J Obstet Gynaecol Res 2021 Feb;47(2):745-756. Epub 2020 Dec 16 doi: 10.1111/jog.14602. PMID: 33331010
Limited frequency of malignant change in lobular endocervical glandular hyperplasia.
Kobara H, Miyamoto T, Ando H, Asaka R, Takatsu A, Ohya A, Asaka S, Shiozawa T
Int J Gynecol Cancer 2020 Oct;30(10):1480-1487. Epub 2020 Sep 3 doi: 10.1136/ijgc-2020-001612. PMID: 32883699Free PMC Article
The spectrum of grossly visible pigmented lesions in the uterine cervix: a prospective study.
Tran TA, Niu G, Tomasello CA, Tran HV, Ross JS, Carlson JA
Int J Gynecol Pathol 2014 Jan;33(1):89-99. doi: 10.1097/PGP.0b013e31827c6343. PMID: 24300541
Nabothian cyst associated with high false-positive incidence of iodine-131 uptake in whole-body scans after treatment for differentiated thyroid cancer.
Liu S, Zhang M, Pan Y, Qu Q, Wu H, Lv J, Zhang Y
Nucl Med Commun 2013 Dec;34(12):1204-7. doi: 10.1097/MNM.0b013e328365911a. PMID: 24077637Free PMC Article
Dynamic half Fourier acquisition, single shot turbo spin-echo magnetic resonance imaging for evaluating the female pelvis.
Gousse AE, Barbaric ZL, Safir MH, Madjar S, Marumoto AK, Raz S
J Urol 2000 Nov;164(5):1606-13. PMID: 11025716

Clinical prediction guides

Usefulness of the 'cosmos pattern' for differentiating between cervical gastric-type mucin-positive lesions and other benign cervical cystic lesions in magnetic resonance images.
Ohya A, Kobara H, Miyamoto T, Komatsu M, Shiozawa T, Fujinaga Y
J Obstet Gynaecol Res 2021 Feb;47(2):745-756. Epub 2020 Dec 16 doi: 10.1111/jog.14602. PMID: 33331010
Methods for Measuring and Staging a Uterine Cervical Adenocarcinoma Showing Intracystic Papillary Growth: A Case Report.
Yoshida H, Ikeda S, Tsukada T, Watanabe R, Hiraoka N, Kato T
Int J Gynecol Pathol 2018 Jul;37(4):364-367. doi: 10.1097/PGP.0000000000000416. PMID: 28700431
Feasibility of office CO2 laser surgery in patients affected by benign pathologies and congenital malformations of female lower genital tract.
Frega A, Verrone A, Schimberni M, Manzara F, Ralli E, Catalano A, Schimberni M, Torcia F, Cozza G, Bianchi P, Marziani R, Lukic A
Eur Rev Med Pharmacol Sci 2015;19(14):2528-36. PMID: 26221878
Dynamic half Fourier acquisition, single shot turbo spin-echo magnetic resonance imaging for evaluating the female pelvis.
Gousse AE, Barbaric ZL, Safir MH, Madjar S, Marumoto AK, Raz S
J Urol 2000 Nov;164(5):1606-13. PMID: 11025716
Markedly high signal intensity lesions in the uterine cervix on T2-weighted imaging: differentiation between mucin-producing carcinomas and nabothian cysts.
Li H, Sugimura K, Okizuka H, Yoshida M, Maruyama R, Takahashi K, Miyazaki K
Radiat Med 1999 Mar-Apr;17(2):137-43. PMID: 10399782

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