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Liver calculus

MedGen UID:
657845
•Concept ID:
C0574143
•
Finding
Synonyms: Hepatolith; Hepatolithiasis
SNOMED CT: Liver calculus (297288000); Hepatolith (297288000)

Definition

The presence of solitary or multiple stones in the intrahepatic bile ducts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver calculus

Professional guidelines

PubMed

Treatment of periodontitis for glycaemic control in people with diabetes mellitus.
Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, Iheozor-Ejiofor Z, Wild SH, Qureshi A, Walker A, Patel VA, Boyers D, Twigg J
Cochrane Database Syst Rev 2022 Apr 14;4(4):CD004714. doi: 10.1002/14651858.CD004714.pub4. PMID: 35420698Free PMC Article
2020 World Society of Emergency Surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis.
Pisano M, Allievi N, Gurusamy K, Borzellino G, Cimbanassi S, Boerna D, Coccolini F, Tufo A, Di Martino M, Leung J, Sartelli M, Ceresoli M, Maier RV, Poiasina E, De Angelis N, Magnone S, Fugazzola P, Paolillo C, Coimbra R, Di Saverio S, De Simone B, Weber DG, Sakakushev BE, Lucianetti A, Kirkpatrick AW, Fraga GP, Wani I, Biffl WL, Chiara O, Abu-Zidan F, Moore EE, Leppäniemi A, Kluger Y, Catena F, Ansaloni L
World J Emerg Surg 2020 Nov 5;15(1):61. doi: 10.1186/s13017-020-00336-x. PMID: 33153472Free PMC Article
Management of post-hepatectomy complications.
Jin S, Fu Q, Wuyun G, Wuyun T
World J Gastroenterol 2013 Nov 28;19(44):7983-91. doi: 10.3748/wjg.v19.i44.7983. PMID: 24307791Free PMC Article

Recent clinical studies

Etiology

Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US.
Unalp-Arida A, Ruhl CE
Hepatology 2023 Jun 1;77(6):1882-1895. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000264. PMID: 36631004
Endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline.
Manes G, Paspatis G, Aabakken L, Anderloni A, Arvanitakis M, Ah-Soune P, Barthet M, Domagk D, Dumonceau JM, Gigot JF, Hritz I, Karamanolis G, Laghi A, Mariani A, Paraskeva K, Pohl J, Ponchon T, Swahn F, Ter Steege RWF, Tringali A, Vezakis A, Williams EJ, van Hooft JE
Endoscopy 2019 May;51(5):472-491. Epub 2019 Apr 3 doi: 10.1055/a-0862-0346. PMID: 30943551
Gallstones.
Lammert F, Gurusamy K, Ko CW, Miquel JF, Méndez-Sánchez N, Portincasa P, van Erpecum KJ, van Laarhoven CJ, Wang DQ
Nat Rev Dis Primers 2016 Apr 28;2:16024. doi: 10.1038/nrdp.2016.24. PMID: 27121416
Cholelithiasis and cholecystitis.
Schirmer BD, Winters KL, Edlich RF
J Long Term Eff Med Implants 2005;15(3):329-38. doi: 10.1615/jlongtermeffmedimplants.v15.i3.90. PMID: 16022643
TRANSHEPATIC CHOLANGIOGRAPHY.
BIRCH JR, SHEA J, CURRIE DJ
Can Med Assoc J 1964 Jun 27;90(26):1442-9. PMID: 14158553Free PMC Article

Diagnosis

Endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline.
Manes G, Paspatis G, Aabakken L, Anderloni A, Arvanitakis M, Ah-Soune P, Barthet M, Domagk D, Dumonceau JM, Gigot JF, Hritz I, Karamanolis G, Laghi A, Mariani A, Paraskeva K, Pohl J, Ponchon T, Swahn F, Ter Steege RWF, Tringali A, Vezakis A, Williams EJ, van Hooft JE
Endoscopy 2019 May;51(5):472-491. Epub 2019 Apr 3 doi: 10.1055/a-0862-0346. PMID: 30943551
Gallstones.
Lammert F, Gurusamy K, Ko CW, Miquel JF, Méndez-Sánchez N, Portincasa P, van Erpecum KJ, van Laarhoven CJ, Wang DQ
Nat Rev Dis Primers 2016 Apr 28;2:16024. doi: 10.1038/nrdp.2016.24. PMID: 27121416
EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones.
European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu
J Hepatol 2016 Jul;65(1):146-181. Epub 2016 Apr 13 doi: 10.1016/j.jhep.2016.03.005. PMID: 27085810
Cholelithiasis and cholecystitis.
Schirmer BD, Winters KL, Edlich RF
J Long Term Eff Med Implants 2005;15(3):329-38. doi: 10.1615/jlongtermeffmedimplants.v15.i3.90. PMID: 16022643
TRANSHEPATIC CHOLANGIOGRAPHY.
BIRCH JR, SHEA J, CURRIE DJ
Can Med Assoc J 1964 Jun 27;90(26):1442-9. PMID: 14158553Free PMC Article

Therapy

The hepatobiliary complications of malnutrition and nutritional support in adults.
McNeice A, Scott R, Rafferty GP, Cash WJ, Turner GB
Ir J Med Sci 2019 Feb;188(1):109-117. Epub 2018 May 31 doi: 10.1007/s11845-018-1836-8. PMID: 29850987
Portal biliopathy.
Khuroo MS, Rather AA, Khuroo NS, Khuroo MS
World J Gastroenterol 2016 Sep 21;22(35):7973-82. doi: 10.3748/wjg.v22.i35.7973. PMID: 27672292Free PMC Article
Acute pancreatitis.
Johnson CD, Besselink MG, Carter R
BMJ 2014 Aug 12;349:g4859. doi: 10.1136/bmj.g4859. PMID: 25116169
Obesity and the liver: developmental perspectives.
Hoppin AG
Semin Liver Dis 2004 Nov;24(4):381-7. doi: 10.1055/s-2004-860867. PMID: 15605306
Percutaneous transhepatic cholangiography.
Okuda K
Lab Res Methods Biol Med 1983;7:405-23. PMID: 6353110

Prognosis

Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US.
Unalp-Arida A, Ruhl CE
Hepatology 2023 Jun 1;77(6):1882-1895. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000264. PMID: 36631004
Gallstones in Patients with Chronic Liver Diseases.
Li X, Guo X, Ji H, Yu G, Gao P
Biomed Res Int 2017;2017:9749802. Epub 2017 Jan 31 doi: 10.1155/2017/9749802. PMID: 28251162Free PMC Article
Management of paediatric liver trauma.
van As AB, Millar AJ
Pediatr Surg Int 2017 Apr;33(4):445-453. Epub 2016 Dec 27 doi: 10.1007/s00383-016-4046-3. PMID: 28028561
Lactoferrin in gastrointestinal disease.
Hayakawa T, Jin CX, Ko SB, Kitagawa M, Ishiguro H
Intern Med 2009;48(15):1251-4. Epub 2009 Aug 3 doi: 10.2169/internalmedicine.48.2199. PMID: 19652425
Cholelithiasis and cholecystitis.
Schirmer BD, Winters KL, Edlich RF
J Long Term Eff Med Implants 2005;15(3):329-38. doi: 10.1615/jlongtermeffmedimplants.v15.i3.90. PMID: 16022643

Clinical prediction guides

Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US.
Unalp-Arida A, Ruhl CE
Hepatology 2023 Jun 1;77(6):1882-1895. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000264. PMID: 36631004
2020 World Society of Emergency Surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis.
Pisano M, Allievi N, Gurusamy K, Borzellino G, Cimbanassi S, Boerna D, Coccolini F, Tufo A, Di Martino M, Leung J, Sartelli M, Ceresoli M, Maier RV, Poiasina E, De Angelis N, Magnone S, Fugazzola P, Paolillo C, Coimbra R, Di Saverio S, De Simone B, Weber DG, Sakakushev BE, Lucianetti A, Kirkpatrick AW, Fraga GP, Wani I, Biffl WL, Chiara O, Abu-Zidan F, Moore EE, Leppäniemi A, Kluger Y, Catena F, Ansaloni L
World J Emerg Surg 2020 Nov 5;15(1):61. doi: 10.1186/s13017-020-00336-x. PMID: 33153472Free PMC Article
Endoscopic assessment of primary sclerosing cholangitis.
De Vries B, Weersma RK
Minerva Gastroenterol Dietol 2016 Mar;62(1):49-62. Epub 2015 Oct 7 PMID: 26446685
Management of post-hepatectomy complications.
Jin S, Fu Q, Wuyun G, Wuyun T
World J Gastroenterol 2013 Nov 28;19(44):7983-91. doi: 10.3748/wjg.v19.i44.7983. PMID: 24307791Free PMC Article
Cholelithiasis and cholecystitis.
Schirmer BD, Winters KL, Edlich RF
J Long Term Eff Med Implants 2005;15(3):329-38. doi: 10.1615/jlongtermeffmedimplants.v15.i3.90. PMID: 16022643

Recent systematic reviews

Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease.
Lyu J, Lin Q, Fang Z, Xu Z, Liu Z
Front Endocrinol (Lausanne) 2022;13:1032557. Epub 2022 Nov 23 doi: 10.3389/fendo.2022.1032557. PMID: 36506064Free PMC Article
Systematic review-pancreatic involvement in inflammatory bowel disease.
Massironi S, Fanetti I, Viganò C, Pirola L, Fichera M, Cristoferi L, Capurso G, Invernizzi P, Danese S
Aliment Pharmacol Ther 2022 Jun;55(12):1478-1491. Epub 2022 May 3 doi: 10.1111/apt.16949. PMID: 35505465Free PMC Article
Treatment of periodontitis for glycaemic control in people with diabetes mellitus.
Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, Iheozor-Ejiofor Z, Wild SH, Qureshi A, Walker A, Patel VA, Boyers D, Twigg J
Cochrane Database Syst Rev 2022 Apr 14;4(4):CD004714. doi: 10.1002/14651858.CD004714.pub4. PMID: 35420698Free PMC Article
Non-alcoholic fatty liver disease and the risk of urolithiasis: A systematic review and meta-analysis.
Qin S, Wang S, Wang X, Wang J
Medicine (Baltimore) 2018 Aug;97(35):e12092. doi: 10.1097/MD.0000000000012092. PMID: 30170429Free PMC Article
Significant Association Between Gallstone Disease and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
Jaruvongvanich V, Sanguankeo A, Upala S
Dig Dis Sci 2016 Aug;61(8):2389-2396. Epub 2016 Mar 18 doi: 10.1007/s10620-016-4125-2. PMID: 26993825

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