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Nail changes

MedGen UID:: 65893
•Concept ID:: C0234909
•: Finding

Synonym:	Nail Changes
SNOMED CT:	Nail changes (416596008)

Definition

Alteration of the normal characteristics of the fingernails or toenails. Examples include thickening, thinning, deformity, and separation from the nail bed. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNail changes

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Site or System
    - Integumentary system finding
      - Nail changes
        Nail dystrophy
        Beau lines
        Central nail canal
        Dystrophic fingernails
        Dystrophic toenail
        Nail discoloration
        Leukonychia
        Nail pits
        Onychomadesis
        Onycholysis
        Onycholysis of fingernails
        Recurrent loss of toenails and fingernails
        Paronychial Inflammation
        Ridged nail

Professional guidelines

PubMed

Diagnosis and surgical treatment of benign nail unit tumors.

Starace M, Rubin AI, Di Chiacchio NG, Pampaloni F, Alessandrini A, Piraccini BM, Iorizzo M
J Dtsch Dermatol Ges 2023 Feb;21(2):116-129. doi: 10.1111/ddg.14942. PMID: 36808456

Optimal diagnosis and management of common nail disorders.

Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267 Free PMC Article

Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.

Miller KK, Gorcey L, McLellan BN
J Am Acad Dermatol 2014 Oct;71(4):787-94. Epub 2014 May 1 doi: 10.1016/j.jaad.2014.03.019. PMID: 24795111

See all (39)

Recent clinical studies

Etiology

Common Skin Conditions During Pregnancy.

Erlandson M, Wertz MC, Rosenfeld E
Am Fam Physician 2023 Feb;107(2):152-158. PMID: 36791447

Nail involvement in autosomal recessive congenital ichthyosis.

Zaouak A, Chamli A, Ben Mansour N, Jouini W, Fenniche S, Hammami H
Clin Dermatol 2022 Jul-Aug;40(4):388-394. Epub 2022 Feb 15 doi: 10.1016/j.clindermatol.2022.02.012. PMID: 35181410

Pediatric Alopecia Areata.

Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186

Psoriatic arthritis and nail changes: exploring the relationship.

Sandre MK, Rohekar S
Semin Arthritis Rheum 2014 Oct;44(2):162-9. Epub 2014 May 6 doi: 10.1016/j.semarthrit.2014.05.002. PMID: 24932889

Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.

Miller KK, Gorcey L, McLellan BN
J Am Acad Dermatol 2014 Oct;71(4):787-94. Epub 2014 May 1 doi: 10.1016/j.jaad.2014.03.019. PMID: 24795111

See all (199)

Diagnosis

Optimal diagnosis and management of common nail disorders.

Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267 Free PMC Article

Nail changes in diabetes.

Yesudian PD, Nwabudike LC, de Berker D
Clin Exp Dermatol 2022 Jan;47(1):9-15. Epub 2021 Sep 21 doi: 10.1111/ced.14859. PMID: 34293827

Common diseases of the nail: Diagnosis and therapy.

Löser CR, Nenoff P, Mainusch O, Dippel E, Balakirski G
J Dtsch Dermatol Ges 2021 Dec;19(12):1761-1775. Epub 2021 Dec 4 doi: 10.1111/ddg.14627. PMID: 34862725

Pediatric Alopecia Areata.

Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186

A review of vitamin B12 in dermatology.

Brescoll J, Daveluy S
Am J Clin Dermatol 2015 Feb;16(1):27-33. doi: 10.1007/s40257-014-0107-3. PMID: 25559140

See all (309)

Therapy

Efficacy and Safety of Nail Psoriasis Targeted Therapies: A Systematic Review.

Hwang JK, Ricardo JW, Lipner SR
Am J Clin Dermatol 2023 Sep;24(5):695-720. Epub 2023 May 20 doi: 10.1007/s40257-023-00786-4. PMID: 37209391

Pediatric Alopecia Areata.

Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186

Nail changes.

Wells T
BMJ 2015 Nov 13;351:h6072. doi: 10.1136/bmj.h6072. PMID: 26567121

A review of vitamin B12 in dermatology.

Brescoll J, Daveluy S
Am J Clin Dermatol 2015 Feb;16(1):27-33. doi: 10.1007/s40257-014-0107-3. PMID: 25559140

Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.

Miller KK, Gorcey L, McLellan BN
J Am Acad Dermatol 2014 Oct;71(4):787-94. Epub 2014 May 1 doi: 10.1016/j.jaad.2014.03.019. PMID: 24795111

See all (272)

Prognosis

Dermatologic Adverse Events in Oncologic Therapies.

Čeović R, Kovačec L, Bukvić Mokos Z, Marinović B
Acta Dermatovenerol Croat 2022 Dec;30(4):237-249. PMID: 36919390

Inflammatory nail conditions. Part 1: nail changes in psoriasis.

Yesudian PD, de Berker DAR
Clin Exp Dermatol 2021 Jan;46(1):9-15. Epub 2020 Jul 31 doi: 10.1111/ced.14351. PMID: 33220008

Pediatric Alopecia Areata.

Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186

Nail changes in alopecia areata: an update and review.

Chelidze K, Lipner SR
Int J Dermatol 2018 Jul;57(7):776-783. Epub 2018 Jan 10 doi: 10.1111/ijd.13866. PMID: 29318582

Chemotherapy-induced hand-foot syndrome and nail changes: a review of clinical presentation, etiology, pathogenesis, and management.

Miller KK, Gorcey L, McLellan BN
J Am Acad Dermatol 2014 Oct;71(4):787-94. Epub 2014 May 1 doi: 10.1016/j.jaad.2014.03.019. PMID: 24795111

See all (140)

Clinical prediction guides

Efficacy and Safety of Nail Psoriasis Targeted Therapies: A Systematic Review.

Hwang JK, Ricardo JW, Lipner SR
Am J Clin Dermatol 2023 Sep;24(5):695-720. Epub 2023 May 20 doi: 10.1007/s40257-023-00786-4. PMID: 37209391

Pediatric Alopecia Areata.

Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186

Psoriatic arthritis and nail changes: exploring the relationship.

Sandre MK, Rohekar S
Semin Arthritis Rheum 2014 Oct;44(2):162-9. Epub 2014 May 6 doi: 10.1016/j.semarthrit.2014.05.002. PMID: 24932889

Drug-induced nail abnormalities.

Piraccini BM, Iorizzo M, Tosti A
Am J Clin Dermatol 2003;4(1):31-7. doi: 10.2165/00128071-200304010-00004. PMID: 12477371

Nail-patella syndrome.

Sabnis SG, Antonovych TT, Argy WP, Rakowski TA, Gandy DR, Salcedo JR
Clin Nephrol 1980 Sep;14(3):148-53. PMID: 7418282

See all (173)

Recent systematic reviews

Efficacy and Safety of Nail Psoriasis Targeted Therapies: A Systematic Review.

Hwang JK, Ricardo JW, Lipner SR
Am J Clin Dermatol 2023 Sep;24(5):695-720. Epub 2023 May 20 doi: 10.1007/s40257-023-00786-4. PMID: 37209391

Metastases to the nail unit and distal phalanx: a systematic review.

Curtis KL, Lipner SR
Arch Dermatol Res 2023 Apr;315(3):347-358. Epub 2022 Oct 19 doi: 10.1007/s00403-022-02411-6. PMID: 36260150

Ibrutinib-associated dermatologic toxicities: A systematic review and meta-analysis.

Nocco S, Andriano TM, Bose A, Chilov M, Godwin K, Dranitsaris G, Wu S, Lacouture ME, Roeker LE, Mato AR, Markova A
Crit Rev Oncol Hematol 2022 Jun;174:103696. Epub 2022 May 6 doi: 10.1016/j.critrevonc.2022.103696. PMID: 35523374

Nail manifestations in atopic dermatitis: a systematic review.

Chng WQ, Yew YW
Int J Dermatol 2020 Jun;59(6):670-676. Epub 2019 Dec 3 doi: 10.1111/ijd.14726. PMID: 31793663

The risk of nail changes with epidermal growth factor receptor inhibitors: a systematic review of the literature and meta-analysis.

Garden BC, Wu S, Lacouture ME
J Am Acad Dermatol 2012 Sep;67(3):400-8. Epub 2011 Nov 16 doi: 10.1016/j.jaad.2011.10.009. PMID: 22088429

See all (11)

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Nail changes

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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